|
2,242
|
| 19190 |
Pyocyanine
|
|
increases_expression of
|
PA14_35160
|
|
| 19194 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
increases_quantity of
|
Pyocyanine
|
|
| 62538 |
Pyocyanine
|
|
increases_expression of
|
mexGHI-opmD multidrug efflux pump
|
|
|
19196266
|
Pseudomonas aeruginosa diseases
|
|
2,285
|
| 19476 |
pqsE
|
|
increases_quantity of
|
Pyocyanine
|
|
| 19516 |
rhlR
|
|
increases_quantity of
|
Pyocyanine
|
|
| 19587 |
ptxR
|
|
decreases_quantity of
|
Pyocyanine
|
|
|
20738404
|
Pseudomonas aeruginosa diseases
|
|
2,781
|
| 25726 |
Pyocyanine
|
|
increases_activity of
|
neutrophil apoptotic process
|
|
|
21184216
|
Pseudomonas aeruginosa diseases
|
|
2,783
|
| 25729 |
desB
|
|
affects_quantity of
|
Pyocyanine
|
|
|
21184216
|
Pseudomonas aeruginosa diseases
|
|
2,787
|
| 25750 |
Pyocyanine
|
|
increases_quantity of
|
Reactive oxygen species
|
|
| 25751 |
Pyocyanine
|
|
decreases_quantity of
|
Glutathione
|
|
| 25752 |
Pyocyanine
|
|
increases_activity of
|
I-kappaB kinase/NF-kappaB signaling
|
|
| 25753 |
Reactive oxygen species
|
|
increases_activity of
|
I-kappaB kinase/NF-kappaB signaling
|
|
| 25754 |
Pyocyanine
|
|
affects_activity of
|
response to oxidative stress
|
|
|
21596130
|
Pseudomonas aeruginosa diseases
|
|
2,853
|
| 26293 |
kinB
|
|
increases_quantity of
|
Pyocyanine
|
in a manner independent of AlgB
|
|
21515773
|
Pseudomonas aeruginosa diseases
|
|
2,932
|
| 26806 |
2-Amino acetophenone, 2-AA
|
|
decreases_quantity of
|
Pyocyanine
|
|
|
21829370
|
Pseudomonas aeruginosa diseases
|
|
3,115
|
| 28636 |
qteE
|
|
affects_quantity of
|
Pyocyanine
|
|
|
20378835
|
Pseudomonas aeruginosa diseases
|
|
3,156
|
| 29040 |
oprF
|
|
increases_quantity of
|
Pyocyanine
|
during the entry into the stationary phase
|
|
21189321
|
Pseudomonas aeruginosa diseases
|
|
3,179
|
| 29154 |
Pyocyanine
|
|
decreases_expression of
|
FOXA2
|
in goblet and epithelial cells
|
| 29155 |
Pyocyanine
|
|
increases_expression of
|
MUC5B
|
in mouse airways
|
| 29156 |
Pyocyanine
|
|
increases_quantity of
|
respiratory mucosa goblet cell hyperplasia, GCH
|
in mouse airways
|
| 29157 |
Pyocyanine
|
|
increases_quantity of
|
respiratory mucosa goblet cell metaplasia, GCM
|
in mouse airways
|
| 29162 |
Pyocyanine
|
|
increases_activity of
|
STAT6
|
in mouse airways
|
| 29164 |
Pyocyanine
|
|
increases_quantity of
|
IL4
|
in mouse airways
|
| 29165 |
Pyocyanine
|
|
increases_quantity of
|
IL13
|
in mouse airways
|
| 29170 |
Pyocyanine
|
|
increases_activity of
|
EGFR
|
in mouse airways
|
| 43320 |
Pyocyanine
|
|
increases_activity of
|
mucus secretion
|
in mouse airways
|
|
22103442
|
Pseudomonas aeruginosa diseases
|
|
3,180
|
| 29158 |
Pyocyanine
|
|
increases_expression of
|
MUC5B
|
higher expression of MUC5B in NCI-H292 cells
|
| 29159 |
Pyocyanine
|
|
decreases_expression of
|
FOXA2
|
|
| 29161 |
Pyocyanine
|
|
increases_activity of
|
STAT6
|
in NCI-H292 epithelial cells
