|
2,123
|
| 17528 |
T3SS
|
|
increases_transport of
|
exoS
|
into the host cell
|
| 17537 |
exoS
|
|
increases_quantity of
|
TNF
|
|
| 17539 |
exoS
|
|
increases_activity of
|
TLR2
|
|
| 17540 |
exoS
|
|
increases_activity of
|
TLR4
|
|
|
15695491
|
Pseudomonas aeruginosa diseases
|
|
2,336
|
| 20362 |
exoS
|
|
interacts (colocalizes) with
|
RAB5
|
|
| 20363 |
exoS
|
|
interacts (colocalizes) with
|
RAB6
|
|
| 20364 |
exoS
|
|
interacts (colocalizes) with
|
RAB9
|
|
| 20367 |
exoS
|
|
decreases_activity of
|
RHOA
|
|
| 20368 |
exoS
|
|
decreases_activity of
|
RAC1
|
|
| 20369 |
exoS
|
|
decreases_activity of
|
CDC42
|
|
| 20370 |
exoS
|
|
decreases_activity of
|
actin cytoskeleton organization
|
|
| 20373 |
exoS
|
|
affects_activity of
|
HRAS
|
|
| 20374 |
exoS
|
|
decreases_activity of
|
EZR
|
|
| 20375 |
exoS
|
|
decreases_activity of
|
RDX
|
|
| 20376 |
exoS
|
|
decreases_activity of
|
MSN
|
|
| 23446 |
exoS
|
|
increases_activity of
|
protein ADP-ribosylation
|
|
| 38846 |
exoS
|
|
is localized in
|
host cell plasma membrane
|
transient localization
|
|
19680249
|
Pseudomonas aeruginosa diseases
|
|
2,346
|
| 20457 |
exoS
|
|
increases_expression of
|
HIF1A
|
|
| 20458 |
exoS
|
|
increases_expression of
|
DUSP10
|
|
| 20459 |
exoS
|
|
increases_expression of
|
STAT5A
|
|
| 20460 |
exoS
|
|
increases_expression of
|
MAP3K8
|
|
| 20461 |
exoS
|
|
increases_expression of
|
PDE4D
|
|
| 20463 |
exoS
|
|
increases_expression of
|
G3BP1
|
|
| 20464 |
exoS
|
|
increases_expression of
|
GDI2
|
|
| 20465 |
exoS
|
|
increases_expression of
|
IFNGR2
|
|
| 20476 |
exoS
|
|
increases_expression of
|
BCL2A1
|
|
| 20477 |
exoS
|
|
increases_expression of
|
ZNF217
|
|
| 20478 |
exoS
|
|
decreases_expression of
|
BAX
|
|
| 20479 |
exoS
|
|
decreases_expression of
|
ADRM1
|
|
| 20480 |
exoS
|
|
decreases_expression of
|
IL4
|
|
| 20486 |
exoS
|
|
decreases_expression of
|
PTMS
|
|
|
16207250
|
Pseudomonas aeruginosa diseases
|
|
2,354
|
| 20591 |
exsA
|
|
increases_expression of
|
exoS
|
|
| 28132 |
RhlR/I-C4-(HSL)-system
|
|
decreases transport of
|
exoS
|
|
|
15901720
|
Pseudomonas aeruginosa diseases
|
|
2,363
|
| 20744 |
Long-chain fatty acid
|
|
decreases_expression of
|
exoS
|
LCFA used in this exp. was oleate, in KEGG C00712
|
| 20787 |
Long-chain fatty acid
|
|
decreases_quantity of
|
exoS
|
LCFA used in this exp. was oleate, in KEGG C00712
|
|
19508282
|
Pseudomonas aeruginosa diseases
|
|
2,372
|
| 20833 |
psrA
|
|
increases_expression of
|
exoS
|
|
|
16428760
|
Pseudomonas aeruginosa diseases
|
|
2,375
|
| 20858 |
exoS
|
|
interacts (colocalizes) with
|
YWHAB
|
in vivo
|
|
10903129
|
Pseudomonas aeruginosa diseases
|
|
2,380
|
| 20900 |
exoS
|
|
increases_activity of
|
CASP3
|
|
|
16966406
|
Pseudomonas aeruginosa diseases
|
|
2,395
|
| 21279 |
exoS
|
|
decreases_phosphorylation of
|
FOXO3
|
|
| 21280 |
exoS
|
|
increases_activity of
|
CASP3
|
|
| 21283 |
protein kinase B signaling
|
|
decreases_activity of
