2,017
|
15983 |
C. burnetii containing vacuole, CCV
|
|
increases_activity of
|
Coxiella burnetii replication
|
in BeWo trophoblasts
|
|
21179488
|
Q fever
|
2,024
|
16092 |
phagosome acidification
|
|
increases_quantity of
|
Coxiella burnetii, LCV
|
|
16155 |
phagosome acidification
|
|
decreases_quantity of
|
Coxiella burnetii, SCV
|
|
16157 |
Coxiella burnetii, phase I
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
|
16158 |
Coxiella burnetii, phase II
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
|
16215 |
RHOA
|
|
affects_activity of
|
phagosome maturation
|
|
16223 |
CDC42
|
|
affects_activity of
|
phagosome maturation
|
|
16246 |
BECN1
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
on the vacuole membrane of infected host cells
|
16262 |
BCL2
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
on the vacuole membrane of infected host cells
|
16263 |
BECN1
|
|
increases_activity of
|
autophagy
|
|
|
21030501
|
Q fever
|
2,043
|
16341 |
CTSD
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
|
16342 |
LAMP1
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
|
16343 |
LAMP2
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
|
16345 |
phagosome acidification
|
|
increases_activity of
|
Coxiella burnetii replication
|
|
16346 |
C. burnetii containing vacuole, CCV
|
|
increases_activity of
|
Coxiella burnetii replication
|
|
16347 |
Coxiella burnetii, SCV
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
|
16348 |
Coxiella burnetii, LCV
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
|
37444 |
CTSD
|
|
is localized in
|
lysosome
|
|
37445 |
LAMP1
|
|
is localized in
|
lysosome
|
|
37447 |
LAMP2
|
|
is localized in
|
lysosome
|
|
|
10217829
|
Q fever
|
2,047
|
16358 |
autophagy
|
|
increases_quantity of
|
C. burnetii containing vacuole, CCV
|
|
16410 |
RAB7
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
|
16411 |
RAB24
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
|
16414 |
Coxiella burnetii infection
|
|
increases_activity of
|
autophagy
|
|
16452 |
BECN1
|
|
increases_quantity of
|
C. burnetii containing vacuole, CCV
|
in HeLa cells; if BECN1 is overexpressed
|
16453 |
BECN1
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
|
16455 |
BECN1
|
|
increases_activity of
|
autophagy
|
|
16459 |
BCL2
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
|
32943 |
LC3-II
|
|
is localized in
|
autophagic vacuole
|
conversion of LC3-I to LC3-II
|
35532 |
LC3-II
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
|
37691 |
RAB7
|
|
is localized in
|
autophagic vacuole
|
|
37693 |
RAB24
|
|
is localized in
|
autophagic vacuole
|
|
|
20023428
|
Q fever
|
2,061
|
16522 |
phagosome acidification
|
|
increases_activity of
|
Coxiella burnetii replication
|
|
|
18813881
|
Q fever
|
2,062
|
16855 |
C. burnetii containing vacuole, CCV
|
|
increases_activity of
|
Coxiella burnetii replication
|
of phase I and phase II organisms
|
17037 |
RAB7
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
associated with late endosome/lysosome fusion
|
17038 |
RAB5
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
associated with early endosome fusion
|
17043 |
Coxiella burnetii infection
|
|
increases_activity of
|
autophagy
|
|
17044 |
autophagy
|
|
increases_activity of
|
Coxiella burnetii replication
|
|
17045 |
autophagy
|
|
increases_quantity of
|
C. burnetii containing vacuole, CCV
|
|
17059 |
Vacuolar proton-transporting V-type ATPase complex
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
phagosome membrane
|
17062 |
LAMP1
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
