General Information:

Id: 10,936 (click here to show other Interactions for entry)
Diseases: Anxiety disorders
Neurological
Homo sapiens
268 patients with anxiety disorder (AD), 541 with unipolar depression
article
Reference: Unschuld PG et al.(2009) Polymorphisms in the GAD2 gene-region are associated with susceptibility for unipolar depression and with a risk factor for anxiety disorders Am. J. Med. Genet. B Neuropsychiatr. Genet. 150 [PMID: 19229853]

Interaction Information:

Comment Glutamate decarboxylase GAD2 isoform plays a role in the conversion of glutamic acid to gamma-aminobutyric acid (GABA). Chronic stress increases GAD2 mRNA expression and availability of GAD65 apoenzyme, responding to short-term demands for GABA. (cited information)
Formal Description
Interaction-ID: 111337

gene/protein

GAD2

increases_quantity of

drug/chemical compound

GABA

mainly in stress situations
Drugbank entries Show/Hide entries for GAD2