CIDeRplusGeneral Information:
| Id: | 1,137 (click here to show other Interactions for entry) |
| Diseases: |
Parkinson disease
|
| Rattus norvegicus | |
| BTO:0000078 microglia | |
| article | |
| Reference: | Lee EJ et al.(2010) Alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1 J. Immunol. 185: 615-623 [PMID: 20511551] |
Interaction Information:
| Comment | Inhibition of MMP-3, -8, or -9 with NNGH, M8I or M9I, suppresses the production of NO, proinflammatory cytokines, and ROS in primary microglia. |
|
Formal Description Interaction-ID: 7420 |
drug/chemical compound 1rmz decreases_activity of drug/chemical compound Reactive oxygen species |