|
2,555
|
| 23823 |
retS
|
|
decreases_expression of
|
vgrG1a
|
|
| 23831 |
ladS
|
|
decreases_activity of
|
retS
|
if ladS is overexpressed
|
| 23836 |
ladS
|
|
increases_expression of
|
T6SS-HSI-1 complex
|
if ladS is overexpressed
|
|
21325275
|
Pseudomonas aeruginosa diseases
|
|
2,565
|
| 24052 |
retS
|
|
increases_expression of
|
T3SS complex
|
|
| 24053 |
retS
|
|
decreases_activity of
|
biofilm formation
|
|
| 24054 |
retS
|
|
decreases_expression of
|
T6SS-HSI-1 complex
|
|
| 24055 |
ladS
|
|
increases_expression of
|
T6SS-HSI-1 complex
|
|
| 24056 |
ladS
|
|
decreases_expression of
|
T3SS complex
|
|
| 24057 |
ladS
|
|
increases_activity of
|
biofilm formation
|
|
| 28406 |
rsmA
|
|
decreases_expression of
|
T6SS-HSI-1 complex
|
DNA microarray approach
|
|
20511495
|
Pseudomonas aeruginosa diseases
|
|
2,592
|
| 24461 |
retS
|
|
decreases_activity of
|
gacS
|
|
| 24462 |
gacS
|
|
increases_activity of
|
gacA
|
|
| 26441 |
retS
|
|
interacts (colocalizes) with
|
gacS
|
|
|
21955777
|
Pseudomonas aeruginosa diseases
|
|
2,853
|
| 26282 |
kinB
|
|
affects_quantity of
|
(alginate)n
|
|
| 26284 |
phoR
|
|
affects_quantity of
|
rhamnolipid
|
|
| 26290 |
copS
|
|
affects_activity of
|
response to copper ion
|
|
| 26292 |
bqsS
|
|
affects_activity of
|
biofilm formation
|
|
| 26293 |
kinB
|
|
increases_quantity of
|
Pyocyanine
|
in a manner independent of AlgB
|
| 26294 |
kinB
|
|
increases_quantity of
|
lasB
|
in a manner independent of AlgB
|
| 26295 |
kinB
|
NOT |
increases_quantity of
|
N-(3-Oxododecanoyl)-HSL
|
|
| 26296 |
kinB
|
NOT |
increases_quantity of
|
N-Butyryl-HSL
|
|
| 26299 |
kinB
|
|
increases_activity of
|
P. aeruginosa infection, acute
|
|
| 26300 |
kinB
|
NOT |
affects_activity of
|
T3SS
|
|
| 26301 |
kinB
|
|
affects_activity of
|
biofilm formation
|
|
| 29743 |
copS
|
|
increases_activity of
|
copR
|
|
| 29744 |
P. aeruginosa infection
|
|
decreases_expression of
|
copR
|
|
| 29745 |
copR
|
|
affects_activity of
|
ptrA
|
|
|
21515773
|
Pseudomonas aeruginosa diseases
|
|
2,854
|
| 26279 |
gacS
|
|
affects_activity of
|
P. aeruginosa infection, acute
|
|
| 26280 |
gacA
|
|
affects_activity of
|
P. aeruginosa infection, acute
|
|
| 26281 |
retS
|
|
affects_activity of
|
P. aeruginosa infection, acute
|
|
| 26297 |
kinB
|
|
increases_activity of
|
algB
|
|
| 26298 |
kinB
|
|
increases_phosphorylation of
|
algB
|
|
| 33965 |
gacS
|
|
affects_activity of
|
P. aeruginosa infection, chronic
|
|
| 33966 |
gacA
|
|
affects_activity of
|
P. aeruginosa infection, chronic
|
|
|
21515773
|
Pseudomonas aeruginosa diseases
|
|
2,855
|
| 26308 |
bqsS
|
|
decreases_activity of
|
biofilm formation
|
|
| 26309 |
bqsR
|
|
decreases_activity of
|
biofilm formation
|
|
| 26311 |
bqsS
|
|
increases_quantity of
|
rhamnolipid
|
|
| 26312 |
bqsR
|
|
increases_quantity of
|
rhamnolipid
|
|
| 26313 |
