|
2,123
|
| 17584 |
P. aeruginosa infection
|
|
increases_quantity of
|
Pyochelin
|
|
| 17585 |
P. aeruginosa infection
|
|
increases_quantity of
|
Pyoverdine I
|
|
| 17589 |
Pyoverdine I
|
|
increases_expression of
|
toxA
|
|
| 17590 |
Pyoverdine I
|
|
increases_expression of
|
prpL
|
|
| 17591 |
Pyoverdine I
|
|
affects_quantity of
|
Pyoverdine I
|
|
| 24223 |
Pyochelin
|
|
increases_activity of
|
iron assimilation
|
|
| 24227 |
Pyoverdine I
|
|
increases_activity of
|
iron assimilation
|
|
|
15695491
|
Pseudomonas aeruginosa diseases
|
|
2,251
|
| 19215 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
interacts (colocalizes) with
|
Fe3+
|
under biological conditions
|
| 19216 |
2-Heptyl-4-quinolone, HHQ
|
NOT |
interacts (colocalizes) with
|
Fe3+
|
under biological conditions
|
| 19221 |
pvdS
|
|
affects_quantity of
|
Pyoverdine I
|
|
| 19222 |
pvdA
|
|
affects_quantity of
|
Pyoverdine I
|
|
| 19223 |
pvdE
|
|
increases_quantity of
|
Pyoverdine I
|
|
| 19224 |
pchE
|
|
increases_quantity of
|
Pyochelin
|
|
| 19231 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
increases_activity of
|
iron assimilation
|
|
|
17254955
|
Pseudomonas aeruginosa diseases
|
|
2,285
|
| 19514 |
lasR
|
|
increases_quantity of
|
Pyoverdine I
|
|
| 19592 |
ppyR
|
|
increases_quantity of
|
Pyoverdine I
|
|
|
20738404
|
Pseudomonas aeruginosa diseases
|
|
2,464
|
| 22832 |
hasAp
|
|
interacts (colocalizes) with
|
Heme
|
|
| 22833 |
hasR
|
|
increases_transport of
|
Heme
|
|
| 22838 |
T1SS (Has)
|
|
increases_transport of
|
hasAp
|
into the extracellular medium
|
| 22906 |
hasAp
|
|
interacts (colocalizes) with
|
hasR
|
|
|
20947426
|
Pseudomonas aeruginosa diseases
|
|
2,492
|
| 28552 |
T1SS (Has)
|
|
increases_transport of
|
hasAp
|
|
| 28553 |
T1SS (Has) complex
|
|
increases_activity of
|
T1SS (Has)
|
|
| 28555 |
hasD
|
|
is_part_of
|
T1SS (Has) complex
|
|
| 28556 |
hasE
|
|
is_part_of
|
T1SS (Has) complex
|
|
| 28557 |
hasF
|
|
is_part_of
|
T1SS (Has) complex
|
|
| 28558 |
hasAp
|
|
interacts (colocalizes) with
|
hasR
|
|
|
21811488
|
Pseudomonas aeruginosa diseases
|
|
2,521
|
| 23502 |
lipA
|
|
affects_expression of
|
pvdS
|
|
| 23503 |
lipA
|
|
increases_quantity of
|
Pyoverdine I
|
under iron-limitation conditions
|
|
21840975
|
Pseudomonas aeruginosa diseases
|
|
2,536
|
| 23624 |
pvdS
|
|
affects_quantity of
|
Pyoverdine I
|
|
| 23631 |
cysB
|
|
increases_quantity of
|
Pyoverdine I
|
|
|
20370820
|
Pseudomonas aeruginosa diseases
|
|
2,857
|
| 26347 |
Fe2+
|
|
increases_expression of
|
bqsR
|
extracellular Fe(II)
|
| 26354 |
Fe2+
|
|
increases_expression of
|
bqsS
|
extracellular Fe(II)
|
| 26356 |
Fe2+
|
|
increases_expression of
|
bqsP
|
extracellular Fe(II)
|
| 26357 |
Fe2+
|
|
increases_expression of
|
bqsQ
|
extracellular Fe(II)
|
| 26371 |
bqsS
|
|
increases_activity of
|
bqsR
|
|
| 26378 |
Fe2+
|
|
increases_activity of
|
bqsS
|
extracellular Fe(II)
|
| 26387 |
Fe3+
|
NOT |
increases_expression of
|
bqsS
|
|
