|
2,123
|
| 17527 |
P. aeruginosa infection
|
|
increases_activity of
|
T3SS
|
|
| 17528 |
T3SS
|
|
increases_transport of
|
exoS
|
into the host cell
|
| 17534 |
T3SS
|
|
increases_transport of
|
exoT
|
into the host cell
|
| 17535 |
T3SS
|
|
increases_transport of
|
exoU
|
into the host cell
|
| 17536 |
T3SS
|
|
increases_transport of
|
exoY
|
into the host cell
|
| 17537 |
exoS
|
|
increases_quantity of
|
TNF
|
|
| 17539 |
exoS
|
|
increases_activity of
|
TLR2
|
|
| 17540 |
exoS
|
|
increases_activity of
|
TLR4
|
|
| 17546 |
exoU
|
|
increases_activity of
|
cell death
|
|
| 17549 |
pcrV
|
|
is_part_of
|
T3SS needle-tip complex
|
|
| 17551 |
pcrV
|
|
increases_quantity of
|
TNF
|
|
|
15695491
|
Pseudomonas aeruginosa diseases
|
|
2,336
|
| 20362 |
exoS
|
|
interacts (colocalizes) with
|
RAB5
|
|
| 20363 |
exoS
|
|
interacts (colocalizes) with
|
RAB6
|
|
| 20364 |
exoS
|
|
interacts (colocalizes) with
|
RAB9
|
|
| 20367 |
exoS
|
|
decreases_activity of
|
RHOA
|
|
| 20368 |
exoS
|
|
decreases_activity of
|
RAC1
|
|
| 20369 |
exoS
|
|
decreases_activity of
|
CDC42
|
|
| 20370 |
exoS
|
|
decreases_activity of
|
actin cytoskeleton organization
|
|
| 20373 |
exoS
|
|
affects_activity of
|
HRAS
|
|
| 20374 |
exoS
|
|
decreases_activity of
|
EZR
|
|
| 20375 |
exoS
|
|
decreases_activity of
|
RDX
|
|
| 20376 |
exoS
|
|
decreases_activity of
|
MSN
|
|
| 20379 |
exoT
|
|
decreases_activity of
|
RAC1
|
|
| 20380 |
exoT
|
|
decreases_activity of
|
RHOA
|
|
| 20381 |
exoT
|
|
decreases_activity of
|
CDC42
|
|
| 20382 |
exoT
|
|
decreases_activity of
|
actin cytoskeleton organization
|
|
| 20384 |
exoT
|
|
affects_activity of
|
CRK
|
|
| 20385 |
exoT
|
|
decreases_activity of
|
phagocytosis
|
|
| 20386 |
exoT
|
|
interacts (colocalizes) with
|
CRK
|
|
| 20387 |
exoT
|
|
interacts (colocalizes) with
|
CBLB
|
|
| 20388 |
CBLB
|
|
increases_ubiquitination/sumoylation of
|
exoT
|
|
| 20389 |
CBLB
|
|
decreases_activity of
|
P. aeruginosa infection
|
|
| 20394 |
exoU
|
|
decreases_quantity of
|
Phospholipid
|
by degradation
|
| 20403 |
exoU
|
|
decreases_quantity of
|
Lysophospholipid
|
by degradation
|
| 20417 |
exoY
|
|
increases_quantity of
|
cAMP
|
in intracellular host cell compartment
|
| 20586 |
SOD1
|
|
increases_activity of
|
exoU
|
|
| 23445 |
exoT
|
|
increases_activity of
|
protein ADP-ribosylation
|
|
| 23446 |
exoS
|
|
increases_activity of
|
protein ADP-ribosylation
|
|
| 38840 |
RAB5
|
|
is localized in
|
early endosome
|
|
| 38841 |
RAB6
|
|
is localized in
|
late endosome
|
|
| 38843 |
RAB9
|
|
is localized in
|
late endosome
|
|
| 38846 |
exoS
|
|
is localized in
|
host cell plasma membrane
|
transient localization
|
|
19680249
|
Pseudomonas aeruginosa diseases
|
|
2,354