bqsS
|
NOT |
affects_quantity of
|
N-(3-Oxododecanoyl)-HSL
|
|
| 26314 |
bqsS
|
|
affects_quantity of
|
N-Butyryl-HSL
|
|
| 26315 |
bqsS
|
|
affects_quantity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
| 26316 |
bqsR
|
NOT |
affects_quantity of
|
N-(3-Oxododecanoyl)-HSL
|
|
| 26317 |
bqsR
|
|
affects_quantity of
|
N-Butyryl-HSL
|
|
| 26318 |
bqsR
|
|
affects_quantity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
|
19513205
|
Pseudomonas aeruginosa diseases
|
|
2,857
|
| 26371 |
bqsS
|
|
increases_activity of
|
bqsR
|
|
| 26399 |
bqsR
|
|
increases_expression of
|
PA14_04180
|
|
|
22194456
|
Pseudomonas aeruginosa diseases
|
|
2,879
|
| 26503 |
retS
|
|
increases_expression of
|
T3SS complex
|
|
| 26540 |
hptB
|
|
interacts (colocalizes) with
|
PA3346
|
|
| 26542 |
PA3346
|
|
interacts (colocalizes) with
|
PA3347
|
|
|
20398205
|
Pseudomonas aeruginosa diseases
|
|
2,892
|
| 26573 |
gacS
|
|
increases_activity of
|
gacA
|
|
| 26575 |
gacS
|
|
increases_phosphorylation of
|
gacA
|
|
|
19602144
|
Pseudomonas aeruginosa diseases
|
|
3,112
|
| 29618 |
fleS
|
|
increases_activity of
|
fleR
|
|
| 29673 |
fleR
|
|
affects_quantity of
|
flagellum
|
|
|
17307856
|
Pseudomonas aeruginosa diseases
|
|
3,206
|
| 29547 |
retS
|
|
decreases_activity of
|
gacS
|
|
| 29548 |
ladS
|
|
increases_activity of
|
gacS
|
|
| 29568 |
PA2284
|
|
increases_phosphorylation of
|
hptB
|
|
| 29570 |
hptB
|
|
increases_phosphorylation of
|
PA3346
|
|
| 29572 |
PA3346
|
|
decreases_phosphorylation of
|
PA3347
|
|
| 29574 |
PA2284
|
|
increases_activity of
|
hptB
|
|
| 29575 |
hptB
|
|
increases_activity of
|
PA3346
|
|
| 29577 |
hptB
|
|
increases_activity of
|
bacterial-type flagellum-dependent swarming motility
|
|
| 29578 |
PA3346
|
|
decreases_activity of
|
bacterial-type flagellum-dependent swarming motility
|
|
| 29579 |
PA3347
|
|
decreases_activity of
|
bacterial-type flagellum-dependent swarming motility
|
|
| 29580 |
hptB
|
|
decreases_activity of
|
biofilm formation
|
|
| 29581 |
PA3347
|
NOT |
affects_activity of
|
biofilm formation
|
|
| 29582 |
PA3346
|
|
decreases_expression of
|
rsmY
|
|
| 29585 |
PA3347
|
|
decreases_expression of
|
rsmY
|
|
| 29608 |
rocA1
|
|
increases_activity of
|
CupB fimbriae assembly
|
|
| 29609 |
rocR
|
|
decreases_activity of
|
rocA1
|
|
| 29610 |
rocS1
|
|
interacts (colocalizes) with
|
rocR
|
|
| 29611 |
rocR
|
|
decreases_phosphorylation of
|
rocA1
|
|
| 29620 |
rocA1
|
|
increases_activity of
|
CupC fimbriae assembly
|
|
| 29687 |
algU
|
|
increases_expression of
|
algR
|
|
|
22354680
|
Pseudomonas aeruginosa diseases
|
|
3,209
|
| 29632 |
rocS1
|
|
increases_activity of
|
rocA1
|
|
| 29633 |
rocS1
|
|
increases_phosphorylation of
|
rocA1
|
|
| 29634 |
rocA1
|
|
increases_activity of
|
CupB fimbriae assembly
|
|
| 29636 |
rocA1
|
|
increases_activity of
|
CupC fimbriae assembly
