|
2,047
|
| 16356 |
Coxiella burnetii infection
|
|
increases_activity of
|
T4BSS
|
|
|
20023428
|
Q fever
|
|
2,062
|
| 17050 |
Coxiella burnetii infection
|
|
increases_activity of
|
T4BSS
|
|
|
17381428
|
Q fever
|
|
3,484
|
| 32372 |
dotaA
|
|
increases_activity of
|
T4BSS
|
analysed in delta-dotA and delta-dotB mutants
|
| 32375 |
dotB
|
|
increases_activity of
|
T4BSS
|
analysed in delta-dotA and delta-dotB mutants
|
| 32376 |
T4BSS
|
|
increases_transport of
|
cpeD
|
in THP-1 macrophages; shown in a CyaA translocation assay
|
| 32379 |
T4BSS
|
|
increases_transport of
|
cpeE
|
in THP-1 macrophages; shown in a CyaA translocation assay
|
| 32396 |
dotaA
|
|
affects_activity of
|
T4BSS
|
|
| 32398 |
dotB
|
|
affects_activity of
|
T4BSS
|
|
| 32412 |
T4BSS
|
|
increases_activity of
|
Coxiella burnetii replication
|
shown in Vero cells; analysed in delta-dotA and delta-dotB mutants
|
| 32414 |
T4BSS
|
|
increases_activity of
|
phagosome maturation
|
shown in Vero cells; analysed in delta-dotA and delta-dotB mutants
|
| 36387 |
cpeD
|
|
is localized in
|
host cell cytosol
|
in THP-1 macrophages; shown in a CyaA translocation assay
|
| 36388 |
cpeE
|
|
is localized in
|
host cell cytosol
|
in THP-1 macrophages; shown in a CyaA translocation assay
|
|
22522687
|
Q fever
|
|
3,491
|
| 32431 |
T4BSS
|
|
increases_transport of
|
cpeC
|
into host cell cytosol; shown in CyaA and BlaM translocation assays
|
| 32433 |
T4BSS
|
|
increases_transport of
|
cpeD
|
into host cell cytosol; shown in CyaA and BlaM translocation assays
|
| 32435 |
T4BSS
|
|
increases_transport of
|
cpeE
|
into host cell cytosol; shown in CyaA and BlaM translocation assays
|
| 32450 |
T4BSS
|
|
increases_transport of
|
cpeA
|
into host cell cytosol; shown in CyaA and BlaM translocation assays
|
| 32451 |
T4BSS
|
|
increases_transport of
|
cpeB
|
into host cell cytosol; shown in CyaA and BlaM translocation assays
|
| 32452 |
T4BSS
|
|
increases_transport of
|
cpeF
|
into host cell cytosol; shown in CyaA and BlaM translocation assays
|
| 32461 |
phagosome maturation
|
|
increases_expression of
|
cpeA
|
at early-log-phase growth (2 and 3 days)
|
| 32465 |
phagosome maturation
|
|
increases_expression of
|
cpeB
|
at early-log-phase growth (2 and 3 days)
|
| 32467 |
phagosome maturation
|
|
increases_expression of
|
cpeC
|
at early-log-phase growth (2 and 3 days)
|
| 32468 |
phagosome maturation
|
|
increases_expression of
|
cpeD
|
at early-log-phase growth (2 and 3 days)
|
| 32469 |
phagosome maturation
|
|
increases_expression of
|
cpeE
|
at early-log-phase growth (2 and 3 days)
|
| 32470 |
phagosome maturation
|
|
increases_expression of
|
cpeF
|
at early-log-phase growth (2 and 3 days)
|
| 36389 |
cpeC
|
|
is localized in
|
host cell cytosol
|
shown in CyaA and BlaM translocation assays
|
| 36390 |
cpeD
|
|
is localized in
|
host cell cytosol
|
shown in CyaA and BlaM translocation assays
|
| 36391 |
cpeE
|
|
is localized in
|
host cell cytosol
|
shown in CyaA and BlaM translocation assays
|
| 36392 |
cpeA
|
|
is localized in
|
host cell cytosol
|
shown in CyaA and BlaM translocation assays
|
| 36393 |
cpeB
|
|
is localized in
|
host cell cytosol
|
shown in CyaA and BlaM translocation assays
|
| 36395 |
cpeF
|
|
is localized in
|
host cell cytosol
|
shown in CyaA and BlaM translocation assays
|
| 36569 |
cpeC
|
|
is_part_of
|
QpH1 plasmid
|
|
| 36570 |
cpeD
|
|
is_part_of
|
QpH1 plasmid
|
|
| 36571 |
cpeE
|
|
is_part_of
|
QpH1 plasmid
|
|
| 36572 |
cpeA
|
|
is_part_of
|
QpH1 plasmid
|
|
| 36573 |
cpeB
|
|
is_part_of
|
QpH1 plasmid
|
|
| 36574 |
cpeF
|
|
is_part_of
|
QpH1 plasmid
|
|
|
21216993
|
Q fever
|
|
3,498
|
| 32477 |
T4BSS
|
|
increases_transport of
|
cpeB
|
to the PV membrane and to autophagosomes; in HeLa cells as fusion to GFP
|
| 32480 |
T4BSS
|
|
increases_transport of
|
cpeD
|
to filamentous structures and partially to the endoplasmic reticulum; in HeLa cells as fusion to GFP
|
| 36285 |
T4BSS
|
|
increases_transport of
|
cpeA
|
to small cytoplasmic puncta; in HeLa cells as fusion to GFP
|
| 36288 |
T4BSS
|
|
increases_transport of
|
cpeC
|
to small cytoplasmic puncta; in HeLa cells as fusion to GFP
|
|
21216993
|
Q fever
|
|
3,504
|
| 32515 |
icmT
|
|
affects_activity of
|
T4BSS
|
|
| 32516 |
icmV
|
|
affects_activity of
|
T4BSS
|
|
| 32517 |
dotH
|
|
affects_activity of
|
T4BSS
|
|
| 32524 |
icmT
|
|
is localized in
|
bacterial cell pole
|
|
| 32790 |
icmV
|
|
is localized in
|
bacterial cell pole
