General Information:

Id: 1,157 (click here to show other Interactions for entry)
Diseases: Epilepsy, temporal lobe
Status epilepticus
Mus musculus
C57BL/6 mice
BTO:0001026 polymorphonuclear leukocyte; BTO:0000142 brain
article
Reference: [PMID: 19029985]

Interaction Information:

Comment The seizures (pilocarpine model) induce elevated expression of vascular cell adhesion molecules and enhanced inflammation-related leukocyte rolling and arrest in brain vessels mediated by the leukocyte mucin P-selectin glycoprotein ligand-1 (PSGL-1) and leukocyte integrins alpha(4)beta(1) and alpha(L)beta(2).
Formal Description
Interaction-ID: 7567

drug/chemical compound

Pilocarpine

affects_activity of

phenotype

convulsive seizures

Drugbank entries Show/Hide entries for Pilocarpine