|
|
| 29637 |
rocR
|
|
decreases_activity of
|
rocA1
|
|
| 29640 |
rocR
|
|
decreases_activity of
|
CupC fimbriae assembly
|
|
| 29641 |
rocS1
|
|
interacts (colocalizes) with
|
rocA1
|
|
| 29642 |
rocS1
|
|
interacts (colocalizes) with
|
rocR
|
|
|
15659157
|
Pseudomonas aeruginosa diseases
|
|
3,211
|
| 29648 |
rcsC
|
|
increases_activity of
|
rcsB
|
|
| 29652 |
pvrS
|
|
increases_activity of
|
pvrR
|
|
| 29653 |
rcsB
|
|
increases_activity of
|
CupD fimbriae assembly
|
|
| 29654 |
rcsB
|
|
decreases_activity of
|
bacterial-type flagellum-dependent swarming motility
|
if rcsB is overexpressed
|
| 29655 |
rcsB
|
|
decreases_activity of
|
type IV pilus-dependent motility
|
if rcsB is overexpressed
|
| 29656 |
pvrR
|
|
decreases_activity of
|
rcsB
|
|
| 29657 |
pvrR
|
|
decreases_activity of
|
CupD fimbriae assembly
|
|
| 29658 |
pvrR
|
|
decreases_quantity of
|
cdiGMP
|
|
|
19547710
|
Pseudomonas aeruginosa diseases
|
|
3,231
|
| 29946 |
pilA
|
|
increases_quantity of
|
type IV pilus
|
|
| 29955 |
pilR
|
|
affects_expression of
|
pilA
|
|
| 29956 |
pilS
|
|
increases_activity of
|
pilR
|
|
| 29972 |
pprA
|
|
increases_activity of
|
pprB
|
|
| 29974 |
pprB
|
|
increases_activity of
|
CupE fimbriae assembly
|
|
| 29977 |
pprB
|
|
increases_quantity of
|
type IVb pilus
|
|
| 29987 |
pilR
|
|
increases_quantity of
|
type IV pilus
|
|
| 30051 |
PA1611
|
|
increases_activity of
|
hptB
|
|
| 30052 |
PA1976
|
|
increases_activity of
|
hptB
|
|
| 30053 |
PA2824
|
|
increases_activity of
|
hptB
|
|
| 30057 |
bfiS
|
|
increases_activity of
|
bfiR
|
|
| 30058 |
bfiR
|
|
increases_activity of
|
biofilm formation
|
biofilm initiation
|
| 30059 |
bfmS
|
|
increases_activity of
|
bfmR
|
|
| 30060 |
bfmR
|
|
increases_activity of
|
biofilm formation
|
biofilm maturation
|
| 30061 |
mifS
|
|
increases_activity of
|
mifR
|
|
| 30063 |
mifR
|
|
increases_activity of
|
biofilm formation
|
microcolony formation
|
| 30064 |
bfiR
|
|
increases_expression of
|
cafA
|
|
| 30067 |
cafA
|
|
decreases_quantity of
|
rsmZ
|
|
| 30069 |
cafA
|
NOT |
decreases_quantity of
|
rsmY
|
|
|
21554516
|
Pseudomonas aeruginosa diseases
|
|
3,233
|
| 29802 |
rocS1
|
|
increases_activity of
|
rocA1
|
|
| 29803 |
rocS1
|
|
increases_phosphorylation of
|
rocA1
|
|
| 29804 |
rocS2
|
|
increases_activity of
|
rocA1
|
|
| 29805 |
rocS2
|
|
increases_phosphorylation of
|
rocA1
|
|
| 29806 |
rocA1
|
|
increases_activity of
|
CupC fimbriae assembly
|
|
| 29807 |
rocS1
|
|
increases_activity of
|
rocA2
|
|
| 29808 |
rocS1
|
|
increases_phosphorylation of
|
rocA2
|
|
| 29809 |
rocS2
|
|
increases_activity of
|
rocA2
|
|
| 29810 |
rocS2
|
|
increases_phosphorylation of
|
rocA2
|
|
| 29811 |
rocA2
|
NOT |
affects_activity of
|
CupC fimbriae assembly
|
|
| 29812 |
rocA1
|
NOT |
affects_activity of
|
CupB fimbriae assembly
|
|
| 29813 |
rocA2
