|
2,464
|
| 22794 |
P. aeruginosa infection
|
|
increases_activity of
|
T2SS (Xcp)
|
|
| 22943 |
T2SS (Xcp)
|
|
increases_transport of
|
lasB
|
into the extracellular medium
|
| 22950 |
T2SS (Xcp)
|
|
increases_transport of
|
lasA
|
into the extracellular medium
|
| 22952 |
T2SS (Xcp)
|
|
increases_transport of
|
plcH
|
into the extracellular medium
|
| 22953 |
T2SS (Xcp)
|
|
increases_transport of
|
plcN
|
into the extracellular medium
|
| 22966 |
T2SS (Xcp)
|
|
increases_transport of
|
plcB
|
into the extracellular medium
|
| 22968 |
T2SS (Xcp)
|
|
increases_transport of
|
cpbD
|
into the extracellular medium
|
| 22969 |
T2SS (Xcp)
|
|
increases_transport of
|
toxA
|
into the extracellular medium
|
| 22972 |
T2SS (Xcp)
|
|
increases_transport of
|
PA0572
|
into the extracellular medium
|
| 22976 |
T2SS (Xcp)
|
|
increases_transport of
|
prpL
|
into the extracellular medium
|
| 22979 |
T2SS (Xcp)
|
|
increases_transport of
|
lipA
|
into the extracellular medium
|
| 22981 |
T2SS (Xcp)
|
|
increases_transport of
|
lipC
|
into the extracellular medium
|
| 22983 |
T2SS (Xcp)
|
|
increases_transport of
|
phoA
|
into the extracellular medium
|
| 22984 |
T2SS (Xcp)
|
|
increases_transport of
|
paaP
|
into the extracellular medium
|
| 26940 |
P. aeruginosa infection
|
|
increases_activity of
|
T2SS (Hxc)
|
|
|
20947426
|
Pseudomonas aeruginosa diseases
|
|
2,763
|
| 25597 |
T2SS (Xcp)
|
|
increases_activity of
|
cell death
|
during lung infection; at a slower rate than T3SS (within 24-44 h)
|
|
21502078
|
Pseudomonas aeruginosa diseases
|
|
2,945
|
| 26853 |
T2SS (Xcp)-associated complexes
|
|
increases_activity of
|
T2SS (Xcp)
|
|
| 26872 |
xcpR
|
|
is_part_of
|
T2SS inner membrane complex
|
|
| 26877 |
xcpS
|
|
is_part_of
|
T2SS inner membrane complex
|
|
| 26879 |
xcpY
|
|
is_part_of
|
T2SS inner membrane complex
|
|
| 26881 |
xcpZ
|
|
is_part_of
|
T2SS inner membrane complex
|
|
| 26883 |
xcpQ
|
|
is_part_of
|
T2SS secretin complex
|
|
| 26887 |
xcpT
|
|
is_part_of
|
T2SS pseudopilus complex
|
|
| 26891 |
xcpU
|
|
is_part_of
|
T2SS pseudopilus complex
|
|
| 26893 |
xcpV
|
|
is_part_of
|
T2SS pseudopilus complex
|
|
| 26895 |
xcpW
|
|
is_part_of
|
T2SS pseudopilus complex
|
|
| 26897 |
xcpX
|
|
is_part_of
|
T2SS pseudopilus complex
|
|
| 26914 |
pilD
|
|
increases_processing of
|
xcpT
|
|
| 26915 |
pilD
|
|
increases_processing of
|
xcpU
|
|
| 26916 |
pilD
|
|
increases_processing of
|
xcpV
|
|
| 26917 |
pilD
|
|
increases_processing of
|
xcpW
|
|
| 26918 |
pilD
|
|
increases_processing of
|
xcpX
|
|
| 26952 |
T2SS pseudopilus complex
|
|
is localized in
|
periplasmic space
|
|
| 27150 |
T2SS inner membrane complex
|
|
is localized in
|
bacterial inner membrane
|
|
| 27151 |
T2SS inner membrane complex
|
|
is_part_of
|
T2SS (Xcp)-associated complexes
|
|
| 27152 |
