|
2,123
|
| 17528 |
T3SS
|
|
increases_transport of
|
exoS
|
into the host cell
|
| 17537 |
exoS
|
|
increases_quantity of
|
TNF
|
|
| 17539 |
exoS
|
|
increases_activity of
|
TLR2
|
|
| 17540 |
exoS
|
|
increases_activity of
|
TLR4
|
|
|
15695491
|
Pseudomonas aeruginosa diseases
|
|
2,336
|
| 20362 |
exoS
|
|
interacts (colocalizes) with
|
RAB5
|
|
| 20363 |
exoS
|
|
interacts (colocalizes) with
|
RAB6
|
|
| 20364 |
exoS
|
|
interacts (colocalizes) with
|
RAB9
|
|
| 20367 |
exoS
|
|
decreases_activity of
|
RHOA
|
|
| 20368 |
exoS
|
|
decreases_activity of
|
RAC1
|
|
| 20369 |
exoS
|
|
decreases_activity of
|
CDC42
|
|
| 20370 |
exoS
|
|
decreases_activity of
|
actin cytoskeleton organization
|
|
| 20373 |
exoS
|
|
affects_activity of
|
HRAS
|
|
| 20374 |
exoS
|
|
decreases_activity of
|
EZR
|
|
| 20375 |
exoS
|
|
decreases_activity of
|
RDX
|
|
| 20376 |
exoS
|
|
decreases_activity of
|
MSN
|
|
| 23446 |
exoS
|
|
increases_activity of
|
protein ADP-ribosylation
|
|
| 38846 |
exoS
|
|
is localized in
|
host cell plasma membrane
|
transient localization
|
|
19680249
|
Pseudomonas aeruginosa diseases
|
|
2,354
|
| 20591 |
exsA
|
|
increases_expression of
|
exoS
|
|
| 28132 |
RhlR/I-C4-(HSL)-system
|
|
decreases transport of
|
exoS
|
|
|
15901720
|
Pseudomonas aeruginosa diseases
|
|
2,464
|
| 23035 |
T3SS
|
|
increases_transport of
|
exoS
|
into the host cell
|
|
20947426
|
Pseudomonas aeruginosa diseases
|
|
2,586
|
| 24364 |
T3SS
|
|
increases_transport of
|
exoS
|
into the host cell
|
|
21833328
|
Pseudomonas aeruginosa diseases
|
|
3,006
|
| 27370 |
T3SS
|
|
increases_transport of
|
exoS
|
in A459, BJAB, Jurkat, differentiated HL-60 and U937 cells
|
| 27372 |
T3SS
|
NOT |
affects transport of
|
exoS
|
in undifferentiated HL-60 or U937 cells
|
| 27377 |
Methyl-beta-cyclodextrin
|
|
decreases transport of
|
exoS
|
by cholesterol removal of cultured cells
|
| 27378 |
actin cytoskeleton organization
|
|
affects transport of
|
exoS
|
|
| 27379 |
Cytochalasin D
|
|
decreases transport of
|
exoS
|
into VD3-dHL-60 cells
|
| 27405 |
Latrunculin B
|
|
decreases transport of
|
exoS
|
into VD3-dHL-60 cells
|
| 27420 |
phosphatidylinositol 3-kinase signaling
|
|
affects transport of
|
exoS
|
|
| 27423 |
Wortmannin
|
|
decreases transport of
|
exoS
|
into VD3-dHL-60 cells
|
| 27425 |
LY 294002
|
|
decreases transport of
|
exoS
|
into VD3-dHL-60 cells
|
| 27427 |
Genistein
|
|
decreases transport of
|
exoS
|
into VD3-dHL-60 cells
|
| 27428 |
PP2 (kinase inhibitor)
|
|
decreases transport of
|
exoS
|
into VD3-dHL-60 cells
|
| 27429 |
PF-5732208
|
|
decreases transport of
|
exoS
|
into VD3-dHL-60 cells
|
|
22299042
|
Pseudomonas aeruginosa diseases
|
|
3,011
|
| 27476 |
Methyl-beta-cyclodextrin
|
|
decreases transport of
|
exoS
|
|
| 27489 |
Perfringolysin O
|
|
decreases transport of
|
exoS
|
|
| 27493 |
RAC1
|
|
increases_transport of
|
exoS
|
|
| 27494 |
CDC42
|
|
increases_transport of
|
exoS
|
|
| 27495 |
ROCK1
|
NOT |
increases_transport of
|
exoS
|
|
|
19910414
|
Pseudomonas aeruginosa diseases
|
|
3,113
|