|
| 20591 |
exsA
|
|
increases_expression of
|
exoS
|
|
| 20592 |
exsA
|
|
increases_expression of
|
exoT
|
|
| 20593 |
exsA
|
|
increases_expression of
|
exoY
|
|
| 28128 |
LasR/I-3OC12-(HSL)-system
|
NOT |
affects_expression of
|
T3SS complex
|
|
| 28130 |
RhlR/I-C4-(HSL)-system
|
|
decreases_expression of
|
T3SS complex
|
|
| 28132 |
RhlR/I-C4-(HSL)-system
|
|
decreases transport of
|
exoS
|
|
| 28134 |
LasR/I-3OC12-(HSL)-system
|
NOT |
affects_expression of
|
exsA
|
|
| 28143 |
RhlR/I-C4-(HSL)-system
|
NOT |
affects_expression of
|
exsA
|
|
|
15901720
|
Pseudomonas aeruginosa diseases
|
|
2,464
|
| 22795 |
P. aeruginosa infection
|
|
increases_activity of
|
T3SS
|
|
| 23018 |
T3SS
|
|
increases_transport of
|
exoU
|
into the host cell
|
| 23033 |
T3SS
|
|
increases_transport of
|
exoT
|
into the host cell
|
| 23034 |
T3SS
|
|
increases_transport of
|
exoY
|
into the host cell
|
| 23035 |
T3SS
|
|
increases_transport of
|
exoS
|
into the host cell
|
|
20947426
|
Pseudomonas aeruginosa diseases
|
|
2,565
|
| 24052 |
retS
|
|
increases_expression of
|
T3SS complex
|
|
| 24056 |
ladS
|
|
decreases_expression of
|
T3SS complex
|
|
|
20511495
|
Pseudomonas aeruginosa diseases
|
|
2,586
|
| 24363 |
P. aeruginosa infection
|
|
increases_activity of
|
T3SS
|
in ameba, insect, zebrafish, and mammalian infection models
|
| 24364 |
T3SS
|
|
increases_transport of
|
exoS
|
into the host cell
|
| 24365 |
T3SS
|
|
increases_transport of
|
exoT
|
into the host cell
|
| 24366 |
T3SS
|
|
increases_transport of
|
exoU
|
into the host cell
|
| 24367 |
T3SS
|
|
increases_transport of
|
exoY
|
into the host cell
|
| 24368 |
T3SS
|
|
increases_transport of
|
fliC
|
into the host cell
|
| 24369 |
T3SS
|
|
decreases_activity of
|
phagocytosis
|
|
| 24371 |
Ca2+
|
|
affects_activity of
|
T3SS
|
|
| 24377 |
Type IV pili-dependent localized adherence to host
|
|
increases_activity of
|
T3SS
|
|
| 24378 |
exsA
|
|
increases_expression of
|
T3SS complex
|
|
| 24379 |
psrA
|
|
increases_expression of
|
T3SS complex
|
|
| 24380 |
Long-chain fatty acid
|
|
decreases_activity of
|
psrA
|
|
|
21833328
|
Pseudomonas aeruginosa diseases
|
|
2,592
|
| 24445 |
P. aeruginosa infection, acute
|
|
increases_activity of
|
T3SS
|
|
| 24480 |
rsmA
|
|
increases_expression of
|
T3SS complex
|
|
|
21955777
|
Pseudomonas aeruginosa diseases
|
|
2,595
|
| 24525 |
cdiGMP
|
|
decreases_quantity of
|
pcrV
|
if c-di-GMP levels are increased
|
| 24527 |
cdiGMP
|
|
decreases_activity of
|
T3SS
|
if c-di-GMP levels are increased
|
| 24548 |
wspR
|
|
increases_quantity of
|
cdiGMP
|
|
| 24552 |
tpbB
|
|
increases_quantity of
|
cdiGMP
|
|
| 24555 |
wspR
|
|
decreases_activity of
|
T3SS
|
if wspR is overexpressed
|
| 24556 |