| 26389 |
Ca2+
|
NOT |
increases_expression of
|
bqsS
|
|
| 26390 |
Cu2+
|
NOT |
increases_expression of
|
bqsS
|
|
| 26391 |
Mg2+
|
NOT |
increases_expression of
|
bqsS
|
|
| 26392 |
Mn2+
|
NOT |
increases_expression of
|
bqsS
|
|
| 26393 |
Zn2+
|
NOT |
increases_expression of
|
bqsS
|
|
| 26399 |
bqsR
|
|
increases_expression of
|
PA14_04180
|
|
|
22194456
|
Pseudomonas aeruginosa diseases
|
|
2,932
|
| 26807 |
2-Amino acetophenone, 2-AA
|
|
decreases_quantity of
|
Pyoverdine I
|
|
|
21829370
|
Pseudomonas aeruginosa diseases
|
|
3,077
|
| 28281 |
fpvA
|
|
increases_transport of
|
Pyoverdine I
|
|
| 28282 |
TAT protein transport complex
|
NOT |
affects transport of
|
fpvA
|
to the outer membrane
|
| 28283 |
TAT protein transport complex
|
NOT |
affects_activity of
|
fpvA
|
|
| 28284 |
pvdN
|
|
increases_quantity of
|
Pyoverdine I
|
|
| 28285 |
TAT protein transport complex
|
|
increases_transport of
|
pvdN
|
across the inner membrane
|
| 28323 |
fpvA
|
|
is localized in
|
bacterial outer membrane
|
|
| 28325 |
fptA
|
|
increases_transport of
|
Pyochelin
|
|
| 28326 |
TAT protein transport complex
|
NOT |
affects transport of
|
fptA
|
to the outer membrane
|
| 28327 |
fptA
|
|
is localized in
|
bacterial outer membrane
|
|
|
16621825
|
Pseudomonas aeruginosa diseases
|
|
3,277
|
| 30168 |
heme uptake system, Phu
|
|
affects transport of
|
Heme
|
|
| 30171 |
heme uptake system, Has
|
|
affects transport of
|
Heme
|
|
| 30172 |
hasAp
|
|
affects_activity of
|
heme uptake system, Has
|
|
| 30173 |
hasR
|
|
affects_activity of
|
heme uptake system, Has
|
|
| 30175 |
phuR
|
|
affects_activity of
|
heme uptake system, Phu
|
|
| 30177 |
hemO
|
|
decreases_quantity of
|
Heme
|
in cytoplasm of bacteria
|
| 30178 |
hemO
|
|
increases_quantity of
|
Biliverdin
|
in cytoplasm of bacteria
|
| 30179 |
hemO
|
|
increases_quantity of
|
Fe2+
|
in cytoplasm of bacteria
|
| 30180 |
phuS
|
|
interacts (colocalizes) with
|
Heme
|
in cytoplasm of bacteria
|
| 30182 |
phuS
|
|
affects_activity of
|
heme uptake system, Phu
|
|
| 30183 |
phuR
|
|
interacts (colocalizes) with
|
Heme
|
|
| 30190 |
Pyoverdine I
|
|
increases_activity of
|
biofilm formation
|
|
| 30214 |
fur
|
|
decreases_expression of
|
pvdS
|
|
| 30217 |
fur
|
|
decreases_expression of
|
fpvA
|
|
| 30228 |
fur
|
|
decreases_expression of
|
pchR
|
|
| 30229 |
fur
|
|
decreases_expression of
|
pfeR
|
|
| 30230 |
fur
|
|
decreases_expression of
|
pirR
|
|
|
20352420
|
Pseudomonas aeruginosa diseases
|
|
3,287
|
| 30231 |
phuR
|
|
affects_activity of
|
heme uptake system, Phu
|
|
| 30233 |
phuS
|
|
affects_activity of
|
heme uptake system, Phu
|
|
| 30234 |
phuT
|
|
affects_activity of
|
heme uptake system, Phu
|
|
| 30235 |
phuU
|
|
affects_activity of
|
heme uptake system, Phu
|
|
| 30236 |
phuV
|
|
affects_activity of
|
heme uptake system, Phu
|
|
| 30237 |
phuW
|
|
affects_activity of
|
heme uptake system, Phu
|
|
| 30238 |
fur
|
|
affects_activity of
|
heme uptake system, Phu
