|
2,120
|
| 17343 |
Acyl-HSL quorum sensing
|
|
increases_activity of
|
biofilm formation
|
in P.aeruginosa
|
| 17344 |
P. aeruginosa infection
|
|
affects_activity of
|
Acyl-HSL quorum sensing
|
|
| 17345 |
rhlI
|
|
increases_quantity of
|
N-Butyryl-HSL
|
|
| 17346 |
lasI
|
|
increases_quantity of
|
N-(3-Oxododecanoyl)-HSL
|
|
| 17347 |
N-(3-Oxododecanoyl)-HSL
|
|
affects_activity of
|
Acyl-HSL quorum sensing
|
in P.aeruginosa
|
| 17348 |
N-(3-Oxododecanoyl)-HSL
|
|
increases_activity of
|
lasR
|
in P.aeruginosa
|
| 17349 |
N-Butyryl-HSL
|
|
increases_activity of
|
rhlR
|
in P.aeruginosa
|
| 17352 |
LasR/I-3OC12-(HSL)-system
|
|
increases_expression of
|
lasB
|
in P.aeruginosa
|
| 17353 |
LasR/I-3OC12-(HSL)-system
|
|
increases_expression of
|
toxA
|
in P.aeruginosa
|
| 17354 |
LasR/I-3OC12-(HSL)-system
|
|
increases_expression of
|
rhlR
|
in P.aeruginosa
|
| 17355 |
lasR
|
|
increases_expression of
|
lasI
|
in P.aeruginosa
|
| 17561 |
N-Butyryl-HSL
|
|
affects_activity of
|
Acyl-HSL quorum sensing
|
in P.aeruginosa
|
| 29491 |
LasR/I-3OC12-(HSL)-system
|
|
affects_activity of
|
Acyl-HSL quorum sensing
|
|
| 29492 |
RhlR/I-C4-(HSL)-system
|
|
affects_activity of
|
Acyl-HSL quorum sensing
|
|
|
10922036
|
Pseudomonas aeruginosa diseases
|
|
2,123
|
| 17553 |
P. aeruginosa infection
|
|
affects_activity of
|
Acyl-HSL quorum sensing
|
|
| 17554 |
N-(3-Oxododecanoyl)-HSL
|
|
affects_activity of
|
Acyl-HSL quorum sensing
|
induced by P. aeruginosa
|
| 17555 |
N-Butyryl-HSL
|
|
affects_activity of
|
Acyl-HSL quorum sensing
|
induced by P. aeruginosa
|
| 17556 |
Acyl-HSL quorum sensing
|
|
increases_activity of
|
biofilm formation
|
in P. aeruginosa infected host
|
| 17557 |
P. aeruginosa infection
|
|
increases_activity of
|
biofilm formation
|
|
| 17558 |
Acyl-HSL quorum sensing
|
NOT |
affects_quantity of
|
(alginate)n
|
in P. aeruginosa infected patients with CF
|
| 17562 |
Acyl-HSL quorum sensing
|
|
increases_activity of
|
I-kappaB kinase/NF-kappaB signaling
|
in P. aeruginosa infected host
|
| 17563 |
I-kappaB kinase/NF-kappaB signaling
|
|
increases_quantity of
|
PTGS2
|
in P. aeruginosa infected host
|
| 17564 |
PTGS2
|
|
affects_quantity of
|
Prostaglandin E2
|
in P. aeruginosa infected host
|
| 17565 |
Prostaglandin E2
|
|
increases_activity of
|
mucus secretion
|
in P. aeruginosa infected host
|
| 17566 |
Prostaglandin E2
|
|
increases_activity of
|
vasodilation
|
in P. aeruginosa infected host
|
| 17579 |
Acyl-HSL quorum sensing
|
|
increases_activity of
|
neutrophil apoptotic process
|
|
| 17839 |
Azithromycin
|
|
decreases_activity of
|
Acyl-HSL quorum sensing
|
|
|
15695491
|
Pseudomonas aeruginosa diseases
|
|
2,144
|
| 17878 |
Acyl-HSL quorum sensing
|
|
increases_activity of
|
apoptotic process
|
in neutrophils of bronchial epithelial cells
|
| 17879 |
N-(3-Oxododecanoyl)-HSL
|
|
increases_quantity of
|
CXCL8
|
in bronchial epithelial cells
|
|
20723140
|
Pseudomonas aeruginosa diseases
|
