|
2,123
|
| 17535 |
T3SS
|
|
increases_transport of
|
exoU
|
into the host cell
|
| 17546 |
exoU
|
|
increases_activity of
|
cell death
|
|
|
15695491
|
Pseudomonas aeruginosa diseases
|
|
2,336
|
| 20394 |
exoU
|
|
decreases_quantity of
|
Phospholipid
|
by degradation
|
| 20403 |
exoU
|
|
decreases_quantity of
|
Lysophospholipid
|
by degradation
|
| 20586 |
SOD1
|
|
increases_activity of
|
exoU
|
|
|
19680249
|
Pseudomonas aeruginosa diseases
|
|
2,464
|
| 23018 |
T3SS
|
|
increases_transport of
|
exoU
|
into the host cell
|
|
20947426
|
Pseudomonas aeruginosa diseases
|
|
2,586
|
| 24366 |
T3SS
|
|
increases_transport of
|
exoU
|
into the host cell
|
|
21833328
|
Pseudomonas aeruginosa diseases
|
|
2,655
|
| 25049 |
UBB
|
|
increases_activity of
|
exoU
|
|
| 25060 |
UBB
|
|
interacts (colocalizes) with
|
exoU
|
affinity for polyubiquitin is greater than monoubiquitin or diubiquitin
|
| 25062 |
ISG15
|
NOT |
increases_activity of
|
exoU
|
|
| 25063 |
UBD
|
NOT |
increases_activity of
|
exoU
|
|
| 25064 |
SUMO1
|
NOT |
increases_activity of
|
exoU
|
|
| 25065 |
NEDD8
|
NOT |
increases_activity of
|
exoU
|
|
| 25066 |
exoU
|
|
decreases_quantity of
|
Phospholipid
|
|
|
22040088
|
Pseudomonas aeruginosa diseases
|
|
2,665
|
| 25090 |
UBB
|
|
interacts (colocalizes) with
|
exoU
|
|
| 25094 |
exoU
|
|
is localized in
|
host cell plasma membrane
|
|
|
16882033
|
Pseudomonas aeruginosa diseases
|
|
2,695
|
| 25179 |
exoU
|
|
decreases_quantity of
|
ICAM1, membrane-bound
|
|
| 25189 |
exoU
|
|
increases_quantity of
|
ICAM1, soluble
|
|
| 25190 |
exoU
|
NOT |
affects_expression of
|
ICAM1, membrane-bound
|
|
| 25191 |
exoU
|
NOT |
affects_expression of
|
ICAM1, soluble
|
|
|
19931407
|
Pseudomonas aeruginosa diseases
|
|
2,791
|
| 25815 |
exoU
|
|
increases_activity of
|
inflammatory response
|
|
| 25816 |
exoU
|
|
increases_quantity of
|
IL6
|
|
| 25817 |
exoU
|
|
increases_quantity of
|
TNF
|
|
| 25818 |
exoU
|
|
affects_activity of
|
blood coagulation
|
|
| 25821 |
exoU
|
|
affects_activity of
|
PAF signaling system
|
|
|
21819560
|
Pseudomonas aeruginosa diseases
|
|
2,792
|
| 25819 |
exoU
|
|
increases_quantity of
|
SERPINE1
|
|
| 25820 |
exoU
|
|
increases_expression of
|
SERPINE1
|
|
| 25822 |
exoU
|
|
affects_activity of
|
PAF signaling system
|
|
|
21819560
|
Pseudomonas aeruginosa diseases
|
|
2,805
|
| 25873 |
exoU
|
|
increases_activity of
|
cell death
|
in macrophages; infected with P. aeruginosa strain PA103 (expressing ExoU)
|
| 25878 |
exoU
|
|
decreases_activity of
|
CASP1
|
in macrophages; infected with P. aeruginosa strain PA103 (expressing ExoU)
|
| 25879 |
exoU
|
|
decreases_quantity of
|
IL1B
|
in macrophages; infected with P. aeruginosa strain PA103 (expressing ExoU)
|
| 25881 |
exoU
|
|
decreases_quantity of
|
IL18
|
in macrophages; infected with P. aeruginosa strain PA103 (expressing ExoU)
|
|
18070936
|
Pseudomonas aeruginosa diseases
|
|
2,812
|
| 25908 |
exoU
|
|
increases_quantity of
|
CXCL8
|
in respiratory epithelial cells
|
| 25909 |
exoU
|
|
increases_activity of
|
MAPK cascade
|
in respiratory epithelial cells
|
| 25910 |
exoU
|
|
increases_activity of
|
MAP2K4
|
in respiratory epithelial cells
|
| 25911 |
exoU
|
|
increases_phosphorylation of
|
MAP2K4
|
in respiratory epithelial cells
|
| 25912 |
exoU
|
|
increases_activity of
|
MAPK9
|
in respiratory epithelial cells
|
| 25913 |
exoU
|
|
increases_phosphorylation of
|
MAPK9
|
in respiratory epithelial cells
|
| 25914 |
exoU
|
|
increases_activity of
|
JUN
|
in respiratory epithelial cells
|
| 25915 |
exoU
|
|
increases_phosphorylation of
|
JUN
|
in respiratory epithelial cells
|
|
16790784
|
Pseudomonas aeruginosa diseases
|
|
3,595
|
| 33642 |
exoU
|
|
increases_expression of
|
CXCL8
|
in human epithelial respiratory and microvascular endothelial cell cultures; analysed by RT-PCR
|
| 33643 |
exoU
|
|
increases_quantity of
|
CXCL8
|
in human epithelial respiratory and microvascular endothelial cell cultures; analysed by ELISA
|
| 33644 |
exoU
|
|
increases_activity of
|
I-kappaB kinase/NF-kappaB signaling
|
in human epithelial respiratory and microvascular endothelial cell cultures; analysed by EMSA
|
|
22848596
|
Pseudomonas aeruginosa diseases
|
|
3,596
|
| 33647 |
exoU
|
|
increases_quantity of
|
Keratinocyte-derived cytokine
|
in bronchoalveolar lavage fluids (BALF) in mice airways; analysed by ELISA
|
| 33651 |
exoU
|
|
increases_activity of
|
neutrophil activation
|
in bronchoalveolar lavage fluids (BALF) in mice airways
|
|
22848596
|
Pseudomonas aeruginosa diseases
|
|
3,862
|
| 38807 |
spcU
|
|
increases_folding of
|
exoU
|
as shown in a crystal structure
|
| 38811 |
spcU
|
|
interacts (colocalizes) with
|
exoU
|
as shown in a crystal structure
|
| 38813 |
exoU
|
|
interacts (colocalizes) with
|
Phosphatidylinositol 4,5-bisphosphate
|
|
| 38816 |
exoU
|
|
is localized in
|
host cell plasma membrane
|
|
| 38818 |
exoU
|
|
is localized in
|
early endosome
|
the ubiquitinated form of ExoU
|
| 38820 |
UBB
|
|
interacts (colocalizes) with
|
exoU
|
targeting ExoU to endosomal compartments
|
|
22496657
|
Pseudomonas aeruginosa diseases
|
|
3,953
|
| 40125 |
Acute pneumonia
|
|
increases_expression of
|
exoU
|
from 3 h postinfection to 12 h postinfection
|
| 40128 |
Acute pneumonia
|
|
increases_quantity of
|
exoU
|
from 3 h postinfection to 12 h postinfection
|
| 40131 |
T3SS
|
|
increases_transport of
|
exoU
|
|
|
23481600
|
Pseudomonas aeruginosa diseases
|
HoPaCI