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General Information:

Id:	1,137
Diseases:	Parkinson disease
Organism:	Rattus norvegicus
Tissue/Cell line:	BTO:0000078 microglia
Publication type:	article
Reference:	Lee EJ et al.(2010) Alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1 J. Immunol. 185: 615-623 [PMID: 20511551]

Interaction Information:

Comment	Alpha-synuclein was found to significantly induce proinflammatory cytokines, like IL-1beta and TNFalpha and to increase the production of NO and ROS in a concentration-dependent manner.
Formal Description Interaction-ID: 7389	gene/protein SNCA increases_quantity of gene/protein IL1B in microglia
Drugbank entries	Show/Hide entries for IL1B
Drugbank DB01017	Minocycline modulator IL1B
Drugbank DB05260	Gallium nitrate antagonist IL1B
Drugbank DB06168	Canakinumab not specified IL1B
Drugbank DB06168	Canakinumab not specified IL1B

Comment	Alpha-synuclein was found to significantly induce proinflammatory cytokines, like IL-1beta and TNFalpha and to increase the production of NO and ROS in a concentration-dependent manner.
Formal Description Interaction-ID: 7392	gene/protein SNCA increases_quantity of gene/protein TNF in microglia
Drugbank entries	Show/Hide entries for TNF
Drugbank DB00005	Etanercept antibody TNF
Drugbank DB00051	Adalimumab antibody TNF
Drugbank DB00065	Infliximab inhibitor TNF
Drugbank DB00608	Chloroquine not specified TNF
Drugbank DB01041	Thalidomide inhibitor TNF
Drugbank DB01296	Glucosamine not specified TNF
Drugbank DB01407	Clenbuterol other/unknown TNF
Drugbank DB01411	Pranlukast other/unknown TNF
Drugbank DB01427	Amrinone inhibitor TNF
Drugbank DB00051	Adalimumab antibody TNF
Drugbank DB00065	Infliximab inhibitor TNF
Drugbank DB01427	Amrinone inhibitor TNF

Comment	Alpha-synuclein was found to significantly induce proinflammatory cytokines, like IL-1beta and TNFalpha and to increase the production of NO and ROS in a concentration-dependent manner.
Formal Description Interaction-ID: 7394	gene/protein SNCA increases_quantity of drug/chemical compound NO in microglia

Comment	Alpha-synuclein was found to significantly induce proinflammatory cytokines, like IL-1beta and TNFalpha and to increase the production of NO and ROS in a concentration-dependent manner.
Formal Description Interaction-ID: 7395	gene/protein SNCA increases_quantity of drug/chemical compound Reactive oxygen species in microglia

Comment	Alpha-synuclein induced mRNA expression of proinflammatory cytokines (TNFalpha and IL-1beta) and iNOS.
Formal Description Interaction-ID: 7396	gene/protein SNCA increases_expression of gene/protein TNF in microglia
Drugbank entries	Show/Hide entries for TNF
Drugbank DB00005	Etanercept antibody TNF
Drugbank DB00051	Adalimumab antibody TNF
Drugbank DB00065	Infliximab inhibitor TNF
Drugbank DB00608	Chloroquine not specified TNF
Drugbank DB01041	Thalidomide inhibitor TNF
Drugbank DB01296	Glucosamine not specified TNF
Drugbank DB01407	Clenbuterol other/unknown TNF
Drugbank DB01411	Pranlukast other/unknown TNF
Drugbank DB01427	Amrinone inhibitor TNF
Drugbank DB00051	Adalimumab antibody TNF
Drugbank DB00065	Infliximab inhibitor TNF
Drugbank DB01427	Amrinone inhibitor TNF

Comment	Alpha-synuclein induced mRNA expression of proinflammatory cytokines (TNFalpha and IL-1beta) and iNOS.
Formal Description Interaction-ID: 7397	gene/protein SNCA increases_expression of gene/protein IL1B in microglia
Drugbank entries	Show/Hide entries for IL1B
Drugbank DB01017	Minocycline modulator IL1B
Drugbank DB05260	Gallium nitrate antagonist IL1B
Drugbank DB06168	Canakinumab not specified IL1B
Drugbank DB06168	Canakinumab not specified IL1B

Comment	Alpha-synuclein induced mRNA expression of proinflammatory cytokines (TNFalpha and IL-1beta) and iNOS.
Formal Description Interaction-ID: 7398	gene/protein SNCA increases_expression of gene/protein NOS2 in microglia
Drugbank entries	Show/Hide entries for NOS2
Drugbank DB00125	L-Arginine not specified NOS2
Drugbank DB00155	L-Citrulline not specified NOS2
Drugbank DB01110	Miconazole inhibitor NOS2
Drugbank DB01234	Dexamethasone negative modulator NOS2
Drugbank DB01686	N,N-dimethylarginine not specified NOS2
Drugbank DB01835	4r-Fluoro-N6-Ethanimidoyl-L-Lysine not specified NOS2
Drugbank DB01997	3-Bromo-7-Nitroindazole not specified NOS2
Drugbank DB02044	N-(3-(Aminomethyl)Benzyl)Acetamidine not specified NOS2
Drugbank DB02207	7-Nitroindazole not specified NOS2
Drugbank DB02234	Ethylisothiourea not specified NOS2
Drugbank DB02462	Thiocoumarin not specified NOS2
Drugbank DB02533	Aminoguanidine inhibitor NOS2
Drugbank DB02539	S-Ethylisothiourea not specified NOS2
Drugbank DB02644	N-Omega-Propyl-L-Arginine not specified NOS2
Drugbank DB02692	(6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin not specified NOS2
Drugbank DB03014	Heme not specified NOS2
Drugbank DB03100	6-Nitroindazole not specified NOS2
Drugbank DB03144	N-Omega-Hydroxy-L-Arginine not specified NOS2
Drugbank DB03271	7,8-Dihydro-L-Biopterin not specified NOS2
Drugbank DB03449	N-(4-(2-((3-Chlorophenylmethyl)Amino)Eth ... not specified NOS2
Drugbank DB03953	L-Thiocitrulline not specified NOS2
Drugbank DB04400	7,8-Dihydrobiopterin not specified NOS2
Drugbank DB04534	5-Nitroindazole not specified NOS2
Drugbank DB06879	5-(4'-AMINO-1'-ETHYL-5',8'-DIFLUORO-1'H- ... not specified NOS2
Drugbank DB06916	N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-( ... not specified NOS2
Drugbank DB07002	4-({4-[(4-methoxypyridin-2-yl)amino]pipe ... not specified NOS2
Drugbank DB07003	(2S)-2-methyl-2,3-dihydrothieno[2,3-f][1 ... not specified NOS2
Drugbank DB07007	(3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7 ... not specified NOS2
Drugbank DB07008	4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMI ... not specified NOS2
Drugbank DB07011	(3S)-1-(1,3-BENZODIOXOL-5-YLMETHYL)-3-[4 ... not specified NOS2
Drugbank DB07029	4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMI ... not specified NOS2
Drugbank DB07306	ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIP ... not specified NOS2
Drugbank DB07318	N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQU ... not specified NOS2
Drugbank DB07388	ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIP ... not specified NOS2
Drugbank DB07389	N-[2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL ... not specified NOS2
Drugbank DB07405	1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFL ... not specified NOS2
Drugbank DB08214	4-(1H-IMIDAZOL-1-YL)PHENOL not specified NOS2
Drugbank DB08750	1-[4-(AMINOMETHYL)BENZOYL]-5'-FLUORO-1'H ... not specified NOS2
Drugbank DB08814	Triflusal agonist NOS2
Drugbank DB00125	L-Arginine not specified NOS2
Drugbank DB00155	L-Citrulline not specified NOS2
Drugbank DB01686	N,N-dimethylarginine not specified NOS2
Drugbank DB01835	4r-Fluoro-N6-Ethanimidoyl-L-Lysine not specified NOS2
Drugbank DB01997	3-Bromo-7-Nitroindazole not specified NOS2
Drugbank DB02207	7-Nitroindazole not specified NOS2
Drugbank DB02234	Ethylisothiourea not specified NOS2
Drugbank DB02533	Aminoguanidine inhibitor NOS2
Drugbank DB02539	S-Ethylisothiourea not specified NOS2
Drugbank DB02644	N-Omega-Propyl-L-Arginine not specified NOS2
Drugbank DB02692	(6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin not specified NOS2
Drugbank DB03014	Heme not specified NOS2
Drugbank DB03100	6-Nitroindazole not specified NOS2
Drugbank DB03144	N-Omega-Hydroxy-L-Arginine not specified NOS2
Drugbank DB03271	7,8-Dihydro-L-Biopterin not specified NOS2
Drugbank DB03953	L-Thiocitrulline not specified NOS2
Drugbank DB04400	7,8-Dihydrobiopterin not specified NOS2
Drugbank DB04534	5-Nitroindazole not specified NOS2