|
2,199
|
| 18364 |
PON1
|
|
decreases_activity of
|
Acyl-HSL quorum sensing
|
|
| 18373 |
PON1
|
|
decreases_quantity of
|
N-(3-Oxododecanoyl)-HSL
|
|
| 18377 |
PON2
|
|
decreases_activity of
|
Acyl-HSL quorum sensing
|
|
| 18378 |
PON2
|
|
decreases_quantity of
|
N-(3-Oxododecanoyl)-HSL
|
|
| 18379 |
PON3
|
|
decreases_activity of
|
Acyl-HSL quorum sensing
|
|
| 18380 |
PON3
|
|
decreases_quantity of
|
N-(3-Oxododecanoyl)-HSL
|
|
|
20338154
|
Pseudomonas aeruginosa diseases
|
|
2,210
|
| 18565 |
N-(3-Oxododecanoyl)-HSL
|
|
increases_activity of
|
qscR
|
|
| 18566 |
qscR
|
|
affects_activity of
|
lasR
|
|
| 18567 |
qscR
|
|
affects_activity of
|
rhlR
|
|
| 18569 |
rhlR
|
|
increases_expression of
|
rhlR
|
|
| 18934 |
Acyl-HSL quorum sensing
|
|
affects_quantity of
|
extracellular DNA, eDNA
|
in the matrix of P. aeruginosa biofilms
|
|
20370936
|
Pseudomonas aeruginosa diseases
|
|
2,214
|
| 18614 |
lasI
|
|
increases_quantity of
|
N-(3-Oxododecanoyl)-HSL
|
|
| 18615 |
N-(3-Oxododecanoyl)-HSL
|
|
increases_activity of
|
lasR
|
|
| 18616 |
rhlI
|
|
increases_quantity of
|
N-Butyryl-HSL
|
|
| 18617 |
N-Butyryl-HSL
|
|
increases_activity of
|
rhlR
|
|
| 18671 |
lasR
|
|
increases_expression of
|
pqsH
|
|
| 18672 |
mvfR
|
|
affects_expression of
|
phnA
|
|
| 18673 |
mvfR
|
|
affects_expression of
|
phnB
|
|
| 18675 |
mvfR
|
|
affects_expression of
|
pqsA
|
|
| 18676 |
mvfR
|
|
affects_expression of
|
pqsB
|
|
| 18677 |
mvfR
|
|
affects_expression of
|
pqsC
|
|
| 18678 |
mvfR
|
|
affects_expression of
|
pqsD
|
|
| 18684 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
increases_expression of
|
rhlI
|
|
| 18685 |
lasR
|
|
increases_activity of
|
mvfR
|
|
| 18686 |
rhlR
|
|
decreases_activity of
|
mvfR
|
|
| 18776 |
N-(3-Oxododecanoyl)-HSL
|
|
decreases_quantity of
|
IL12
|
|
| 18809 |
N-(3-Oxododecanoyl)-HSL
|
|
decreases_quantity of
|
TNF
|
|
| 18810 |
N-(3-Oxododecanoyl)-HSL
|
|
decreases_activity of
|
T cell proliferation
|
|
|
18704225
|
Pseudomonas aeruginosa diseases
|
|
2,242
|
| 19106 |
Acyl-HSL quorum sensing
|
|
affects_expression of
|
pelA
|
|
| 19113 |
Acyl-HSL quorum sensing
|
|
affects_expression of
|
pelB
|
|
| 19114 |
Acyl-HSL quorum sensing
|
|
affects_expression of
|
pelC
|
|
| 19116 |
Acyl-HSL quorum sensing
|
|
affects_expression of
|
pelD
|
|
| 19117 |
Acyl-HSL quorum sensing
|
|
affects_expression of
|
pelE
|
|
| 19118 |
Acyl-HSL quorum sensing
|
|
affects_expression of
|
pelF
|
|
| 19120 |
Acyl-HSL quorum sensing
|
|
affects_expression of
|
pelG
|
|
| 19145 |
Acyl-HSL quorum sensing
|
|
affects_activity of
|
rhlA
|
|
| 19148 |
Acyl-HSL quorum sensing
|
|
affects_activity of
|
rhlB
|
|
| 19149 |
Acyl-HSL quorum sensing
|
|
affects_activity of
|
rhlC
|
|
|
19196266
|
Pseudomonas aeruginosa diseases
|
|
2,285
|
| 19513 |
lasR
|
|
increases_quantity of
|
lasB
|
|
| 19514 |
lasR
|
|
increases_quantity of
|
Pyoverdine I
|
|
| 19515 |
rhlR
|
|
increases_quantity of
|
rhamnolipid
|
|
