|
2,210
|
| 18867 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
increases_expression of
|
rhlI
|
|
| 18933 |
PQS quorum sensing
|
|
affects_quantity of
|
extracellular DNA, eDNA
|
in the matrix of P. aeruginosa biofilms
|
|
20370936
|
Pseudomonas aeruginosa diseases
|
|
2,214
|
| 18613 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
affects_activity of
|
PQS quorum sensing
|
|
| 18618 |
2-Heptyl-4-quinolone, HHQ
|
|
affects_activity of
|
PQS quorum sensing
|
|
| 18619 |
2-Nonyl-4-hydroxyquinoline, NHQ
|
|
affects_activity of
|
PQS quorum sensing
|
|
| 18620 |
2-Heptyl-4-quinolone N-oxide, HHQNO
|
|
affects_activity of
|
PQS quorum sensing
|
|
| 18621 |
phnA
|
|
increases_quantity of
|
Anthranilate
|
|
| 18623 |
phnB
|
|
increases_quantity of
|
Anthranilate
|
|
| 18635 |
kynA
|
|
increases_quantity of
|
Anthranilate
|
|
| 18642 |
kynB
|
|
increases_quantity of
|
Anthranilate
|
|
| 18644 |
kynU
|
|
increases_quantity of
|
Anthranilate
|
|
| 18646 |
Anthranilate
|
|
affects_activity of
|
P. aeruginosa infection
|
|
| 18664 |
Anthranilate
|
|
increases_quantity of
|
2-Heptyl-4-quinolone, HHQ
|
|
| 18665 |
2-Heptyl-4-quinolone, HHQ
|
|
increases_quantity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
| 18666 |
pqsA
|
|
increases_quantity of
|
2-Heptyl-4-quinolone, HHQ
|
|
| 18667 |
pqsB
|
|
increases_quantity of
|
2-Heptyl-4-quinolone, HHQ
|
|
| 18668 |
pqsC
|
|
increases_quantity of
|
2-Heptyl-4-quinolone, HHQ
|
|
| 18669 |
pqsD
|
|
increases_quantity of
|
2-Heptyl-4-quinolone, HHQ
|
|
| 18670 |
pqsH
|
|
increases_quantity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
| 18671 |
lasR
|
|
increases_expression of
|
pqsH
|
|
| 18672 |
mvfR
|
|
affects_expression of
|
phnA
|
|
| 18673 |
mvfR
|
|
affects_expression of
|
phnB
|
|
| 18675 |
mvfR
|
|
affects_expression of
|
pqsA
|
|
| 18676 |
mvfR
|
|
affects_expression of
|
pqsB
|
|
| 18677 |
mvfR
|
|
affects_expression of
|
pqsC
|
|
| 18678 |
mvfR
|
|
affects_expression of
|
pqsD
|
|
| 18679 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
increases_activity of
|
mvfR
|
|
| 18680 |
2-Heptyl-4-quinolone, HHQ
|
|
increases_activity of
|
mvfR
|
|
| 18684 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
increases_expression of
|
rhlI
|
|
| 18687 |
rhamnolipid
|
|
increases_activity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
| 18711 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
affects_activity of
|
biofilm formation
|
|
| 18815 |
Dynorphin
|
|
increases_quantity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
| 18816 |
Dynorphin
|
|
increases_quantity of
|
2-Heptyl-4-quinolone, HHQ
|
|
| 18817 |
Dynorphin
|
|
increases_quantity of
|
2-Heptyl-4-quinolone N-oxide, HHQNO
|
|
| 19225 |
mvfR
|
|
affects_expression of
|
pqsE
|
|
|
18704225
|
Pseudomonas aeruginosa diseases
|
|
2,242
|
| 19194 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
increases_quantity of
|
Pyocyanine
|
|
|
19196266
|
Pseudomonas aeruginosa diseases
|
|
2,251
|
| 19215 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
interacts (colocalizes) with
|
Fe3+
|
under biological conditions
|
| 19216 |
2-Heptyl-4-quinolone, HHQ
|
NOT |
interacts (colocalizes) with
|
Fe3+
|
under biological conditions
|
| 19217 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
increases_expression of
|
pvdS
|
|
| 19218 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
increases_expression of
|
pvdA
|
|
| 19219 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
increases_expression of
|
pvdE
|
|
| 19220 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
increases_expression of
|
pchE
|
|
| 19231 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
increases_activity of
|
iron assimilation
|
|
| 19234 |
2-Heptyl-4-quinolone, HHQ
|
|
increases_expression of
|
pqsA
|
|
| 19235 |