phagosome membrane
|
17063 |
LAMP2
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
phagosome membrane
|
17064 |
CD63
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
phagosome membrane
|
17065 |
FLOT1
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
phagosome membrane
|
17066 |
FLOT2
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
phagosome membrane
|
17068 |
RAB24
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
phagosome membrane
|
32936 |
autophagy
|
|
increases_activity of
|
phagosome maturation
|
|
37448 |
LAMP1
|
|
is localized in
|
lysosome
|
|
37449 |
LAMP2
|
|
is localized in
|
lysosome
|
|
37450 |
CD63
|
|
is localized in
|
lysosome
|
|
37452 |
RAB24
|
|
is localized in
|
autophagic vacuole
|
|
|
17381428
|
Q fever
|
2,103
|
17280 |
EEA1
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
associated with early endosome fusion
|
17281 |
RAB5
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
associated with early endosome fusion
|
17282 |
RAB7
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
associated with late endosome/lysosome fusion
|
17285 |
LAMP1
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
associated with late endosome/lysosome fusion
|
17287 |
Vacuolar proton-transporting V-type ATPase complex
|
|
increases_activity of
|
phagosome acidification
|
|
17290 |
phagosome-lysosome fusion
|
|
increases_activity of
|
phagosome maturation
|
|
17293 |
phagosome-lysosome fusion
|
|
affects_quantity of
|
C. burnetii containing vacuole, CCV
|
|
17300 |
Coxiella burnetii, phase I
|
|
decreases_activity of
|
phagosome-lysosome fusion
|
in human monocytes and macrophages
|
17301 |
Coxiella burnetii, phase I
|
NOT |
interacts (colocalizes) with
|
CTSD
|
in human monocytes and macrophages
|
17302 |
Coxiella burnetii, phase II
|
|
increases_activity of
|
phagosome-lysosome fusion
|
in human monocytes and macrophages
|
17303 |
Coxiella burnetii, phase II
|
|
interacts (colocalizes) with
|
CTSD
|
in human monocytes and macrophages
|
17304 |
phagosome-lysosome fusion
|
|
decreases_activity of
|
pathogen survival
|
in human monocytes and macrophages
|
17305 |
TLR4
|
NOT |
affects_activity of
|
phagosome maturation
|
in human monocytes and macrophages
|
17312 |
IFNG
|
|
increases_activity of
|
phagosome-lysosome fusion
|
in C. burnetii-infected monocytes
|
17319 |
IL10
|
|
affects_activity of
|
phagosome maturation
|
in human monocytes
|
32300 |
IFNG
|
NOT |
affects_activity of
|
phagosome acidification
|
in C. burnetii-infected monocytes
|
32935 |
phagosome acidification
|
|
increases_activity of
|
phagosome maturation
|
|
37439 |
EEA1
|
|
is localized in
|
early endosome
|
|
37440 |
RAB5
|
|
is localized in
|
early endosome
|
|
37441 |
RAB7
|
|
is localized in
|
late endosome
|
|
37442 |
LAMP1
|
|
is localized in
|
late endosome
|
|
37802 |
IFNG
|
|
affects_activity of
|
phagosome acidification
|
in C. burnetii-infected monocytes; treated with IFN-gamma prior to infection
|
|
19538264
|
Q fever
|
3,498
|
32477 |
T4BSS
|
|
increases_transport of
|
cpeB
|
to the PV membrane and to autophagosomes; in HeLa cells as fusion to GFP
|
|
21216993
|
Q fever
|
3,521
|
32816 |
Chloramphenicol
|
|
decreases_activity of
|
Coxiella burnetii replication
|
|
32820 |
Chloramphenicol
|
|
decreases_activity of
|
phagosome maturation
|
|
|
22711632
|
Q fever
|
3,544
|
32959 |
phagosome maturation
|
|
increases_quantity of
|
C. burnetii containing vacuole, CCV
|
|
32960 |
actin cytoskeleton organization
|
|
affects_activity of
|
phagosome maturation
|
|
32961 |
CDC42
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
