General Information:

Id: 1,391 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Mus musculus
BTO:0003945 MN-9D cell
article
Reference: Wang J et al.(2009) 14-3-3zeta contributes to tyrosine hydroxylase activity in MN9D cells: localization of dopamine regulatory proteins to mitochondria J. Biol. Chem. 284 [PMID: 19289463]

Interaction Information:

Comment Knockdown of 14-3-3zeta but not 14-3-3eta reduced the levels of DOPA and DA in MN9D cells, suggesting the possibility that an interaction between 14-3-3zeta and TH physiologically contributes to DA synthesis in midbrain dopaminergic neuronal cells.
Formal Description
Interaction-ID: 9657

gene/protein

YWHAZ

increases_quantity of

drug/chemical compound

Dopamine

via interaction of 14-3-3zeta with TH resulting in activation of TH
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