2-Heptyl-4-quinolone, HHQ
|
|
increases_expression of
|
lecA
|
to a lesser extent than 2-heptyl-3-hydroxy-4-quinolone, PQS
|
| 19238 |
pqsA
|
|
increases_quantity of
|
2-Heptyl-4-quinolone, HHQ
|
|
| 19239 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
increases_expression of
|
lecA
|
|
| 19241 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
increases_quantity of
|
Pyocyanine
|
|
| 19242 |
2-Heptyl-4-quinolone, HHQ
|
|
affects_activity of
|
PQS quorum sensing
|
|
|
17254955
|
Pseudomonas aeruginosa diseases
|
|
2,285
|
| 19466 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
is localized in
|
bacterial outer membrane
|
|
| 19470 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
is localized in
|
bacterial membrane vesicle, MV
|
|
| 19472 |
pqsL
|
|
increases_quantity of
|
2-Heptyl-4-hydroxyquinoline N-oxide, HQNO
|
|
| 19483 |
pqsH
|
|
increases_quantity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
| 19484 |
lasR
|
|
increases_expression of
|
pqsH
|
|
| 19486 |
mvfR
|
NOT |
affects_expression of
|
pqsH
|
|
| 19508 |
2-Heptyl-4-quinolone, HHQ
|
NOT |
affects_quantity of
|
2-Heptyl-4-hydroxyquinoline N-oxide, HQNO
|
|
| 19510 |
pqsD
|
|
increases_quantity of
|
2,4-Dihydroxyquinoline, DHQ
|
independent of PqsB and PqsC
|
| 19520 |
2-Heptyl-4-quinolone, HHQ
|
|
increases_activity of
|
mvfR
|
|
| 19521 |
2-Nonyl-4-hydroxyquinoline, NHQ
|
|
increases_activity of
|
mvfR
|
|
| 19522 |
2-Nonyl-4-hydroxyquinoline, NHQ
|
|
affects_activity of
|
PQS quorum sensing
|
|
| 19523 |
2-Heptyl-4-quinolone, HHQ
|
|
affects_activity of
|
PQS quorum sensing
|
|
| 19524 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
affects_activity of
|
PQS quorum sensing
|
|
| 19572 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
increases_expression of
|
lasB
|
|
| 19573 |
N-Butyryl-HSL
|
|
increases_expression of
|
lasB
|
|
| 19574 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
increases_expression of
|
lecA
|
|
| 19575 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
increases_quantity of
|
Pyocyanine
|
|
| 19578 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
increases_expression of
|
rsmZ
|
|
| 19579 |
2-Heptyl-4-quinolone, HHQ
|
NOT |
increases_expression of
|
rsmZ
|
|
| 19608 |
P. aeruginosa infection, chronic
|
|
increases_quantity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
in sputum of CF patients
|
| 19609 |
P. aeruginosa infection, chronic
|
|
increases_quantity of
|
2-Heptyl-4-quinolone, HHQ
|
in sputum of CF patients
|
| 19610 |
P. aeruginosa infection, chronic
|
|
increases_quantity of
|
2-Heptyl-4-hydroxyquinoline N-oxide, HQNO
|
in sputum of CF patients
|
| 19611 |
P. aeruginosa infection, chronic
|
|
increases_quantity of
|
2-Nonyl-4-hydroxyquinoline N-oxide, NQNO
|
in sputum of CF patients
|
| 19612 |
P. aeruginosa infection, chronic
|
|
increases_quantity of
|
2-Undecyl-4-hydroxyquinoline N-oxide, UQNO
|
in sputum of CF patients
|
| 19613 |
P. aeruginosa infection, chronic
|
|
increases_expression of
|
phnA
|
in sputum of CF patients
|
| 19614 |
P. aeruginosa infection, chronic
|
|
increases_expression of
|
phnB
|
in sputum of CF patients
|
| 19615 |
P. aeruginosa infection, chronic
|
|
increases_expression of
|
pqsA
|
in sputum of CF patients
|
| 19616 |
P. aeruginosa infection, chronic
|
|
increases_expression of
|
pqsB
|
in sputum of CF patients
|
| 19618 |
P. aeruginosa infection, chronic
|
|
increases_expression of
|
pqsC
|
in sputum of CF patients
|
| 19619 |
P. aeruginosa infection, chronic
|
|
increases_expression of
|
pqsD
|
in sputum of CF patients
|
| 19621 |
P. aeruginosa infection, chronic
|
|
increases_expression of
|
pqsE
|
in sputum of CF patients
|
| 19631 |
2-trans,6-trans-Farnesol
|
|
decreases_expression of
|
pqsA
|
|
| 19632 |
2-trans,6-trans-Farnesol
|
|