|
32962 |
RHOA
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
|
32963 |
CDC42
|
|
affects_activity of
|
actin cytoskeleton organization
|
|
32964 |
RHOA
|
|
affects_activity of
|
actin cytoskeleton organization
|
|
32967 |
Vacuolar proton-transporting V-type ATPase complex
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
|
32968 |
LAMP1
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
|
32969 |
LAMP2
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
|
32970 |
CD63
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
|
32971 |
STX8
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
|
32980 |
Coxiella burnetii, phase II
|
|
interacts (colocalizes) with
|
RAB7
|
in the C. burnetii containing vacuole, CCV; to a higher extent than phase I
|
32981 |
Coxiella burnetii, phase I
|
NOT |
interacts (colocalizes) with
|
RAB7
|
in the C. burnetii containing vacuole, CCV; only to a low extent
|
32982 |
RAB7
|
|
increases_activity of
|
phagosome-lysosome fusion
|
|
32983 |
Coxiella burnetii, phase II
|
|
interacts (colocalizes) with
|
CTSD
|
in the C. burnetii containing vacuole, CCV
|
32984 |
Coxiella burnetii, phase I
|
NOT |
interacts (colocalizes) with
|
CTSD
|
in the phagolysosome
|
32985 |
phagosome-lysosome fusion
|
|
decreases_activity of
|
pathogen survival
|
in mononuclear phagocytes
|
37710 |
STX8
|
|
affects_activity of
|
phagosome-lysosome fusion
|
|
37713 |
CTSD
|
|
affects_activity of
|
phagosome-lysosome fusion
|
|
|
22711631
|
Q fever
|
3,553
|
32998 |
RAB1B
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
from 6 -24 h postinfection
|
33004 |
RAB11
|
NOT |
is localized in
|
C. burnetii containing vacuole, CCV
|
|
33005 |
RAB1B
|
|
increases_activity of
|
phagosome maturation
|
also shown in HeLa cells silenced with Rab1b siRNA
|
33006 |
Brefeldin A
|
|
decreases_activity of
|
early secretory pathway
|
|
33007 |
Brefeldin A
|
|
decreases_activity of
|
phagosome maturation
|
|
33008 |
secretory pathway
|
|
affects_activity of
|
phagosome maturation
|
|
|
20937765
|
Q fever
|
3,568
|
33348 |
PTP4A1
|
|
increases_activity of
|
phagosome maturation
|
|
33349 |
Protein kinase C
|
|
increases_activity of
|
phagosome maturation
|
|
33350 |
Protein kinase A
|
|
increases_activity of
|
phagosome maturation
|
|
33351 |
MYLK
|
|
increases_activity of
|
phagosome maturation
|
|
33352 |
Coxiella burnetii, phase II
|
|
increases_activity of
|
p38 MAPK
|
in THP-1 cells
|
33353 |
Coxiella burnetii, phase II
|
|
increases_phosphorylation of
|
p38 MAPK
|
in THP-1 cells
|
33354 |
Coxiella burnetii, phase II
|
|
increases_activity of
|
MYLK
|
in THP-1 cells
|
33355 |
MYLK
|
|
increases_phosphorylation of
|
MYL2
|
|
33356 |
Coxiella burnetii, phase II
|
|
increases_activity of
|
Protein kinase A
|
in THP-1 cells
|
33358 |
Coxiella burnetii, phase II
|
|
increases_activity of
|
Protein kinase C
|
in THP-1 cells
|
33381 |
Coxiella burnetii, phase II
|
|
increases_activity of
|
PTP4A1
|
in THP-1 cells
|
33382 |
Protein kinase C
|
|
increases_activity of
|
MARCKS
|
in THP-1 cells; experiments done with virulent and avirulent strains
|
33383 |
Protein kinase C
|
|
increases_phosphorylation of
|
MARCKS
|
in THP-1 cells; experiments done with virulent and avirulent strains
|
33385 |
MYLK
|
|
increases_activity of
|
MYL2
|
|
36865 |
Coxiella burnetii, phase I
|
|
increases_activity of
|
Protein kinase C
|
in THP-1 cells
|
|
21772829
|
Q fever
|
3,572
|
33402 |
Coxiella burnetii, phase I
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
in THP-1 and HMDM cells
|
33427 |
Coxiella burnetii, phase II