Comment	Alpha-synuclein, especially aggregated alpha-synuclein, causes microglial activation.
Formal Description Interaction-ID: 7399	gene/protein SNCA increases_activity of process microglial cell activation

Comment	Inhibition of MMP-3, -8, or -9 with NNGH, M8I or M9I, suppresses the production of NO, proinflammatory cytokines, and ROS in primary microglia.
Formal Description Interaction-ID: 7402	gene/protein MMP3 affects_quantity of drug/chemical compound NO after stimulation with alpha-synuclein
Drugbank entries	Show/Hide entries for MMP3
Drugbank DB00786	Marimastat antagonist MMP3
Drugbank DB01877	N-Hydroxy 1n(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB01996	3-Methylpyridine not specified MMP3
Drugbank DB02090	A Disubstituted Succinyl Caprolactam Hyd ... not specified MMP3
Drugbank DB02350	N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl] ... not specified MMP3
Drugbank DB02367	(1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hyd ... not specified MMP3
Drugbank DB02449	3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperid ... not specified MMP3
Drugbank DB02697	Hydroxyaminovaline not specified MMP3
Drugbank DB03033	1-Methyloxy-4-Sulfone-Benzene not specified MMP3
Drugbank DB03368	5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine ... not specified MMP3
Drugbank DB04140	1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6 ... not specified MMP3
Drugbank DB04232	N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB04416	R-2-{[4'-Methoxy-(1,1'-Biphenyl)-4-Yl]-S ... not specified MMP3
Drugbank DB07390	2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YL) ... not specified MMP3
Drugbank DB07986	[4-(4-PHENYL-PIPERIDIN-1-YL)-BENZENESULF ... not specified MMP3
Drugbank DB07987	[2-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YLCAR ... not specified MMP3
Drugbank DB07988	2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2YL)- ... not specified MMP3
Drugbank DB08029	N~2~-(biphenyl-4-ylsulfonyl)-N-hydroxy-N ... not specified MMP3
Drugbank DB08030	3-[(4'-cyanobiphenyl-4-yl)oxy]-N-hydroxy ... not specified MMP3
Drugbank DB08271	N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GL ... not specified MMP3
Drugbank DB08507	N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT-4-YL ... not specified MMP3
Drugbank DB08643	2-(2-{2-[(BIPHENYL-4-YLMETHYL)-AMINO]-3- ... not specified MMP3
Drugbank DB01877	N-Hydroxy 1n(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB01996	3-Methylpyridine not specified MMP3
Drugbank DB02090	A Disubstituted Succinyl Caprolactam Hyd ... not specified MMP3
Drugbank DB02350	N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl] ... not specified MMP3
Drugbank DB02367	(1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hyd ... not specified MMP3
Drugbank DB02449	3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperid ... not specified MMP3
Drugbank DB02697	Hydroxyaminovaline not specified MMP3
Drugbank DB03033	1-Methyloxy-4-Sulfone-Benzene not specified MMP3
Drugbank DB03368	5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine ... not specified MMP3
Drugbank DB04140	1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6 ... not specified MMP3
Drugbank DB04232	N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB04416	R-2-{[4'-Methoxy-(1,1'-Biphenyl)-4-Yl]-S ... not specified MMP3

Comment	Inhibition of MMP-3, -8, or -9 with NNGH, M8I or M9I, suppresses the production of NO, proinflammatory cytokines, and ROS in primary microglia.
Formal Description Interaction-ID: 7404	gene/protein MMP3 affects_quantity of gene/protein TNF after stimulation with alpha-synuclein
Drugbank entries	Show/Hide entries for MMP3 or TNF
Drugbank DB00786	Marimastat antagonist MMP3
Drugbank DB01877	N-Hydroxy 1n(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB01996	3-Methylpyridine not specified MMP3
Drugbank DB02090	A Disubstituted Succinyl Caprolactam Hyd ... not specified MMP3
Drugbank DB02350	N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl] ... not specified MMP3
Drugbank DB02367	(1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hyd ... not specified MMP3
Drugbank DB02449	3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperid ... not specified MMP3
Drugbank DB02697	Hydroxyaminovaline not specified MMP3
Drugbank DB03033	1-Methyloxy-4-Sulfone-Benzene not specified MMP3
Drugbank DB03368	5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine ... not specified MMP3
Drugbank DB04140	1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6 ... not specified MMP3
Drugbank DB04232	N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB04416	R-2-{[4'-Methoxy-(1,1'-Biphenyl)-4-Yl]-S ... not specified MMP3
Drugbank DB07390	2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YL) ... not specified MMP3
Drugbank DB07986	[4-(4-PHENYL-PIPERIDIN-1-YL)-BENZENESULF ... not specified MMP3
Drugbank DB07987	[2-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YLCAR ... not specified MMP3
Drugbank DB07988	2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2YL)- ... not specified MMP3
Drugbank DB08029	N~2~-(biphenyl-4-ylsulfonyl)-N-hydroxy-N ... not specified MMP3
Drugbank DB08030	3-[(4'-cyanobiphenyl-4-yl)oxy]-N-hydroxy ... not specified MMP3
Drugbank DB08271	N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GL ... not specified MMP3
Drugbank DB08507	N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT-4-YL ... not specified MMP3
Drugbank DB08643	2-(2-{2-[(BIPHENYL-4-YLMETHYL)-AMINO]-3- ... not specified MMP3
Drugbank DB01877	N-Hydroxy 1n(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB01996	3-Methylpyridine not specified MMP3
Drugbank DB02090	A Disubstituted Succinyl Caprolactam Hyd ... not specified MMP3
Drugbank DB02350	N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl] ... not specified MMP3
Drugbank DB02367	(1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hyd ... not specified MMP3
Drugbank DB02449	3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperid ... not specified MMP3
Drugbank DB02697	Hydroxyaminovaline not specified MMP3
Drugbank DB03033	1-Methyloxy-4-Sulfone-Benzene not specified MMP3
Drugbank DB03368	5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine ... not specified MMP3
Drugbank DB04140	1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6 ... not specified MMP3
Drugbank DB04232	N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB04416	R-2-{[4'-Methoxy-(1,1'-Biphenyl)-4-Yl]-S ... not specified MMP3
Drugbank DB00005	Etanercept antibody TNF
Drugbank DB00051	Adalimumab antibody TNF
Drugbank DB00065	Infliximab inhibitor TNF
Drugbank DB00608	Chloroquine not specified TNF
Drugbank DB01041	Thalidomide inhibitor TNF
Drugbank DB01296	Glucosamine not specified TNF
Drugbank DB01407	Clenbuterol other/unknown TNF
Drugbank DB01411	Pranlukast other/unknown TNF
Drugbank DB01427	Amrinone inhibitor TNF
Drugbank DB00051	Adalimumab antibody TNF
Drugbank DB00065	Infliximab inhibitor TNF
Drugbank DB01427	Amrinone inhibitor TNF