|
NOT |
affects_activity of
|
CupB fimbriae assembly
|
|
| 29814 |
rocR
|
|
decreases_activity of
|
rocA1
|
|
| 29815 |
rocR
|
|
decreases_activity of
|
rocA2
|
|
| 29816 |
rocS1
|
|
interacts (colocalizes) with
|
rocA1
|
|
| 29817 |
rocS1
|
|
interacts (colocalizes) with
|
rocA2
|
|
| 29818 |
rocS2
|
|
interacts (colocalizes) with
|
rocA1
|
|
| 29819 |
rocS2
|
|
interacts (colocalizes) with
|
rocA2
|
|
| 29820 |
rocS1
|
|
interacts (colocalizes) with
|
rocR
|
|
| 29821 |
rocS2
|
|
interacts (colocalizes) with
|
rocR
|
|
| 29822 |
mexA
|
|
is_part_of
|
mexAB-oprM multidrug efflux complex
|
|
| 29823 |
mexB
|
|
is_part_of
|
mexAB-oprM multidrug efflux complex
|
|
| 29824 |
oprM
|
|
is_part_of
|
mexAB-oprM multidrug efflux complex
|
|
| 29825 |
mexR
|
|
affects_expression of
|
mexAB-oprM multidrug efflux complex
|
|
| 29826 |
rocA2
|
|
decreases_quantity of
|
mexAB-oprM multidrug efflux complex
|
|
| 29827 |
rocA2
|
|
decreases_activity of
|
antibiotic resistance
|
|
| 29828 |
P. aeruginosa infection, chronic
|
|
decreases_activity of
|
mexAB-oprM multidrug efflux complex
|
|
| 44468 |
mexAB-oprM multidrug efflux complex
|
|
increases_activity of
|
antibiotic resistance
|
|
|
21205015
|
Pseudomonas aeruginosa diseases
|
|
3,247
|
| 29958 |
algR
|
|
increases_activity of
|
type IV pilus-dependent motility
|
|
| 29962 |
algZ
|
|
increases_activity of
|
algR
|
|
|
8790418
|
Pseudomonas aeruginosa diseases
|
|
3,277
|
| 30229 |
fur
|
|
decreases_expression of
|
pfeR
|
|
| 30230 |
fur
|
|
decreases_expression of
|
pirR
|
|
|
20352420
|
Pseudomonas aeruginosa diseases
|
|
3,437
|
| 32030 |
cbrA
|
|
increases_activity of
|
cbrB
|
|
| 32032 |
cbrA
|
|
affects_activity of
|
carbon catabolite regulation of transcription
|
|
| 32033 |
cbrB
|
|
affects_activity of
|
carbon catabolite regulation of transcription
|
|
| 32046 |
cbrB
|
|
increases_expression of
|
crcZ
|
in the absence of preferred growth substrates
|
|
21607656
|
Pseudomonas aeruginosa diseases
|
|
3,683
|
| 35323 |
adhesion of symbiont to host
|
|
increases_activity of
|
phoQ
|
during adherence to HBE cells
|
| 35343 |
phoQ
|
|
increases_activity of
|
phoP
|
|
| 35345 |
phoQ
|
|
increases_expression of
|
phoP
|
during adherence to HBE cells
|
| 35347 |
phoQ
|
|
increases_expression of
|
oprH
|
during adherence to HBE cells
|
| 35348 |
phoQ
|
|
increases_expression of
|
pmrB
|
during adherence to HBE cells
|
| 35351 |
phoQ
|
|
increases_expression of
|
arnB
|
during adherence to HBE cells
|
| 35362 |
phoQ
|
|
increases_expression of
|
lasB
|
during adherence to HBE cells
|
| 35365 |
phoQ
|
|
increases_expression of
|
piv
|
during adherence to HBE cells
|
| 35366 |
phoQ
|
|
increases_expression of
|
lipA
|
during adherence to HBE cells
|
| 35368 |
phoQ
|
|
increases_expression of
|
lipC
|
during adherence to HBE cells
|
| 35371 |
phoQ
|
|