|
|
| 30239 |
hasR
|
|
affects_activity of
|
heme uptake system, Has
|
|
| 30240 |
hasAp
|
|
affects_activity of
|
heme uptake system, Has
|
|
| 30241 |
phuR
|
|
is localized in
|
bacterial outer membrane
|
|
| 30242 |
hasR
|
|
is localized in
|
bacterial outer membrane
|
|
| 30243 |
fur
|
|
affects_activity of
|
heme uptake system, Has
|
|
| 30286 |
heme uptake system, Phu
|
|
increases_activity of
|
iron assimilation
|
|
| 30287 |
heme uptake system, Has
|
|
increases_activity of
|
iron assimilation
|
|
|
10658665
|
Pseudomonas aeruginosa diseases
|
|
3,296
|
| 30288 |
fur
|
|
affects_activity of
|
cellular response to iron ion starvation
|
|
| 30292 |
fur
|
|
interacts (colocalizes) with
|
Fe2+
|
|
|
10658665
|
Pseudomonas aeruginosa diseases
|
|
3,299
|
| 30309 |
pvdRT-opmQ efflux complex
|
|
increases_transport of
|
Pyoverdine I
|
from the periplasm to the extracellular milieu
|
| 30310 |
pvdR
|
|
is_part_of
|
pvdRT-opmQ efflux complex
|
|
| 30311 |
pvdT
|
|
is_part_of
|
pvdRT-opmQ efflux complex
|
|
| 30312 |
opmQ
|
|
is_part_of
|
pvdRT-opmQ efflux complex
|
|
| 30313 |
fpvA
|
|
increases_transport of
|
Pyoverdine I
|
of ferri-PVD (pyoverdine) into the periplasmic space
|
| 30314 |
mexAB-oprM multidrug efflux complex
|
NOT |
affects transport of
|
Pyoverdine I
|
|
| 30315 |
pvdE
|
|
affects transport of
|
Pyoverdine I
|
of the nonfluorescent PVD precursor ferribactin from the cytosol to the periplasm
|
|
19906986
|
Pseudomonas aeruginosa diseases
|
|
3,348
|
| 30759 |
fur
|
|
affects_expression of
|
T6SS-HSI-2 complex
|
|
|
22665491
|
Pseudomonas aeruginosa diseases
|
|
3,437
|
| 31959 |
high iron level
|
|
increases_activity of
|
fur
|
in the cytoplasm
|
| 31963 |
fur
|
|
decreases_expression of
|
prrF1
|
|
| 31964 |
fur
|
|
decreases_expression of
|
prrF2
|
|
| 31965 |
low iron level
|
|
decreases_activity of
|
fur
|
|
| 31966 |
low iron level
|
|
increases_expression of
|
prrF1
|
|
| 31968 |
low iron level
|
|
increases_expression of
|
prrF2
|
|
| 31969 |
prrF1
|
|
decreases_quantity of
|
sodB
|
|
| 31970 |
prrF2
|
|
decreases_quantity of
|
sodB
|
|
| 31971 |
prrF1
|
|
decreases_quantity of
|
katA
|
|
| 31972 |
prrF2
|
|
decreases_quantity of
|
katA
|
|
| 31973 |
prrF1
|
|
decreases_quantity of
|
bfrB
|
|
| 31974 |
prrF2
|
|
decreases_quantity of
|
bfrB
|
|
| 31975 |
prrF1
|
|
affects_quantity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
| 31977 |
prrF2
|
|
affects_quantity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
| 40811 |
prrF1
|
|
decreases_quantity of
|
PA4880
|
|
| 40814 |
prrF2
|
|
decreases_quantity of
|
PA4880
|
|
| 40815 |
prrF1
|
|
decreases_quantity of
|
sdhC
|
|
| 40818 |
prrF2
|
|
decreases_quantity of
|
sdhC
|
|
| 40819 |
prrF1
|
|
decreases_quantity of
|
sdhD
|
|
| 40820 |
prrF2
|
|
decreases_quantity of
|
sdhD
|
|
| 40821 |
prrF1
|
|
decreases_quantity of
|
sdhA
|
|
| 40824 |
prrF2
|
|
decreases_quantity of
|
sdhA
|
|
| 40825 |
prrF1
|
|
decreases_quantity of
|
sdhB
|
|