Comment	Inhibition of MMP-3, -8, or -9 with NNGH, M8I or M9I, suppresses the production of NO, proinflammatory cytokines, and ROS in primary microglia.
Formal Description Interaction-ID: 7405	gene/protein MMP3 affects_quantity of gene/protein IL1B after stimulation with alpha-synuclein
Drugbank entries	Show/Hide entries for MMP3 or IL1B
Drugbank DB00786	Marimastat antagonist MMP3
Drugbank DB01877	N-Hydroxy 1n(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB01996	3-Methylpyridine not specified MMP3
Drugbank DB02090	A Disubstituted Succinyl Caprolactam Hyd ... not specified MMP3
Drugbank DB02350	N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl] ... not specified MMP3
Drugbank DB02367	(1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hyd ... not specified MMP3
Drugbank DB02449	3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperid ... not specified MMP3
Drugbank DB02697	Hydroxyaminovaline not specified MMP3
Drugbank DB03033	1-Methyloxy-4-Sulfone-Benzene not specified MMP3
Drugbank DB03368	5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine ... not specified MMP3
Drugbank DB04140	1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6 ... not specified MMP3
Drugbank DB04232	N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB04416	R-2-{[4'-Methoxy-(1,1'-Biphenyl)-4-Yl]-S ... not specified MMP3
Drugbank DB07390	2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YL) ... not specified MMP3
Drugbank DB07986	[4-(4-PHENYL-PIPERIDIN-1-YL)-BENZENESULF ... not specified MMP3
Drugbank DB07987	[2-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YLCAR ... not specified MMP3
Drugbank DB07988	2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2YL)- ... not specified MMP3
Drugbank DB08029	N~2~-(biphenyl-4-ylsulfonyl)-N-hydroxy-N ... not specified MMP3
Drugbank DB08030	3-[(4'-cyanobiphenyl-4-yl)oxy]-N-hydroxy ... not specified MMP3
Drugbank DB08271	N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GL ... not specified MMP3
Drugbank DB08507	N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT-4-YL ... not specified MMP3
Drugbank DB08643	2-(2-{2-[(BIPHENYL-4-YLMETHYL)-AMINO]-3- ... not specified MMP3
Drugbank DB01877	N-Hydroxy 1n(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB01996	3-Methylpyridine not specified MMP3
Drugbank DB02090	A Disubstituted Succinyl Caprolactam Hyd ... not specified MMP3
Drugbank DB02350	N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl] ... not specified MMP3
Drugbank DB02367	(1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hyd ... not specified MMP3
Drugbank DB02449	3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperid ... not specified MMP3
Drugbank DB02697	Hydroxyaminovaline not specified MMP3
Drugbank DB03033	1-Methyloxy-4-Sulfone-Benzene not specified MMP3
Drugbank DB03368	5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine ... not specified MMP3
Drugbank DB04140	1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6 ... not specified MMP3
Drugbank DB04232	N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB04416	R-2-{[4'-Methoxy-(1,1'-Biphenyl)-4-Yl]-S ... not specified MMP3
Drugbank DB01017	Minocycline modulator IL1B
Drugbank DB05260	Gallium nitrate antagonist IL1B
Drugbank DB06168	Canakinumab not specified IL1B
Drugbank DB06168	Canakinumab not specified IL1B

Comment	Inhibition of MMP-3, -8, or -9 with NNGH, M8I or M9I, suppresses the production of NO, proinflammatory cytokines, and ROS in primary microglia.
Formal Description Interaction-ID: 7406	gene/protein MMP3 affects_quantity of drug/chemical compound Reactive oxygen species after stimulation with alpha-synuclein
Drugbank entries	Show/Hide entries for MMP3
Drugbank DB00786	Marimastat antagonist MMP3
Drugbank DB01877	N-Hydroxy 1n(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB01996	3-Methylpyridine not specified MMP3
Drugbank DB02090	A Disubstituted Succinyl Caprolactam Hyd ... not specified MMP3
Drugbank DB02350	N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl] ... not specified MMP3
Drugbank DB02367	(1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hyd ... not specified MMP3
Drugbank DB02449	3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperid ... not specified MMP3
Drugbank DB02697	Hydroxyaminovaline not specified MMP3
Drugbank DB03033	1-Methyloxy-4-Sulfone-Benzene not specified MMP3
Drugbank DB03368	5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine ... not specified MMP3
Drugbank DB04140	1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6 ... not specified MMP3
Drugbank DB04232	N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB04416	R-2-{[4'-Methoxy-(1,1'-Biphenyl)-4-Yl]-S ... not specified MMP3
Drugbank DB07390	2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YL) ... not specified MMP3
Drugbank DB07986	[4-(4-PHENYL-PIPERIDIN-1-YL)-BENZENESULF ... not specified MMP3
Drugbank DB07987	[2-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YLCAR ... not specified MMP3
Drugbank DB07988	2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2YL)- ... not specified MMP3
Drugbank DB08029	N~2~-(biphenyl-4-ylsulfonyl)-N-hydroxy-N ... not specified MMP3
Drugbank DB08030	3-[(4'-cyanobiphenyl-4-yl)oxy]-N-hydroxy ... not specified MMP3
Drugbank DB08271	N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GL ... not specified MMP3
Drugbank DB08507	N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT-4-YL ... not specified MMP3
Drugbank DB08643	2-(2-{2-[(BIPHENYL-4-YLMETHYL)-AMINO]-3- ... not specified MMP3
Drugbank DB01877	N-Hydroxy 1n(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB01996	3-Methylpyridine not specified MMP3
Drugbank DB02090	A Disubstituted Succinyl Caprolactam Hyd ... not specified MMP3
Drugbank DB02350	N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl] ... not specified MMP3
Drugbank DB02367	(1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hyd ... not specified MMP3
Drugbank DB02449	3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperid ... not specified MMP3
Drugbank DB02697	Hydroxyaminovaline not specified MMP3
Drugbank DB03033	1-Methyloxy-4-Sulfone-Benzene not specified MMP3
Drugbank DB03368	5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine ... not specified MMP3
Drugbank DB04140	1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6 ... not specified MMP3
Drugbank DB04232	N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB04416	R-2-{[4'-Methoxy-(1,1'-Biphenyl)-4-Yl]-S ... not specified MMP3