|
|
| 32791 |
dotH
|
|
is localized in
|
bacterial cell pole
|
|
| 32792 |
T4BSS
|
|
is localized in
|
bacterial cell pole
|
|
|
20199576
|
Q fever
|
|
3,521
|
| 32721 |
Coxiella burnetii infection
|
|
increases_expression of
|
icmW
|
during the initial 16 h of infection
|
| 32739 |
Coxiella burnetii infection
|
|
increases_expression of
|
CBU_1651
|
during the initial 16 h of infection
|
| 32741 |
Coxiella burnetii infection
|
|
increases_expression of
|
icmX
|
during the initial 16 h of infection
|
| 32743 |
Coxiella burnetii infection
|
|
increases_expression of
|
icmV
|
during the initial 16 h of infection
|
| 32744 |
Coxiella burnetii infection
|
|
increases_expression of
|
dotaA
|
during the initial 16 h of infection
|
| 32745 |
Coxiella burnetii infection
|
|
increases_expression of
|
CBU_1647
|
during the initial 16 h of infection
|
| 32748 |
Coxiella burnetii infection
|
|
increases_expression of
|
icmT
|
during the initial 16 h of infection
|
| 32749 |
Coxiella burnetii infection
|
|
increases_expression of
|
icmS
|
during the initial 16 h of infection
|
| 32750 |
Coxiella burnetii infection
|
|
increases_expression of
|
icmD
|
during the initial 16 h of infection
|
| 32752 |
Coxiella burnetii infection
|
|
increases_expression of
|
icmC
|
during the initial 16 h of infection
|
| 32753 |
Coxiella burnetii infection
|
|
increases_expression of
|
icmB
|
during the initial 16 h of infection
|
| 32755 |
Coxiella burnetii infection
|
|
increases_expression of
|
CBU_1646
|
during the initial 16 h of infection
|
| 32756 |
Coxiella burnetii infection
|
|
increases_activity of
|
T4BSS
|
during the initial 16 h of infection
|
| 32763 |
icmW
|
|
affects_activity of
|
T4BSS
|
|
| 32765 |
CBU_1651
|
|
affects_activity of
|
T4BSS
|
|
| 32766 |
icmX
|
|
affects_activity of
|
T4BSS
|
|
| 32767 |
icmV
|
|
affects_activity of
|
T4BSS
|
|
| 32768 |
dotaA
|
|
affects_activity of
|
T4BSS
|
|
| 32769 |
CBU_1647
|
|
affects_activity of
|
T4BSS
|
|
| 32770 |
icmT
|
|
affects_activity of
|
T4BSS
|
|
| 32771 |
icmS
|
|
affects_activity of
|
T4BSS
|
|
| 32773 |
icmD
|
|
affects_activity of
|
T4BSS
|
|
| 32774 |
icmC
|
|
affects_activity of
|
T4BSS
|
|
| 32775 |
icmB
|
|
affects_activity of
|
T4BSS
|
|
| 32776 |
CBU_1646
|
|
affects_activity of
|
T4BSS
|
|
| 32783 |
pmrA
|
|
increases_activity of
|
T4BSS
|
|
| 32804 |
Coxiella burnetii infection
|
|
increases_expression of
|
dotB
|
in Vero cells
|
| 32805 |
Coxiella burnetii infection
|
|
increases_expression of
|
icmQ
|
in Vero cells
|
| 32806 |
Coxiella burnetii infection
|
|
increases_expression of
|
icmS
|
in Vero cells
|
| 32807 |
Coxiella burnetii infection
|
|
increases_expression of
|
icmW
|
in Vero cells
|
| 32812 |
dotB
|
|
increases_activity of
|
Coxiella burnetii replication
|
|
| 32813 |
icmS
|
|
increases_activity of
|
Coxiella burnetii replication
|
|
| 32814 |
icmW
|
|
increases_activity of
|
Coxiella burnetii replication
|
|
| 32815 |
icmW
|
|
interacts (colocalizes) with
|
icmS
|
|
| 32816 |
Chloramphenicol
|
|
decreases_activity of
|
Coxiella burnetii replication
|
|
| 32820 |
Chloramphenicol
|
|
decreases_activity of
|
phagosome maturation
|
|
| 32823 |
Coxiella burnetii infection
|
|
decreases_activity of
|
host cell apoptosis
|
|
| 32825 |
Chloramphenicol
|
|
increases_activity of
|
host cell apoptosis
|
induced by pathogen
|
| 32827 |
icmL.1
|
|
increases_activity of
|
Coxiella burnetii replication
|
|
| 32832 |
icmL.1
|
|
affects_activity of
|
T4BSS
|
|
| 32834 |
T4BSS
|
|
increases_transport of
|
ankG
|
|
| 32835 |
T4BSS
|
|
increases_transport of
|
CBU_0077
|
|
| 32838 |
T4BSS
|
|
increases_transport of
|
ankA
|
shown in a Cya translocation assay
|
| 32842 |
T4BSS
|
|
increases_transport of
|
ankB
|
shown in a Cya translocation assay
|
| 32844 |
T4BSS
|
|
increases_transport of
|
ankF
|
shown in a Cya translocation assay
|
| 32845 |
T4BSS
|
|
increases_transport of
|
ankG
|
shown in a Cya translocation assay
|
| 32851 |
icmS
|
|
affects transport of
|
ankA
|
|
| 32852 |
icmS
|
|
affects transport of
|
ankF
|
|
| 32853 |
icmS
|
|
affects transport of
|
ankG
|
|
| 32854 |
icmS
|
|
affects transport of
|
ankP
|
|
| 32858 |
ankG
|
|
decreases_activity of
|
host cell apoptosis
|
|
| 35830 |
icmQ
|
|
affects_activity of
|
T4BSS
|
|
|
22711632
|
Q fever
|
|
3,666
|
| 35087 |
Coxiella burnetii infection
|
|
increases_activity of
|
T4BSS
|
|
| 35089 |
ankG
|
|
interacts (colocalizes) with
|
C1QBP
|
shown in transfected HEK293 cells