|
| 29174 |
Pyocyanine
|
|
increases_activity of
|
EGFR
|
in NCI-H292 epithelial cells
|
| 29175 |
Pyocyanine
|
|
increases_phosphorylation of
|
EGFR
|
in NCI-H292 epithelial cells
|
| 29176 |
Pyocyanine
|
|
increases_phosphorylation of
|
RAF1
|
in NCI-H292 epithelial cells
|
| 29177 |
Pyocyanine
|
|
increases_phosphorylation of
|
MAP2K1
|
in NCI-H292 epithelial cells
|
| 29178 |
Pyocyanine
|
|
increases_phosphorylation of
|
MAP2K2
|
in NCI-H292 epithelial cells
|
| 29179 |
Pyocyanine
|
|
increases_phosphorylation of
|
MAPK3
|
in NCI-H292 epithelial cells
|
| 29180 |
Pyocyanine
|
|
increases_phosphorylation of
|
MAPK1
|
in NCI-H292 epithelial cells
|
|
22103442
|
Pseudomonas aeruginosa diseases
|
|
3,183
|
| 29193 |
P. aeruginosa infection, chronic
|
|
increases_quantity of
|
Pyocyanine
|
in CF patients
|
| 29194 |
Pyocyanine
|
|
affects_activity of
|
response to oxidative stress
|
|
| 29195 |
Pyocyanine
|
|
increases_quantity of
|
Reactive oxygen species
|
|
|
22103442
|
Pseudomonas aeruginosa diseases
|
|
3,902
|
| 40314 |
phz2-operon
|
|
increases_quantity of
|
Phenazine-1-carboxylic acid
|
|
| 40315 |
phz1-operon
|
|
increases_quantity of
|
Phenazine-1-carboxylic acid
|
|
|
21169497
|
Pseudomonas aeruginosa diseases
|
|
3,969
|
| 40316 |
Phenazine-1-carboxylic acid
|
|
is_part_of
|
Pyocyanine
|
|
| 40320 |
phzH
|
|
increases_quantity of
|
phenazine-1-carboxamide
|
|
| 40321 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
increases_expression of
|
phz1-operon
|
|
| 62301 |
phzM
|
|
increases_quantity of
|
Pyocyanine
|
|
| 62302 |
phzS
|
|
increases_quantity of
|
Pyocyanine
|
|
| 62314 |
phzH
|
|
decreases_quantity of
|
Phenazine-1-carboxylic acid
|
|
|
23129634
|
Pseudomonas aeruginosa diseases
|
|
3,973
|
| 40326 |
phz1-operon
|
|
increases_quantity of
|
Phenazine-1-carboxylic acid
|
in liquid culture
|
| 40328 |
phz2-operon
|
|
increases_quantity of
|
Phenazine-1-carboxylic acid
|
in colony biofilms
|
| 40329 |
phz2-operon
|
|
increases_activity of
|
biofilm formation
|
|
| 40336 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
increases_expression of
|
phz2-operon
|
|
| 40346 |
2-Heptyl-4-quinolone, HHQ
|
|
increases_expression of
|
phz2-operon
|
|
| 40349 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
increases_expression of
|
phz1-operon
|
|
|
23129634
|
Pseudomonas aeruginosa diseases
|
|
4,202
|
| 43127 |
PA3699
|
|
decreases_quantity of
|
Pyocyanine
|
|
|
23861975
|
Pseudomonas aeruginosa diseases
|
|
4,354
|
| 44612 |
parR
|
|
decreases_quantity of
|
Pyocyanine
|
|
| 44616 |
parR
|
|
decreases_expression of
|
phz1-operon
|
|
| 62307 |
parR
|
|
decreases_expression of
|
phz2-operon
|
|
| 62308 |
parR
|
|
decreases_expression of
|
phzM
|
|
|
24034668
|
Pseudomonas aeruginosa diseases
|
|
4,659
|
| 46377 |
CAMP
|
|
increases_quantity of
|
Pyocyanine
|
physiological concentrations of LL-37
|
|
24349231
|
Pseudomonas aeruginosa diseases