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
in THP-1 and HMDM cells
|
33428 |
Coxiella burnetii, phase I
|
|
increases_activity of
|
phagosome maturation
|
in THP-1 cells
|
33429 |
Coxiella burnetii, phase II
|
|
increases_activity of
|
phagosome maturation
|
in THP-1 cells
|
33430 |
Coxiella burnetii, phase I
|
|
increases_activity of
|
phagosome-lysosome fusion
|
in THP-1 cells
|
33431 |
Coxiella burnetii, phase II
|
|
increases_activity of
|
phagosome-lysosome fusion
|
in THP-1 cells
|
33432 |
C. burnetii containing vacuole, CCV
|
|
increases_activity of
|
proteolysis
|
in THP-1 cells in PVs of both C. burnetii variant NMI or NMII
|
33433 |
CTSD
|
|
increases_activity of
|
proteolysis
|
in THP-1 cells in PVs of both C. burnetii variant NMI or NMII
|
33434 |
CTSB
|
|
increases_activity of
|
proteolysis
|
in THP-1 cells in PVs of both C. burnetii variant NMI or NMII
|
33435 |
CTSB
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
in THP-1 cells in PVs of both C. burnetii variant NMI or NMII
|
33436 |
CTSK
|
|
increases_activity of
|
proteolysis
|
in THP-1 cells in PVs of both C. burnetii variant NMI or NMII
|
33437 |
CTSK
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
in THP-1 cells in PVs of both C. burnetii variant NMI or NMII
|
33438 |
CTSL
|
|
increases_activity of
|
proteolysis
|
in THP-1 cells in PVs of both C. burnetii variant NMI or NMII
|
33439 |
CTSL
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
in THP-1 cells in PVs of both C. burnetii variant NMI or NMII
|
37004 |
Coxiella burnetii, phase II
|
|
interacts (colocalizes) with
|
RAB5
|
in THP-1 cells
|
37006 |
Coxiella burnetii, phase II
|
|
interacts (colocalizes) with
|
RAB7
|
in THP-1 cells
|
37007 |
Coxiella burnetii, phase II
|
|
interacts (colocalizes) with
|
CD63
|
in THP-1 cells
|
37008 |
Coxiella burnetii, phase II
|
|
interacts (colocalizes) with
|
CTSD
|
in THP-1 cells
|
37009 |
Coxiella burnetii, phase I
|
|
interacts (colocalizes) with
|
RAB5
|
in THP-1 cells
|
37010 |
Coxiella burnetii, phase I
|
|
interacts (colocalizes) with
|
RAB7
|
in THP-1 cells
|
37011 |
Coxiella burnetii, phase I
|
|
interacts (colocalizes) with
|
CD63
|
in THP-1 cells
|
37012 |
Coxiella burnetii, phase I
|
|
interacts (colocalizes) with
|
CTSD
|
in THP-1 cells
|
|
20515926
|
Q fever
|
3,598
|
33717 |
host cell cholesterol
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
in the phagolysosomal membrane
|
33720 |
host cell cholesterol
|
|
is_part_of
|
membrane raft
|
|
33763 |
membrane raft
|
|
affects_activity of
|
phagosome maturation
|
|
33764 |
membrane raft
|
|
is_part_of
|
C. burnetii containing vacuole, CCV
|
|
33767 |
host cell cholesterol
|
|
increases_activity of
|
phagosome maturation
|
in the phagolysosomal membrane
|
33768 |
host cell cholesterol
|
NOT |
affects_activity of
|
phagosome maturation
|
in in vitro models
|
|
22711633
|
Q fever
|
3,648
|
34622 |
phagosome acidification
|
|
decreases_quantity of
|
scvA
|
|
|
22711629
|
Q fever
|
3,695
|
35651 |
T4BSS
|
|
increases_activity of
|
phagosome maturation
|
in THP-1 cells
|
35672 |
phagosome acidification
|
|
increases_quantity of
|
Coxiella burnetii, LCV
|
|
|
22010216
|
Q fever
|
3,740
|
36329 |
RAB5
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
20 min post-infection
|
36330 |
RAB7
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
approximately 1 h post-infection and remaining
|
36331 |
RAB5
|
|
increases_activity of
|
phagosome maturation
|
|
36332 |
RAB7
|
|
increases_activity of
|
phagosome maturation
|
|
36333 |
RAB7
|
|
increases_activity of
|
phagosome-lysosome fusion