| 28610 |
flagellum
|
|
decreases transport of
|
exoS
|
|
| 28619 |
gacA
|
|
decreases transport of
|
exoS
|
|
|
17307856
|
Pseudomonas aeruginosa diseases
|
|
3,140
|
| 28926 |
exoS
|
|
decreases_activity of
|
establishment of epithelial cell polarity
|
|
| 28928 |
exoS
|
|
decreases_activity of
|
establishment of skin barrier
|
|
| 28956 |
exoS
|
|
decreases_activity of
|
CDC42
|
|
| 28957 |
exoS
|
|
decreases_activity of
|
RAC1
|
|
| 28958 |
exoS
|
|
decreases_activity of
|
RHOA
|
|
| 28962 |
exoS
|
|
decreases_activity of
|
TJP1
|
|
| 28963 |
exoS
|
|
decreases_activity of
|
OCLN
|
|
| 28964 |
exoS
|
|
decreases_activity of
|
EZR
|
|
|
21747810
|
Pseudomonas aeruginosa diseases
|
|
3,156
|
| 29038 |
oprF
|
|
increases_transport of
|
exoS
|
|
|
21189321
|
Pseudomonas aeruginosa diseases
|
|
4,475
|
| 45043 |
exoS
|
|
increases_activity of
|
membrane bleb niche formation
|
in human corneal epithelial cells (hTCEpi)
|
| 45048 |
exoS
|
|
increases_activity of
|
P. aeruginosa intracellular replication
|
in membrane bleb niches of human corneal epithelial cells (hTCEpi)
|
|
20732998
|
Pseudomonas aeruginosa diseases
|
|
4,511
|
| 45115 |
exoS
|
|
decreases_activity of
|
protein catabolic process in the vacuole
|
|
| 45117 |
exoS
|
|
decreases_quantity of
|
acidified bacteria-occupied vacuole
|
|
| 45118 |
exoS
|
|
decreases_activity of
|
vacuolar acidification
|
|
|
24058462
|
Pseudomonas aeruginosa diseases
|
|
4,943
|
| 48850 |
exoS
|
|
decreases_activity of
|
actin cytoskeleton organization
|
in primary endothelial cells
|
| 48852 |
exoS
|
|
decreases_activity of
|
establishment of endothelial barrier
|
in primary endothelial cells
|
| 48855 |
exoS
|
|
decreases_activity of
|
focal adhesion assembly
|
in primary endothelial cells
|
| 48859 |
exoS
|
|
decreases_activity of
|
PTK2
|
in primary endothelial cells
|
| 48861 |
exoS
|
|
decreases_phosphorylation of
|
CFL1
|
in primary endothelial cells
|
| 48866 |
exoS
|
|
decreases_phosphorylation of
|
LIMK1
|
in primary endothelial cells
|
| 48867 |
exoS
|
|
decreases_phosphorylation of
|
LIMK2
|
in primary endothelial cells
|
| 48874 |
exoS
|
|
decreases_activity of
|
RHOA
|
in primary endothelial cells
|
| 48876 |
exoS
|
|
decreases_activity of
|
RAC1
|
in primary endothelial cells
|
| 48878 |
exoS
|
|
decreases_activity of
|
CDC42
|
in primary endothelial cells
|
|
23974244
|
Pseudomonas aeruginosa diseases
|
|
6,402
|
| 60379 |
exoS
|
NOT |
affects_activity of
|
biofilm formation
|
as shown on MDCK epithelial cells and in a murine model of acute neumonia
|
|
25375398
|
Pseudomonas aeruginosa diseases
|
|
6,526
|
| 62085 |
exoS
|
|
decreases_activity of
|
IPAF inflammasome complex
|
|
|
25845843
|
Pseudomonas aeruginosa diseases
|
|
6,550
|
| 62267 |
exoS
|
|
increases_activity of
|
inflammatory response
|
|
| 62272 |
exoS
|
|
decreases_activity of
|
phagocytosis
|
as shown in infected J774 macrophage-like cells and in phagocytes
from mice with pneumonia.
|
| 62273 |
exoS
|
|
decreases_activity of
|
HRAS
|
|
|
24917597
|
Pseudomonas aeruginosa diseases
|
HoPaCI