| 19516 |
rhlR
|
|
increases_quantity of
|
Pyocyanine
|
|
| 19517 |
rhlR
|
|
increases_quantity of
|
lasB
|
|
| 19572 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
increases_expression of
|
lasB
|
|
| 19573 |
N-Butyryl-HSL
|
|
increases_expression of
|
lasB
|
|
| 19578 |
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
increases_expression of
|
rsmZ
|
|
| 19579 |
2-Heptyl-4-quinolone, HHQ
|
NOT |
increases_expression of
|
rsmZ
|
|
|
20738404
|
Pseudomonas aeruginosa diseases
|
|
2,354
|
| 28128 |
LasR/I-3OC12-(HSL)-system
|
NOT |
affects_expression of
|
T3SS complex
|
|
| 28130 |
RhlR/I-C4-(HSL)-system
|
|
decreases_expression of
|
T3SS complex
|
|
| 28132 |
RhlR/I-C4-(HSL)-system
|
|
decreases transport of
|
exoS
|
|
| 28134 |
LasR/I-3OC12-(HSL)-system
|
NOT |
affects_expression of
|
exsA
|
|
| 28143 |
RhlR/I-C4-(HSL)-system
|
NOT |
affects_expression of
|
exsA
|
|
|
15901720
|
Pseudomonas aeruginosa diseases
|
|
2,363
|
| 20770 |
Long-chain fatty acid
|
|
increases_quantity of
|
N-Butyryl-HSL
|
LCFA used in this exp. was oleate, in KEGG C00712
|
| 20771 |
Long-chain fatty acid
|
|
affects_activity of
|
Acyl-HSL quorum sensing
|
LCFA used in this exp. was oleate, in KEGG C00712
|
|
19508282
|
Pseudomonas aeruginosa diseases
|
|
2,526
|
| 23521 |
Acyl-HSL quorum sensing
|
|
affects_expression of
|
plcB
|
|
|
15306013
|
Pseudomonas aeruginosa diseases
|
|
2,541
|
| 23646 |
P. aeruginosa infection, chronic
|
|
increases_quantity of
|
azu
|
in sera of CF patients (from stationary-phase cultures)
|
| 23649 |
P. aeruginosa infection, chronic
|
|
increases_quantity of
|
lasB
|
in sera of CF patients (from stationary-phase cultures)
|
| 23650 |
P. aeruginosa infection, chronic
|
|
increases_quantity of
|
prpL
|
in sera of CF patients (from stationary-phase cultures)
|
| 23651 |
P. aeruginosa infection, chronic
|
|
increases_quantity of
|
pasP
|
in sera of CF patients (from stationary-phase cultures)
|
| 23652 |
Acyl-HSL quorum sensing
|
|
affects_quantity of
|
azu
|
in sera of CF patients (from stationary-phase cultures)
|
| 23653 |
Acyl-HSL quorum sensing
|
|
affects_quantity of
|
lasB
|
in sera of CF patients (from stationary-phase cultures)
|
| 23654 |
Acyl-HSL quorum sensing
|
|
affects_quantity of
|
prpL
|
in sera of CF patients (from stationary-phase cultures)
|
| 23655 |
Acyl-HSL quorum sensing
|
|
affects_quantity of
|
pasP
|
in sera of CF patients (from stationary-phase cultures)
|
|
18663005
|
Pseudomonas aeruginosa diseases
|
|
2,612
|
| 24753 |
rhlR
|
|
increases_activity of
|
P. aeruginosa infection
|
in a Drosophila melanogaster oral infection model
|
| 24761 |
lasR
|
NOT |
affects_activity of
|
P. aeruginosa infection
|
in a Drosophila melanogaster oral infection model
|
| 24763 |
rhlR
|
|
affects_activity of
|
immune response
|
in a Drosophila melanogaster oral infection model
|
|
21987808
|
Pseudomonas aeruginosa diseases
|
|
2,742
|
| 25398 |
Acyl-HSL quorum sensing
|
NOT |
