|
2,024
|
| 16241 |
Coxiella burnetii infection
|
|
decreases_activity of
|
host cell apoptosis
|
in infected host cells
|
| 16242 |
Coxiella burnetii infection
|
|
increases_activity of
|
protein kinase B signaling
|
in infected host cells
|
| 16243 |
Coxiella burnetii infection
|
|
increases_activity of
|
ERK1 and ERK2 cascade
|
in infected host cells
|
| 16246 |
BECN1
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
on the vacuole membrane of infected host cells
|
| 16262 |
BCL2
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
on the vacuole membrane of infected host cells
|
| 16263 |
BECN1
|
|
increases_activity of
|
autophagy
|
|
| 16264 |
BCL2
|
|
decreases_activity of
|
host cell apoptosis
|
|
|
21030501
|
Q fever
|
|
2,047
|
| 16358 |
autophagy
|
|
increases_quantity of
|
C. burnetii containing vacuole, CCV
|
|
| 16414 |
Coxiella burnetii infection
|
|
increases_activity of
|
autophagy
|
|
| 16452 |
BECN1
|
|
increases_quantity of
|
C. burnetii containing vacuole, CCV
|
in HeLa cells; if BECN1 is overexpressed
|
| 16453 |
BECN1
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
|
| 16454 |
BECN1
|
|
affects_activity of
|
PIK3C3
|
|
| 16455 |
BECN1
|
|
increases_activity of
|
autophagy
|
|
| 16458 |
BECN1
|
|
interacts (colocalizes) with
|
BCL2
|
|
| 16460 |
Coxiella burnetii infection
|
|
decreases_activity of
|
host cell apoptosis
|
|
| 16462 |
BECN1
|
|
affects_activity of
|
BCL2
|
|
| 16463 |
BCL2
|
|
decreases_activity of
|
host cell apoptosis
|
|
|
20023428
|
Q fever
|
|
2,062
|
| 17043 |
Coxiella burnetii infection
|
|
increases_activity of
|
autophagy
|
|
| 17045 |
autophagy
|
|
increases_quantity of
|
C. burnetii containing vacuole, CCV
|
|
|
17381428
|
Q fever
|
|
3,521
|
| 32823 |
Coxiella burnetii infection
|
|
decreases_activity of
|
host cell apoptosis
|
|
| 32825 |
Chloramphenicol
|
|
increases_activity of
|
host cell apoptosis
|
induced by pathogen
|
| 32858 |
ankG
|
|
decreases_activity of
|
host cell apoptosis
|
|
|
22711632
|
Q fever
|
|
3,653
|
| 34842 |
Coxiella burnetii infection
|
|
decreases_activity of
|
host cell apoptosis
|
in macrophages
|
| 34843 |
Coxiella burnetii infection
|
|
increases_quantity of
|
BCL2A1
|
in macrophages
|
| 34844 |
Coxiella burnetii infection
|
|
increases_quantity of
|
BIRC3
|
in macrophages
|
| 34845 |
BCL2A1
|
|
decreases_activity of
|
host cell apoptosis
|
in macrophages
|
| 34846 |
BIRC3
|
|
decreases_activity of
|
host cell apoptosis
|
in macrophages
|
| 34852 |
pathogen survival
|
|
decreases_activity of
|
host cell apoptosis
|
|
|
22711638
|
Q fever
|
|
3,666
|
| 35087 |
Coxiella burnetii infection
|
|
increases_activity of
|
T4BSS
|
|
| 35089 |
ankG
|
|
interacts (colocalizes) with
|
C1QBP
|
shown in transfected HEK293 cells
|
| 35090 |
ankG
|
|
decreases_activity of
|
host cell apoptosis
|
shown in transfected CHO and HEK293 cells
|
| 35092 |
C1QBP
|
|
increases_activity of
|
host cell apoptosis
|
|
|
20944063
|
Q fever
|
|
3,668
|
| 35102 |
ankG
|
|
decreases_activity of
|
host cell apoptosis
|
shown in dentritic cells of B6 mice
|
| 35103 |
T4BSS
|
|
increases_transport of
|
ankG
|
shown in CHO Fc-gamma-RII cells
|
| 35104 |
C1QBP
|
|
increases_activity of
|
host cell apoptosis
|
shown in dentritic cells of B6 mice
|
|
20944063
|
Q fever
|
|
3,688
|
| 35419 |
IFNG
|
|
increases_activity of
|
host cell apoptosis
|
of C. burnetii-infected macrophages
|
| 35425 |
IFNG
|
|
increases_quantity of
|
TNF
|
|
| 35429 |
TNF
|
|
increases_activity of
|
host cell apoptosis
|
of C. burnetii-infected macrophages
|
| 35430 |
TNF
|
|
decreases_activity of
|
pathogen survival
|
of C. burnetii-infected macrophages
|
|
22711637
|
Q fever
|
|
3,695
|
| 35656 |
T4BSS
|
