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Field	Query

	Field	Term

General Information:

Id:	1,157
Diseases:	Epilepsy, temporal lobe Status epilepticus
Organism:	Mus musculus
Organism Model:	C57BL/6 mice
Tissue/Cell line:	BTO:0001026 polymorphonuclear leukocyte; BTO:0000142 brain
Publication type:	article
Reference:	[PMID: 19029985]

Interaction Information:

Comment	The seizures (pilocarpine model) induce elevated expression of vascular cell adhesion molecules and enhanced inflammation-related leukocyte rolling and arrest in brain vessels mediated by the leukocyte mucin P-selectin glycoprotein ligand-1 (PSGL-1) and leukocyte integrins alpha(4)beta(1) and alpha(L)beta(2).
Formal Description Interaction-ID: 7567	drug/chemical compound Pilocarpine affects_activity of phenotype convulsive seizures
Drugbank entries	Show/Hide entries for Pilocarpine
Drugbank DB01085	Pilocarpine agonist CHRM1
Drugbank DB01085	Pilocarpine agonist CHRM2
Drugbank DB01085	Pilocarpine agonist CHRM3

Comment	The seizures (pilocarpine model) induce elevated expression of vascular cell adhesion molecules and enhanced inflammation-related leukocyte rolling and arrest in brain vessels mediated by the leukocyte mucin P-selectin glycoprotein ligand-1 (PSGL-1) and leukocyte integrins alpha(4)beta(1) and alpha(L)beta(2).
Formal Description Interaction-ID: 7598	phenotype convulsive seizures increases_expression of gene/protein VCAM1
Drugbank entries	Show/Hide entries for VCAM1
Drugbank DB01136	Carvedilol inhibitor VCAM1

Comment	The seizures (pilocarpine model) induce elevated expression of vascular cell adhesion molecules and enhanced inflammation-related leukocyte rolling and arrest in brain vessels mediated by the leukocyte mucin P-selectin glycoprotein ligand-1 (PSGL-1) and leukocyte integrins alpha(4)beta(1) and alpha(L)beta(2).
Formal Description Interaction-ID: 7600	phenotype convulsive seizures increases_activity of process leukocyte activation-dependent arrest

Comment	The seizures (pilocarpine model) induce elevated expression of vascular cell adhesion molecules and enhanced inflammation-related leukocyte rolling and arrest in brain vessels mediated by the leukocyte mucin P-selectin glycoprotein ligand-1 (PSGL-1) and leukocyte integrins alpha(4)beta(1) and alpha(L)beta(2).
Formal Description Interaction-ID: 7608	phenotype convulsive seizures increases_expression of gene/protein ICAM1
Drugbank entries	Show/Hide entries for ICAM1
Drugbank DB00108	Natalizumab not specified ICAM1
Drugbank DB00108	Natalizumab not specified ICAM1

Comment	The interation of VCAM1 with alpha(4)beta(1) integrin and P-selectin with PSGL-1 cause adhesion of leukocytes to the brain vessels walls, where they produce leakage of the BBB and local inflammation.
Formal Description Interaction-ID: 7613	gene/protein VCAM1 interacts (colocalizes) with complex/PPI ITGA4-ITGB1 complex
Drugbank entries	Show/Hide entries for VCAM1
Drugbank DB01136	Carvedilol inhibitor VCAM1

Comment	The interation of VCAM1 with alpha(4)beta(1) integrin and P-selectin with PSGL-1 cause adhesion of leukocytes to the brain vessels walls, where they produce leakage of the BBB and local inflammation.
Formal Description Interaction-ID: 7614	complex/PPI VCAM1-ITGA4-ITGB1 complex increases_activity of process leukocyte activation-dependent arrest

