General Information:

Id: 1,249 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Mammalia
CDC cell culture (85% neuronal/12% astrocytic cultures)
article
Reference: Bal-Price A and Brown GC(2001) Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity J. Neurosci. 21: 6480-6491 [PMID: 11517237]

Interaction Information:

Comment Nitric oxide produced by activated microglia or astrocytes rapidly and reversibly inhibits mitochondrial respiration of surrounding neurons.
Formal Description
Interaction-ID: 8457

drug/chemical compound

NO

decreases_activity of

process

oxidative phosphorylation

in mitochondria