Comment	Inhibition of MMP-3, -8, or -9 with NNGH, M8I or M9I, suppresses the production of NO, proinflammatory cytokines, and ROS in primary microglia.
Formal Description Interaction-ID: 7407	gene/protein MMP8 affects_quantity of drug/chemical compound NO after stimulation with alpha-synuclein
Drugbank entries	Show/Hide entries for MMP8
Drugbank DB00786	Marimastat inhibitor MMP8
Drugbank DB02326	1-Hydroxyamine-2-Isobutylmalonic Acid not specified MMP8
Drugbank DB02953	2-Thiomethyl-3-Phenylpropanoic Acid not specified MMP8
Drugbank DB03207	2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahyd ... not specified MMP8
Drugbank DB03622	2-Hydroxy-5-[4-(2-Hydroxy-Ethyl)-Piperid ... not specified MMP8
Drugbank DB03636	Glycinamid not specified MMP8
Drugbank DB03880	Batimastat not specified MMP8
Drugbank DB06971	N-{2-[(4'-CYANO-1,1'-BIPHENYL-4-YL)OXY]E ... not specified MMP8
Drugbank DB07397	(5S)-5-(2-amino-2-oxoethyl)-4-oxo-N-[(3- ... not specified MMP8
Drugbank DB07713	(1S)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL) ... not specified MMP8
Drugbank DB07772	(1R)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL) ... not specified MMP8
Drugbank DB07900	3-FORMYL-2-HYDROXY-5-METHYL-HEXANOIC ACI ... not specified MMP8
Drugbank DB08028	BUT-3-ENYL-[5-(4-CHLORO-PHENYL)-3,6-DIHY ... not specified MMP8
Drugbank DB08403	METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAM ... not specified MMP8
Drugbank DB08476	3-AMINO-AZACYCLOTRIDECAN-2-ONE not specified MMP8
Drugbank DB02326	1-Hydroxyamine-2-Isobutylmalonic Acid not specified MMP8
Drugbank DB02953	2-Thiomethyl-3-Phenylpropanoic Acid not specified MMP8
Drugbank DB03207	2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahyd ... not specified MMP8
Drugbank DB03622	2-Hydroxy-5-[4-(2-Hydroxy-Ethyl)-Piperid ... not specified MMP8
Drugbank DB03636	Glycinamid not specified MMP8
Drugbank DB03880	Batimastat not specified MMP8

Comment	Inhibition of MMP-3, -8, or -9 with NNGH, M8I or M9I, suppresses the production of NO, proinflammatory cytokines, and ROS in primary microglia.
Formal Description Interaction-ID: 7408	gene/protein MMP8 affects_quantity of gene/protein TNF after stimulation with alpha-synuclein
Drugbank entries	Show/Hide entries for MMP8 or TNF
Drugbank DB00786	Marimastat inhibitor MMP8
Drugbank DB02326	1-Hydroxyamine-2-Isobutylmalonic Acid not specified MMP8
Drugbank DB02953	2-Thiomethyl-3-Phenylpropanoic Acid not specified MMP8
Drugbank DB03207	2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahyd ... not specified MMP8
Drugbank DB03622	2-Hydroxy-5-[4-(2-Hydroxy-Ethyl)-Piperid ... not specified MMP8
Drugbank DB03636	Glycinamid not specified MMP8
Drugbank DB03880	Batimastat not specified MMP8
Drugbank DB06971	N-{2-[(4'-CYANO-1,1'-BIPHENYL-4-YL)OXY]E ... not specified MMP8
Drugbank DB07397	(5S)-5-(2-amino-2-oxoethyl)-4-oxo-N-[(3- ... not specified MMP8
Drugbank DB07713	(1S)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL) ... not specified MMP8
Drugbank DB07772	(1R)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL) ... not specified MMP8
Drugbank DB07900	3-FORMYL-2-HYDROXY-5-METHYL-HEXANOIC ACI ... not specified MMP8
Drugbank DB08028	BUT-3-ENYL-[5-(4-CHLORO-PHENYL)-3,6-DIHY ... not specified MMP8
Drugbank DB08403	METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAM ... not specified MMP8
Drugbank DB08476	3-AMINO-AZACYCLOTRIDECAN-2-ONE not specified MMP8
Drugbank DB02326	1-Hydroxyamine-2-Isobutylmalonic Acid not specified MMP8
Drugbank DB02953	2-Thiomethyl-3-Phenylpropanoic Acid not specified MMP8
Drugbank DB03207	2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahyd ... not specified MMP8
Drugbank DB03622	2-Hydroxy-5-[4-(2-Hydroxy-Ethyl)-Piperid ... not specified MMP8
Drugbank DB03636	Glycinamid not specified MMP8
Drugbank DB03880	Batimastat not specified MMP8
Drugbank DB00005	Etanercept antibody TNF
Drugbank DB00051	Adalimumab antibody TNF
Drugbank DB00065	Infliximab inhibitor TNF
Drugbank DB00608	Chloroquine not specified TNF
Drugbank DB01041	Thalidomide inhibitor TNF
Drugbank DB01296	Glucosamine not specified TNF
Drugbank DB01407	Clenbuterol other/unknown TNF
Drugbank DB01411	Pranlukast other/unknown TNF
Drugbank DB01427	Amrinone inhibitor TNF
Drugbank DB00051	Adalimumab antibody TNF
Drugbank DB00065	Infliximab inhibitor TNF
Drugbank DB01427	Amrinone inhibitor TNF

Comment	Inhibition of MMP-3, -8, or -9 with NNGH, M8I or M9I, suppresses the production of NO, proinflammatory cytokines, and ROS in primary microglia.
Formal Description Interaction-ID: 7409	gene/protein MMP8 affects_quantity of gene/protein IL1B after stimulation with alpha-synuclein
Drugbank entries	Show/Hide entries for MMP8 or IL1B
Drugbank DB00786	Marimastat inhibitor MMP8
Drugbank DB02326	1-Hydroxyamine-2-Isobutylmalonic Acid not specified MMP8
Drugbank DB02953	2-Thiomethyl-3-Phenylpropanoic Acid not specified MMP8
Drugbank DB03207	2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahyd ... not specified MMP8
Drugbank DB03622	2-Hydroxy-5-[4-(2-Hydroxy-Ethyl)-Piperid ... not specified MMP8
Drugbank DB03636	Glycinamid not specified MMP8
Drugbank DB03880	Batimastat not specified MMP8
Drugbank DB06971	N-{2-[(4'-CYANO-1,1'-BIPHENYL-4-YL)OXY]E ... not specified MMP8
Drugbank DB07397	(5S)-5-(2-amino-2-oxoethyl)-4-oxo-N-[(3- ... not specified MMP8
Drugbank DB07713	(1S)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL) ... not specified MMP8
Drugbank DB07772	(1R)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL) ... not specified MMP8
Drugbank DB07900	3-FORMYL-2-HYDROXY-5-METHYL-HEXANOIC ACI ... not specified MMP8
Drugbank DB08028	BUT-3-ENYL-[5-(4-CHLORO-PHENYL)-3,6-DIHY ... not specified MMP8
Drugbank DB08403	METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAM ... not specified MMP8
Drugbank DB08476	3-AMINO-AZACYCLOTRIDECAN-2-ONE not specified MMP8
Drugbank DB02326	1-Hydroxyamine-2-Isobutylmalonic Acid not specified MMP8
Drugbank DB02953	2-Thiomethyl-3-Phenylpropanoic Acid not specified MMP8
Drugbank DB03207	2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahyd ... not specified MMP8
Drugbank DB03622	2-Hydroxy-5-[4-(2-Hydroxy-Ethyl)-Piperid ... not specified MMP8
Drugbank DB03636	Glycinamid not specified MMP8
Drugbank DB03880	Batimastat not specified MMP8
Drugbank DB01017	Minocycline modulator IL1B
Drugbank DB05260	Gallium nitrate antagonist IL1B
Drugbank DB06168	Canakinumab not specified IL1B
Drugbank DB06168	Canakinumab not specified IL1B