|
|
6,543
|
| 62212 |
Pyocyanine
|
|
interacts (colocalizes) with
|
AHR
|
|
| 62213 |
1-hydroxyphenazine
|
|
interacts (colocalizes) with
|
AHR
|
|
| 62214 |
Pyocyanine
|
|
increases_activity of
|
AHR
|
as shown by AhR reporter cells (THP-1, A549 and H358), stimulated for 24 h
|
| 62217 |
1-hydroxyphenazine
|
|
increases_activity of
|
AHR
|
as shown by AhR reporter cells (THP-1, A549 and H358), stimulated for 24 h
|
| 62219 |
AHR
|
|
decreases_activity of
|
P. aeruginosa infection
|
as shown in infected mice
|
| 62223 |
AHR
|
|
decreases_quantity of
|
Pyocyanine
|
as shown in supernatants of
A549 Scramble and AhR-KD cells, 48 h after stimulation
|
| 62224 |
AHR
|
|
decreases_quantity of
|
1-hydroxyphenazine
|
as shown in supernatants of
A549 Scramble and AhR-KD cells, 48 h after stimulation
|
|
25119038
|
Pseudomonas aeruginosa diseases
|
|
6,556
|
| 62300 |
Pyocyanine
|
|
increases_expression of
|
CXCL8
|
in PMA-differentiated U937 cells
|
| 62331 |
Pyocyanine
|
|
increases_activity of
|
I-kappaB kinase/NF-kappaB signaling
|
in PMA-differentiated U937 cells
|
|
24499192
|
Pseudomonas aeruginosa diseases
|
|
6,557
|
| 62303 |
phzM
|
|
increases_quantity of
|
Pyocyanine
|
|
| 62304 |
phzS
|
|
increases_quantity of
|
Pyocyanine
|
|
| 62305 |
phzS
|
|
increases_quantity of
|
1-hydroxyphenazine
|
|
| 62310 |
phzM
|
|
decreases_quantity of
|
Phenazine-1-carboxylic acid
|
|
| 62311 |
phzS
|
|
decreases_quantity of
|
Phenazine-1-carboxylic acid
|
|
| 62312 |
phzS
|
|
decreases_quantity of
|
Phenazine-1-carboxylic acid
|
|
|
11591691
|
Pseudomonas aeruginosa diseases
|
|
6,561
|
| 62344 |
Pyocyanine
|
|
decreases_activity of
|
DUOX1
|
primary normal human bronchial epithelial cells (NHBE)
|
| 62495 |
Glutathione
|
|
decreases_activity of
|
Pyocyanine
|
in primary normal human bronchial and NCI-H292 cells
|
| 62500 |
Acetylcysteine
|
|
decreases_activity of
|
Pyocyanine
|
in primary normal human bronchial and NCI-H292 cells
|
| 62507 |
Pyocyanine
|
|
affects_activity of
|
response to oxidative stress
|
|
| 62509 |
LPO
|
|
decreases_activity of
|
Pyocyanine
|
in human pulmonary carcinoma NCI-H292 cells
|
| 62511 |
MPO
|
|
decreases_activity of
|
Pyocyanine
|
in human pulmonary carcinoma NCI-H292 cells
|
| 62861 |
Pyocyanine
|
|
increases_quantity of
|
Reactive oxygen species
|
in human pulmonary carcinoma NCI-H292 cells
|
|
18802092
|
Pseudomonas aeruginosa diseases
|
|
6,613
|
| 62985 |
Pyocyanine
|
|
decreases_activity of
|
CAT
|
in human alveolar type II cell line A549 and normal human bronchial epithelial (NHBE) cells
|
| 62986 |
Pyocyanine
|
|
decreases_quantity of
|
CAT
|
in human alveolar type II cell line A549 and normal human bronchial epithelial (NHBE) cells
|
| 62987 |
Pyocyanine
|
NOT |
affects_quantity of
|
SOD1
|
in normal human bronchial epithelial (NHBE) cells
|
| 62988 |
Pyocyanine
|
NOT |
affects_quantity of
|
SOD2
|
in normal human bronchial epithelial (NHBE) cells
