CIDeRplusGeneral Information:
| Id: | 1,218 (click here to show other Interactions for entry) |
| Diseases: |
Parkinson disease
|
| Mus musculus | |
| SYN-WT+/+, transgenic mouse model overexpressing human wild-type SYN under control of the 9-kb rat tyrosine hydroxylase promoter | |
| BTO:0000078 microglia | |
| article | |
| Reference: | Su X et al.(2008) Synuclein activates microglia in a model of Parkinsons disease Neurobiol. Aging 29: 1690-1701 [PMID: 17537546] |
Interaction Information:
| Comment | SYN triggers microglial-derived proinflammatory events including up-regulation of cytokines (TNFalpha, IL1beta, IL6), enzymes (COX2, NOX2,INOS) and subsequently mediators of reactive oxygen species generation. |
|
Formal Description Interaction-ID: 8197 |
gene/protein increases_quantity of drug/chemical compound Reactive oxygen species |