affects_expression of
|
BDKRB1
|
in airway epithelial A549 cells; 4 h post treatment
|
|
22092568
|
Pseudomonas aeruginosa diseases
|
|
2,832
|
| 26135 |
LasR/I-3OC12-(HSL)-system
|
|
decreases_expression of
|
T6SS-HSI-1 complex
|
|
|
22017253
|
Pseudomonas aeruginosa diseases
|
|
2,853
|
| 26293 |
kinB
|
|
increases_quantity of
|
Pyocyanine
|
in a manner independent of AlgB
|
| 26294 |
kinB
|
|
increases_quantity of
|
lasB
|
in a manner independent of AlgB
|
| 26295 |
kinB
|
NOT |
increases_quantity of
|
N-(3-Oxododecanoyl)-HSL
|
|
| 26296 |
kinB
|
NOT |
increases_quantity of
|
N-Butyryl-HSL
|
|
|
21515773
|
Pseudomonas aeruginosa diseases
|
|
2,855
|
| 26313 |
bqsS
|
NOT |
affects_quantity of
|
N-(3-Oxododecanoyl)-HSL
|
|
| 26314 |
bqsS
|
|
affects_quantity of
|
N-Butyryl-HSL
|
|
| 26315 |
bqsS
|
|
affects_quantity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
| 26316 |
bqsR
|
NOT |
affects_quantity of
|
N-(3-Oxododecanoyl)-HSL
|
|
| 26317 |
bqsR
|
|
affects_quantity of
|
N-Butyryl-HSL
|
|
| 26318 |
bqsR
|
|
affects_quantity of
|
2-Heptyl-3-hydroxy-4-quinolone, PQS
|
|
|
19513205
|
Pseudomonas aeruginosa diseases
|
|
3,066
|
| 28119 |
lasR
|
|
affects_activity of
|
LasR/I-3OC12-(HSL)-system
|
|
| 28120 |
lasI
|
|
affects_activity of
|
LasR/I-3OC12-(HSL)-system
|
|
| 28122 |
N-(3-Oxododecanoyl)-HSL
|
|
affects_activity of
|
LasR/I-3OC12-(HSL)-system
|
|
| 28123 |
rhlR
|
|
affects_activity of
|
RhlR/I-C4-(HSL)-system
|
|
| 28124 |
rhlI
|
|
affects_activity of
|
RhlR/I-C4-(HSL)-system
|
|
| 28126 |
N-Butyryl-HSL
|
|
affects_activity of
|
RhlR/I-C4-(HSL)-system
|
|
| 28127 |
LasR/I-3OC12-(HSL)-system
|
|
increases_expression of
|
rhlR
|
|
|
15901720
|
Pseudomonas aeruginosa diseases
|
|
3,089
|
| 28355 |
LasR/I-3OC12-(HSL)-system
|
|
increases_expression of
|
T6SS-HSI-2 complex
|
shown in a microarray and qRT-PCR approach
|
| 28358 |
LasR/I-3OC12-(HSL)-system
|
|
increases_expression of
|
T6SS-HSI-3 complex
|
shown in a microarray and qRT-PCR approach
|
| 28361 |
LasR/I-3OC12-(HSL)-system
|
|
decreases_expression of
|
T6SS-HSI-1 complex
|
shown in a microarray and qRT-PCR approach
|
|
19497948
|
Pseudomonas aeruginosa diseases
|
|
3,115
|
| 28627 |
qteE
|
|
affects_activity of
|
Acyl-HSL quorum sensing
|
|
|
20378835
|
Pseudomonas aeruginosa diseases
|
|
3,151
|
| 29023 |
lasR
|
|
affects_quantity of
|
PA0572
|
|
|
22309196
|
Pseudomonas aeruginosa diseases
|
|
3,156
|
| 29044 |
oprF
|
|
increases_quantity of
|
N-(3-Oxododecanoyl)-HSL
|
|
| 29045 |
oprF
|
|
affects_quantity of
|
N-Butyryl-HSL
|
|
|
21189321
|
Pseudomonas aeruginosa diseases
|
|
3,202
|
| 29498 |
LasR/I-3OC12-(HSL)-system
|
|
increases_activity of
|
RhlR/I-C4-(HSL)-system
|
|
| 29499 |
rsaL
|
|
decreases_expression of
|
lasI
|
|
| 29501 |
LasR/I-3OC12-(HSL)-system
|
|
increases_expression of
|
rsaL
|
|
| 29502 |
P. aeruginosa infection, chronic
|
|
increases_expression of
|
rsaL
|
in patients with CF
|
| 29514 |
qslA
|
|
interacts (colocalizes) with
