CIDeRplusGeneral Information:
| Id: | 1,356 (click here to show other Interactions for entry) |
| Diseases: |
Parkinson disease
|
| Mus musculus | |
| article | |
| Reference: | Perier C et al.(2005) Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage Proc. Natl. Acad. Sci. U.S.A. 52 [PMID: 16365298] |
Interaction Information:
| Comment | ROS generated by complex I inhibition with MPTP oxidize the inner mitochondrial lipid cardiolipin. Oxidative modifications of cardiolipin induce the release of cytochrome c from the inner mitochondrial membrane. |
|
Formal Description Interaction-ID: 9280 |
drug/chemical compound increases_quantity of drug/chemical compound Reactive oxygen species |