T2SS secretin complex
|
|
is localized in
|
bacterial outer membrane
|
|
| 27154 |
T2SS secretin complex
|
|
is_part_of
|
T2SS (Xcp)-associated complexes
|
|
| 27155 |
T2SS pseudopilus complex
|
|
is_part_of
|
T2SS (Xcp)-associated complexes
|
|
| 33340 |
hxcQ
|
|
is_part_of
|
T2SS secretin complex
|
|
| 33341 |
T2SS secretin complex
|
|
is_part_of
|
T2SS (Hxc)-associated complexes
|
|
| 33343 |
cellular response to phosphate starvation
|
|
increases_expression of
|
T2SS (Hxc)-associated complexes
|
|
| 33344 |
T2SS (Hxc)-associated complexes
|
|
increases_activity of
|
T2SS (Hxc)
|
|
| 33345 |
xcpR
|
|
interacts (colocalizes) with
|
xcpY
|
|
| 33346 |
xcpR
|
|
increases_activity of
|
T2SS (Xcp)
|
|
| 33347 |
xcpP
|
|
is_part_of
|
T2SS inner membrane complex
|
|
|
22411978
|
Pseudomonas aeruginosa diseases
|
|
2,952
|
| 26929 |
xcpP
|
|
is_part_of
|
T2SS inner membrane complex
|
|
|
21949187
|
Pseudomonas aeruginosa diseases
|
|
2,953
|
| 26932 |
xcpP
|
|
interacts (colocalizes) with
|
xcpQ
|
experiments performed with the periplasmic soluble domains
|
| 26937 |
xcpP
|
|
interacts (colocalizes) with
|
lasB
|
experiments performed with the periplasmic soluble domains
|
| 26938 |
xcpP
|
|
interacts (colocalizes) with
|
lipA
|
experiments performed with the periplasmic soluble domains
|
| 26943 |
xcpQ
|
|
interacts (colocalizes) with
|
lasB
|
experiments performed with the periplasmic soluble domains
|
| 26946 |
lasB
|
|
interacts (colocalizes) with
|
xcpU
|
experiments performed with the periplasmic soluble domains
|
| 26948 |
lasB
|
|
interacts (colocalizes) with
|
xcpV
|
experiments performed with the periplasmic soluble domains
|
| 26949 |
lasB
|
|
interacts (colocalizes) with
|
xcpX
|
experiments performed with the periplasmic soluble domains
|
|
21949187
|
Pseudomonas aeruginosa diseases
|
|
3,076
|
| 28279 |
TAT protein transport complex
|
|
increases_activity of
|
T2SS (Xcp)
|
|
|
11726509
|
Pseudomonas aeruginosa diseases
|
|
3,113
|
| 28612 |
flagellum
|
NOT |
affects transport of
|
lasB
|
|
|
17307856
|
Pseudomonas aeruginosa diseases
|
|
3,202
|
| 29417 |
vfr
|
|
increases_activity of
|
T2SS (Xcp)
|
|
|
22354680
|
Pseudomonas aeruginosa diseases
|
|
3,739
|
| 36326 |
xcpQ
|
|
interacts (colocalizes) with
|
xcpQ
|
|
|
23188826
|
Pseudomonas aeruginosa diseases
|
|
3,855
|
| 38724 |
lasB
|
|
increases_activity of
|
immune evasion
|
|
| 38725 |
lasB
|
|
decreases_activity of
|
complement component C3b binding
|
|
|
17709513
|
Pseudomonas aeruginosa diseases
|
|
3,945
|
| 40075 |
T2SS (Hxc)
|
|
increases_transport of
|
lapA
|
|
| 40076 |
T2SS (Hxc)
|
|
increases_transport of
|
lapB
|
|
| 40081 |
cellular response to phosphate starvation
|
|
increases_quantity of
|
lapA
|
|
| 40082 |
cellular response to phosphate starvation
|
|
increases_quantity of
|
lapB
|
|
|
22835944