Comment	Inhibition of MMP-3, -8, or -9 with NNGH, M8I or M9I, suppresses the production of NO, proinflammatory cytokines, and ROS in primary microglia.
Formal Description Interaction-ID: 7410	gene/protein MMP8 affects_quantity of drug/chemical compound Reactive oxygen species after stimulation with alpha-synuclein
Drugbank entries	Show/Hide entries for MMP8
Drugbank DB00786	Marimastat inhibitor MMP8
Drugbank DB02326	1-Hydroxyamine-2-Isobutylmalonic Acid not specified MMP8
Drugbank DB02953	2-Thiomethyl-3-Phenylpropanoic Acid not specified MMP8
Drugbank DB03207	2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahyd ... not specified MMP8
Drugbank DB03622	2-Hydroxy-5-[4-(2-Hydroxy-Ethyl)-Piperid ... not specified MMP8
Drugbank DB03636	Glycinamid not specified MMP8
Drugbank DB03880	Batimastat not specified MMP8
Drugbank DB06971	N-{2-[(4'-CYANO-1,1'-BIPHENYL-4-YL)OXY]E ... not specified MMP8
Drugbank DB07397	(5S)-5-(2-amino-2-oxoethyl)-4-oxo-N-[(3- ... not specified MMP8
Drugbank DB07713	(1S)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL) ... not specified MMP8
Drugbank DB07772	(1R)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL) ... not specified MMP8
Drugbank DB07900	3-FORMYL-2-HYDROXY-5-METHYL-HEXANOIC ACI ... not specified MMP8
Drugbank DB08028	BUT-3-ENYL-[5-(4-CHLORO-PHENYL)-3,6-DIHY ... not specified MMP8
Drugbank DB08403	METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAM ... not specified MMP8
Drugbank DB08476	3-AMINO-AZACYCLOTRIDECAN-2-ONE not specified MMP8
Drugbank DB02326	1-Hydroxyamine-2-Isobutylmalonic Acid not specified MMP8
Drugbank DB02953	2-Thiomethyl-3-Phenylpropanoic Acid not specified MMP8
Drugbank DB03207	2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahyd ... not specified MMP8
Drugbank DB03622	2-Hydroxy-5-[4-(2-Hydroxy-Ethyl)-Piperid ... not specified MMP8
Drugbank DB03636	Glycinamid not specified MMP8
Drugbank DB03880	Batimastat not specified MMP8

Comment	Inhibition of MMP-3, -8, or -9 with NNGH, M8I or M9I, suppresses the production of NO, proinflammatory cytokines, and ROS in primary microglia.
Formal Description Interaction-ID: 7411	gene/protein MMP9 affects_quantity of drug/chemical compound NO after stimulation with alpha-synuclein

Comment	Inhibition of MMP-3, -8, or -9 with NNGH, M8I or M9I, suppresses the production of NO, proinflammatory cytokines, and ROS in primary microglia.
Formal Description Interaction-ID: 7412	gene/protein MMP9 affects_quantity of gene/protein TNF after stimulation with alpha-synuclein
Drugbank entries	Show/Hide entries for TNF
Drugbank DB00005	Etanercept antibody TNF
Drugbank DB00051	Adalimumab antibody TNF
Drugbank DB00065	Infliximab inhibitor TNF
Drugbank DB00608	Chloroquine not specified TNF
Drugbank DB01041	Thalidomide inhibitor TNF
Drugbank DB01296	Glucosamine not specified TNF
Drugbank DB01407	Clenbuterol other/unknown TNF
Drugbank DB01411	Pranlukast other/unknown TNF
Drugbank DB01427	Amrinone inhibitor TNF
Drugbank DB00051	Adalimumab antibody TNF
Drugbank DB00065	Infliximab inhibitor TNF
Drugbank DB01427	Amrinone inhibitor TNF

Comment	Inhibition of MMP-3, -8, or -9 with NNGH, M8I or M9I, suppresses the production of NO, proinflammatory cytokines, and ROS in primary microglia.
Formal Description Interaction-ID: 7413	gene/protein MMP9 affects_quantity of gene/protein IL1B after stimulation with alpha-synuclein
Drugbank entries	Show/Hide entries for IL1B
Drugbank DB01017	Minocycline modulator IL1B
Drugbank DB05260	Gallium nitrate antagonist IL1B
Drugbank DB06168	Canakinumab not specified IL1B
Drugbank DB06168	Canakinumab not specified IL1B

Comment	Inhibition of MMP-3, -8, or -9 with NNGH, M8I or M9I, suppresses the production of NO, proinflammatory cytokines, and ROS in primary microglia.
Formal Description Interaction-ID: 7414	gene/protein MMP9 affects_quantity of drug/chemical compound Reactive oxygen species after stimulation with alpha-synuclein

Comment	Inhibition of MMP-3, -8, or -9 with NNGH, M8I or M9I, suppresses the production of NO, proinflammatory cytokines, and ROS in primary microglia.
Formal Description Interaction-ID: 7416	drug/chemical compound 1rmz decreases_activity of gene/protein MMP3
Drugbank entries	Show/Hide entries for MMP3
Drugbank DB00786	Marimastat antagonist MMP3
Drugbank DB01877	N-Hydroxy 1n(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB01996	3-Methylpyridine not specified MMP3
Drugbank DB02090	A Disubstituted Succinyl Caprolactam Hyd ... not specified MMP3
Drugbank DB02350	N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl] ... not specified MMP3
Drugbank DB02367	(1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hyd ... not specified MMP3
Drugbank DB02449	3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperid ... not specified MMP3
Drugbank DB02697	Hydroxyaminovaline not specified MMP3
Drugbank DB03033	1-Methyloxy-4-Sulfone-Benzene not specified MMP3
Drugbank DB03368	5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine ... not specified MMP3
Drugbank DB04140	1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6 ... not specified MMP3
Drugbank DB04232	N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB04416	R-2-{[4'-Methoxy-(1,1'-Biphenyl)-4-Yl]-S ... not specified MMP3
Drugbank DB07390	2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YL) ... not specified MMP3
Drugbank DB07986	[4-(4-PHENYL-PIPERIDIN-1-YL)-BENZENESULF ... not specified MMP3
Drugbank DB07987	[2-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YLCAR ... not specified MMP3
Drugbank DB07988	2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2YL)- ... not specified MMP3
Drugbank DB08029	N~2~-(biphenyl-4-ylsulfonyl)-N-hydroxy-N ... not specified MMP3
Drugbank DB08030	3-[(4'-cyanobiphenyl-4-yl)oxy]-N-hydroxy ... not specified MMP3
Drugbank DB08271	N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GL ... not specified MMP3
Drugbank DB08507	N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT-4-YL ... not specified MMP3
Drugbank DB08643	2-(2-{2-[(BIPHENYL-4-YLMETHYL)-AMINO]-3- ... not specified MMP3
Drugbank DB01877	N-Hydroxy 1n(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB01996	3-Methylpyridine not specified MMP3
Drugbank DB02090	A Disubstituted Succinyl Caprolactam Hyd ... not specified MMP3
Drugbank DB02350	N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl] ... not specified MMP3
Drugbank DB02367	(1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hyd ... not specified MMP3
Drugbank DB02449	3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperid ... not specified MMP3
Drugbank DB02697	Hydroxyaminovaline not specified MMP3
Drugbank DB03033	1-Methyloxy-4-Sulfone-Benzene not specified MMP3
Drugbank DB03368	5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine ... not specified MMP3
Drugbank DB04140	1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6 ... not specified MMP3
Drugbank DB04232	N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB04416	R-2-{[4'-Methoxy-(1,1'-Biphenyl)-4-Yl]-S ... not specified MMP3