|
exoS
|
|
|
16611230
|
Pseudomonas aeruginosa diseases
|
|
2,398
|
| 21328 |
exoS
|
|
affects_activity of
|
HRAS
|
by ADP-ribosylation in vitro and in vivo
|
| 21351 |
exoS
|
|
affects_activity of
|
RAB5
|
by ADP-ribosylation in vitro and in vivo
|
| 21352 |
exoS
|
|
affects_activity of
|
RAB8
|
by ADP-ribosylation in vitro and in vivo
|
| 21353 |
exoS
|
|
affects_activity of
|
RAB7
|
by ADP-ribosylation in vitro and in vivo
|
| 21354 |
exoS
|
|
affects_activity of
|
RAB11
|
by ADP-ribosylation in vitro and in vivo
|
| 21356 |
exoS
|
|
affects_activity of
|
RAC1
|
by ADP-ribosylation in vitro and in vivo
|
| 21357 |
exoS
|
NOT |
affects_activity of
|
CDC42
|
by ADP-ribosylation in vivo
|
| 21358 |
exoS
|
NOT |
affects_activity of
|
RHOA
|
by ADP-ribosylation in vivo
|
| 21359 |
exoS
|
NOT |
affects_activity of
|
RHOB
|
by ADP-ribosylation in vivo
|
| 21360 |
exoS
|
NOT |
affects_activity of
|
RHOC
|
by ADP-ribosylation in vivo
|
| 21361 |
exoS
|
|
affects_activity of
|
RALA
|
by ADP-ribosylation in vivo
|
| 21362 |
exoS
|
|
increases_activity of
|
protein ADP-ribosylation
|
the most efficient substrate modification was consistently detected in the membrane fraction
|
|
11829467
|
Pseudomonas aeruginosa diseases
|
|
2,400
|
| 21367 |
exoS
|
|
increases_activity of
|
MAPK8
|
at 2-4 hours postinfection
|
| 21368 |
exoS
|
|
increases_phosphorylation of
|
MAPK8
|
at 2-4 hours postinfection
|
| 21369 |
exoS
|
|
increases_activity of
|
MAPK9
|
at 2-4 hours postinfection
|
| 21370 |
exoS
|
|
increases_phosphorylation of
|
MAPK9
|
at 2-4 hours postinfection
|
| 21371 |
exoS
|
|
decreases_activity of
|
p38 MAPK
|
at 2-4 hours postinfection
|
| 21372 |
exoS
|
|
decreases_phosphorylation of
|
p38 MAPK
|
at 2-4 hours postinfection
|
| 21373 |
exoS
|
|
decreases_activity of
|
MAPK3
|
at 2-4 hours postinfection
|
| 21374 |
exoS
|
|
decreases_phosphorylation of
|
MAPK3
|
at 2-4 hours postinfection
|
| 21375 |
exoS
|
|
decreases_activity of
|
MAPK1
|
at 2-4 hours postinfection
|
| 21376 |
exoS
|
|
decreases_phosphorylation of
|
MAPK1
|
at 2-4 hours postinfection
|
| 21378 |
exoS
|
|
increases_activity of
|
JNK cascade
|
|
| 21380 |
exoS
|
|
increases_activity of
|
apoptotic process
|
|
|
12761120
|
Pseudomonas aeruginosa diseases
|
|
2,401
|
| 21389 |
YWHAZ
|
|
increases_activity of
|
exoS
|
|
| 21390 |
YWHAB
|
|
increases_activity of
|
exoS
|
|
| 21391 |
YWHAH
|
|
increases_activity of
|
exoS
|
|
| 21392 |
SFN
|
|
increases_activity of
|
exoS
|
|
| 21393 |
YWHAQ
|
|
increases_activity of
|
exoS
|
|
|
10508420
|
Pseudomonas aeruginosa diseases
|
|
2,464
|
| 23035 |
T3SS
|
|
increases_transport of
|
exoS
|
into the host cell
|
|
20947426
|
Pseudomonas aeruginosa diseases
|
|
2,586
|
| 24364 |
T3SS
|
|
increases_transport of
|
exoS
|
into the host cell
|
|
21833328
|
Pseudomonas aeruginosa diseases
|
|
2,813
|
| 25995 |
exoS
|
|
increases_quantity of
|
OGG1
|
delta-ExoS 6.5-fold versus delta-ExoT 2.6-fold reduction