|
decreases_activity of
|
host cell apoptosis
|
in THP-1 cells
|
|
22010216
|
Q fever
|
|
3,707
|
| 35953 |
Coxiella burnetii infection
|
|
decreases_activity of
|
host cell apoptosis
|
|
| 35958 |
Coxiella burnetii infection
|
|
decreases_processing of
|
CASP3
|
in THP-1 macrophage-like cells
|
| 35959 |
Coxiella burnetii infection
|
|
decreases_processing of
|
CASP9
|
in THP-1 macrophage-like cells
|
| 35960 |
Coxiella burnetii infection
|
|
decreases_processing of
|
PARP1
|
in THP-1 macrophage-like cells
|
| 35962 |
Coxiella burnetii infection
|
|
decreases_activity of
|
release of cytochrome c from mitochondria
|
in HeLa and CHO cells
|
| 35964 |
CASP3
|
|
increases_activity of
|
host cell apoptosis
|
|
| 35965 |
CASP9
|
|
increases_activity of
|
host cell apoptosis
|
|
| 35966 |
PARP1
|
|
increases_activity of
|
host cell apoptosis
|
|
| 35969 |
release of cytochrome c from mitochondria
|
|
increases_activity of
|
host cell apoptosis
|
in HeLa and CHO cells
|
| 35970 |
Coxiella burnetii infection
|
|
increases_expression of
|
BIRC3
|
in THP-1 cells
|
| 35972 |
Coxiella burnetii infection
|
|
increases_quantity of
|
BIRC3
|
in THP-1 cells
|
| 35973 |
BIRC3
|
|
decreases_activity of
|
host cell apoptosis
|
|
| 35974 |
Coxiella burnetii infection
|
|
increases_expression of
|
BCL2A1
|
in THP-1 cells
|
| 35976 |
Coxiella burnetii infection
|
|
increases_quantity of
|
BCL2A1
|
in THP-1 cells
|
| 35977 |
BCL2A1
|
|
decreases_activity of
|
host cell apoptosis
|
|
| 35979 |
Coxiella burnetii infection
|
|
increases_expression of
|
BAG1
|
in THP-1 cells
|
| 35980 |
BAG1
|
|
decreases_activity of
|
host cell apoptosis
|
|
| 35981 |
Coxiella burnetii infection
|
|
decreases_expression of
|
BAX
|
in THP-1 cells
|
| 35986 |
Coxiella burnetii infection
|
|
decreases_expression of
|
BCL2L11
|
in THP-1 cells
|
| 35988 |
Coxiella burnetii infection
|
|
decreases_expression of
|
BIK
|
in THP-1 cells
|
| 35990 |
Coxiella burnetii infection
|
|
decreases_expression of
|
CASP2
|
in THP-1 cells
|
| 35991 |
Coxiella burnetii infection
|
|
decreases_expression of
|
CASP6
|
in THP-1 cells
|
| 35993 |
BAX
|
|
increases_activity of
|
host cell apoptosis
|
|
| 35994 |
BCL2L11
|
|
increases_activity of
|
host cell apoptosis
|
|
| 35995 |
BIK
|
|
increases_activity of
|
host cell apoptosis
|
|
| 35996 |
CASP2
|
|
increases_activity of
|
host cell apoptosis
|
|
| 35997 |
CASP6
|
|
increases_activity of
|
host cell apoptosis
|
|
| 36000 |
I-kappaB kinase/NF-kappaB signaling
|
|
affects_expression of
|
BCL2A1
|
|
| 36002 |
I-kappaB kinase/NF-kappaB signaling
|
|
affects_expression of
|
BIRC3
|
|
| 36012 |
BECN1
|
|
interacts (colocalizes) with
|
BCL2
|
|
| 36013 |
protein kinase B signaling
|
|
decreases_activity of
|
host cell apoptosis
|
induced by C. burnetii infection
|
| 36025 |
ERK1 and ERK2 cascade
|
|
decreases_activity of
|
host cell apoptosis
|
induced by C. burnetii infection
|
| 36909 |
Coxiella burnetii infection
|
|
increases_activity of
|
I-kappaB kinase/NF-kappaB signaling
|
|
|
22711630
|
Q fever
|
|
3,711
|
| 36071 |
caeA
|
|
decreases_activity of
|
host cell apoptosis
|
in CHO-FcR or HEK293 cells, transfected with GFP-tagged CaeA; to a lower extend than CaeB
|
| 36073 |
caeB
|
|
decreases_activity of
|
host cell apoptosis
|
in CHO-FcR or HEK293 cells, transfected with GFP-tagged CaeB; to a higher extend than CaeA
|
| 36076 |
caeB
|
NOT |
affects_quantity of
|
BCL2
|
in HEK293 cells, expressing GFP-CaeB
|
| 36077 |
caeB
|
NOT |
affects_quantity of
|
BCL2L1
|
in HEK293 cells, expressing GFP-CaeB
|
| 36078 |
caeB
|
NOT |
affects_quantity of
|
MCL1
|
in HEK293 cells, expressing GFP-CaeB
|
| 36079 |
caeB
|
NOT |
increases_quantity of
|
BCL2L11
|
