Alzheimer and AMPK

AMPK is a master regulator of cellular energy homeostasis and a central player in glucose and lipid metabolism. It is potentially involved in the pathogenesis of Alzheimer’s disease (AD), as its activity decreases in AD brain, indicating decreased mitochondrial biogenesis and function. Both drugs, Metformin, an important drug for the treatment of type 2 diabetes, and Resveratrol, increase the activity of AMPK. AMPK activation in turn decreases mTOR signaling activity to facilitate autophagy and promotes lysosomal degradation of Abeta that is found in plaques in brains of patients with Alzheimer's disease.

Statistics

Interactions7Proteins/Genes2Chemical compounds/drugs2
Biological Process(GO)1Phenotype1

Proteins/Genes

Amyloid beta peptide2
MTOR2

Biological Process(GO)

autophagy2

Chemical compounds/drugs

Metformin1
Resveratrol1