|
|
20956573
|
Pseudomonas aeruginosa diseases
|
|
3,006
|
| 27370 |
T3SS
|
|
increases_transport of
|
exoS
|
in A459, BJAB, Jurkat, differentiated HL-60 and U937 cells
|
| 27372 |
T3SS
|
NOT |
affects transport of
|
exoS
|
in undifferentiated HL-60 or U937 cells
|
| 27377 |
Methyl-beta-cyclodextrin
|
|
decreases transport of
|
exoS
|
by cholesterol removal of cultured cells
|
| 27378 |
actin cytoskeleton organization
|
|
affects transport of
|
exoS
|
|
| 27379 |
Cytochalasin D
|
|
decreases transport of
|
exoS
|
into VD3-dHL-60 cells
|
| 27405 |
Latrunculin B
|
|
decreases transport of
|
exoS
|
into VD3-dHL-60 cells
|
| 27420 |
phosphatidylinositol 3-kinase signaling
|
|
affects transport of
|
exoS
|
|
| 27423 |
Wortmannin
|
|
decreases transport of
|
exoS
|
into VD3-dHL-60 cells
|
| 27425 |
LY 294002
|
|
decreases transport of
|
exoS
|
into VD3-dHL-60 cells
|
| 27427 |
Genistein
|
|
decreases transport of
|
exoS
|
into VD3-dHL-60 cells
|
| 27428 |
PP2 (kinase inhibitor)
|
|
decreases transport of
|
exoS
|
into VD3-dHL-60 cells
|
| 27429 |
PF-5732208
|
|
decreases transport of
|
exoS
|
into VD3-dHL-60 cells
|
|
22299042
|
Pseudomonas aeruginosa diseases
|
|
3,011
|
| 27476 |
Methyl-beta-cyclodextrin
|
|
decreases transport of
|
exoS
|
|
| 27489 |
Perfringolysin O
|
|
decreases transport of
|
exoS
|
|
| 27493 |
RAC1
|
|
increases_transport of
|
exoS
|
|
| 27494 |
CDC42
|
|
increases_transport of
|
exoS
|
|
| 27495 |
ROCK1
|
NOT |
increases_transport of
|
exoS
|
|
|
19910414
|
Pseudomonas aeruginosa diseases
|
|
3,113
|
| 28610 |
flagellum
|
|
decreases transport of
|
exoS
|
|
| 28619 |
gacA
|
|
decreases transport of
|
exoS
|
|
|
17307856
|
Pseudomonas aeruginosa diseases
|
|
3,140
|
| 28926 |
exoS
|
|
decreases_activity of
|
establishment of epithelial cell polarity
|
|
| 28928 |
exoS
|
|
decreases_activity of
|
establishment of skin barrier
|
|
| 28956 |
exoS
|
|
decreases_activity of
|
CDC42
|
|
| 28957 |
exoS
|
|
decreases_activity of
|
RAC1
|
|
| 28958 |
exoS
|
|
decreases_activity of
|
RHOA
|
|
| 28962 |
exoS
|
|
decreases_activity of
|
TJP1
|
|
| 28963 |
exoS
|
|
decreases_activity of
|
OCLN
|
|
| 28964 |
exoS
|
|
decreases_activity of
|
EZR
|
|
|
21747810
|
Pseudomonas aeruginosa diseases
|
|
3,156
|
| 29038 |
oprF
|
|
increases_transport of
|
exoS
|
|
|
21189321
|
Pseudomonas aeruginosa diseases
|
|
3,415
|
| 31692 |
exoS
|
|
decreases_quantity of
|
CXCL8
|
in the culture medium of Caco-2 monolayers
|
| 31700 |
exoS
|
|
increases_expression of
|
CXCL8
|
in the culture medium of Caco-2 monolayers
|
| 31705 |
exoS
|
|
affects_activity of
|
mucD
|
|
|
21626303
|
Pseudomonas aeruginosa diseases
|
|
3,416
|
| 31706 |
exoS
|
|
decreases_activity of
|
neutrophil extravasation
|
|
|
21626303
|
Pseudomonas aeruginosa diseases
|
|
3,419
|
| 31744 |
exoS
|
|
decreases_activity of
|
establishment of skin barrier
|
in MDCK cell monolayers and Caco-2 colon epithelial cells
|
| 31766 |
exoS