|
| 35090 |
ankG
|
|
decreases_activity of
|
host cell apoptosis
|
shown in transfected CHO and HEK293 cells
|
| 35092 |
C1QBP
|
|
increases_activity of
|
host cell apoptosis
|
|
|
20944063
|
Q fever
|
|
3,668
|
| 35102 |
ankG
|
|
decreases_activity of
|
host cell apoptosis
|
shown in dentritic cells of B6 mice
|
| 35103 |
T4BSS
|
|
increases_transport of
|
ankG
|
shown in CHO Fc-gamma-RII cells
|
| 35104 |
C1QBP
|
|
increases_activity of
|
host cell apoptosis
|
shown in dentritic cells of B6 mice
|
|
20944063
|
Q fever
|
|
3,695
|
| 35651 |
T4BSS
|
|
increases_activity of
|
phagosome maturation
|
in THP-1 cells
|
| 35654 |
T4BSS
|
|
increases_activity of
|
Coxiella burnetii replication
|
in THP-1 cells
|
| 35656 |
T4BSS
|
|
decreases_activity of
|
host cell apoptosis
|
in THP-1 cells
|
| 35657 |
T4BSS
|
NOT |
affects_activity of
|
axenic cell growth
|
|
| 35659 |
T4BSS
|
NOT |
affects_activity of
|
entry of bacterium into host cell
|
of C. burnetii into host
|
| 35673 |
Coxiella burnetii, LCV
|
|
increases_activity of
|
T4BSS
|
|
|
22010216
|
Q fever
|
|
3,711
|
| 36071 |
caeA
|
|
decreases_activity of
|
host cell apoptosis
|
in CHO-FcR or HEK293 cells, transfected with GFP-tagged CaeA; to a lower extend than CaeB
|
| 36073 |
caeB
|
|
decreases_activity of
|
host cell apoptosis
|
in CHO-FcR or HEK293 cells, transfected with GFP-tagged CaeB; to a higher extend than CaeA
|
| 36076 |
caeB
|
NOT |
affects_quantity of
|
BCL2
|
in HEK293 cells, expressing GFP-CaeB
|
| 36077 |
caeB
|
NOT |
affects_quantity of
|
BCL2L1
|
in HEK293 cells, expressing GFP-CaeB
|
| 36078 |
caeB
|
NOT |
affects_quantity of
|
MCL1
|
in HEK293 cells, expressing GFP-CaeB
|
| 36079 |
caeB
|
NOT |
increases_quantity of
|
BCL2L11
|
in HEK293 cells, expressing GFP-CaeB
|
| 36122 |
caeB
|
NOT |
increases_quantity of
|
BBC3
|
in HEK293 cells, expressing GFP-CaeB
|
| 36142 |
caeB
|
|
increases_quantity of
|
BID
|
in HEK293 cells, expressing GFP-CaeB
|
| 36145 |
caeB
|
NOT |
increases_quantity of
|
BAK1
|
in HEK293 cells, expressing GFP-CaeB
|
| 36146 |
caeB
|
NOT |
increases_quantity of
|
BAX
|
in HEK293 cells, expressing GFP-CaeB
|
| 36147 |
BCL2
|
|
decreases_activity of
|
host cell apoptosis
|
|
| 36149 |
BCL2L1
|
|
decreases_activity of
|
host cell apoptosis
|
|
| 36150 |
MCL1
|
|
decreases_activity of
|
host cell apoptosis
|
|
| 36151 |
BCL2L11
|
|
increases_activity of
|
host cell apoptosis
|
|
| 36153 |
BBC3
|
|
increases_activity of
|
host cell apoptosis
|
|
| 36154 |
BAK1
|
|
increases_activity of
|
host cell apoptosis
|
|
| 36156 |
BAX
|
|
increases_activity of
|
host cell apoptosis
|
|
| 36158 |
BID
|
|
increases_activity of
|
host cell apoptosis
|
|
| 36163 |
caeB
|
|
decreases_processing of
|
CASP9
|
in HEK293 cells, expressing GFP-CaeB
|
| 36164 |
caeB
|
|
decreases_processing of
|
CASP7
|
in HEK293 cells, expressing GFP-CaeB
|
| 36165 |
ankG
|
|
interacts (colocalizes) with
|
C1QBP
|
in HEK293 cells, expressing GFP-AnkG
|
| 36166 |
caeB
|
NOT |
interacts (colocalizes) with
|
C1QBP
|
in HEK293 cells, expressing GFP-CaeB
|
| 36178 |
T4BSS
|
|
increases_transport of
|
caeB
|
into mitochodria of HEK293 cells, expressing GFP-CaeB
|
| 36415 |
caeB
|
|
is localized in
|
host cell mitochondrion
|
in HEK 293 cells
|
|
23126667
|
Q fever
|
|
3,720
|
| 36129 |
T4BSS
|
|
increases_transport of
|
caeA
|
into host cell nucleus
|
| 36130 |
T4BSS
|
|
increases_transport of
|
caeB
|
into host cell mitochondria
|
| 36416 |
caeA
|
|
is localized in
|
host cell nucleus
|
|
| 36417 |
caeB
|
|
is localized in
|
host cell mitochondrion
|
|
|
23126667
|
Q fever
|
|
3,724
|
| 36193 |
T4BSS
|
|
increases_transport of
|
CBU_0077
|
into the host lysosomal membrane of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36200 |
T4BSS
|
|
increases_transport of
|
CBU_0080
|
into the host cell cytosol of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36202 |
T4BSS
|
|
increases_transport of
|
CBU_0295
|
into the host cell cytosol of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36204 |
T4BSS
|
|
increases_transport of
|
CBU_0329
|
into the host cell cytosol of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36207 |
T4BSS
|
|
increases_transport of
|
cirB
|
into the host cell cytosol of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36209 |
T4BSS
|
|
increases_transport of
|
CBU_0635
|
into the host cell Golgi vesicles of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36212 |
T4BSS
|
|