Comment	Inhibition of MMP-3, -8, or -9 with NNGH, M8I or M9I, suppresses the production of NO, proinflammatory cytokines, and ROS in primary microglia.
Formal Description Interaction-ID: 7418	drug/chemical compound M8I decreases_activity of gene/protein MMP8
Drugbank entries	Show/Hide entries for MMP8
Drugbank DB00786	Marimastat inhibitor MMP8
Drugbank DB02326	1-Hydroxyamine-2-Isobutylmalonic Acid not specified MMP8
Drugbank DB02953	2-Thiomethyl-3-Phenylpropanoic Acid not specified MMP8
Drugbank DB03207	2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahyd ... not specified MMP8
Drugbank DB03622	2-Hydroxy-5-[4-(2-Hydroxy-Ethyl)-Piperid ... not specified MMP8
Drugbank DB03636	Glycinamid not specified MMP8
Drugbank DB03880	Batimastat not specified MMP8
Drugbank DB06971	N-{2-[(4'-CYANO-1,1'-BIPHENYL-4-YL)OXY]E ... not specified MMP8
Drugbank DB07397	(5S)-5-(2-amino-2-oxoethyl)-4-oxo-N-[(3- ... not specified MMP8
Drugbank DB07713	(1S)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL) ... not specified MMP8
Drugbank DB07772	(1R)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL) ... not specified MMP8
Drugbank DB07900	3-FORMYL-2-HYDROXY-5-METHYL-HEXANOIC ACI ... not specified MMP8
Drugbank DB08028	BUT-3-ENYL-[5-(4-CHLORO-PHENYL)-3,6-DIHY ... not specified MMP8
Drugbank DB08403	METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAM ... not specified MMP8
Drugbank DB08476	3-AMINO-AZACYCLOTRIDECAN-2-ONE not specified MMP8
Drugbank DB02326	1-Hydroxyamine-2-Isobutylmalonic Acid not specified MMP8
Drugbank DB02953	2-Thiomethyl-3-Phenylpropanoic Acid not specified MMP8
Drugbank DB03207	2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahyd ... not specified MMP8
Drugbank DB03622	2-Hydroxy-5-[4-(2-Hydroxy-Ethyl)-Piperid ... not specified MMP8
Drugbank DB03636	Glycinamid not specified MMP8
Drugbank DB03880	Batimastat not specified MMP8

Comment	Inhibition of MMP-3, -8, or -9 with NNGH, M8I or M9I, suppresses the production of NO, proinflammatory cytokines, and ROS in primary microglia.
Formal Description Interaction-ID: 7419	drug/chemical compound M9I decreases_activity of gene/protein MMP9

Comment	Inhibition of MMP-3, -8, or -9 with NNGH, M8I or M9I, suppresses the production of NO, proinflammatory cytokines, and ROS in primary microglia.
Formal Description Interaction-ID: 7420	drug/chemical compound 1rmz decreases_activity of drug/chemical compound Reactive oxygen species in microglia; after stimulation with alpha-synuclein

Comment	Inhibition of MMP-3, -8, or -9 with NNGH, M8I or M9I, suppresses the production of NO, proinflammatory cytokines, and ROS in primary microglia.
Formal Description Interaction-ID: 7421	drug/chemical compound 1rmz decreases_activity of gene/protein IL1B in microglia; after stimulation with alpha-synuclein
Drugbank entries	Show/Hide entries for IL1B
Drugbank DB01017	Minocycline modulator IL1B
Drugbank DB05260	Gallium nitrate antagonist IL1B
Drugbank DB06168	Canakinumab not specified IL1B
Drugbank DB06168	Canakinumab not specified IL1B

Comment	Inhibition of MMP-3, -8, or -9 with NNGH, M8I or M9I, suppresses the production of NO, proinflammatory cytokines, and ROS in primary microglia.
Formal Description Interaction-ID: 7422	drug/chemical compound M9I decreases_activity of drug/chemical compound Reactive oxygen species in microglia; after stimulation with alpha-synuclein

Comment	Inhibition of MMP-3, -8, or -9 with NNGH, M8I or M9I, suppresses the production of NO, proinflammatory cytokines, and ROS in primary microglia.
Formal Description Interaction-ID: 7423	drug/chemical compound M9I decreases_activity of gene/protein IL1B in microglia; after stimulation with alpha-synuclein
Drugbank entries	Show/Hide entries for IL1B
Drugbank DB01017	Minocycline modulator IL1B
Drugbank DB05260	Gallium nitrate antagonist IL1B
Drugbank DB06168	Canakinumab not specified IL1B
Drugbank DB06168	Canakinumab not specified IL1B

Comment	Alpha-synuclein was found to significantly increase the DNA binding activities of NF-kappaB and AP-1, and this binding was suppressed by the MMP-3 and MMP-9 inhibitors.
Formal Description Interaction-ID: 7435	gene/protein SNCA increases_activity of complex/PPI NF-kappaB complex in microglia; together with MMP3 and MMP9

Comment	Alpha-synuclein was found to significantly increase the DNA binding activities of NF-kappaB and AP-1, and this binding was suppressed by the MMP-3 and MMP-9 inhibitors.
Formal Description Interaction-ID: 7437	gene/protein SNCA increases_activity of gene/protein JUN in microglia; together with MMP3 and MMP9
Drugbank entries	Show/Hide entries for JUN
Drugbank DB00570	Vinblastine other/unknown JUN
Drugbank DB01029	Irbesartan other/unknown JUN
Drugbank DB01169	Arsenic trioxide inducer JUN
Drugbank DB01029	Irbesartan other/unknown JUN

Comment	Alpha-synuclein was found to induce the phosphorylation of the three MAPKs, ERK(1,2), JNK(p46) and p38 MAPK, and treatment with MMP-3 or MMP-9 inhibitor remarkably suppressed the phosphorylation of all three MAPKs.
Formal Description Interaction-ID: 7438	gene/protein SNCA increases_phosphorylation of gene/protein MAPK3 in microglia; together with MMP3 and MMP9
Drugbank entries	Show/Hide entries for MAPK3
Drugbank DB00605	Sulindac inhibitor MAPK3
Drugbank DB01169	Arsenic trioxide inducer MAPK3
Drugbank DB02733	Purvalanol inhibitor MAPK3
Drugbank DB04604	5-iodotubercidin not specified MAPK3
Drugbank DB02733	Purvalanol inhibitor MAPK3