|
Pseudomonas aeruginosa diseases
|
|
3,946
|
| 40077 |
T2SS (Hxc)
|
|
increases_transport of
|
lapC
|
|
| 40078 |
phoB
|
|
increases_activity of
|
T2SS (Hxc)
|
|
| 40079 |
phoB
|
|
increases_activity of
|
cellular response to phosphate starvation
|
|
| 40080 |
cellular response to phosphate starvation
|
|
increases_quantity of
|
lapC
|
|
|
22835944
|
Pseudomonas aeruginosa diseases
|
|
3,948
|
| 40084 |
phoR
|
|
increases_activity of
|
phoB
|
|
|
3138529
|
Pseudomonas aeruginosa diseases
|
|
3,956
|
| 40145 |
LasR/I-3OC12-(HSL)-system
|
|
increases_expression of
|
xcpP
|
|
| 40151 |
LasR/I-3OC12-(HSL)-system
|
|
increases_expression of
|
xcpR
|
|
| 40154 |
RhlR/I-C4-(HSL)-system
|
|
increases_expression of
|
xcpP
|
|
| 40157 |
RhlR/I-C4-(HSL)-system
|
|
increases_expression of
|
xcpR
|
|
|
9218766
|
Pseudomonas aeruginosa diseases
|
|
3,958
|
| 40169 |
LasR/I-3OC12-(HSL)-system
|
|
increases_expression of
|
T2SS (Xcp)-associated complexes
|
|
| 40170 |
RhlR/I-C4-(HSL)-system
|
|
increases_expression of
|
T2SS (Xcp)-associated complexes
|
|
| 40171 |
cellular response to phosphate starvation
|
|
increases_expression of
|
T2SS (Hxc)-associated complexes
|
|
| 40178 |
LasR/I-3OC12-(HSL)-system
|
NOT |
affects_expression of
|
xphA
|
|
| 40179 |
LasR/I-3OC12-(HSL)-system
|
NOT |
affects_expression of
|
xqhA
|
|
| 40180 |
RhlR/I-C4-(HSL)-system
|
NOT |
affects_expression of
|
xphA
|
|
| 40181 |
RhlR/I-C4-(HSL)-system
|
NOT |
affects_expression of
|
xqhA
|
|
|
17351035
|
Pseudomonas aeruginosa diseases
|
|
3,959
|
| 40189 |
xphA
|
|
is_part_of
|
T2SS (hybrid-Xcp)-associated complexes
|
|
| 40190 |
xqhA
|
|
is_part_of
|
T2SS (hybrid-Xcp)-associated complexes
|
|
| 40191 |
T2SS (hybrid-Xcp)-associated complexes
|
|
increases_activity of
|
T2SS (hybrid-Xcp)
|
|
| 40192 |
T2SS (hybrid-Xcp)
|
|
increases_transport of
|
cpbD
|
|
| 40193 |
T2SS (hybrid-Xcp)
|
|
increases_transport of
|
lasB
|
|
| 40194 |
T2SS (hybrid-Xcp)
|
|
increases_transport of
|
prpL
|
|
| 40195 |
T2SS (hybrid-Xcp)
|
NOT |
increases_transport of
|
paaP
|
|
|
17351035
|
Pseudomonas aeruginosa diseases
|
|
4,094
|
| 42340 |
xcpQ
|
|
is_part_of
|
T2SS secretin complex
|
|
| 42342 |
xqhA
|
|
is_part_of
|
T2SS (hybrid-Xcp)-associated complexes
|
|
| 42343 |
xqhA
|
|
interacts (colocalizes) with
|
xqhA
|
|
|
9680212
|
Pseudomonas aeruginosa diseases
|
|
4,099
|
| 42360 |
T2SS (Hxc)
|
|
increases_transport of
|
lapA
|
|
| 42367 |
cellular response to phosphate starvation
|
|
increases_expression of
|
T2SS (Hxc)-associated complexes
|
|
| 42371 |
hxcT
|
|
is_part_of
|
T2SS pseudopilus complex
|
|
| 42376 |
pilD
|
|
increases_processing of
|
hxcT
|
|
| 42378 |
T2SS pseudopilus complex
|
|
is_part_of
|
T2SS (Hxc)-associated complexes
|
|
| 42459 |
hxcU
|
|
is_part_of
|
T2SS pseudopilus complex
|
|
| 42460 |
hxcV
|
|