tpbB
|
|
decreases_activity of
|
T3SS
|
if PA1120 is overexpressed
|
| 24557 |
PA2133
|
|
decreases_quantity of
|
cdiGMP
|
if PA2133 is overexpressed
|
| 24558 |
PA2133
|
|
increases_activity of
|
T3SS
|
if PA2133 is overexpressed
|
| 24559 |
PA2133
|
|
decreases_activity of
|
T6SS-HSI-1
|
if PA2133 is overexpressed
|
|
21955777
|
Pseudomonas aeruginosa diseases
|
|
2,610
|
| 24726 |
exsB
|
|
is localized in
|
bacterial outer membrane
|
upon induction of the T3SS
|
|
21839744
|
Pseudomonas aeruginosa diseases
|
|
2,616
|
| 24852 |
exsD
|
|
decreases_activity of
|
exsA
|
|
| 24853 |
exsA
|
|
increases_expression of
|
T3SS complex
|
|
|
21531801
|
Pseudomonas aeruginosa diseases
|
|
2,620
|
| 24901 |
fimL
|
|
affects_expression of
|
exoT
|
|
| 24902 |
cyaB
|
|
affects_expression of
|
exoT
|
|
| 24903 |
vfr
|
|
affects_expression of
|
exoT
|
|
|
21264306
|
Pseudomonas aeruginosa diseases
|
|
2,621
|
| 24892 |
P. aeruginosa infection, acute
|
|
increases_activity of
|
T3SS
|
|
|
21264306
|
Pseudomonas aeruginosa diseases
|
|
2,742
|
| 25396 |
T3SS
|
NOT |
affects_expression of
|
BDKRB1
|
|
|
22092568
|
Pseudomonas aeruginosa diseases
|
|
2,763
|
| 25599 |
T3SS
|
|
increases_activity of
|
cell death
|
during lung infection; at a more rapid rate than T2SS (within 24 h)
|
|
21502078
|
Pseudomonas aeruginosa diseases
|
|
2,796
|
| 25833 |
pscI
|
|
increases_activity of
|
NLRC4
|
|
| 25834 |
pscI
|
|
is_part_of
|
T3SS multi-ring base needle complex
|
|
|
20133635
|
Pseudomonas aeruginosa diseases
|
|
2,801
|
| 25842 |
pcrV
|
|
is_part_of
|
T3SS needle-tip complex
|
|
| 25844 |
popB
|
|
is_part_of
|
T3SS translocon complex
|
|
| 25845 |
popD
|
|
is_part_of
|
T3SS translocon complex
|
|
| 25846 |
T3SS complex
|
|
increases_activity of
|
T3SS
|
|
| 25849 |
pcrV
|
|
increases_folding of
|
popB
|
into host plasma membrane
|
| 25850 |
pcrV
|
|
increases_folding of
|
popD
|
into host plasma membranes
|
|
21479247
|
Pseudomonas aeruginosa diseases
|
|
2,853
|
| 26300 |
kinB
|
NOT |
affects_activity of
|
T3SS
|
|
|
21515773
|
Pseudomonas aeruginosa diseases
|
|
2,879
|
| 26503 |
retS
|
|
increases_expression of
|
T3SS complex
|
|
| 26510 |
hptB
|
|
increases_expression of
|
T3SS complex
|
|
|
20398205
|
Pseudomonas aeruginosa diseases
|
|
2,972
|
| 27053 |
T3SS extracellular needle complex
|
|
is_part_of
|
T3SS complex
|
|
| 27055 |
T3SS needle-tip complex
|
|
is_part_of
|
T3SS complex
|
|
| 27057 |
T3SS translocon complex
|
|
is_part_of
|
T3SS complex
|
|
| 27066 |
pcrV
|
|
is_part_of
|
T3SS needle-tip complex
|
|
| 27073 |
pcrV
|
|
interacts (colocalizes) with
|
pcrV
|
|
| 27075 |
pcrV
|
|
increases_activity of
|
P. aeruginosa infection
|
|
| 27082 |
pcrG
|
|
increases_folding of