|
lasR
|
|
| 29516 |
qslA
|
|
affects_activity of
|
Acyl-HSL quorum sensing
|
|
| 29517 |
qscR
|
|
affects_activity of
|
Acyl-HSL quorum sensing
|
|
|
22354680
|
Pseudomonas aeruginosa diseases
|
|
3,206
|
| 29682 |
vfr
|
|
increases_expression of
|
lasR
|
|
| 29684 |
vfr
|
|
increases_expression of
|
rhlR
|
|
|
22354680
|
Pseudomonas aeruginosa diseases
|
|
3,348
|
| 30751 |
LasR/I-3OC12-(HSL)-system
|
|
increases_expression of
|
T6SS-HSI-2 complex
|
|
| 30755 |
RhlR/I-C4-(HSL)-system
|
|
increases_expression of
|
T6SS-HSI-2 complex
|
|
|
22665491
|
Pseudomonas aeruginosa diseases
|
|
3,379
|
| 31446 |
N-(3-Oxododecanoyl)-HSL
|
|
increases_activity of
|
neutrophil chemotaxis
|
|
| 31451 |
SB203580
|
|
decreases_activity of
|
p38 MAPK
|
induced by AHL-12
|
| 31452 |
N-(3-Oxododecanoyl)-HSL
|
|
increases_phosphorylation of
|
p38 MAPK
|
|
| 31454 |
N-(3-Oxododecanoyl)-HSL
|
|
increases_activity of
|
p38 MAPK
|
|
| 31455 |
p38 MAPK
|
|
increases_phosphorylation of
|
MAPKAPK2
|
|
| 31456 |
p38 MAPK
|
|
increases_activity of
|
MAPKAPK2
|
|
| 31458 |
MAPKAPK2
|
|
increases_phosphorylation of
|
LSP1
|
|
| 31459 |
N-(3-Oxododecanoyl)-HSL
|
|
affects_activity of
|
actin cytoskeleton organization
|
in PMN (polymorphonuclear neutrophils)
|
| 31604 |
p38 MAPK
|
|
increases_activity of
|
neutrophil chemotaxis
|
induced by AHL-12
|
| 31609 |
MAPKAPK2
|
|
increases_activity of
|
LSP1
|
|
| 31611 |
LSP1
|
|
affects_activity of
|
actin cytoskeleton organization
|
induced by AHL-12
|
|
22401915
|
Pseudomonas aeruginosa diseases
|
|
3,386
|
| 31626 |
LasR/I-3OC12-(HSL)-system
|
|
affects_quantity of
|
rhamnolipid
|
|
| 31634 |
RhlR/I-C4-(HSL)-system
|
|
affects_quantity of
|
rhamnolipid
|
|
|
21667084
|
Pseudomonas aeruginosa diseases
|
|
3,585
|
| 33549 |
pvdQ
|
|
decreases_quantity of
|
N-(3-Oxododecanoyl)-HSL
|
|
|
18245294
|
Pseudomonas aeruginosa diseases
|
|
3,866
|
| 38862 |
N-(3-Oxododecanoyl)-HSL
|
|
increases_phosphorylation of
|
EIF2S1
|
|
| 38865 |
N-(3-Oxododecanoyl)-HSL
|
|
increases_phosphorylation of
|
EIF2AK2
|
|
| 38867 |
EIF2AK2
|
|
increases_phosphorylation of
|
EIF2S1
|
|
| 38868 |
N-(3-Oxododecanoyl)-HSL
|
NOT |
increases_phosphorylation of
|
EIF2AK4
|
|
| 38869 |
EIF2AK4
|
|
increases_phosphorylation of
|
EIF2S1
|
|
| 38871 |
EIF2AK2
|
|
increases_phosphorylation of
|
p38 MAPK
|
|
| 38872 |
EIF2AK2
|
|
increases_activity of
|
p38 MAPK
|
|
| 38873 |
N-(3-Oxododecanoyl)-HSL
|
|
decreases_activity of
|
translation
|
|
| 38874 |
N-(3-Oxododecanoyl)-HSL
|
|
increases_activity of
|
autophagy
|
|
|
22991039
|
Pseudomonas aeruginosa diseases
|
|
3,956
|
| 40145 |
LasR/I-3OC12-(HSL)-system
|
|
increases_expression of
|
xcpP
|
|
| 40151 |
LasR/I-3OC12-(HSL)-system
|
|
increases_expression of
|
xcpR
|
|
| 40154 |
RhlR/I-C4-(HSL)-system
|
|
increases_expression of
|
xcpP
|
|
| 40157 |
RhlR/I-C4-(HSL)-system
|
|
increases_expression of
|
xcpR
|
|
|
9218766
|
Pseudomonas aeruginosa diseases
|
HoPaCI