Comment	The interation of VCAM1 with alpha(4)beta(1) integrin and P-selectin with PSGL-1 cause adhesion of leukocytes to the brain vessels walls, where they produce leakage of the BBB and local inflammation.
Formal Description Interaction-ID: 7617	gene/protein SELPLG interacts (colocalizes) with gene/protein SELP
Drugbank entries	Show/Hide entries for SELP
Drugbank DB01109	Heparin inhibitor SELP
Drugbank DB03721	O-Sialic Acid not specified SELP
Drugbank DB03965	Fucose not specified SELP
Drugbank DB06779	Dalteparin inhibitor SELP
Drugbank DB08813	Nadroparin inhibitor SELP
Drugbank DB03721	O-Sialic Acid not specified SELP

Comment	The interation of VCAM1 with alpha(4)beta(1) integrin and P-selectin with PSGL-1 cause adhesion of leukocytes to the brain vessels walls, where they produce leakage of the BBB and local inflammation.
Formal Description Interaction-ID: 7618	complex/PPI SELPG-SELP complex increases_activity of process leukocyte activation-dependent arrest

Comment	The interation of VCAM1 with alpha(4)beta(1) integrin and P-selectin with PSGL-1 cause adhesion of leukocytes to the brain vessels walls, where they produce leakage of the BBB and local inflammation.
Formal Description Interaction-ID: 7619	process leukocyte activation-dependent arrest increases_activity of phenotype abnormal blood-brain barrier function

Comment	The interation of VCAM1 with alpha(4)beta(1) integrin and P-selectin with PSGL-1 cause adhesion of leukocytes to the brain vessels walls, where they produce leakage of the BBB and local inflammation.
Formal Description Interaction-ID: 7620	phenotype abnormal blood-brain barrier function increases_activity of phenotype CNS inflammation

Comment	Rolling interactions and arrest of PMN cells (polymorphonuclear leukocyte) after SE were dramatically inhibited by antibody blockade of pro-inflammatory proteins alpha4 integrin or its vascular counter ligand VCAM-1, or by blockade of P-selectin glycoprotein ligand-1 (PSGL-1) or its principal vascular ligand P-selectin.
Formal Description Interaction-ID: 7649	complex/PPI VCAM-1-antibody decreases_activity of process leukocyte activation-dependent arrest

Comment	Rolling interactions and arrest of PMN cells (polymorphonuclear leukocyte) after SE were dramatically inhibited by antibody blockade of pro-inflammatory proteins alpha4 integrin or its vascular counter ligand VCAM-1, or by blockade of P-selectin glycoprotein ligand-1 (PSGL-1) or its principal vascular ligand P-selectin.
Formal Description Interaction-ID: 7655	complex/PPI ITGA4-antibody decreases_activity of process leukocyte activation-dependent arrest

Comment	Rolling interactions and arrest of PMN cells (polymorphonuclear leukocyte) after SE were dramatically inhibited by antibody blockade of pro-inflammatory proteins alpha4 integrin or its vascular counter ligand VCAM-1, or by blockade of P-selectin glycoprotein ligand-1 (PSGL-1) or its principal vascular ligand P-selectin.
Formal Description Interaction-ID: 7656	complex/PPI SELP-antibody decreases_activity of process leukocyte activation-dependent arrest

Comment	Rolling interactions and arrest of PMN cells (polymorphonuclear leukocyte) after SE were dramatically inhibited by antibody blockade of pro-inflammatory proteins alpha4 integrin or its vascular counter ligand VCAM-1, or by blockade of P-selectin glycoprotein ligand-1 (PSGL-1) or its principal vascular ligand P-selectin.
Formal Description Interaction-ID: 7657	complex/PPI SELPG-antibody decreases_activity of process leukocyte activation-dependent arrest

Comment	The mice pretreated with ITGA4-antibodies had decreased recurrent spontaneous convulsions and lower inflammatory-related BBB damage compared to untreated mice in pilocarpine-induced epilepsy model.
Formal Description Interaction-ID: 7658	complex/PPI ITGA4-antibody decreases_activity of phenotype abnormal blood-brain barrier function

Comment	The mice pretreated with ITGA4-antibodies had decreased recurrent spontaneous convulsions and lower inflammatory-related BBB damage compared to untreated mice in pilocarpine-induced epilepsy model.
Formal Description Interaction-ID: 7660	complex/PPI ITGA4-antibody decreases_activity of phenotype convulsive seizures

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