CIDeRplusGeneral Information:
| Id: | 1,356 |
| Diseases: |
Parkinson disease
|
| Mus musculus | |
| article | |
| Reference: | Perier C et al.(2005) Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage Proc. Natl. Acad. Sci. U.S.A. 52 [PMID: 16365298] |
Interaction Information:
| Comment | Deficits of complex I stimulate intramitochondrial oxidative stress, which, in turn, increase the releasable soluble pool of cytochrome c within the mitochondrial intermembrane space. |
|
Formal Description Interaction-ID: 9250 |
complex/PPI Mitochondrial respiratory chain complex I decreases_activity of process |
| Comment | Deficits of complex I stimulate intramitochondrial oxidative stress, which, in turn, increase the releasable soluble pool of cytochrome c within the mitochondrial intermembrane space. |
|
Formal Description Interaction-ID: 9251 |
process increases_quantity of gene/protein |
| Drugbank entries | Show/Hide entries for CYCS |
| Comment | Mitochondrial release of cytochrome c does occur in MPTP-intoxicated mice. |
|
Formal Description Interaction-ID: 9252 |
drug/chemical compound increases_quantity of gene/protein |
| Drugbank entries | Show/Hide entries for CYCS |
| Comment | Relocation of Bax from the cytosol to the mitochondria is accompanied with a mitochondrial release of cytochrome c and activation of caspase-9 and -3. |
|
Formal Description Interaction-ID: 9253 |
gene/protein increases_activity of |
| Comment | Relocation of Bax from the cytosol to the mitochondria is accompanied with a mitochondrial release of cytochrome c and activation of caspase-9 and -3. |
|
Formal Description Interaction-ID: 9259 |
gene/protein increases_activity of process |
| Drugbank entries | Show/Hide entries for CYCS |
| Comment | Relocation of Bax from the cytosol to the mitochondria is accompanied with a mitochondrial release of cytochrome c and activation of caspase-9 and -3. |
|
Formal Description Interaction-ID: 9260 |
|
| Drugbank entries | Show/Hide entries for CYCS |
| Comment | Relocation of Bax from the cytosol to the mitochondria is accompanied with a mitochondrial release of cytochrome c and activation of caspase-9 and -3. |
|
Formal Description Interaction-ID: 9261 |
|
| Drugbank entries | Show/Hide entries for CYCS or CASP3 |
| Comment | MPTP causes neuronal apoptosis. |
|
Formal Description Interaction-ID: 9262 |
drug/chemical compound increases_activity of process |
| Comment | ROS generated by complex I inhibition with MPTP oxidize the inner mitochondrial lipid cardiolipin. Oxidative modifications of cardiolipin induce the release of cytochrome c from the inner mitochondrial membrane. |
|
Formal Description Interaction-ID: 9280 |
drug/chemical compound increases_quantity of drug/chemical compound Reactive oxygen species |
| Comment | ROS generated by complex I inhibition with MPTP oxidize the inner mitochondrial lipid cardiolipin. Oxidative modifications of cardiolipin induce the release of cytochrome c from the inner mitochondrial membrane. |
|
Formal Description Interaction-ID: 9281 |
drug/chemical compound increases_activity of |
| Drugbank entries | Show/Hide entries for Cardiolipin |
| Comment | ROS generated by complex I inhibition with MPTP oxidize the inner mitochondrial lipid cardiolipin. Oxidative modifications of cardiolipin induce the release of cytochrome c from the inner mitochondrial membrane. |
|
Formal Description Interaction-ID: 9494 |
drug/chemical compound increases_activity of process |
| Comment | Mitochondrial release of cytochrome c does occur in MPTP-intoxicated mice. |
|
Formal Description Interaction-ID: 13592 |
drug/chemical compound increases_activity of |
| Comment | Relocation of Bax from the cytosol to the mitochondria is accompanied with a mitochondrial release of cytochrome c and activation of caspase-9 and -3. |
|
Formal Description Interaction-ID: 13593 |
increases_activity of process |