|
|
36335 |
RAB24
|
|
interacts (colocalizes) with
|
LC3-II
|
|
36336 |
autophagy
|
|
increases_activity of
|
phagosome maturation
|
|
36337 |
RAB1B
|
|
increases_activity of
|
phagosome maturation
|
|
36353 |
RAB1B
|
|
increases_activity of
|
early secretory pathway
|
|
36942 |
RAB5
|
|
increases_activity of
|
early endosome fusion
|
|
36962 |
RAB24
|
|
is localized in
|
autophagic vacuole
|
|
36963 |
LC3-II
|
|
is localized in
|
autophagic vacuole
|
|
36969 |
RAB1B
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
|
36978 |
RAB24
|
|
increases_activity of
|
phagosome maturation
|
|
36980 |
LC3-II
|
|
increases_activity of
|
phagosome maturation
|
|
36981 |
autophagy
|
|
affects_activity of
|
RAB24
|
|
37801 |
early endosome fusion
|
|
increases_activity of
|
phagosome maturation
|
|
|
23176480
|
Q fever
|
3,770
|
36760 |
Coxiella burnetii, phase II
|
|
interacts (colocalizes) with
|
LAMP1
|
in BMDMs; infected with avirulent C. burnetii or avirulent LPS
|
36765 |
Coxiella burnetii, phase II
|
|
interacts (colocalizes) with
|
RAB7
|
in BMDMs; infected with avirulent C. burnetii or avirulent LPS
|
36766 |
Coxiella burnetii, phase II
|
|
interacts (colocalizes) with
|
CTSD
|
in BMDMs; infected with avirulent C. burnetii or avirulent LPS
|
36768 |
Coxiella burnetii, phase I
|
|
interacts (colocalizes) with
|
LAMP1
|
in BMDMs; infected with virulent C. burnetii or virulent LPS
|
36769 |
Coxiella burnetii, phase I
|
NOT |
interacts (colocalizes) with
|
RAB7
|
in BMDMs; infected with virulent C. burnetii or virulent LPS
|
36770 |
Coxiella burnetii, phase I
|
NOT |
interacts (colocalizes) with
|
CTSD
|
in BMDMs; infected with virulent C. burnetii or virulent LPS
|
36773 |
Coxiella burnetii, phase I
|
|
interacts (colocalizes) with
|
RAB5
|
in BMDMs; infected with virulent LPS
|
36774 |
Coxiella burnetii, phase II
|
|
interacts (colocalizes) with
|
RAB5
|
in BMDMs; infected with avirulent LPS
|
36791 |
Coxiella burnetii, phase I
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
in BMDMs; infected with virulent LPS
|
36792 |
Coxiella burnetii, phase I
|
|
increases_activity of
|
MAPK8
|
in BMDMs; infected with virulent LPS
|
36793 |
Coxiella burnetii, phase II
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
in BMDMs; infected with avirulent LPS
|
36794 |
Coxiella burnetii, phase II
|
|
increases_activity of
|
MAPK8
|
in BMDMs; infected with avirulent LPS
|
36795 |
Coxiella burnetii, phase II
|
|
increases_activity of
|
p38 MAPK
|
in BMDMs; infected with avirulent LPS or avirulent C. burnetii
|
36796 |
Coxiella burnetii, phase I
|
NOT |
increases_activity of
|
p38 MAPK
|
in BMDMs; infected with virulent LPS or virulent C. burnetii
|
36797 |
Coxiella burnetii, phase II
|
|
increases_phosphorylation of
|
p38 MAPK
|
in BMDMs; infected with avirulent LPS or avirulent C. burnetii
|
36798 |
Coxiella burnetii, phase I
|
NOT |
increases_phosphorylation of
|
p38 MAPK
|
in BMDMs; infected with virulent LPS or virulent C. burnetii
|
36799 |
MAP2K3
|
|
increases_activity of
|
p38 MAPK
|
|
36800 |
MAP2K6
|
|
increases_activity of
|
p38 MAPK
|
|
36801 |
Coxiella burnetii, phase I
|
NOT |
increases_activity of
|
MAP2K3
|
in BMDMs; infected with virulent LPS
|
36802 |
Coxiella burnetii, phase I
|
NOT |
increases_activity of
|
MAP2K6
|
in BMDMs; infected with virulent LPS
|
36803 |
Coxiella burnetii, phase II
|
|
increases_activity of
|
MAP2K3
|
in BMDMs; infected with avirulent LPS
|
36804 |
Coxiella burnetii, phase II
|
|
increases_activity of
|
MAP2K6
|
in BMDMs; infected with avirulent LPS
|
36806 |
TLR4
|
|
affects_activity of
