General Information:

Id: 1,397
Diseases: Parkinson disease
Mus musculus
BTO:0000142 brain; BTO:0003945 MN-9D cell
article
Reference: Perez RG et al.(2002) A role for alpha-synuclein in the regulation of dopamine biosynthesis J. Neurosci. 22: 3090-3099 [PMID: 11943812]

Interaction Information:

Comment Alpha-synuclein interacts with tyrosine hydroxylase in brain homogenates and MN9D dopaminergic cells.
Formal Description
Interaction-ID: 9665

gene/protein

SNCA

interacts (colocalizes) with

gene/protein

TH

Drugbank entries Show/Hide entries for TH
Comment Overexpression of wild-type or A53T mutant alpha-synuclein did not significantly alter tyrosine hydroxylase protein levels in our stably transfected cells. However, overexpressing cell lines had significantly reduced tyrosine hydroxylase activity and a corresponding reduction in dopamine synthesis.
Formal Description
Interaction-ID: 9666

gene/protein

SNCA

decreases_activity of

gene/protein

TH

if SNCA is overexpressed
Drugbank entries Show/Hide entries for TH
Comment Overexpression of wild-type or A53T mutant alpha-synuclein did not significantly alter tyrosine hydroxylase protein levels in our stably transfected cells. However, overexpressing cell lines had significantly reduced tyrosine hydroxylase activity and a corresponding reduction in dopamine synthesis.
Formal Description
Interaction-ID: 9667

gene/protein mutant

SNCA-p.A53T

decreases_activity of

gene/protein

TH

Drugbank entries Show/Hide entries for TH
Comment Overexpression of wild-type or A53T mutant alpha-synuclein did not significantly alter tyrosine hydroxylase protein levels in our stably transfected cells. However, overexpressing cell lines had significantly reduced tyrosine hydroxylase activity and a corresponding reduction in dopamine synthesis.
Formal Description
Interaction-ID: 9668

gene/protein

SNCA

decreases_quantity of

drug/chemical compound

Dopamine

via reduction of TH activity
Drugbank entries Show/Hide entries for
Comment Overexpression of wild-type or A53T mutant alpha-synuclein did not significantly alter tyrosine hydroxylase protein levels in our stably transfected cells. However, overexpressing cell lines had significantly reduced tyrosine hydroxylase activity and a corresponding reduction in dopamine synthesis.
Formal Description
Interaction-ID: 9669

gene/protein mutant

SNCA-p.A53T

decreases_activity of

drug/chemical compound

Dopamine

via reduction of TH activity
Drugbank entries Show/Hide entries for
Comment Alpha-synuclein mutant A53T interacts with tyrosine hydroxylase in brain homogenates and MN9D dopaminergic cells.
Formal Description
Interaction-ID: 9670

gene/protein mutant

SNCA-p.A53T

interacts (colocalizes) with

gene/protein

TH

Drugbank entries Show/Hide entries for TH