Comment	Alpha-synuclein was found to induce the phosphorylation of the three MAPKs, ERK(1,2), JNK(p46) and p38 MAPK, and treatment with MMP-3 or MMP-9 inhibitor remarkably suppressed the phosphorylation of all three MAPKs.
Formal Description Interaction-ID: 7440	gene/protein SNCA increases_phosphorylation of gene/protein MAPK1 in microglia; together with MMP3 and MMP9
Drugbank entries	Show/Hide entries for MAPK1
Drugbank DB01064	Isoproterenol inducer MAPK1
Drugbank DB01169	Arsenic trioxide inducer MAPK1
Drugbank DB02116	Olomoucine not specified MAPK1
Drugbank DB02482	Phosphonothreonine not specified MAPK1
Drugbank DB02733	Purvalanol inhibitor MAPK1
Drugbank DB04338	SB220025 not specified MAPK1
Drugbank DB06877	N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL ... not specified MAPK1
Drugbank DB07010	N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZO ... not specified MAPK1
Drugbank DB07264	(S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYD ... not specified MAPK1
Drugbank DB07788	(3R,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-M ... not specified MAPK1
Drugbank DB07794	5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)- ... not specified MAPK1
Drugbank DB07905	(1aR,8S,13S,14S,15aR)-5,13,14-trihydroxy ... not specified MAPK1
Drugbank DB08513	[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENY ... not specified MAPK1
Drugbank DB08521	4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFI ... not specified MAPK1
Drugbank DB02482	Phosphonothreonine not specified MAPK1
Drugbank DB02733	Purvalanol inhibitor MAPK1

Comment	Alpha-synuclein was found to induce the phosphorylation of the three MAPKs, ERK(1,2), JNK(p46) and p38 MAPK, and treatment with MMP-3 or MMP-9 inhibitor remarkably suppressed the phosphorylation of all three MAPKs.
Formal Description Interaction-ID: 7441	gene/protein SNCA increases_phosphorylation of gene/protein MAPK8 in microglia; together with MMP3 and MMP9
Drugbank entries	Show/Hide entries for MAPK8
Drugbank DB01782	2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One not specified MAPK8
Drugbank DB07218	6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHY ... not specified MAPK8
Drugbank DB07268	2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN- ... not specified MAPK8
Drugbank DB07272	N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL) ... not specified MAPK8
Drugbank DB07276	5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXY ... not specified MAPK8
Drugbank DB07845	2-fluoro-6-{[2-({2-methoxy-4-[(methylsul ... not specified MAPK8

Comment	Alpha-synuclein was found to induce the phosphorylation of the three MAPKs, ERK(1,2), JNK(p46) and p38 MAPK, and treatment with MMP-3 or MMP-9 inhibitor remarkably suppressed the phosphorylation of all three MAPKs.
Formal Description Interaction-ID: 7442	gene/protein SNCA increases_phosphorylation of gene/protein p38 MAPK in microglia; together with MMP3 and MMP9

Comment	PAR-1 is involved in alpha-synuclein-induced microglial activation. Modulation of Par-1 activity might provide a new therapeutic strategy for Parkinson's disease.
Formal Description Interaction-ID: 7446	gene/protein F2R affects_activity of process microglial cell activation in microglia; induced by alpha-synuclein
Drugbank entries	Show/Hide entries for F2R
Drugbank DB00086	Streptokinase cleavage F2R
Drugbank DB00086	Streptokinase cleavage F2R

Comment	PAR1 is a substrate of MMP8 MMP3 and MMP9.
Formal Description Interaction-ID: 7447	gene/protein MMP8 increases_activity of gene/protein F2R
Drugbank entries	Show/Hide entries for MMP8 or F2R
Drugbank DB00786	Marimastat inhibitor MMP8
Drugbank DB02326	1-Hydroxyamine-2-Isobutylmalonic Acid not specified MMP8
Drugbank DB02953	2-Thiomethyl-3-Phenylpropanoic Acid not specified MMP8
Drugbank DB03207	2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahyd ... not specified MMP8
Drugbank DB03622	2-Hydroxy-5-[4-(2-Hydroxy-Ethyl)-Piperid ... not specified MMP8
Drugbank DB03636	Glycinamid not specified MMP8
Drugbank DB03880	Batimastat not specified MMP8
Drugbank DB06971	N-{2-[(4'-CYANO-1,1'-BIPHENYL-4-YL)OXY]E ... not specified MMP8
Drugbank DB07397	(5S)-5-(2-amino-2-oxoethyl)-4-oxo-N-[(3- ... not specified MMP8
Drugbank DB07713	(1S)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL) ... not specified MMP8
Drugbank DB07772	(1R)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL) ... not specified MMP8
Drugbank DB07900	3-FORMYL-2-HYDROXY-5-METHYL-HEXANOIC ACI ... not specified MMP8
Drugbank DB08028	BUT-3-ENYL-[5-(4-CHLORO-PHENYL)-3,6-DIHY ... not specified MMP8
Drugbank DB08403	METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAM ... not specified MMP8
Drugbank DB08476	3-AMINO-AZACYCLOTRIDECAN-2-ONE not specified MMP8
Drugbank DB02326	1-Hydroxyamine-2-Isobutylmalonic Acid not specified MMP8
Drugbank DB02953	2-Thiomethyl-3-Phenylpropanoic Acid not specified MMP8
Drugbank DB03207	2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahyd ... not specified MMP8
Drugbank DB03622	2-Hydroxy-5-[4-(2-Hydroxy-Ethyl)-Piperid ... not specified MMP8
Drugbank DB03636	Glycinamid not specified MMP8
Drugbank DB03880	Batimastat not specified MMP8
Drugbank DB00086	Streptokinase cleavage F2R
Drugbank DB00086	Streptokinase cleavage F2R

Comment	Alpha-synuclein increases PAR3 expression in microglia.
Formal Description Interaction-ID: 7448	gene/protein SNCA increases_expression of gene/protein F2RL2 in microglia

Comment	PAR1 is a substrate of MMP8 MMP3 and MMP9.
Formal Description Interaction-ID: 7449	gene/protein MMP3 increases_activity of gene/protein F2R
Drugbank entries	Show/Hide entries for MMP3 or F2R
Drugbank DB00786	Marimastat antagonist MMP3
Drugbank DB01877	N-Hydroxy 1n(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB01996	3-Methylpyridine not specified MMP3
Drugbank DB02090	A Disubstituted Succinyl Caprolactam Hyd ... not specified MMP3
Drugbank DB02350	N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl] ... not specified MMP3
Drugbank DB02367	(1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hyd ... not specified MMP3
Drugbank DB02449	3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperid ... not specified MMP3
Drugbank DB02697	Hydroxyaminovaline not specified MMP3
Drugbank DB03033	1-Methyloxy-4-Sulfone-Benzene not specified MMP3
Drugbank DB03368	5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine ... not specified MMP3
Drugbank DB04140	1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6 ... not specified MMP3
Drugbank DB04232	N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB04416	R-2-{[4'-Methoxy-(1,1'-Biphenyl)-4-Yl]-S ... not specified MMP3
Drugbank DB07390	2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YL) ... not specified MMP3
Drugbank DB07986	[4-(4-PHENYL-PIPERIDIN-1-YL)-BENZENESULF ... not specified MMP3
Drugbank DB07987	[2-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YLCAR ... not specified MMP3
Drugbank DB07988	2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2YL)- ... not specified MMP3
Drugbank DB08029	N~2~-(biphenyl-4-ylsulfonyl)-N-hydroxy-N ... not specified MMP3
Drugbank DB08030	3-[(4'-cyanobiphenyl-4-yl)oxy]-N-hydroxy ... not specified MMP3
Drugbank DB08271	N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GL ... not specified MMP3
Drugbank DB08507	N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT-4-YL ... not specified MMP3
Drugbank DB08643	2-(2-{2-[(BIPHENYL-4-YLMETHYL)-AMINO]-3- ... not specified MMP3
Drugbank DB01877	N-Hydroxy 1n(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB01996	3-Methylpyridine not specified MMP3
Drugbank DB02090	A Disubstituted Succinyl Caprolactam Hyd ... not specified MMP3
Drugbank DB02350	N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl] ... not specified MMP3
Drugbank DB02367	(1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hyd ... not specified MMP3
Drugbank DB02449	3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperid ... not specified MMP3
Drugbank DB02697	Hydroxyaminovaline not specified MMP3
Drugbank DB03033	1-Methyloxy-4-Sulfone-Benzene not specified MMP3
Drugbank DB03368	5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine ... not specified MMP3
Drugbank DB04140	1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6 ... not specified MMP3
Drugbank DB04232	N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB04416	R-2-{[4'-Methoxy-(1,1'-Biphenyl)-4-Yl]-S ... not specified MMP3
Drugbank DB00086	Streptokinase cleavage F2R
Drugbank DB00086	Streptokinase cleavage F2R

