CIDeRplusGeneral Information:
| Id: | 1,218 |
| Diseases: |
Parkinson disease
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| Mus musculus | |
| SYN-WT+/+, transgenic mouse model overexpressing human wild-type SYN under control of the 9-kb rat tyrosine hydroxylase promoter | |
| BTO:0000078 microglia | |
| article | |
| Reference: | Su X et al.(2008) Synuclein activates microglia in a model of Parkinsons disease Neurobiol. Aging 29: 1690-1701 [PMID: 17537546] |
Interaction Information:
| Comment | Number of activated microglia cells increases after overexpression of alpha-synuclein. Total number o microglia is unchanged. |
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Formal Description Interaction-ID: 8180 |
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| Comment | Expression of the microglial cell markers Iba 1 and F4/80 increases in SYN-WT+/+ compared to age-match NTG mice. |
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Formal Description Interaction-ID: 8181 |
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| Comment | Expression of TNFalpha increases in SYN-WT+/+ compared to age-match NTG mice. The up-regulation of this proinflammatory molecule supports a role for inflammation and microglial activation in this model of SYN overexpression. |
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Formal Description Interaction-ID: 8182 |
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| Drugbank entries | Show/Hide entries for TNF |
| Comment | Expression of TNFalpha increases in SYN-WT+/+ compared to age-match NTG mice. The up-regulation of this proinflammatory molecule supports a role for inflammation and microglial activation in this model of SYN overexpression. |
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Formal Description Interaction-ID: 8183 |
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| Drugbank entries | Show/Hide entries for TNF |
| Comment | Expression of TNFalpha increases in SYN-WT+/+ compared to age-match NTG mice. The up-regulation of this proinflammatory molecule supports a role for inflammation and microglial activation in this model of SYN overexpression. |
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Formal Description Interaction-ID: 8184 |
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| Drugbank entries | Show/Hide entries for TNF |
| Comment | SYN triggers microglial-derived proinflammatory events including up-regulation of cytokines (TNFalpha, IL1beta, IL6), enzymes (COX2, NOX2,INOS) and subsequently mediators of reactive oxygen species generation. |
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Formal Description Interaction-ID: 8191 |
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| Drugbank entries | Show/Hide entries for IL1B |
| Comment | SYN triggers microglial-derived proinflammatory events including up-regulation of cytokines (TNFalpha, IL1beta, IL6), enzymes (COX2, NOX2,INOS) and subsequently mediators of reactive oxygen species generation. |
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Formal Description Interaction-ID: 8192 |
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| Drugbank entries | Show/Hide entries for IL6 |
| Comment | SYN triggers microglial-derived proinflammatory events including up-regulation of cytokines (TNFalpha, IL1beta, IL6), enzymes (COX2, NOX2,INOS) and subsequently mediators of reactive oxygen species generation. |
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Formal Description Interaction-ID: 8193 |
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| Drugbank entries | Show/Hide entries for TNF |
| Comment | SYN triggers microglial-derived proinflammatory events including up-regulation of cytokines (TNFalpha, IL1beta, IL6), enzymes (COX2, NOX2,INOS) and subsequently mediators of reactive oxygen species generation. |
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Formal Description Interaction-ID: 8194 |
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| Drugbank entries | Show/Hide entries for PTGS2 |
| Comment | SYN triggers microglial-derived proinflammatory events including up-regulation of cytokines (TNFalpha, IL1beta, IL6), enzymes (COX2, NOX2,INOS) and subsequently mediators of reactive oxygen species generation. |
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Formal Description Interaction-ID: 8195 |
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| Comment | SYN triggers microglial-derived proinflammatory events including up-regulation of cytokines (TNFalpha, IL1beta, IL6), enzymes (COX2, NOX2,INOS) and subsequently mediators of reactive oxygen species generation. |
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Formal Description Interaction-ID: 8196 |
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| Drugbank entries | Show/Hide entries for NOS2 |
| Comment | SYN triggers microglial-derived proinflammatory events including up-regulation of cytokines (TNFalpha, IL1beta, IL6), enzymes (COX2, NOX2,INOS) and subsequently mediators of reactive oxygen species generation. |
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Formal Description Interaction-ID: 8197 |
gene/protein increases_quantity of drug/chemical compound Reactive oxygen species |
| Comment | The scavenger receptor CD36 is involved in SYN-mediated microglial cell activation. |
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Formal Description Interaction-ID: 8198 |
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| Comment | The scavenger receptor CD36 is involved in SYN-mediated microglial cell activation. |
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Formal Description Interaction-ID: 8199 |
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