General Information:

Id: 1,391
Diseases: Parkinson disease
Mus musculus
BTO:0003945 MN-9D cell
article
Reference: Wang J et al.(2009) 14-3-3zeta contributes to tyrosine hydroxylase activity in MN9D cells: localization of dopamine regulatory proteins to mitochondria J. Biol. Chem. 284 [PMID: 19289463]

Interaction Information:

Comment Co-immunoprecipitation of 14-3-3 brings down phosphorylated TH in MN9D cells.
Formal Description
Interaction-ID: 9597

gene/protein

14-3-3 protein

interacts (colocalizes) with

gene/protein

TH

Drugbank entries Show/Hide entries for TH
Comment Knockdown of 14-3-3zeta but not 14-3-3eta reduced the levels of DOPA and DA in MN9D cells, suggesting the possibility that an interaction between 14-3-3zeta and TH physiologically contributes to DA synthesis in midbrain dopaminergic neuronal cells.
Formal Description
Interaction-ID: 9657

gene/protein

YWHAZ

increases_quantity of

drug/chemical compound

Dopamine

via interaction of 14-3-3zeta with TH resulting in activation of TH
Drugbank entries Show/Hide entries for
Comment 14-3-3zeta siRNA significantly reduced phosphorylation of mitochondrial TH.
Formal Description
Interaction-ID: 9659

gene/protein

YWHAZ

increases_phosphorylation of

gene/protein

TH

Drugbank entries Show/Hide entries for TH
Comment Knockdown of 14-3-3zeta but not 14-3-3eta reduced the levels of DOPA and DA in MN9D cells, suggesting the possibility that an interaction between 14-3-3zeta and TH physiologically contributes to DA synthesis in midbrain dopaminergic neuronal cells.
Formal Description
Interaction-ID: 9660

gene/protein

YWHAH

NOT increases_quantity of

drug/chemical compound

Dopamine

Drugbank entries Show/Hide entries for
Comment TH and 14-3-3zeta co-localized to mitochondria in MN9D cells.
Formal Description
Interaction-ID: 9662

gene/protein

YWHAZ

is localized in

cellular component

mitochondrion

Comment TH and 14-3-3zeta co-localized to mitochondria in MN9D cells.
Formal Description
Interaction-ID: 9664

gene/protein

TH

is localized in

cellular component

mitochondrion

Drugbank entries Show/Hide entries for TH