increases_expression of
|
lipH
|
during adherence to HBE cells
|
| 35376 |
lipA
|
|
decreases_activity of
|
surfactant homeostasis
|
|
| 35377 |
lipC
|
|
decreases_activity of
|
surfactant homeostasis
|
|
| 35379 |
phoQ
|
NOT |
affects_expression of
|
exoS
|
|
| 35381 |
phoQ
|
NOT |
affects_expression of
|
toxA
|
|
| 35382 |
arnB
|
|
affects_activity of
|
lipid modification
|
|
| 35385 |
phoQ
|
|
affects_activity of
|
inflammatory response
|
|
| 35388 |
P. aeruginosa infection
|
|
increases_activity of
|
adhesion of symbiont to host
|
|
|
22710876
|
Pseudomonas aeruginosa diseases
|
|
3,903
|
| 39606 |
pprA
|
|
increases_activity of
|
pprB
|
|
| 39607 |
pprB
|
|
increases_quantity of
|
type IVb pilus
|
|
| 39608 |
pprB
|
|
increases_expression of
|
pqsA
|
|
| 39609 |
pprB
|
|
increases_expression of
|
pqsB
|
|
| 39610 |
pprB
|
|
increases_expression of
|
pqsC
|
|
| 39611 |
pprB
|
|
increases_expression of
|
pqsD
|
|
| 39612 |
pprB
|
|
increases_expression of
|
pqsE
|
|
| 39613 |
pprB
|
|
increases_expression of
|
phnA
|
|
| 39614 |
pprB
|
|
increases_expression of
|
phnB
|
|
| 39615 |
pprB
|
|
decreases_expression of
|
PA14_16990
|
|
| 39616 |
pprB
|
|
increases_expression of
|
hvnA
|
|
| 39621 |
pprB
|
|
increases_expression of
|
bapA
|
|
| 39622 |
pprB
|
|
increases_expression of
|
bapB
|
|
| 39623 |
pprB
|
|
increases_expression of
|
bapC
|
|
| 39624 |
pprB
|
|
increases_expression of
|
bapD
|
|
|
23209420
|
Pseudomonas aeruginosa diseases
|
|
3,905
|
| 39626 |
bapA
|
|
increases_quantity of
|
PprBK hyper-biofilm phenotype
|
|
| 39627 |
CupE fimbriae assembly
|
|
increases_quantity of
|
PprBK hyper-biofilm phenotype
|
|
| 39628 |
type IVb pilus
|
|
increases_quantity of
|
PprBK hyper-biofilm phenotype
|
|
| 39629 |
extracellular DNA, eDNA
|
|
increases_quantity of
|
PprBK hyper-biofilm phenotype
|
|
| 39630 |
T1SS (Bap)
|
|
increases_transport of
|
bapA
|
|
| 39631 |
T1SS (Bap) complex
|
|
increases_activity of
|
T1SS (Bap)
|
|
| 39632 |
bapB
|
|
is_part_of
|
T1SS (Bap) complex
|
|
| 39633 |
bapC
|
|
is_part_of
|
T1SS (Bap) complex
|
|
| 39634 |
bapD
|
|
is_part_of
|
T1SS (Bap) complex
|
|
| 39636 |
PprBK hyper-biofilm phenotype
|
|
decreases_activity of
|
P. aeruginosa infection
|
in orally infected Drosophila flies
|
| 39663 |
pprB
|
|
increases_quantity of
|
PprBK hyper-biofilm phenotype
|
|
| 39664 |
pprB
|
|
decreases_activity of
|
T3SS
|
|
| 39671 |
bapA
|
|
increases_activity of
|
adhesion of symbiont to host
|
in orally infected Drosophila flies
|
| 39678 |
PprBK hyper-biofilm phenotype
|
|
decreases_activity of
|
antibiotic resistance
|
against tobramycin
|
|
23209420
|
Pseudomonas aeruginosa diseases
|
|
3,946
|
| 40078 |
phoB
|
|
increases_activity of
|
T2SS (Hxc)
|
|
| 40079 |
phoB
|
|
increases_activity of
|
cellular response to phosphate starvation
|
|
|
22835944
|
Pseudomonas aeruginosa diseases