|
pcrV
|
|
| 27086 |
Ca2+
|
|
affects_activity of
|
T3SS
|
|
| 27088 |
pcrV
|
|
affects_activity of
|
response to calcium ion
|
|
| 27100 |
pcrV
|
|
increases_folding of
|
popD
|
into host membranes
|
| 27224 |
pcrV
|
|
increases_folding of
|
popB
|
into host membranes
|
| 27225 |
T3SS translocon complex
|
|
increases_activity of
|
hemolysis by symbiont of host erythrocytes
|
|
| 27226 |
pcrV
|
|
increases_activity of
|
T3SS translocon complex
|
|
| 27355 |
pcrV
|
|
increases_transport of
|
popD
|
into host membranes
|
| 27356 |
pcrV
|
|
increases_transport of
|
popB
|
into host membranes
|
|
21772833
|
Pseudomonas aeruginosa diseases
|
|
2,997
|
| 27283 |
T3SS multi-ring base needle complex
|
|
is_part_of
|
T3SS complex
|
|
| 27284 |
T3SS extracellular needle complex
|
|
is_part_of
|
T3SS complex
|
|
| 27285 |
pscF
|
|
is_part_of
|
T3SS extracellular needle complex
|
|
| 27287 |
pscN
|
|
is_part_of
|
T3SS multi-ring base needle complex
|
|
| 27289 |
pscL
|
|
affects_activity of
|
pscN
|
|
| 27292 |
pscC
|
|
is_part_of
|
T3SS multi-ring base needle complex
|
|
| 27293 |
pscW
|
|
increases_folding of
|
pscC
|
|
| 27296 |
pscC
|
|
is localized in
|
bacterial outer membrane
|
|
| 27299 |
pscJ
|
|
is_part_of
|
T3SS multi-ring base needle complex
|
|
| 27304 |
popB
|
|
is_part_of
|
T3SS translocon complex
|
|
| 27305 |
popD
|
|
is_part_of
|
T3SS translocon complex
|
|
| 27306 |
popD
|
|
interacts (colocalizes) with
|
popB
|
|
| 27308 |
T3SS translocon complex
|
|
is localized in
|
host cell plasma membrane
|
|
| 27309 |
pcrV
|
|
increases_folding of
|
popB
|
|
| 27310 |
pcrV
|
|
increases_folding of
|
popD
|
|
| 27311 |
T3SS complex
|
|
increases_activity of
|
NLRC4
|
in the absence of any of the known effector proteins
|
|
19680249
|
Pseudomonas aeruginosa diseases
|
|
3,006
|
| 27370 |
T3SS
|
|
increases_transport of
|
exoS
|
in A459, BJAB, Jurkat, differentiated HL-60 and U937 cells
|
| 27371 |
T3SS
|
|
increases_transport of
|
exoY
|
in A459, BJAB, Jurkat, differentiated HL-60 and U937 cells
|
| 27372 |
T3SS
|
NOT |
affects transport of
|
exoS
|
in undifferentiated HL-60 or U937 cells
|
| 27373 |
T3SS
|
NOT |
affects transport of
|
exoY
|
in undifferentiated HL-60 or U937 cells
|
| 27374 |
T3SS translocon complex
|
|
is localized in
|
host cell plasma membrane
|
in undifferentiated, or VD3-differentiated HL-60 cells
|
| 27377 |
Methyl-beta-cyclodextrin
|
|
decreases transport of
|
exoS
|
by cholesterol removal of cultured cells
|
| 27378 |
actin cytoskeleton organization
|
|
affects transport of
|
exoS
|
|
| 27379 |
Cytochalasin D
|
|
decreases transport of
|
exoS
|
into VD3-dHL-60 cells
|
| 27380 |
Cytochalasin D
|
|
decreases_activity of
|
actin cytoskeleton organization