increases_transport of
|
CBU_1107
|
into the host cell cytosol of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36213 |
T4BSS
|
|
increases_transport of
|
CBU_1108
|
into the host cell cytosol of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36215 |
T4BSS
|
|
increases_transport of
|
caeA
|
into the host cell nucleus of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36217 |
T4BSS
|
|
increases_transport of
|
CBU_1525
|
into the host cell cytosol of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36218 |
T4BSS
|
|
increases_transport of
|
caeB
|
into the host cell mitochondria of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36219 |
T4BSS
|
|
increases_transport of
|
CBU_1776
|
into the host cell cytosol of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36220 |
T4BSS
|
|
increases_transport of
|
CBU_1823
|
into the host cell cytosol of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36221 |
T4BSS
|
|
increases_transport of
|
CBU_1825
|
into the host cell mitochondria of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36223 |
T4BSS
|
|
increases_transport of
|
CBU_1963
|
into the host cell cytosol of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36224 |
T4BSS
|
|
increases_transport of
|
cirD
|
into the host cell cytosol of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36226 |
T4BSS
|
|
increases_transport of
|
CBU_2056
|
into the host cell cytosol of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36227 |
T4BSS
|
|
increases_transport of
|
cirE
|
into the host cell cytosol of HeLa cells; shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36396 |
CBU_0080
|
|
is localized in
|
host cell cytosol
|
shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36397 |
CBU_0295
|
|
is localized in
|
host cell cytosol
|
shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36398 |
CBU_0329
|
|
is localized in
|
host cell cytosol
|
shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36399 |
cirB
|
|
is localized in
|
host cell cytosol
|
shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36400 |
CBU_0635
|
|
is localized in
|
Golgi-associated vesicle
|
shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36401 |
CBU_1107
|
|
is localized in
|
host cell cytosol
|
shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36402 |
CBU_1108
|
|
is localized in
|
host cell cytosol
|
shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36403 |
caeA
|
|
is localized in
|
host cell nucleus
|
shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36404 |
CBU_1525
|
|
is localized in
|
host cell cytosol
|
shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36405 |
caeB
|
|
is localized in
|
host cell mitochondrion
|
shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36406 |
CBU_1776
|
|
is localized in
|
host cell cytosol
|
shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36407 |
CBU_1823
|
|
is localized in
|
host cell cytosol
|
shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36408 |
CBU_1825
|
|
is localized in
|
host cell mitochondrion
|
shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36409 |
CBU_1963
|
|
is localized in
|
host cell cytosol
|
shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36410 |
cirD
|
|
is localized in
|
host cell cytosol
|
shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36411 |
CBU_2056
|
|
is localized in
|
host cell cytosol
|
shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36412 |
cirE
|
|
is localized in
|
host cell cytosol
|
shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 36414 |
CBU_0077
|
|
is localized in
|
lysosomal membrane
|
shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
|
21637816
|
Q fever
|
|
3,725
|
| 36230 |
CBU_0635
|
|
affects_activity of
|
secretory pathway
|
in HEK 293 cells
|
|
21637816
|
Q fever
|
|
3,726
|
| 36234 |
T4BSS
|
|
increases_activity of
|
Coxiella burnetii replication
|
in HeLa and Vero cells
|
| 36237 |
Chloramphenicol
|
|
decreases_activity of
|
Coxiella burnetii replication
|
in HeLa and Vero cells
|
| 36238 |
T4BSS
|
NOT |
affects_activity of
|
pathogen survival
|
in HeLa and Vero cells
|
| 36239 |
T4BSS
|
NOT |
affects_activity of
|
axenic cell growth
|
|
| 36240 |
T4BSS
|
|
increases_transport of
|
CBU_0077
|
into HeLa cells; shown in a BlaM translocation assay
|
| 36247 |
T4BSS
|
|
increases_transport of
|
CBU_0635
|
into HeLa cells; shown in a BlaM translocation assay
|
| 36248 |
T4BSS
|
|
increases_transport of
