CIDeRplusGeneral Information:
| Id: | 10,936 |
| Diseases: |
Anxiety disorders
Neurological |
| Homo sapiens | |
| 268 patients with anxiety disorder (AD), 541 with unipolar depression | |
| article | |
| Reference: | Unschuld PG et al.(2009) Polymorphisms in the GAD2 gene-region are associated with susceptibility for unipolar depression and with a risk factor for anxiety disorders Am. J. Med. Genet. B Neuropsychiatr. Genet. 150 [PMID: 19229853] |
Interaction Information:
| Comment | Glutamate decarboxylase GAD2 isoform plays a role in the conversion of glutamic acid to gamma-aminobutyric acid (GABA). Chronic stress increases GAD2 mRNA expression and availability of GAD65 apoenzyme, responding to short-term demands for GABA. (cited information) |
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Formal Description Interaction-ID: 111337 |
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| Drugbank entries | Show/Hide entries for GAD2 |
| Comment | Glutamate decarboxylase GAD2 isoform plays a role in the conversion of glutamic acid to gamma-aminobutyric acid (GABA). Chronic stress increases GAD2 mRNA expression and availability of GAD65 apoenzyme, responding to short-term demands for GABA. (cited information) |
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Formal Description Interaction-ID: 111343 |
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| Drugbank entries | Show/Hide entries for GAD2 |
| Comment | SNPs in the GAD2 gene-region are associated with susceptibility for unipolar depression and with a risk factor for anxiety disorders. healthy controls were analyzed for GAD2 SNPs associated with theses diseases. |
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Formal Description Interaction-ID: 111344 |
|
| Drugbank entries | Show/Hide entries for GAD2 |
| Comment | SNPs in the GAD2 gene-region are associated with susceptibility for unipolar depression and with a risk factor for anxiety disorders. healthy controls were analyzed for GAD2 SNPs associated with theses diseases. |
|
Formal Description Interaction-ID: 111345 |
|
| Drugbank entries | Show/Hide entries for GAD2 |