in HEK293 cells, expressing GFP-CaeB
|
| 36122 |
caeB
|
NOT |
increases_quantity of
|
BBC3
|
in HEK293 cells, expressing GFP-CaeB
|
| 36142 |
caeB
|
|
increases_quantity of
|
BID
|
in HEK293 cells, expressing GFP-CaeB
|
| 36145 |
caeB
|
NOT |
increases_quantity of
|
BAK1
|
in HEK293 cells, expressing GFP-CaeB
|
| 36146 |
caeB
|
NOT |
increases_quantity of
|
BAX
|
in HEK293 cells, expressing GFP-CaeB
|
| 36147 |
BCL2
|
|
decreases_activity of
|
host cell apoptosis
|
|
| 36149 |
BCL2L1
|
|
decreases_activity of
|
host cell apoptosis
|
|
| 36150 |
MCL1
|
|
decreases_activity of
|
host cell apoptosis
|
|
| 36151 |
BCL2L11
|
|
increases_activity of
|
host cell apoptosis
|
|
| 36153 |
BBC3
|
|
increases_activity of
|
host cell apoptosis
|
|
| 36154 |
BAK1
|
|
increases_activity of
|
host cell apoptosis
|
|
| 36156 |
BAX
|
|
increases_activity of
|
host cell apoptosis
|
|
| 36158 |
BID
|
|
increases_activity of
|
host cell apoptosis
|
|
| 36163 |
caeB
|
|
decreases_processing of
|
CASP9
|
in HEK293 cells, expressing GFP-CaeB
|
| 36164 |
caeB
|
|
decreases_processing of
|
CASP7
|
in HEK293 cells, expressing GFP-CaeB
|
| 36165 |
ankG
|
|
interacts (colocalizes) with
|
C1QBP
|
in HEK293 cells, expressing GFP-AnkG
|
| 36166 |
caeB
|
NOT |
interacts (colocalizes) with
|
C1QBP
|
in HEK293 cells, expressing GFP-CaeB
|
| 36178 |
T4BSS
|
|
increases_transport of
|
caeB
|
into mitochodria of HEK293 cells, expressing GFP-CaeB
|
| 36415 |
caeB
|
|
is localized in
|
host cell mitochondrion
|
in HEK 293 cells
|
|
23126667
|
Q fever
|
|
4,410
|
| 44825 |
Coxiella burnetii infection
|
|
increases_activity of
|
Protein kinase A
|
as shown with the specific inhibitors H-89 and Rp-cAMPS
|
| 44826 |
Coxiella burnetii infection
|
|
decreases_processing of
|
PARP1
|
|
| 44828 |
Coxiella burnetii infection
|
|
increases_activity of
|
protein kinase B signaling
|
increased Ser136 phosphorylation was observed as early as 12 hpi
|
| 44829 |
protein kinase B signaling
|
|
increases_phosphorylation of
|
BAD
|
increased Ser136 phosphorylation was observed as early as 12 hpi
|
| 44830 |
Protein kinase A
|
|
increases_phosphorylation of
|
BAD
|
Ser155 phosphorylation levels increased between 24 and 48 hpi
|
| 44831 |
protein kinase B signaling
|
|
decreases_activity of
|
BAD
|
|
| 44832 |
Protein kinase A
|
|
decreases_activity of
|
BAD
|
|
| 44833 |
BAD
|
|
increases_activity of
|
host cell apoptosis
|
|
|
24028560
|
Q fever
|
|
4,411
|
| 44834 |
Protein kinase A
|
|
increases_phosphorylation of
|
BAD
|
|
|
24028560
|
Q fever
|
|
4,420
|
| 44852 |
BAD
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
with the membrane of PV
|
| 44853 |
YWHAQ
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
with the membrane of PV
|
| 44854 |
Protein kinase A
|
|
affects_activity of
|
BAD
|
resulting in sequestering Bad away from mitochondria during apoptosis after C. burnetii infection
|
|
24028560
|
Q fever
|
|
4,949
|
| 48912 |
ankG
|
|
interacts (colocalizes) with
|
C1QBP
|
|
| 48914 |
ankG
|
NOT |
affects_quantity of
|
C1QBP
|
as shown in HeLa cells, transfected with plasmids encoding GFP or GFP-tagged AnkG
|
| 48915 |
C1QBP
|
|
is localized in
|
host cell nucleus
|
to some extend
|
| 48916 |
C1QBP
|
|
is localized in
|
host cell mitochondrion
|
for the most part
|
| 48917 |
C1QBP
|
|
affects transport of
|
ankG
|
into the host cell nucleus; as shown in CHO-FcR cells, transfected with GFP-tagged AnkG, incubated with staurosporine
|
| 48919 |
ankG
|
|
decreases_activity of
|
host cell apoptosis
|
|
| 48920 |
ankG
|
|
is localized in
|
host cell nucleus
|
as shown in CHO-FcR cells, transfected with GFP-tagged AnkG, incubated with staurosporine
|
|
24733095
|
Q fever
|
HoPaCI