Search Results for "Phosphatidylinositol-4,5-bisphosphate" - 50 interactions found in 16 entries.

Entry-ID
Interactor1 (Subject) Interaction type Interactor2 (Object) additional information
PubMed-ID
Diseases
439
1915 PLCG1 affects_quantity of Phosphatidylinositol-4,5-bisphosphate in pilocarpine model
1924 Phosphatidylinositol-4,5-bisphosphate affects_activity of Diacylglycerol in pilocarpine model
1925 Phosphatidylinositol-4,5-bisphosphate affects_activity of Inositol 1,4,5-trisphosphate in pilocarpine model
1471196 Status epilepticus
2,533
24149 Phosphatidylinositol-4,5-bisphosphate affects_activity of Gamma-secretase complex in liposomes
24150 Phosphatidylinositol-4,5-bisphosphate affects_quantity of Amyloid beta peptide (42) in cultured fibroblasts
21448224 Alzheimer disease
2,596
24508 Amyloid beta peptide (oligomer) decreases_quantity of Phosphatidylinositol-4,5-bisphosphate
24523 Phosphatidylinositol-4,5-bisphosphate affects_activity of Phosphatidylinositol-4,5-bisphosphate 5-phosphatase
24537 SYNJ1 affects_quantity of Phosphatidylinositol-4,5-bisphosphate in the brain and at the synapses
18391946 Alzheimer disease
4,329
44329 AGPAT2 increases_quantity of Phosphatidylinositol-4,5-bisphosphate
22872237 Metabolic
Lipodystrophy
5,058
49754 PLCB2 decreases_quantity of Phosphatidylinositol-4,5-bisphosphate
8245028 Neurological
6,492
61664 Inositol increases_quantity of Phosphatidylinositol-4,5-bisphosphate
61665 PLC decreases_quantity of Phosphatidylinositol-4,5-bisphosphate
62202 Phosphatidylinositol-4,5-bisphosphate increases_quantity of Diacylglycerol
62203 Phosphatidylinositol-4,5-bisphosphate increases_quantity of Inositol 1,4,5-trisphosphate
15471909 Metabolic
6,496
61697 Phosphatidylinositol-4,5-bisphosphate interacts (colocalizes) with KCNQ2
61704 Phosphatidylinositol-4,5-bisphosphate increases_activity of KCNQ2
24277843 Metabolic
6,579
62763 Phosphatidylinositol 3-kinase decreases_quantity of Phosphatidylinositol-4,5-bisphosphate
22363263 Metabolic
8,164
82179 Phosphatidylinositol-4,5-bisphosphate decreases_activity of MCOLN1 in lysosome
25668017 Metabolic
10,191
106043 Phosphatidylinositol-4,5-bisphosphate interacts (colocalizes) with SLC6A4 complex, oligomer stabilization of the oligomeric SERT complexes is mediated by the direct binding to phosphoinositide phosphatidylinositol-4,5-biphosphate (PIP2)
106044 Phosphatidylinositol-4,5-bisphosphate increases_activity of SLC6A4 complex, oligomer stabilization of the oligomeric SERT complexes is mediated by the direct binding to phosphoinositide phosphatidylinositol-4,5-biphosphate (PIP2)
106047 Phosphatidylinositol-4,5-bisphosphate increases_quantity of SLC6A4 complex, oligomer stabilization of the oligomeric SERT complexes is mediated by the direct binding to PIP2
28102201 Neurological
Metabolic
11,157
112828 PIP4K2A increases_quantity of Phosphatidylinositol-4,5-bisphosphate PI42A catalyzes the formation of phosphatidylinositol 4,5bisphosphate (PtdIns(4,5)P2), referred to as PIP2 which has been proposed as a key regulator of clathrin endocytosis
112829 Phosphatidylinositol-4,5-bisphosphate affects_activity of clathrin-dependent endocytosis PI42A catalyzes PIP2 which has been proposed as a key regulator of clathrin endocytosis
27636840 Alzheimer disease
11,517
114942 APOE (isoform E4) decreases_quantity of Phosphatidylinositol-4,5-bisphosphate in postmortem human brain tissues of ApoE4 carriers
114947 APOE (isoform E4) decreases_quantity of Phosphatidylinositol-4,5-bisphosphate even in normal aged ApoE4 carriers