|
caeA
|
into HeLa cells; shown in a BlaM translocation assay
|
|
21637816
|
Q fever
|
|
3,805
|
| 37850 |
T4BSS
|
|
increases_transport of
|
CBU_0077
|
into HeLa cells; not detected before 8 hours post-infection, shown in a BlaM translocation assay
|
| 37868 |
T4BSS
|
|
increases_transport of
|
caeA
|
into HeLa cells; not detected before 8 hours post-infection, shown in a BlaM translocation assay
|
| 37870 |
T4BSS
|
|
increases_transport of
|
CBU_1823
|
into HeLa cells; not detected before 8 hours post-infection, shown in a BlaM translocation assay
|
| 37877 |
phagosome acidification
|
|
increases_activity of
|
T4BSS
|
in C. burnetii infected HeLa cells
|
| 37889 |
Bafilomycin A
|
|
decreases_activity of
|
phagosome acidification
|
in C. burnetii infected HeLa cells
|
| 37890 |
Bafilomycin A
|
|
decreases_activity of
|
Vacuolar proton-transporting V-type ATPase complex
|
in C. burnetii infected HeLa cells
|
| 37898 |
RAB5
|
|
increases_activity of
|
T4BSS
|
in C. burnetii infected HeLa cells
|
| 37899 |
RAB7
|
|
increases_activity of
|
T4BSS
|
in C. burnetii infected HeLa cells
|
| 37900 |
RAB1
|
NOT |
increases_activity of
|
T4BSS
|
in C. burnetii infected HeLa cells
|
| 37907 |
RAB1
|
|
increases_activity of
|
early secretory pathway
|
|
| 37909 |
phagosome maturation
|
|
increases_activity of
|
T4BSS
|
in C. burnetii infected HeLa cells
|
|
23349930
|
Q fever
|
|
3,806
|
| 37936 |
T4BSS
|
|
increases_transport of
|
CBU_0077
|
into BMMs; detected at four hours post-infection, shown in a BlaM translocation assay
|
| 37937 |
T4BSS
|
|
increases_transport of
|
caeA
|
into BMMs; detected at four hours post-infection, shown in a BlaM translocation assay
|
| 37938 |
T4BSS
|
|
increases_transport of
|
CBU_1823
|
into BMMs; detected at four hours post-infection, shown in a BlaM translocation assay
|
| 37939 |
Bafilomycin A
|
|
decreases_activity of
|
phagosome acidification
|
in C. burnetii infected BMMs
|
| 37941 |
phagosome acidification
|
|
increases_activity of
|
T4BSS
|
in C. burnetii infected BMMs
|
|
23349930
|
Q fever
|
|
3,810
|
| 38074 |
VPS35
|
|
increases_transport of
|
CBU_0077
|
in C. burnetii infected HeLa cells; analysed by treatment with VPS35 siRNA and the BlaM translocation assay
|
| 38078 |
Retromer complex
|
|
increases_activity of
|
T4BSS
|
|
| 38081 |
STX17
|
NOT |
affects transport of
|
CBU_0077
|
in C. burnetii infected HeLa cells; analysed by treatment with STX17 siRNA and the BlaM translocation assay
|
| 38082 |
VPS16
|
NOT |
affects transport of
|
CBU_0077
|
in C. burnetii infected HeLa cells; analysed by treatment with VPS16 siRNA and the BlaM translocation assay
|
| 38085 |
VPS16
|
NOT |
affects transport of
|
CBU_1823
|
in C. burnetii infected HeLa cells; analysed by treatment with VPS16 siRNA and the BlaM translocation assay
|
| 38086 |
VPS16
|
NOT |
affects transport of
|
caeA
|
in C. burnetii infected HeLa cells; analysed by treatment with VPS16 siRNA and the BlaM translocation assay
|
| 38087 |
RAB7A
|
|
increases_transport of
|
CBU_0077
|
in C. burnetii infected HeLa cells; analysed by treatment with RAB7A siRNA and the BlaM translocation assay
|
| 38090 |
RAB7A
|
|
increases_transport of
|
CBU_1823
|
in C. burnetii infected HeLa cells; analysed by treatment with RAB7A siRNA and the BlaM translocation assay
|
| 38092 |
RAB7A
|
|
increases_transport of
|
caeA
|
in C. burnetii infected HeLa cells; analysed by treatment with RAB7A siRNA and the BlaM translocation assay
|
| 38095 |
VPS35
|
|
increases_activity of
|
T4BSS
|
|
| 38098 |
STX17
|
NOT |
affects_activity of
|
T4BSS
|
|
| 38099 |
VPS16
|
NOT |
affects_activity of
|
T4BSS
|
|
| 38100 |
RAB7A
|
|
increases_activity of
|
T4BSS
|
|
| 38106 |
SNX2
|
|
increases_transport of
|
CBU_0077
|
in C. burnetii infected HeLa cells; analysed by treatment with SNX2 siRNA and the BlaM translocation assay
|
| 38108 |
SNX3
|
|
increases_transport of
|
CBU_0077
|
in C. burnetii infected HeLa cells; analysed by treatment with SNX3 siRNA and the BlaM translocation assay
|
| 38109 |
SNX5
|
|
increases_transport of
|
CBU_0077
|
in C. burnetii infected HeLa cells; analysed by treatment with SNX5 siRNA and the BlaM translocation assay
|
| 38110 |
SNX6
|
|
increases_transport of
|
CBU_0077
|
in C. burnetii infected HeLa cells; analysed by treatment with SNX6 siRNA and the BlaM translocation assay
|
| 38111 |
SNX1
|
NOT |
affects transport of
|
CBU_0077
|