|
| 62989 |
Pyocyanine
|
|
decreases_expression of
|
CAT
|
in human alveolar type II cell line A549
|
| 62990 |
CAT
|
|
increases_activity of
|
response to oxidative stress
|
|
|
12871859
|
Pseudomonas aeruginosa diseases
|
|
6,614
|
| 62992 |
Pyocyanine
|
|
decreases_activity of
|
CFTR
|
in human CF bronchial epithelial cells (CFBE41o-)
|
| 62994 |
Pyocyanine
|
|
decreases_quantity of
|
Glutathione
|
in human CF bronchial epithelial cells (CFBE41o-)
|
| 62995 |
Pyocyanine
|
|
decreases_quantity of
|
ATP
|
in human CF bronchial epithelial cells (CFBE41o-)
|
|
18845244
|
Pseudomonas aeruginosa diseases
|
|
6,615
|
| 63000 |
Pyocyanine
|
|
decreases_activity of
|
SERPINA1
|
in A549 (or human bronchial epithelial cell (HBE) mono-layers
|
|
10024562
|
Pseudomonas aeruginosa diseases
|
|
6,616
|
| 63004 |
Pyocyanine
|
|
increases_expression of
|
MUC5AC
|
|
| 63005 |
Pyocyanine
|
|
increases_quantity of
|
MUC5AC
|
|
| 63006 |
Pyocyanine
|
|
increases_expression of
|
MUC2
|
|
| 63007 |
Pyocyanine
|
|
increases_quantity of
|
MUC2
|
|
| 63008 |
MUC5AC
|
|
increases_activity of
|
mucus secretion
|
|
| 63009 |
MUC2
|
|
increases_activity of
|
mucus secretion
|
|
| 63010 |
MUC5B
|
|
increases_activity of
|
mucus secretion
|
|
| 63011 |
Pyocyanine
|
|
increases_expression of
|
IL1A
|
|
| 63012 |
Pyocyanine
|
|
increases_expression of
|
IL1B
|
|
| 63013 |
Pyocyanine
|
|
increases_expression of
|
IL6
|
|
| 63014 |
Pyocyanine
|
|
increases_expression of
|
TNF
|
|
| 63015 |
Pyocyanine
|
|
increases_expression of
|
TGFA
|
|
| 63016 |
Pyocyanine
|
|
increases_expression of
|
HBEGF
|
|
| 63017 |
Pyocyanine
|
|
increases_expression of
|
CXCL8
|
|
| 63022 |
IL1B
|
|
increases_quantity of
|
MUC5AC
|
|
| 63023 |
IL6
|
|
increases_quantity of
|
MUC5AC
|
|
| 63024 |
TNF
|
|
increases_quantity of
|
MUC5AC
|
|
| 63025 |
TGFA
|
|
increases_quantity of
|
MUC5AC
|
|
| 63026 |
Pyocyanine
|
|
increases_expression of
|
CSF3
|
|
| 63027 |
Pyocyanine
|
|
increases_expression of
|
CSF2
|
|
| 63028 |
Pyocyanine
|
|
increases_expression of
|
CXCL1
|
|
| 63029 |
Pyocyanine
|
|
increases_expression of
|
IL23A
|
|
| 63030 |
Pyocyanine
|
|
increases_expression of
|
IL1RN
|
|
| 63031 |
Pyocyanine
|
|
increases_expression of
|
SAA1
|
|
| 63032 |
Pyocyanine
|
|
increases_expression of
|
IL24
|
|
| 63033 |
Pyocyanine
|
|
increases_expression of
|
IL1R2
|
|
| 63036 |
Pyocyanine
|
|
increases_expression of
|
CXCL2
|
|
| 63037 |
Pyocyanine
|
|
increases_expression of
|
CXCL3
|
|
| 63038 |
Pyocyanine
|
|
increases_expression of
|
CCL20
|
|
| 63040 |
Pyocyanine
|
|
increases_expression of
|
CXCR4
|
|
| 63043 |
Pyocyanine
|
|
increases_expression of
|
SOD2
|
|
| 63044 |
Pyocyanine
|
|
decreases_expression of
|
CAT
|
|
| 63046 |
Pyocyanine
|
|
increases_expression of
|
GDF15
|
|
| 63055 |
Reactive oxygen species
|
|
increases_activity of
|
mucus secretion
|
|
|
20962773
|
Pseudomonas aeruginosa diseases
|
HoPaCI