114953 sex, female decreases_quantity of Phosphatidylinositol-4,5-bisphosphate brain PIP2 levels of female subjects were lower than those of male subjects in cohorts; the reduction of PIP2 levels over the course of disease development and progression was more closely correlated in female subjects than in the overall population
124742 female brain decreases_quantity of Phosphatidylinositol-4,5-bisphosphate in female brains; compared to male brains
124743 male brain increases_quantity of Phosphatidylinositol-4,5-bisphosphate in male brains; compared to female brains
26372964 Alzheimer disease
11,518
114943 APOE (isoform E4) decreases_quantity of Phosphatidylinositol-4,5-bisphosphate in the brains of ApoE4 knock-in (KI) mice; compared to APOE3 counterparts
114946 decreased SYNJ1 expression increases_quantity of Phosphatidylinositol-4,5-bisphosphate in the brains of ApoE4 knock-in (KI) mice; and rescues AD-related cognitive deficits in these mice
141817 SYNJ1 decreases_quantity of Phosphatidylinositol-4,5-bisphosphate in the brains of ApoE4 knock-in (KI) mice
26372964 Alzheimer disease
11,523
114993 Phosphatidylinositol-4,5-bisphosphate interacts (colocalizes) with SLC6A4
114994 Phosphatidylinositol-4,5-bisphosphate increases_activity of response to amphetamine not being a requirement for neurotransmitter uptake
114998 Phosphatidylinositol-4,5-bisphosphate increases_quantity of Inositol 1,4,5-trisphosphate PIP2 is the precursor of inositol triphosphate (IP3) resulting from cleavage by phospholipase C (PLC)
115000 Phosphatidylinositol-4,5-bisphosphate increases_activity of protein membrane anchor serving as an anchor for protein kinase C
115001 Phosphatidylinositol-4,5-bisphosphate affects_activity of exocytosis
115003 Phosphatidylinositol-4,5-bisphosphate NOT affects_activity of SLC6A1
115024 Phosphatidylinositol increases_quantity of Phosphatidylinositol-4,5-bisphosphate through sequential phosphorylation of phosphatidylinositol via PI-4 kinase and PIP-5 kinase
115025 Phosphatidylinositol-4,5-bisphosphate increases_quantity of Diacylglycerol PIP2 is the precursor of DAG resulting from cleavage by phospholipase C (PLC)
115026 PLC increases_processing of Phosphatidylinositol-4,5-bisphosphate resulting in DAG and IP3
115057 Phosphatidylinositol-4,5-bisphosphate is localized in membrane raft enriched in membrane rafts
115058 Phosphatidylinositol-4,5-bisphosphate affects_activity of endocytosis
115059 Phosphatidylinositol-4,5-bisphosphate affects_activity of ion transmembrane transport
23798435 Metabolic
15,119
141699 Phosphatidylinositol-4,5-bisphosphate affects_activity of autophagy via regulation of two essential steps of autophagy
141759 APOE (isoform E4) decreases_quantity of Phosphatidylinositol-4,5-bisphosphate in postmortem human brain tissues of APOE4 carriers, in the brains of mice knocked in for human APOE4, as well as in primary neurons and astrocytes derived from these mice; compared with APOE3
141760 SYNJ1 decreases_quantity of Phosphatidylinositol-4,5-bisphosphate specifically degrading PI(4,5)P2
141765 decreased SYNJ1 level increases_quantity of Phosphatidylinositol-4,5-bisphosphate in an AD mouse model and in APOE4 knock-in mice
141878 APOE (isoform E3) increases_quantity of Phosphatidylinositol-4,5-bisphosphate in postmortem human brain tissues of APOE4 carriers, in the brains of mice knocked in for human APOE4, as well as in primary neurons and astrocytes derived from these mice; compared with APOE4
Alzheimer disease
15,290
144877 PIKFYVE increases_quantity of Phosphatidylinositol-4,5-bisphosphate for initiation of autolysosome tubulation
144878 Phosphatidylinositol-4,5-bisphosphate increases_activity of initiation of autolysosome tubulation
Alzheimer disease
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