|
p38 MAPK
|
in BMDMs; infected with virulent LPS
|
36807 |
p38 MAPK
|
|
increases_activity of
|
phagosome-lysosome fusion
|
in BMDMs and MEFs; infected with avirulent LPS
|
36820 |
Coxiella burnetii, phase II
|
|
increases_activity of
|
VPS41
|
in BMDMs; infected with avirulent LPS
|
36821 |
Coxiella burnetii, phase II
|
|
increases_phosphorylation of
|
VPS41
|
in BMDMs; infected with avirulent LPS
|
36822 |
Coxiella burnetii, phase I
|
NOT |
increases_activity of
|
VPS41
|
in BMDMs; infected with virulent LPS
|
36823 |
Coxiella burnetii, phase I
|
NOT |
increases_phosphorylation of
|
VPS41
|
in BMDMs; infected with virulent LPS
|
36824 |
Coxiella burnetii, phase II
|
|
interacts (colocalizes) with
|
VPS41
|
in BMDMs; infected with avirulent LPS
|
36825 |
Coxiella burnetii, phase I
|
NOT |
interacts (colocalizes) with
|
VPS41
|
in BMDMs; infected with virulent LPS
|
36826 |
p38 MAPK
|
|
increases_activity of
|
VPS41
|
in BMDMs; infected with avirulent LPS
|
36827 |
p38 MAPK
|
|
increases_phosphorylation of
|
VPS41
|
in BMDMs; infected with avirulent LPS
|
36829 |
p38 MAPK
|
|
interacts (colocalizes) with
|
VPS41
|
in BMDMs; infected with avirulent LPS
|
36830 |
VPS41
|
|
increases_activity of
|
phagosome-lysosome fusion
|
in BMDMs; infected with avirulent LPS
|
36839 |
Coxiella burnetii, phase II
|
|
increases_activity of
|
TLR4
|
in BMDMs; infected with avirulent LPS
|
36840 |
Coxiella burnetii, phase I
|
|
decreases_activity of
|
TLR4
|
in BMDMs; infected with virulent LPS
|
36899 |
Coxiella burnetii, phase I
|
|
increases_phosphorylation of
|
MAPK8
|
in BMDMs; infected with virulent LPS
|
36901 |
Coxiella burnetii, phase II
|
|
increases_phosphorylation of
|
MAPK8
|
in BMDMs; infected with avirulent LPS
|
38611 |
p38 MAPK
|
NOT |
increases_activity of
|
phagosome-lysosome fusion
|
in BMDMs and MEFs; infected with virulent LPS
|
|
23245320
|
Q fever
|
3,771
|
36771 |
RAB5
|
|
is localized in
|
early endosome
|
|
36772 |
RAB7
|
|
is localized in
|
late endosome
|
|
|
23245320
|
Q fever
|
3,782
|
37287 |
Fluoroquinolone
|
|
decreases_activity of
|
phagosome acidification
|
|
|
23163207
|
Q fever
|
3,797
|
37751 |
Coxiella burnetii, phase I
|
|
increases_activity of
|
pseudopodium assembly
|
on the surface of monocytes
|
37757 |
Coxiella burnetii, phase I
|
|
interacts (colocalizes) with
|
Alphav-beta3 integrin complex
|
on the surface of monocytes
|
37758 |
Coxiella burnetii, phase I
|
|
interacts (colocalizes) with
|
CD47
|
on the surface of monocytes
|
37759 |
Coxiella burnetii, phase I
|
|
interacts (colocalizes) with
|
TLR4
|
on the surface of monocytes
|
37760 |
Coxiella burnetii, phase I
|
NOT |
interacts (colocalizes) with
|
AlphaM-beta2 integrin complex
|
on the surface of monocytes
|
37762 |
Coxiella burnetii, phase II
|
NOT |
affects_activity of
|
actin cytoskeleton organization
|
on the surface of monocytes
|
37770 |
Coxiella burnetii, phase I
|
|
affects_activity of
|
actin cytoskeleton organization
|
on the surface of monocytes
|
37773 |
Coxiella burnetii, phase II
|
|
interacts (colocalizes) with
|
Alphav-beta3 integrin complex
|
on the surface of monocytes
|
37774 |
Coxiella burnetii, phase II
|
|
interacts (colocalizes) with
|
CD47
|
on the surface of monocytes
|
37776 |
Coxiella burnetii, phase II
|
|
interacts (colocalizes) with
|
AlphaM-beta2 integrin complex
|
on the surface of monocytes
|
37777 |
Coxiella burnetii, phase II
|
NOT |
interacts (colocalizes) with
|
TLR4
|
on the surface of monocytes
|
37787 |
CCL5
|
|
increases_transport of
|
AlphaM-beta2 integrin complex
|
to the front of pseudopodal extensions