in C. burnetii infected HeLa cells; analysed by treatment with SNX1 siRNA and the BlaM translocation assay
|
| 38161 |
SNX2
|
|
increases_activity of
|
T4BSS
|
in C. burnetii infected HeLa cells; analysed by treatment with SNX2 siRNA and the BlaM translocation assay
|
| 38162 |
SNX3
|
|
increases_activity of
|
T4BSS
|
in C. burnetii infected HeLa cells; analysed by treatment with SNX3 siRNA and the BlaM translocation assay
|
| 38163 |
SNX5
|
|
increases_activity of
|
T4BSS
|
in C. burnetii infected HeLa cells; analysed by treatment with SNX5 siRNA and the BlaM translocation assay
|
| 38164 |
SNX6
|
|
increases_activity of
|
T4BSS
|
in C. burnetii infected HeLa cells; analysed by treatment with SNX6 siRNA and the BlaM translocation assay
|
|
23362322
|
Q fever
|
|
3,822
|
| 38247 |
T4BSS
|
|
increases_transport of
|
CBU_1724
|
shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 38248 |
T4BSS
|
|
increases_transport of
|
CBU_1686
|
shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 38249 |
T4BSS
|
|
increases_transport of
|
CBU_0021
|
shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 38250 |
T4BSS
|
|
increases_transport of
|
CBU_0388
|
shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 38251 |
T4BSS
|
|
increases_transport of
|
CBU_0885
|
shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 38252 |
T4BSS
|
|
increases_transport of
|
CBU_0626
|
shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
| 38256 |
T4BSS
|
|
increases_transport of
|
CBU_2056
|
shown in a CyaA translocation assay of C. burnetii proteins by the L. pneumophila Dot/Icm apparatus
|
|
23382224
|
Q fever
|
|
4,009
|
| 41162 |
cpeG
|
|
is_part_of
|
QpH1 plasmid
|
|
| 41163 |
T4BSS
|
|
increases_transport of
|
cpeG
|
|
| 41164 |
cpeH
|
|
is_part_of
|
QpH1 plasmid
|
|
| 41165 |
T4BSS
|
|
increases_transport of
|
cpeH
|
|
| 41167 |
cpeG
|
|
is localized in
|
host cell cytosol
|
|
| 41168 |
cpeH
|
|
is localized in
|
host cell cytosol
|
|
|
23687269
|
Q fever
|
|
4,010
|
| 41186 |
cpeH
|
|
is_part_of
|
QpRS plasmid
|
|
| 41190 |
T4BSS
|
|
increases_transport of
|
cpeH
|
|
|
23687269
|
Q fever
|
|
4,011
|
| 41195 |
cpeH
|
|
is_part_of
|
QpDG plasmid
|
|
| 41196 |
cpeI
|
|
is_part_of
|
QpDG plasmid
|
|
| 41197 |
cpeJ
|
|
is_part_of
|
QpDG plasmid
|
|
| 41198 |
cpeK
|
|
is_part_of
|
QpDG plasmid
|
|
| 41199 |
cpeL
|
|
is_part_of
|
QpDG plasmid
|
|
| 41200 |
T4BSS
|
|
increases_transport of
|
cpeH
|
|
| 41201 |
T4BSS
|
|
increases_transport of
|
cpeI
|
|
| 41202 |
T4BSS
|
|
increases_transport of
|
cpeJ
|
|
| 41203 |
T4BSS
|
|
increases_transport of
|
cpeK
|
|
| 41205 |
T4BSS
|
|
increases_transport of
|
cpeL
|
|
| 41206 |
cpeH
|
|
is localized in
|
host cell cytosol
|
|
| 41212 |
cpeI
|
|
is localized in
|
host cell cytosol
|
|
| 41213 |
cpeJ
|
|
is localized in
|
host cell cytosol
|
|
| 41214 |
cpeK
|
|
is localized in
|
host cell cytosol
|
|
| 41215 |
cpeL
|
|
is localized in
|
host cell cytosol
|
|
| 41217 |
cpeL
|
|
interacts (colocalizes) with
|
LC3-II
|
|
|
23687269
|
Q fever
|
|
4,280
|
| 43798 |
T4BSS
|
|
increases_transport of
|
CBU_0012
|
shown in a TEM translocation assay
|
| 43808 |
T4BSS
|
|
increases_transport of
|
CBU_0069
|
shown in a TEM translocation assay
|
| 43811 |
T4BSS
|
|
increases_transport of
|
CBU_0080
|
shown in a TEM translocation assay
|
| 43812 |
T4BSS
|
|
increases_transport of
|
CBU_0113
|
shown in a TEM translocation assay
|
| 43813 |
T4BSS
|
|
increases_transport of
|
CBU_0183
|
shown in a TEM translocation assay
|
| 43816 |
T4BSS
|
|
increases_transport of
|
CBU_0201
|
shown in a TEM translocation assay
|
| 43817 |
T4BSS
|
|
increases_transport of
|
CBU_0212
|
shown in a TEM translocation assay
|
| 43819 |
T4BSS
|
|
increases_transport of
|
CBU_0270
|
shown in a TEM translocation assay
|
| 43821 |
T4BSS
|
|
increases_transport of
|
CBU_0295
|
shown in a TEM translocation assay
|
| 43822 |
T4BSS
|
|
increases_transport of
|
CBU_0344
|
shown in a TEM translocation assay
|
| 43825 |
T4BSS
|
|
increases_transport of
|
CBU_0372
|
shown in a TEM translocation assay
|
| 43826 |
T4BSS
|
|
increases_transport of
|
CBU_0375
|
shown in a TEM translocation assay
|
| 43827 |
T4BSS
|
|
increases_transport of
|
CBU_0376
|
shown in a TEM translocation assay
|
| 43828 |
T4BSS
|
|
increases_transport of
|
CBU_0388
|
shown in a TEM translocation assay
|
| 43829 |
T4BSS
|
|
increases_transport of
|
CBU_0393
|
shown in a TEM translocation assay
|
| 43830 |
T4BSS
|
|
increases_transport of
|
cirB
|
shown in a TEM translocation assay