Comment	PAR1 is a substrate of MMP8 MMP3 and MMP9.
Formal Description Interaction-ID: 7450	gene/protein MMP9 increases_activity of gene/protein F2R
Drugbank entries	Show/Hide entries for F2R
Drugbank DB00086	Streptokinase cleavage F2R
Drugbank DB00086	Streptokinase cleavage F2R

Comment	Alpha-synuclein, especially aggregated alpha-synuclein, causes microglial activation.
Formal Description Interaction-ID: 11692	phenotype alpha-synuclein inclusion body increases_activity of process microglial cell activation

Comment	Alpha-synuclein induced the expression of MMP-1, -3, -8 and -9.
Formal Description Interaction-ID: 11693	gene/protein SNCA affects_expression of gene/protein MMP1 in microglia
Drugbank entries	Show/Hide entries for MMP1
Drugbank DB00786	Marimastat inhibitor MMP1
Drugbank DB07556	N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFON ... not specified MMP1
Drugbank DB07926	N-[3-(N'-HYDROXYCARBOXAMIDO)-2-(2-METHYL ... not specified MMP1
Drugbank DB08403	METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAM ... not specified MMP1
Drugbank DB08482	[[1-[N-HYDROXY-ACETAMIDYL]-3-METHYL-BUTY ... not specified MMP1
Drugbank DB08491	N-HYDROXY-2-[4-(4-PHENOXY-BENZENESULFONY ... not specified MMP1

Comment	Alpha-synuclein induced the expression of MMP-1, -3, -8 and -9.
Formal Description Interaction-ID: 11694	gene/protein SNCA affects_expression of gene/protein MMP3 in microglia
Drugbank entries	Show/Hide entries for MMP3
Drugbank DB00786	Marimastat antagonist MMP3
Drugbank DB01877	N-Hydroxy 1n(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB01996	3-Methylpyridine not specified MMP3
Drugbank DB02090	A Disubstituted Succinyl Caprolactam Hyd ... not specified MMP3
Drugbank DB02350	N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl] ... not specified MMP3
Drugbank DB02367	(1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hyd ... not specified MMP3
Drugbank DB02449	3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperid ... not specified MMP3
Drugbank DB02697	Hydroxyaminovaline not specified MMP3
Drugbank DB03033	1-Methyloxy-4-Sulfone-Benzene not specified MMP3
Drugbank DB03368	5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine ... not specified MMP3
Drugbank DB04140	1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6 ... not specified MMP3
Drugbank DB04232	N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB04416	R-2-{[4'-Methoxy-(1,1'-Biphenyl)-4-Yl]-S ... not specified MMP3
Drugbank DB07390	2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YL) ... not specified MMP3
Drugbank DB07986	[4-(4-PHENYL-PIPERIDIN-1-YL)-BENZENESULF ... not specified MMP3
Drugbank DB07987	[2-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YLCAR ... not specified MMP3
Drugbank DB07988	2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2YL)- ... not specified MMP3
Drugbank DB08029	N~2~-(biphenyl-4-ylsulfonyl)-N-hydroxy-N ... not specified MMP3
Drugbank DB08030	3-[(4'-cyanobiphenyl-4-yl)oxy]-N-hydroxy ... not specified MMP3
Drugbank DB08271	N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GL ... not specified MMP3
Drugbank DB08507	N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT-4-YL ... not specified MMP3
Drugbank DB08643	2-(2-{2-[(BIPHENYL-4-YLMETHYL)-AMINO]-3- ... not specified MMP3
Drugbank DB01877	N-Hydroxy 1n(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB01996	3-Methylpyridine not specified MMP3
Drugbank DB02090	A Disubstituted Succinyl Caprolactam Hyd ... not specified MMP3
Drugbank DB02350	N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl] ... not specified MMP3
Drugbank DB02367	(1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hyd ... not specified MMP3
Drugbank DB02449	3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperid ... not specified MMP3
Drugbank DB02697	Hydroxyaminovaline not specified MMP3
Drugbank DB03033	1-Methyloxy-4-Sulfone-Benzene not specified MMP3
Drugbank DB03368	5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine ... not specified MMP3
Drugbank DB04140	1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6 ... not specified MMP3
Drugbank DB04232	N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4- ... not specified MMP3
Drugbank DB04416	R-2-{[4'-Methoxy-(1,1'-Biphenyl)-4-Yl]-S ... not specified MMP3

Comment	Alpha-synuclein induced the expression of MMP-1, -3, -8 and -9.
Formal Description Interaction-ID: 11695	gene/protein SNCA affects_expression of gene/protein MMP8 in microglia
Drugbank entries	Show/Hide entries for MMP8
Drugbank DB00786	Marimastat inhibitor MMP8
Drugbank DB02326	1-Hydroxyamine-2-Isobutylmalonic Acid not specified MMP8
Drugbank DB02953	2-Thiomethyl-3-Phenylpropanoic Acid not specified MMP8
Drugbank DB03207	2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahyd ... not specified MMP8
Drugbank DB03622	2-Hydroxy-5-[4-(2-Hydroxy-Ethyl)-Piperid ... not specified MMP8
Drugbank DB03636	Glycinamid not specified MMP8
Drugbank DB03880	Batimastat not specified MMP8
Drugbank DB06971	N-{2-[(4'-CYANO-1,1'-BIPHENYL-4-YL)OXY]E ... not specified MMP8
Drugbank DB07397	(5S)-5-(2-amino-2-oxoethyl)-4-oxo-N-[(3- ... not specified MMP8
Drugbank DB07713	(1S)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL) ... not specified MMP8
Drugbank DB07772	(1R)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL) ... not specified MMP8
Drugbank DB07900	3-FORMYL-2-HYDROXY-5-METHYL-HEXANOIC ACI ... not specified MMP8
Drugbank DB08028	BUT-3-ENYL-[5-(4-CHLORO-PHENYL)-3,6-DIHY ... not specified MMP8
Drugbank DB08403	METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAM ... not specified MMP8
Drugbank DB08476	3-AMINO-AZACYCLOTRIDECAN-2-ONE not specified MMP8
Drugbank DB02326	1-Hydroxyamine-2-Isobutylmalonic Acid not specified MMP8
Drugbank DB02953	2-Thiomethyl-3-Phenylpropanoic Acid not specified MMP8
Drugbank DB03207	2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahyd ... not specified MMP8
Drugbank DB03622	2-Hydroxy-5-[4-(2-Hydroxy-Ethyl)-Piperid ... not specified MMP8
Drugbank DB03636	Glycinamid not specified MMP8
Drugbank DB03880	Batimastat not specified MMP8

Comment	Alpha-synuclein induced the expression of MMP-1, -3, -8 and -9.
Formal Description Interaction-ID: 11696	gene/protein SNCA affects_expression of gene/protein MMP9 in microglia