is_part_of
|
T2SS pseudopilus complex
|
|
| 42461 |
hxcW
|
|
is_part_of
|
T2SS pseudopilus complex
|
|
| 42462 |
hxcX
|
|
is_part_of
|
T2SS pseudopilus complex
|
|
|
11985723
|
Pseudomonas aeruginosa diseases
|
|
4,121
|
| 42453 |
cell-surface signaling system PUMA3
|
|
increases_expression of
|
hxcU
|
|
| 42454 |
cell-surface signaling system PUMA3
|
|
increases_expression of
|
hxcP
|
|
| 42455 |
cell-surface signaling system PUMA3
|
|
increases_expression of
|
hxcX
|
|
| 42456 |
cell-surface signaling system PUMA3
|
|
increases_expression of
|
hxcY
|
|
| 42457 |
cell-surface signaling system PUMA3
|
|
increases_expression of
|
hxcZ
|
|
| 42458 |
cell-surface signaling system PUMA3
|
|
increases_expression of
|
hxcQ
|
|
|
19730690
|
Pseudomonas aeruginosa diseases
|
|
4,941
|
| 48845 |
lasB
|
|
decreases_quantity of
|
CDH5
|
in infected HUVEC cells
|
| 48846 |
CDH5
|
|
increases_activity of
|
adherens junction organization
|
in endothelial cells
|
| 48848 |
lasB
|
NOT |
decreases_quantity of
|
CDH1
|
in epithelial cells
|
|
24626230
|
Pseudomonas aeruginosa diseases
|
|
4,942
|
| 48847 |
lasB
|
|
decreases_quantity of
|
CDH5
|
in a mouse model of acute pneumonia
|
|
24626230
|
Pseudomonas aeruginosa diseases
|
|
5,271
|
| 51499 |
ttsS
|
|
interacts (colocalizes) with
|
ttsR
|
|
| 51500 |
ttsR
|
|
increases_expression of
|
cbpE
|
|
| 51501 |
ttsR
|
|
increases_expression of
|
T2SS (Txc)-associated complexes
|
|
| 51502 |
T2SS (Txc)-associated complexes
|
|
increases_activity of
|
T2SS (Txc)
|
|
| 51503 |
T2SS (Txc)
|
|
increases_transport of
|
cbpE
|
|
| 51516 |
T2SS (Txc)
|
|
increases_transport of
|
cpbD
|
|
| 51520 |
T2SS (Txc)
|
|
increases_transport of
|
lasB
|
|
| 51522 |
T2SS (Txc)
|
|
increases_transport of
|
lapC
|
under conditions of phosphate starvation
|
| 51528 |
txcP
|
|
is_part_of
|
T2SS (Txc)-associated complexes
|
|
| 51537 |
txcQ
|
|
is_part_of
|
T2SS (Txc)-associated complexes
|
|
| 51538 |
txcR
|
|
is_part_of
|
T2SS (Txc)-associated complexes
|
|
| 51539 |
txcS
|
|
is_part_of
|
T2SS (Txc)-associated complexes
|
|
| 51540 |
txcT
|
|
is_part_of
|
T2SS (Txc)-associated complexes
|
|
| 51541 |
txcU
|
|
is_part_of
|
T2SS (Txc)-associated complexes
|
|
| 51542 |
txcV
|
|
is_part_of
|
T2SS (Txc)-associated complexes
|
|
| 51544 |
txcW
|
|
is_part_of
|
T2SS (Txc)-associated complexes
|
|
| 51545 |
txcX
|
|
is_part_of
|
T2SS (Txc)-associated complexes
|
|
| 51546 |
txcY
|
|
is_part_of
|
T2SS (Txc)-associated complexes
|
|
| 51547 |
txcZ
|
|
is_part_of
|
T2SS (Txc)-associated complexes
|
|
|
24748613
|
Pseudomonas aeruginosa diseases
|
|
6,463
|
| 61875 |
morA
|
|
affects_activity of
|
T2SS (Xcp)
|
|
| 61883 |
morA
|
|
affects_quantity of
|
cdiGMP
|
|
| 61885 |
cdiGMP
|
|
affects_activity of
|
T2SS (Xcp)
|
|
|
25894344
|
Pseudomonas aeruginosa diseases
|
HoPaCI