|
| 43832 |
T4BSS
|
|
increases_transport of
|
CBU_0469
|
shown in a TEM translocation assay
|
| 43833 |
T4BSS
|
|
increases_transport of
|
CBU_0513
|
shown in a TEM translocation assay
|
| 43834 |
T4BSS
|
|
increases_transport of
|
CBU_0590
|
shown in a TEM translocation assay
|
| 43835 |
T4BSS
|
|
increases_transport of
|
CBU_0606
|
shown in a TEM translocation assay
|
| 43836 |
T4BSS
|
|
increases_transport of
|
CBU_0637
|
shown in a TEM translocation assay
|
| 43837 |
T4BSS
|
|
increases_transport of
|
cvpA
|
shown in a TEM translocation assay
|
| 43838 |
T4BSS
|
|
increases_transport of
|
phnB
|
shown in a TEM translocation assay
|
| 43840 |
T4BSS
|
|
increases_transport of
|
CBU_0885
|
shown in a TEM translocation assay
|
| 43842 |
T4BSS
|
|
increases_transport of
|
CBU_1079
|
shown in a TEM translocation assay
|
| 43843 |
T4BSS
|
|
increases_transport of
|
CBU_1102
|
shown in a TEM translocation assay
|
| 43844 |
T4BSS
|
|
increases_transport of
|
CBU_1110
|
shown in a TEM translocation assay
|
| 43845 |
T4BSS
|
|
increases_transport of
|
CBU_1150
|
shown in a TEM translocation assay
|
| 43848 |
T4BSS
|
|
increases_transport of
|
CBU_1198
|
shown in a TEM translocation assay
|
| 43849 |
T4BSS
|
|
increases_transport of
|
CBU_1434
|
shown in a TEM translocation assay
|
| 43850 |
T4BSS
|
|
increases_transport of
|
CBU_1525
|
shown in a TEM translocation assay
|
| 43851 |
T4BSS
|
|
increases_transport of
|
CBU_1566
|
shown in a TEM translocation assay
|
| 43852 |
T4BSS
|
|
increases_transport of
|
CBU_1576
|
shown in a TEM translocation assay
|
| 43853 |
T4BSS
|
|
increases_transport of
|
CBU_1594
|
shown in a TEM translocation assay
|
| 43854 |
T4BSS
|
|
increases_transport of
|
CBU_1607
|
shown in a TEM translocation assay
|
| 43855 |
T4BSS
|
|
increases_transport of
|
CBU_1620
|
shown in a TEM translocation assay
|
| 43856 |
T4BSS
|
|
increases_transport of
|
CBU_1639
|
shown in a TEM translocation assay
|
| 43857 |
T4BSS
|
|
increases_transport of
|
CBU_1665
|
shown in a TEM translocation assay
|
| 43859 |
T4BSS
|
|
increases_transport of
|
CBU_1677
|
shown in a TEM translocation assay
|
| 43861 |
T4BSS
|
|
increases_transport of
|
CBU_1685
|
shown in a TEM translocation assay
|
| 43862 |
T4BSS
|
|
increases_transport of
|
CBU_1754
|
shown in a TEM translocation assay
|
| 43863 |
T4BSS
|
|
increases_transport of
|
CBU_1789
|
shown in a TEM translocation assay
|
| 43864 |
T4BSS
|
|
increases_transport of
|
CBU_1790
|
shown in a TEM translocation assay
|
| 43865 |
T4BSS
|
|
increases_transport of
|
CBU_2007
|
shown in a TEM translocation assay
|
| 43867 |
T4BSS
|
|
increases_transport of
|
CBU_2013
|
shown in a TEM translocation assay
|
| 43868 |
T4BSS
|
|
increases_transport of
|
CBU_2016
|
shown in a TEM translocation assay
|
| 43869 |
T4BSS
|
|
increases_transport of
|
CBU_2028
|
shown in a TEM translocation assay
|
| 43871 |
T4BSS
|
|
increases_transport of
|
cirE
|
shown in a TEM translocation assay
|
| 43872 |
T4BSS
|
|
increases_transport of
|
CBU_2064
|
shown in a TEM translocation assay
|
| 43873 |
T4BSS
|
|
increases_transport of
|
CBU_2076
|
shown in a TEM translocation assay
|
| 43874 |
T4BSS
|
|
increases_transport of
|
CBUA0015
|
shown in a TEM translocation assay
|
| 43875 |
T4BSS
|
|
increases_transport of
|
CBUA0019
|
shown in a TEM translocation assay
|
| 43876 |
T4BSS
|
|
increases_transport of
|
CBUA0020
|
shown in a TEM translocation assay
|
|
23813730
|
Q fever
|
|
4,282
|
| 43881 |
CBU_0393
|
|
is localized in
|
host cell nucleus
|
if ectopically expressed in HeLa cells
|
| 43886 |
CBU_0388
|
|
is localized in
|
host cell nucleus
|
if ectopically expressed in HeLa cells
|
| 43887 |
CBU_0372
|
|
is localized in
|
host cell endoplasmic reticulum
|
if ectopically expressed in HeLa cells
|
| 43889 |
CBU_1576
|
|
is localized in
|
host cell endoplasmic reticulum
|
if ectopically expressed in HeLa cells
|
| 43890 |
CBUA0020
|
|
is localized in
|
host cell mitochondrion
|
if ectopically expressed in HeLa cells
|
| 43891 |
cirB
|
|
is localized in
|
host cell cytosol
|
if ectopically expressed in HeLa cells
|
| 43895 |
CBU_0513
|
|
is localized in
|
host cell cytosol
|
if ectopically expressed in HeLa cells
|
| 43896 |
CBU_0606
|
|
is localized in
|
host cell cytosol
|
if ectopically expressed in HeLa cells
|
| 43897 |
cvpA
|
|
is localized in
|
host cell cytosol
|
if ectopically expressed in HeLa cells
|
| 43898 |
CBU_0885
|
|
is localized in