|
|
| 27405 |
Latrunculin B
|
|
decreases transport of
|
exoS
|
into VD3-dHL-60 cells
|
| 27406 |
Latrunculin B
|
|
decreases_activity of
|
actin cytoskeleton organization
|
|
| 27420 |
phosphatidylinositol 3-kinase signaling
|
|
affects transport of
|
exoS
|
|
| 27423 |
Wortmannin
|
|
decreases transport of
|
exoS
|
into VD3-dHL-60 cells
|
| 27424 |
Wortmannin
|
|
decreases_activity of
|
phosphatidylinositol 3-kinase signaling
|
|
| 27425 |
LY 294002
|
|
decreases transport of
|
exoS
|
into VD3-dHL-60 cells
|
| 27426 |
LY 294002
|
|
decreases_activity of
|
phosphatidylinositol 3-kinase signaling
|
|
| 27427 |
Genistein
|
|
decreases transport of
|
exoS
|
into VD3-dHL-60 cells
|
| 27428 |
PP2 (kinase inhibitor)
|
|
decreases transport of
|
exoS
|
into VD3-dHL-60 cells
|
| 27429 |
PF-5732208
|
|
decreases transport of
|
exoS
|
into VD3-dHL-60 cells
|
| 27430 |
PF-5732208
|
|
decreases_activity of
|
PTK2
|
into VD3-dHL-60 cells
|
| 27431 |
PF-5732208
|
|
decreases_activity of
|
PTK2B
|
|
| 27432 |
Cytochalasin D
|
NOT |
decreases_folding of
|
T3SS translocon complex
|
at the host plasma membrane (VD3-dHL-60 cells)
|
| 27437 |
Latrunculin B
|
NOT |
decreases_folding of
|
T3SS translocon complex
|
at the host plasma membrane (VD3-dHL-60 cells)
|
| 27438 |
Wortmannin
|
NOT |
decreases_folding of
|
T3SS translocon complex
|
at the host plasma membrane (VD3-dHL-60 cells)
|
| 27439 |
LY 294002
|
NOT |
decreases_folding of
|
T3SS translocon complex
|
at the host plasma membrane (VD3-dHL-60 cells)
|
| 27440 |
Genistein
|
NOT |
decreases_folding of
|
T3SS translocon complex
|
at the host plasma membrane (VD3-dHL-60 cells)
|
| 27441 |
PP2 (kinase inhibitor)
|
NOT |
decreases_folding of
|
T3SS translocon complex
|
at the host plasma membrane (VD3-dHL-60 cells)
|
| 27442 |
PF-5732208
|
NOT |
decreases_folding of
|
T3SS translocon complex
|
at the host plasma membrane (VD3-dHL-60 cells)
|
| 27554 |
Methyl-beta-cyclodextrin
|
|
decreases_quantity of
|
membrane raft
|
|
|
22299042
|
Pseudomonas aeruginosa diseases
|
|
3,011
|
| 27476 |
Methyl-beta-cyclodextrin
|
|
decreases transport of
|
exoS
|
|
| 27485 |
Methyl-beta-cyclodextrin
|
|
decreases_quantity of
|
membrane raft
|
|
| 27486 |
Methyl-beta-cyclodextrin
|
|
decreases_quantity of
|
popB
|
|
| 27487 |
membrane raft
|
|
affects_folding of
|
T3SS translocon complex
|
|
| 27488 |
Methyl-beta-cyclodextrin
|
|
decreases_folding of
|
T3SS translocon complex
|
|
| 27489 |
Perfringolysin O
|
|
decreases transport of
|
exoS
|
|
| 27490 |
Perfringolysin O
|
NOT |
decreases_quantity of
|
popB
|
|
| 27491 |
Perfringolysin O
|
NOT |
decreases_folding of
|
T3SS translocon complex
|
|
| 27492 |
Perfringolysin O
|
|
affects_quantity of
|