|
37789 |
CCL5
|
|
increases_activity of
|
AlphaM-beta2 integrin complex
|
|
37791 |
Coxiella burnetii, phase I
|
|
decreases_activity of
|
phagosome-lysosome fusion
|
|
|
15792739
|
Q fever
|
3,805
|
37895 |
RAB5
|
|
increases_activity of
|
early endosome fusion
|
|
37897 |
RAB7
|
|
increases_activity of
|
phagosome-lysosome fusion
|
|
37909 |
phagosome maturation
|
|
increases_activity of
|
T4BSS
|
in C. burnetii infected HeLa cells
|
|
23349930
|
Q fever
|
3,807
|
38009 |
RAB7A
|
|
increases_quantity of
|
C. burnetii containing vacuole, CCV
|
in C. burnetii infected HeLa cells; analysed by treatment with RAB7A siRNA
|
38010 |
RAB5A
|
|
increases_quantity of
|
C. burnetii containing vacuole, CCV
|
in C. burnetii infected HeLa cells; analysed by treatment with RAB5A siRNA
|
38011 |
Vacuolar proton-transporting V-type ATPase complex
|
|
increases_quantity of
|
C. burnetii containing vacuole, CCV
|
in C. burnetii infected HeLa cells; analysed by treatment with ATP6V1D siRNA
|
38012 |
ATP6V1D
|
|
is_part_of
|
Vacuolar proton-transporting V-type ATPase complex
|
|
38015 |
VPS35
|
|
increases_quantity of
|
C. burnetii containing vacuole, CCV
|
in C. burnetii infected HeLa cells; analysed by treatment with VPS35 siRNA
|
38020 |
VPS16
|
|
increases_quantity of
|
C. burnetii containing vacuole, CCV
|
in C. burnetii infected HeLa cells; analysed by treatment with VPS16 siRNA
|
38022 |
USP10
|
|
decreases_quantity of
|
C. burnetii containing vacuole, CCV
|
in C. burnetii infected HeLa cells; analysed by treatment with USP10 siRNA
|
38036 |
STX17
|
|
decreases_quantity of
|
C. burnetii containing vacuole, CCV
|
in C. burnetii infected HeLa cells; analysed by treatment with STX17 siRNA
|
38038 |
STX17
|
|
increases_activity of
|
vacuole fusion, non-autophagic
|
of the C. burnetii vacuoles
|
38045 |
VPS29
|
|
increases_quantity of
|
C. burnetii containing vacuole, CCV
|
in C. burnetii infected HeLa cells; analysed by treatment with VPS29 siRNA
|
38046 |
VPS26A
|
NOT |
affects_quantity of
|
C. burnetii containing vacuole, CCV
|
in C. burnetii infected HeLa cells; analysed by treatment with VPS26A siRNA
|
38049 |
VPS26B
|
NOT |
affects_quantity of
|
C. burnetii containing vacuole, CCV
|
in C. burnetii infected HeLa cells; analysed by treatment with VPS26B siRNA
|
38050 |
VPS35
|
|
is_part_of
|
Retromer complex
|
|
38051 |
VPS29
|
|
is_part_of
|
Retromer complex
|
|
38052 |
VPS26A
|
|
is_part_of
|
Retromer complex
|
|
38053 |
Retromer complex
|
|
increases_activity of
|
retrograde transport, endosome to Golgi
|
|
38055 |
SNX2
|
|
increases_quantity of
|
C. burnetii containing vacuole, CCV
|
|
38061 |
SNX3
|
|
increases_quantity of
|
C. burnetii containing vacuole, CCV
|
|
38062 |
SNX5
|
|
increases_quantity of
|
C. burnetii containing vacuole, CCV
|
|
38063 |
SNX6
|
|
increases_quantity of
|
C. burnetii containing vacuole, CCV
|
|
38065 |
SNX1
|
NOT |
affects_quantity of
|
C. burnetii containing vacuole, CCV
|
|
38066 |
SNX2
|
|
is_part_of
|
Retromer complex
|
|
38067 |
SNX3
|
|
is_part_of
|
Retromer complex
|
|
38068 |
SNX5
|
|
is_part_of
|
Retromer complex
|
|
38069 |
SNX6
|
|
is_part_of
|
Retromer complex
|
|
38070 |
SNX1
|
|
is_part_of
|
Retromer complex
|
|
38167 |
VPS26B
|
|
is_part_of
|
Retromer complex
|
|
|
23362322
|
Q fever
|
4,011
|
41217 |
cpeL
|
|
interacts (colocalizes) with
|
LC3-II
|
|
|
23687269
|
Q fever
|
4,283
|
43913 |
cirA
|
|
increases_activity of
|
Coxiella burnetii replication
|
in HeLa and J774A.1 cells
|
43917 |
cirB
|
|
increases_activity of
|
Coxiella burnetii replication
|
in HeLa and J774A.1 cells