|
host cell cytosol
|
if ectopically expressed in HeLa cells
|
| 43899 |
CBU_1525
|
|
is localized in
|
host cell cytosol
|
if ectopically expressed in HeLa cells
|
| 43900 |
CBU_1790
|
|
is localized in
|
host cell cytosol
|
if ectopically expressed in HeLa cells
|
| 43901 |
CBU_2007
|
|
is localized in
|
host cell cytosol
|
if ectopically expressed in HeLa cells
|
| 43902 |
CBU_2013
|
|
is localized in
|
host cell cytosol
|
if ectopically expressed in HeLa cells
|
| 43903 |
cirE
|
|
is localized in
|
host cell cytosol
|
if ectopically expressed in HeLa cells
|
| 43904 |
CBUA0019
|
|
is localized in
|
host cell cytosol
|
if ectopically expressed in HeLa cells
|
|
23813730
|
Q fever
|
|
4,283
|
| 43913 |
cirA
|
|
increases_activity of
|
Coxiella burnetii replication
|
in HeLa and J774A.1 cells
|
| 43917 |
cirB
|
|
increases_activity of
|
Coxiella burnetii replication
|
in HeLa and J774A.1 cells
|
| 43932 |
cirC
|
|
increases_activity of
|
Coxiella burnetii replication
|
in HeLa and J774A.1 cells
|
| 43933 |
cirD
|
|
increases_activity of
|
Coxiella burnetii replication
|
in HeLa and J774A.1 cells
|
| 43935 |
cirE
|
|
increases_activity of
|
Coxiella burnetii replication
|
in HeLa and J774A.1 cells
|
| 43936 |
CBU_0388
|
|
increases_activity of
|
Coxiella burnetii replication
|
in HeLa and J774A.1 cells
|
| 43937 |
cirA
|
|
increases_activity of
|
phagosome maturation
|
in HeLa and J774A.1 cells
|
| 43938 |
cirB
|
|
increases_activity of
|
phagosome maturation
|
in HeLa and J774A.1 cells
|
| 43939 |
cirC
|
|
increases_activity of
|
phagosome maturation
|
in HeLa and J774A.1 cells
|
| 43940 |
cirD
|
|
increases_activity of
|
phagosome maturation
|
in HeLa and J774A.1 cells
|
| 43941 |
cirE
|
|
increases_activity of
|
phagosome maturation
|
in HeLa and J774A.1 cells
|
| 43942 |
CBU_0388
|
|
increases_activity of
|
phagosome maturation
|
in HeLa and J774A.1 cells
|
| 43943 |
CBU_0012
|
|
increases_activity of
|
Coxiella burnetii replication
|
in J774A.1 cells
|
| 43944 |
CBU_1198
|
|
increases_activity of
|
Coxiella burnetii replication
|
in J774A.1 cells
|
| 43945 |
CBU_1457
|
|
increases_activity of
|
Coxiella burnetii replication
|
in J774A.1 cells
|
| 43946 |
CBU_2013
|
|
increases_activity of
|
Coxiella burnetii replication
|
in J774A.1 cells
|
| 43947 |
CBU_0012
|
|
increases_activity of
|
phagosome maturation
|
in J774A.1 cells
|
| 43948 |
CBU_1198
|
|
increases_activity of
|
phagosome maturation
|
in J774A.1 cells
|
| 43949 |
CBU_1457
|
|
increases_activity of
|
phagosome maturation
|
in J774A.1 cells
|
| 43950 |
CBU_2013
|
|
increases_activity of
|
phagosome maturation
|
in J774A.1 cells
|
|
23813730
|
Q fever
|
|
4,410
|
| 44856 |
T4BSS
|
|
increases_transport of
|
Protein kinase A
|
to the parasitophorous vacuole, PV
|
| 44857 |
Protein kinase A
|
|
is localized in
|
C. burnetii containing vacuole, CCV
|
to the parasitophorous vacuole, PV
|
|
24028560
|
Q fever
|
|
4,606
|
| 45838 |
T4BSS
|
|
increases_transport of
|
cvpA
|
shown in a CyaA translocation assay
|
| 45843 |
cvpA
|
|
increases_activity of
|
Coxiella burnetii replication
|
shown in a mutant analysis in THP-1 cells
|
| 45844 |
cvpA
|
|
increases_activity of
|
phagosome maturation
|
shown in a mutant analysis in THP-1 cells
|
|
24248335
|
Q fever
|
|
4,949
|
| 48912 |
ankG
|
|
interacts (colocalizes) with
|
C1QBP
|
|
| 48914 |
ankG
|
NOT |
affects_quantity of
|
C1QBP
|
as shown in HeLa cells, transfected with plasmids encoding GFP or GFP-tagged AnkG
|
| 48915 |
C1QBP
|
|
is localized in
|
host cell nucleus
|
to some extend
|
| 48916 |
C1QBP
|
|
is localized in
|
host cell mitochondrion
|
for the most part
|
| 48917 |
C1QBP
|
|
affects transport of
|
ankG
|
into the host cell nucleus; as shown in CHO-FcR cells, transfected with GFP-tagged AnkG, incubated with staurosporine
|
| 48919 |
ankG
|
|
decreases_activity of
|
host cell apoptosis
|
|
| 48920 |
ankG
|
|
is localized in
|
host cell nucleus
|
as shown in CHO-FcR cells, transfected with GFP-tagged AnkG, incubated with staurosporine
|
|
24733095
|
Q fever
|
|
6,618
|
| 63073 |
T4BSS
|
|
increases_transport of
|
CBU_1823
|
into murine macrophages
|
| 63074 |
CBU_1823
|
|
affects_activity of
|
pore formation in membrane of other organism
|
in macrophages, induced by L. pneumophila
|
| 63075 |
CBU_1823
|
|
decreases_activity of
|
CASP4
|
in macrophages
|
| 63076 |
CBU_1823
|
|
affects_activity of
|
NLRP3 inflammasome complex
|
|
|
26687278
|
Q fever
|
HoPaCI