| 40826 |
prrF2
|
|
decreases_quantity of
|
sdhB
|
|
| 40828 |
prrF1
|
|
decreases_quantity of
|
acnA
|
|
| 40832 |
prrF2
|
|
decreases_quantity of
|
acnA
|
|
| 40833 |
prrF1
|
|
decreases_quantity of
|
acnB
|
|
| 40835 |
prrF2
|
|
decreases_quantity of
|
acnB
|
|
| 40836 |
prrF1
|
|
decreases_quantity of
|
prpB
|
|
| 40839 |
prrF2
|
|
decreases_quantity of
|
prpB
|
|
| 40840 |
prrF1
|
|
decreases_quantity of
|
antA
|
|
| 40843 |
prrF2
|
|
decreases_quantity of
|
antA
|
|
| 40844 |
prrF1
|
|
decreases_quantity of
|
antB
|
|
| 40848 |
prrF2
|
|
decreases_quantity of
|
antB
|
|
| 40849 |
prrF1
|
|
decreases_quantity of
|
antC
|
|
| 40850 |
prrF2
|
|
decreases_quantity of
|
antC
|
|
| 40851 |
prrF1
|
|
decreases_quantity of
|
catA
|
|
| 40852 |
prrF2
|
|
decreases_quantity of
|
catA
|
|
| 40853 |
prrF1
|
|
decreases_quantity of
|
catB
|
|
| 40854 |
prrF2
|
|
decreases_quantity of
|
catB
|
|
| 40855 |
prrF1
|
|
decreases_quantity of
|
catC
|
|
| 40857 |
prrF2
|
|
decreases_quantity of
|
catC
|
|
|
21607656
|
Pseudomonas aeruginosa diseases
|
|
3,585
|
| 33552 |
pvdQ
|
|
affects_quantity of
|
Pyoverdine I
|
|
|
18245294
|
Pseudomonas aeruginosa diseases
|
|
3,858
|
| 38758 |
pvdE
|
|
increases_quantity of
|
Pyoverdine I
|
|
| 38765 |
pvdE
|
|
increases_activity of
|
entry of bacterium into host cell
|
of P.aeruginosa into host
|
| 38768 |
pvdE
|
|
increases_expression of
|
exoS
|
|
| 38771 |
exoS
|
|
increases_activity of
|
entry of bacterium into host cell
|
of P.aeruginosa into host
|
|
22080193
|
Pseudomonas aeruginosa diseases
|
|
3,859
|
| 38781 |
pvdE
|
|
increases_activity of
|
entry of bacterium into host cell
|
of P.aeruginosa into silkworms
|
| 38783 |
exoS
|
NOT |
increases_activity of
|
entry of bacterium into host cell
|
of P.aeruginosa into silkworms
|
|
22080193
|
Pseudomonas aeruginosa diseases
|
|
3,989
|
| 40589 |
Heme
|
|
decreases_expression of
|
prrH
|
|
| 40593 |
Fe2+
|
|
decreases_expression of
|
prrH
|
|
| 40594 |
Heme
|
|
decreases_expression of
|
prrF1
|
|
| 40595 |
Heme
|
|
decreases_expression of
|
prrF2
|
|
| 40596 |
Fe2+
|
|
decreases_expression of
|
prrF1
|
|
| 40597 |
Fe2+
|
|
decreases_expression of
|
prrF2
|
|
| 40600 |
Heme
|
|
increases_expression of
|
sdhD
|
|
| 40601 |
Fe2+
|
|
increases_expression of
|
sdhD
|
|
| 40602 |
Heme
|
|
increases_expression of
|
m-acnA
|
|
| 40603 |
Fe2+
|
|
increases_expression of
|
m-acnA
|
|
| 40604 |
Heme
|
|
increases_expression of
|
acnB
|
|
| 40605 |
Fe2+
|
|
increases_expression of
|
acnB
|
|
| 40606 |
phuR
|
|
affects_expression of
|
prrH
|
induced by heme
|
| 40607 |
hasR
|
|
affects_expression of
|
prrH
|
induced by heme
|
| 40608 |
prrH
|
|
decreases_quantity of
|
m-acnA
|
under low iron conditions
|
| 40609 |
Heme
|
|
increases_expression of
|
nirL
|
|
| 40610 |
Fe2+
|
|
increases_expression of
|
nirL
|
|
| 40611 |
prrH
|
|
decreases_quantity of
|
nirL
|
induced by heme
|
|
20386693
|
Pseudomonas aeruginosa diseases
|
|
3,993
|
| 40780 |