membrane raft
|
|
| 27493 |
RAC1
|
|
increases_transport of
|
exoS
|
|
| 27494 |
CDC42
|
|
increases_transport of
|
exoS
|
|
| 27495 |
ROCK1
|
NOT |
increases_transport of
|
exoS
|
|
|
19910414
|
Pseudomonas aeruginosa diseases
|
|
3,015
|
| 27552 |
T3SS
|
|
affects_activity of
|
actin cytoskeleton organization
|
|
| 27553 |
T3SS
|
|
affects_activity of
|
host cell projection
|
|
|
19910414
|
Pseudomonas aeruginosa diseases
|
|
3,066
|
| 28115 |
exsA
|
|
increases_expression of
|
T3SS complex
|
|
| 28116 |
exsD
|
|
decreases_activity of
|
exsA
|
|
| 28117 |
exsC
|
|
increases_activity of
|
exsA
|
|
| 28118 |
exsC
|
|
interacts (colocalizes) with
|
exsD
|
|
|
15901720
|
Pseudomonas aeruginosa diseases
|
|
3,113
|
| 28603 |
exsA
|
|
increases_activity of
|
T3SS
|
|
| 28604 |
exsA
|
|
increases_expression of
|
T3SS complex
|
|
| 28605 |
exsA
|
|
decreases_expression of
|
fliA
|
if ExsA is overexpressed
|
| 28608 |
flagellum
|
|
decreases_activity of
|
T3SS
|
|
| 28609 |
flagellum
|
|
decreases_expression of
|
T3SS complex
|
|
| 28610 |
flagellum
|
|
decreases transport of
|
exoS
|
|
| 28619 |
gacA
|
|
decreases transport of
|
exoS
|
|
| 28620 |
gacA
|
|
decreases_activity of
|
T3SS
|
|
|
17307856
|
Pseudomonas aeruginosa diseases
|
|
3,140
|
| 28926 |
exoS
|
|
decreases_activity of
|
establishment of epithelial cell polarity
|
|
| 28928 |
exoS
|
|
decreases_activity of
|
establishment of skin barrier
|
|
| 28929 |
exoT
|
|
decreases_activity of
|
establishment of epithelial cell polarity
|
|
| 28930 |
exoT
|
|
decreases_activity of
|
establishment of skin barrier
|
|
| 28956 |
exoS
|
|
decreases_activity of
|
CDC42
|
|
| 28957 |
exoS
|
|
decreases_activity of
|
RAC1
|
|
| 28958 |
exoS
|
|
decreases_activity of
|
RHOA
|
|
| 28959 |
exoT
|
|
decreases_activity of
|
CDC42
|
|
| 28960 |
exoT
|
|
decreases_activity of
|
RAC1
|
|
| 28961 |
exoT
|
|
decreases_activity of
|
RHOA
|
|
| 28962 |
exoS
|
|
decreases_activity of
|
TJP1
|
|
| 28963 |
exoS
|
|
decreases_activity of
|
OCLN
|
|
| 28964 |
exoS
|
|
decreases_activity of
|
EZR
|
|
|
21747810
|
Pseudomonas aeruginosa diseases
|
|
3,156
|
| 29037 |
oprF
|
|
increases_activity of
|
T3SS
|
|
| 29038 |
oprF
|
|
increases_transport of
|
exoS
|
|
| 29039 |
oprF
|
|
increases_transport of
|
exoT
|
|
|
21189321
|
Pseudomonas aeruginosa diseases
|
|
3,202
|
| 29416 |
vfr
|
|
increases_activity of
|
T3SS
|
|
|
22354680
|
Pseudomonas aeruginosa diseases
|
|
3,206
|
| 29544 |
rsmA
|
|
increases_expression of
|
T3SS complex
|
|
| 29691 |
mucoid strain
|
|
decreases_activity of
|
T3SS
|
|
|
22354680
|
Pseudomonas aeruginosa diseases
|
|
3,442
|
| 32119 |
crc
|
|
increases_activity of
|
T3SS
|
|
|
20626455
|
Pseudomonas aeruginosa diseases
|
HoPaCI