decreases_quantity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
| 19633 |
2-trans,6-trans-Farnesol
|
|
decreases_quantity of
|
Pyocyanine
|
|
| 19634 |
2-trans,6-trans-Farnesol
|
|
affects_activity of
|
mvfR
|
|
|
20738404
|
Pseudomonas aeruginosa diseases
|
|
2,565
|
| 24116 |
mvfR
|
|
affects_quantity of
|
2-Heptyl-4-quinolone, HHQ
|
4-hydroxy-2-alkylquinoline, HAQs include HHQ
|
| 28450 |
mvfR
|
|
affects_quantity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
4-hydroxy-2-alkylquinoline, HAQs include PQS
|
|
20511495
|
Pseudomonas aeruginosa diseases
|
|
2,855
|
| 26313 |
bqsS
|
NOT |
affects_quantity of
|
N-(3-Oxododecanoyl)-HSL
|
|
| 26314 |
bqsS
|
|
affects_quantity of
|
N-Butyryl-HSL
|
|
| 26315 |
bqsS
|
|
affects_quantity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
| 26316 |
bqsR
|
NOT |
affects_quantity of
|
N-(3-Oxododecanoyl)-HSL
|
|
| 26317 |
bqsR
|
|
affects_quantity of
|
N-Butyryl-HSL
|
|
| 26318 |
bqsR
|
|
affects_quantity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
|
19513205
|
Pseudomonas aeruginosa diseases
|
|
2,932
|
| 26802 |
2-Amino acetophenone, 2-AA
|
|
decreases_expression of
|
pqsA
|
|
| 26803 |
2,4-Dihydroxyquinoline, DHQ
|
NOT |
decreases_expression of
|
pqsA
|
|
| 26805 |
2-Amino acetophenone, 2-AA
|
|
decreases_quantity of
|
2-Heptyl-4-quinolone, HHQ
|
|
|
21829370
|
Pseudomonas aeruginosa diseases
|
|
3,101
|
| 28452 |
6FABA
|
|
decreases_quantity of
|
2-Heptyl-4-quinolone, HHQ
|
|
| 28453 |
6FABA
|
|
decreases_quantity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
| 28454 |
6FABA
|
|
decreases_quantity of
|
2-Heptyl-4-hydroxyquinoline N-oxide, HQNO
|
|
| 28455 |
6CABA
|
|
decreases_quantity of
|
2-Heptyl-4-quinolone, HHQ
|
|
| 28456 |
6CABA
|
|
decreases_quantity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
| 28457 |
6CABA
|
|
decreases_quantity of
|
2-Heptyl-4-hydroxyquinoline N-oxide, HQNO
|
|
| 28458 |
4CABA
|
|
decreases_quantity of
|
2-Heptyl-4-quinolone, HHQ
|
|
| 28459 |
4CABA
|
|
decreases_quantity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
| 28460 |
4CABA
|
|
decreases_quantity of
|
2-Heptyl-4-hydroxyquinoline N-oxide, HQNO
|
|
|
17941706
|
Pseudomonas aeruginosa diseases
|
|
3,130
|
| 28834 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
is localized in
|
bacterial membrane vesicle, MV
|
|
| 28835 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
increases_activity of
|
bacterial membrane budding
|
|
| 28837 |
bacterial membrane vesicle, MV
|
|
affects transport of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
|
22103313
|
Pseudomonas aeruginosa diseases
|
|
3,156
|
| 29047 |
oprF
|
|
increases_quantity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
| 29049 |
oprF
|
|
affects_quantity of
|
2-Heptyl-4-quinolone, HHQ
|
|
|
21189321
|
Pseudomonas aeruginosa diseases
|
|
3,307
|
| 30373 |
2-Heptyl-4-quinolone, HHQ
|
|
decreases_expression of
|
TNF
|
in J774A.1 and primary BAL cells
|
| 30378 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
decreases_expression of
|
TNF
|
in J774A.1 and primary BAL cells
|
| 30379 |
2-Heptyl-4-quinolone, HHQ
|
|
decreases_expression of
|
IL6
|
in J774A.1 and primary BAL cells
|
| 30380 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
decreases_expression of
|
IL6
|
in J774A.1 and primary BAL cells
|
| 30382 |
2-Heptyl-4-quinolone, HHQ
|
|
decreases_activity of
|
I-kappaB kinase/NF-kappaB signaling
|
in J774A.1 cells
|
| 30384 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
decreases_activity of
|
I-kappaB kinase/NF-kappaB signaling
|
in J774A.1 cells
|
| 30385 |
2-Heptyl-4-quinolone, HHQ
|
|
decreases_activity of
|
immune response
|
|
| 30386 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
decreases_activity of
|
immune response
|
|
|
20102415
|
Pseudomonas aeruginosa diseases
|
|
3,437
|
| 31975 |