|
|
3,948
|
| 40084 |
phoR
|
|
increases_activity of
|
phoB
|
|
|
3138529
|
Pseudomonas aeruginosa diseases
|
|
4,354
|
| 44485 |
parS
|
|
increases_activity of
|
parR
|
|
| 44491 |
parR
|
|
increases_activity of
|
mexEF-oprN multidrug efflux complex
|
|
| 44500 |
mexE
|
|
is_part_of
|
mexEF-oprN multidrug efflux complex
|
|
| 44501 |
mexF
|
|
is_part_of
|
mexEF-oprN multidrug efflux complex
|
|
| 44502 |
oprN
|
|
is_part_of
|
mexEF-oprN multidrug efflux complex
|
|
| 44503 |
parR
|
|
increases_expression of
|
mexS
|
|
| 44507 |
mexS
|
|
affects_activity of
|
mexEF-oprN multidrug efflux complex
|
|
| 44512 |
parR
|
|
decreases_expression of
|
qteE
|
|
| 44514 |
parR
|
|
decreases_expression of
|
rhlI
|
|
| 44515 |
parR
|
|
decreases_expression of
|
rhlR
|
|
| 44516 |
parR
|
|
decreases_expression of
|
rsaL
|
|
| 44603 |
parR
|
|
decreases_activity of
|
PQS quorum sensing
|
|
| 44612 |
parR
|
|
decreases_quantity of
|
Pyocyanine
|
|
| 44614 |
parR
|
|
decreases_activity of
|
bacterial-type flagellum-dependent swarming motility
|
|
| 44616 |
parR
|
|
decreases_expression of
|
phz1-operon
|
|
| 44617 |
parR
|
|
decreases_expression of
|
rhlA
|
|
| 44618 |
parR
|
|
decreases_expression of
|
rhlB
|
|
| 62307 |
parR
|
|
decreases_expression of
|
phz2-operon
|
|
| 62308 |
parR
|
|
decreases_expression of
|
phzM
|
|
|
24034668
|
Pseudomonas aeruginosa diseases
|
|
4,661
|
| 46396 |
cbrA
|
|
increases_activity of
|
P. aeruginosa infection
|
shown in mouse models of acute lung infection and peritoneal infection
|
| 46397 |
cbrB
|
NOT |
increases_activity of
|
P. aeruginosa infection
|
|
| 46399 |
cbrA
|
|
decreases_activity of
|
phagocytosis
|
as analyzed by human and murine macrophages
|
| 46400 |
cbrB
|
NOT |
affects_activity of
|
phagocytosis
|
as analyzed by human and murine macrophages
|
| 46401 |
cbrA
|
|
decreases_activity of
|
neutrophil mediated killing of bacterium
|
|
|
24379284
|
Pseudomonas aeruginosa diseases
|
|
4,665
|
| 46414 |
cbrA
|
|
increases_activity of
|
P. aeruginosa infection
|
as shown in D. discoideum, used as a simple non-mammalian host system model
|
| 46418 |
cbrA
|
|
affects_activity of
|
response to oxidative stress
|
as shown in D. discoideum, used as a simple non-mammalian host system model
|
| 46419 |
cbrA
|
|
affects_activity of
|
iron assimilation
|
as shown in D. discoideum, used as a simple non-mammalian host system model
|
|
24379284
|
Pseudomonas aeruginosa diseases
|
|
5,271
|
| 51499 |
ttsS
|
|
interacts (colocalizes) with
|
ttsR
|
|
| 51500 |
ttsR
|
|
increases_expression of
|
cbpE
|
|
| 51501 |
ttsR
|
|
increases_expression of
|
T2SS (Txc)-associated complexes
|
|
| 51502 |
T2SS (Txc)-associated complexes
|
|
increases_activity of
|
T2SS (Txc)
|
|
| 51503 |
T2SS (Txc)
|
|
increases_transport of
|
cbpE
|
|
|
24748613
|
Pseudomonas aeruginosa diseases
|
HoPaCI