|
43932 |
cirC
|
|
increases_activity of
|
Coxiella burnetii replication
|
in HeLa and J774A.1 cells
|
43933 |
cirD
|
|
increases_activity of
|
Coxiella burnetii replication
|
in HeLa and J774A.1 cells
|
43935 |
cirE
|
|
increases_activity of
|
Coxiella burnetii replication
|
in HeLa and J774A.1 cells
|
43936 |
CBU_0388
|
|
increases_activity of
|
Coxiella burnetii replication
|
in HeLa and J774A.1 cells
|
43937 |
cirA
|
|
increases_activity of
|
phagosome maturation
|
in HeLa and J774A.1 cells
|
43938 |
cirB
|
|
increases_activity of
|
phagosome maturation
|
in HeLa and J774A.1 cells
|
43939 |
cirC
|
|
increases_activity of
|
phagosome maturation
|
in HeLa and J774A.1 cells
|
43940 |
cirD
|
|
increases_activity of
|
phagosome maturation
|
in HeLa and J774A.1 cells
|
43941 |
cirE
|
|
increases_activity of
|
phagosome maturation
|
in HeLa and J774A.1 cells
|
43942 |
CBU_0388
|
|
increases_activity of
|
phagosome maturation
|
in HeLa and J774A.1 cells
|
43943 |
CBU_0012
|
|
increases_activity of
|
Coxiella burnetii replication
|
in J774A.1 cells
|
43944 |
CBU_1198
|
|
increases_activity of
|
Coxiella burnetii replication
|
in J774A.1 cells
|
43945 |
CBU_1457
|
|
increases_activity of
|
Coxiella burnetii replication
|
in J774A.1 cells
|
43946 |
CBU_2013
|
|
increases_activity of
|
Coxiella burnetii replication
|
in J774A.1 cells
|
43947 |
CBU_0012
|
|
increases_activity of
|
phagosome maturation
|
in J774A.1 cells
|
43948 |
CBU_1198
|
|
increases_activity of
|
phagosome maturation
|
in J774A.1 cells
|
43949 |
CBU_1457
|
|
increases_activity of
|
phagosome maturation
|
in J774A.1 cells
|
43950 |
CBU_2013
|
|
increases_activity of
|
phagosome maturation
|
in J774A.1 cells
|
|
23813730
|
Q fever
|
4,288
|
44009 |
CBU_1556
|
|
affects_activity of
|
secretory pathway
|
shown in the secreted embryonic alkaline phosphatase (SEAP) assay
|
44013 |
CBU_1825
|
|
affects_activity of
|
secretory pathway
|
shown in the secreted embryonic alkaline phosphatase (SEAP) assay
|
44014 |
CBUA0019
|
|
affects_activity of
|
secretory pathway
|
shown in the secreted embryonic alkaline phosphatase (SEAP) assay
|
|
23813730
|
Q fever
|
4,410
|
44856 |
T4BSS
|
|
increases_transport of
|
Protein kinase A
|
to the parasitophorous vacuole, PV
|
44857 |
Protein kinase A
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
to the parasitophorous vacuole, PV
|
|
24028560
|
Q fever
|
4,420
|
44852 |
BAD
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
with the membrane of PV
|
44853 |
YWHAQ
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
with the membrane of PV
|
44854 |
Protein kinase A
|
|
affects_activity of
|
BAD
|
resulting in sequestering Bad away from mitochondria during apoptosis after C. burnetii infection
|
|
24028560
|
Q fever
|
4,423
|
44860 |
Protein kinase A
|
|
increases_activity of
|
phagosome maturation
|
in THP-1 cells, infected with avirulent C. burnetii NMII RSA439
|
44865 |
Protein kinase A
|
|
increases_activity of
|
Coxiella burnetii replication
|
in THP-1 cells, infected with avirulent C. burnetii NMII RSA439
|
44881 |
Coxiella burnetii infection
|
|
increases_activity of
|
Protein kinase A
|
in THP-1 cells, infected with avirulent C. burnetii NMII RSA439
|
|
22473604
|
Q fever
|
4,606
|
45838 |
T4BSS
|
|
increases_transport of
|
cvpA
|
shown in a CyaA translocation assay
|
45843 |
cvpA
|
|
increases_activity of
|
Coxiella burnetii replication
|
shown in a mutant analysis in THP-1 cells
|
45844 |
cvpA
|
|
increases_activity of
|
phagosome maturation
|
shown in a mutant analysis in THP-1 cells
|
|
24248335
|
Q fever
|