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Field	Query

	Field	Term

General Information:

Id:	1,249
Diseases:	Parkinson disease
Organism:	Mammalia
Tissue/Cell line:	CDC cell culture (85% neuronal/12% astrocytic cultures)
Publication type:	article
Reference:	Bal-Price A and Brown GC(2001) Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity J. Neurosci. 21: 6480-6491 [PMID: 11517237]

Interaction Information:

Comment	Nitric oxide produced by activated microglia and astrocytes induces excitotoxic cell death of CGCs in culture.
Formal Description Interaction-ID: 8454	process microglial cell activation increases_quantity of drug/chemical compound NO

Comment	Nitric oxide produced by activated microglia and astrocytes induces excitotoxic cell death of CGCs in culture.
Formal Description Interaction-ID: 8455	drug/chemical compound NO increases_activity of process neuron death

Comment	Nitric oxide produced by activated microglia and astrocytes induces excitotoxic cell death of CGCs in culture.
Formal Description Interaction-ID: 8456	process astrocyte activation increases_quantity of drug/chemical compound NO

Comment	Nitric oxide produced by activated microglia or astrocytes rapidly and reversibly inhibits mitochondrial respiration of surrounding neurons.
Formal Description Interaction-ID: 8457	drug/chemical compound NO decreases_activity of process oxidative phosphorylation in mitochondria

Comment	Nitric oxide causes glutamate release from neurons.
Formal Description Interaction-ID: 8459	drug/chemical compound NO increases_quantity of drug/chemical compound Glutamate

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