|
|
decreases_activity of
|
tight junction assembly
|
in MDCK cell monolayers and Caco-2 colon epithelial cells
|
| 31769 |
exoS
|
|
interacts (colocalizes) with
|
FXYD3
|
in a GST pulldown assay and Caco-2 cell lysates
|
| 31789 |
exoS
|
|
decreases_activity of
|
sodium:potassium-exchanging ATPase activity
|
in Caco-2 cells
|
| 31791 |
exoS
|
|
decreases_activity of
|
FXYD3
|
in Caco-2 cells
|
| 31793 |
exoS
|
|
decreases_quantity of
|
OCLN
|
in Caco-2 cells
|
| 31800 |
exoS
|
|
decreases_quantity of
|
TJP1
|
in Caco-2 cells
|
|
20805335
|
Pseudomonas aeruginosa diseases
|
|
3,683
|
| 35379 |
phoQ
|
NOT |
affects_expression of
|
exoS
|
|
|
22710876
|
Pseudomonas aeruginosa diseases
|
|
3,858
|
| 38768 |
pvdE
|
|
increases_expression of
|
exoS
|
|
| 38771 |
exoS
|
|
increases_activity of
|
entry of bacterium into host cell
|
of P.aeruginosa into host
|
|
22080193
|
Pseudomonas aeruginosa diseases
|
|
3,859
|
| 38783 |
exoS
|
NOT |
increases_activity of
|
entry of bacterium into host cell
|
of P.aeruginosa into silkworms
|
|
22080193
|
Pseudomonas aeruginosa diseases
|
|
4,081
|
| 42099 |
exoS
|
|
decreases_activity of
|
phagocytosis
|
during the internalization of live (to a larger extend) or heat-inactivated P. aeruginosa
|
| 42109 |
exoS
|
|
decreases_activity of
|
RAB5
|
|
|
23630954
|
Pseudomonas aeruginosa diseases
|
|
4,475
|
| 45043 |
exoS
|
|
increases_activity of
|
membrane bleb niche formation
|
in human corneal epithelial cells (hTCEpi)
|
| 45048 |
exoS
|
|
increases_activity of
|
P. aeruginosa intracellular replication
|
in membrane bleb niches of human corneal epithelial cells (hTCEpi)
|
|
20732998
|
Pseudomonas aeruginosa diseases
|
|
4,511
|
| 45115 |
exoS
|
|
decreases_activity of
|
protein catabolic process in the vacuole
|
|
| 45117 |
exoS
|
|
decreases_quantity of
|
acidified bacteria-occupied vacuole
|
|
| 45118 |
exoS
|
|
decreases_activity of
|
vacuolar acidification
|
|
|
24058462
|
Pseudomonas aeruginosa diseases
|
|
4,943
|
| 48850 |
exoS
|
|
decreases_activity of
|
actin cytoskeleton organization
|
in primary endothelial cells
|
| 48852 |
exoS
|
|
decreases_activity of
|
establishment of endothelial barrier
|
in primary endothelial cells
|
| 48855 |
exoS
|
|
decreases_activity of
|
focal adhesion assembly
|
in primary endothelial cells
|
| 48859 |
exoS
|
|
decreases_activity of
|
PTK2
|
in primary endothelial cells
|
| 48861 |
exoS
|
|
decreases_phosphorylation of
|
CFL1
|
in primary endothelial cells
|
| 48866 |
exoS
|
|
decreases_phosphorylation of
|
LIMK1
|
in primary endothelial cells
|
| 48867 |
exoS
|
|
decreases_phosphorylation of
|
LIMK2
|
in primary endothelial cells
|
| 48874 |
exoS
|
|
decreases_activity of
|
RHOA
|
in primary endothelial cells
|
| 48876 |
exoS
|
|
decreases_activity of
|
RAC1
|
in primary endothelial cells
|
| 48878 |
exoS
|
|
decreases_activity of
|
CDC42
|
in primary endothelial cells
|
|
23974244
|
Pseudomonas aeruginosa diseases
|
HoPaCI