prrF1
|
|
affects_quantity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
| 31977 |
prrF2
|
|
affects_quantity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
| 32001 |
phrS
|
|
increases_quantity of
|
mvfR
|
|
| 32028 |
phrS
|
|
increases_quantity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
| 40840 |
prrF1
|
|
decreases_quantity of
|
antA
|
|
| 40843 |
prrF2
|
|
decreases_quantity of
|
antA
|
|
| 40844 |
prrF1
|
|
decreases_quantity of
|
antB
|
|
| 40848 |
prrF2
|
|
decreases_quantity of
|
antB
|
|
| 40849 |
prrF1
|
|
decreases_quantity of
|
antC
|
|
| 40850 |
prrF2
|
|
decreases_quantity of
|
antC
|
|
| 40851 |
prrF1
|
|
decreases_quantity of
|
catA
|
|
| 40852 |
prrF2
|
|
decreases_quantity of
|
catA
|
|
| 40853 |
prrF1
|
|
decreases_quantity of
|
catB
|
|
| 40854 |
prrF2
|
|
decreases_quantity of
|
catB
|
|
| 40855 |
prrF1
|
|
decreases_quantity of
|
catC
|
|
| 40857 |
prrF2
|
|
decreases_quantity of
|
catC
|
|
|
21607656
|
Pseudomonas aeruginosa diseases
|
|
3,900
|
| 39556 |
N-Acetyl-D-glucosamine
|
|
increases_quantity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
in P. aeruginosa
|
| 39557 |
peptidoglycan, exogenous
|
|
increases_quantity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
in P. aeruginosa
|
|
23277552
|
Pseudomonas aeruginosa diseases
|
|
3,903
|
| 39608 |
pprB
|
|
increases_expression of
|
pqsA
|
|
| 39609 |
pprB
|
|
increases_expression of
|
pqsB
|
|
| 39610 |
pprB
|
|
increases_expression of
|
pqsC
|
|
| 39611 |
pprB
|
|
increases_expression of
|
pqsD
|
|
| 39612 |
pprB
|
|
increases_expression of
|
pqsE
|
|
| 39613 |
pprB
|
|
increases_expression of
|
phnA
|
|
| 39614 |
pprB
|
|
increases_expression of
|
phnB
|
|
|
23209420
|
Pseudomonas aeruginosa diseases
|
|
3,969
|
| 40321 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
increases_expression of
|
phz1-operon
|
|
| 40322 |
low oxygen level
|
|
increases_quantity of
|
2-Heptyl-4-quinolone, HHQ
|
|
|
23129634
|
Pseudomonas aeruginosa diseases
|
|
3,973
|
| 40336 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
increases_expression of
|
phz2-operon
|
|
| 40346 |
2-Heptyl-4-quinolone, HHQ
|
|
increases_expression of
|
phz2-operon
|
|
| 40349 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
increases_expression of
|
phz1-operon
|
|
|
23129634
|
Pseudomonas aeruginosa diseases
|
|
4,354
|
| 44603 |
parR
|
|
decreases_activity of
|
PQS quorum sensing
|
|
|
24034668
|
Pseudomonas aeruginosa diseases
|
|
4,385
|
| 44672 |
mexS
|
|
affects_quantity of
|
2-Heptyl-4-quinolone, HHQ
|
|
| 44673 |
mexS
|
|
affects_quantity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
| 44674 |
mexS
|
NOT |
affects_quantity of
|
2-Heptyl-4-hydroxyquinoline N-oxide, HQNO
|
|
| 44675 |
mexEF-oprN multidrug efflux complex
|
|
increases_quantity of
|
2-Heptyl-4-quinolone, HHQ
|
shown in a mexS(-) mutant (MGL01), overexpressing mexEF-oprN efflux pump
|
| 44676 |
mexS
|
|
affects_expression of
|
mexEF-oprN multidrug efflux complex
|
|
| 44677 |
mexEF-oprN multidrug efflux complex
|
|
decreases_quantity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
shown in a mexS(-) mutant (MGL01), overexpressing mexEF-oprN efflux pump
|
| 44799 |
mexS
|
|
affects_expression of
|
pqsH
|
shown in a mexS(-) mutant (MGL01), overexpressing mexEF-oprN efflux pump
|
| 44804 |
mexEF-oprN multidrug efflux complex
|
|
increases_transport of
|
2-Heptyl-4-quinolone, HHQ
|
shown in a mexS(-) mutant (MGL01), overexpressing mexEF-oprN efflux pump
|
|
21957445
|
Pseudomonas aeruginosa diseases
|
|
4,659
|
| 46384 |
CAMP
|
|
increases_quantity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
physiological concentrations of LL-37
|
| 46386 |
CAMP
|
|
affects_activity of
|
pqsE
|
physiological concentrations of LL-37
|
|
24349231
|
Pseudomonas aeruginosa diseases
|
HoPaCI