low iron level
|
|
increases_expression of
|
prrF1
|
|
| 40781 |
low iron level
|
|
increases_expression of
|
prrF2
|
|
| 40782 |
prrF1
|
|
decreases_quantity of
|
sodB
|
|
| 40783 |
prrF1
|
|
decreases_quantity of
|
sdhD
|
|
| 40784 |
prrF2
|
|
decreases_quantity of
|
sodB
|
|
| 40785 |
prrF2
|
|
decreases_quantity of
|
sdhD
|
|
| 40786 |
prrF1
|
|
decreases_quantity of
|
PA4880
|
|
| 40787 |
prrF2
|
|
decreases_quantity of
|
PA4880
|
|
| 40864 |
fur
|
|
decreases_expression of
|
prrF1
|
|
| 40865 |
fur
|
|
decreases_expression of
|
prrF2
|
|
|
15210934
|
Pseudomonas aeruginosa diseases
|
|
4,261
|
| 43570 |
oxyR
|
|
affects_expression of
|
dps
|
in response to H2O2
|
| 43571 |
oxyR
|
|
affects_expression of
|
pvdS
|
in response to H2O2
|
| 43578 |
oxyR
|
NOT |
affects_expression of
|
fur
|
in response to H2O2
|
|
22275523
|
Pseudomonas aeruginosa diseases
|
|
4,337
|
| 44355 |
P. aeruginosa infection, chronic
|
|
increases_expression of
|
pvdS
|
in sputum of most but not all CF patients
|
| 44369 |
P. aeruginosa infection, chronic
|
|
increases_expression of
|
pvdH
|
in sputum of most but not all CF patients
|
| 44370 |
P. aeruginosa infection, chronic
|
|
increases_expression of
|
pvdL
|
in sputum of most but not all CF patients
|
| 44372 |
P. aeruginosa infection, chronic
|
|
increases_expression of
|
pchF
|
in sputum of most but not all CF patients
|
| 44381 |
P. aeruginosa infection, chronic
|
|
affects_quantity of
|
Pyoverdine I
|
in sputum of most but not all CF patients
|
| 44384 |
P. aeruginosa infection, chronic
|
|
affects_quantity of
|
Pyochelin
|
in sputum of most but not all CF patients
|
| 44385 |
pchF
|
|
affects_quantity of
|
Pyochelin
|
|
| 44387 |
pvdS
|
|
affects_quantity of
|
Pyoverdine I
|
|
| 44389 |
pvdH
|
|
affects_quantity of
|
Pyoverdine I
|
|
| 44390 |
pvdL
|
|
affects_quantity of
|
Pyoverdine I
|
|
| 44395 |
P. aeruginosa infection, chronic
|
|
increases_activity of
|
heme uptake system, Has
|
in sputum of most but not all CF patients
|
| 44396 |
P. aeruginosa infection, chronic
|
|
increases_activity of
|
heme uptake system, Phu
|
in sputum of most but not all CF patients
|
| 44397 |
P. aeruginosa infection, chronic
|
|
increases_expression of
|
feoB
|
in sputum of all CF patients
|
| 44457 |
feoB
|
|
increases_activity of
|
iron assimilation
|
in sputum of all CF patients
|
| 44458 |
feoB
|
|
increases_transport of
|
Fe2+
|
in sputum of all CF patients
|
|
23690396
|
Pseudomonas aeruginosa diseases
|
|
5,009
|
| 49416 |
rsmA
|
|
decreases_expression of
|
pvdS
|
under iron-depleted conditions
|
| 49420 |
rsmA
|
|
decreases_expression of
|
pchR
|
under iron-depleted conditions
|
| 49422 |
rsmA
|
|
decreases_quantity of
|
Pyoverdine I
|
under iron-depleted conditions
|
| 49424 |
rsmA
|
|
decreases_quantity of
|
Pyochelin
|
under iron-depleted conditions
|
| 49426 |
rsmA
|
|
decreases_quantity of
|
cdiGMP
|
under iron-depleted conditions
|
|
23796404
|
Pseudomonas aeruginosa diseases
|
HoPaCI