Search Results for "Inositol 1,4,5-trisphosphate" - 49 interactions found in 19 entries.

Entry-ID

	Interactor1 (Subject)		Interaction type	Interactor2 (Object)	additional information

PubMed-ID

Diseases

439

1925

Phosphatidylinositol-4,5-bisphosphate

affects_activity of

Inositol 1,4,5-trisphosphate

in pilocarpine model

1471196

Status epilepticus

440

1940

Inositol 1,4,5-trisphosphate

interacts (colocalizes) with

ITPR1

in pilocarpine model

1648604

Neurological
Status epilepticus

4,660

46388	PLC	increases_quantity of	Inositol 1,4,5-trisphosphate	in pancreas, in pancreatic islets
46390	Inositol 1,4,5-trisphosphate	increases_activity of	calcium-mediated signaling	in pancreas, in pancreatic islets
46447	Inositol 1,4,5-trisphosphate	increases_activity of	ITPR	in pancreas, in pancreatic islets; via binding to the receptor

21966580

Diabetes mellitus, type II
Schizophrenia
Insulin resistance

4,686

46621	PLCB		increases_quantity of	Inositol 1,4,5-trisphosphate	in pancreas, in pancreatic islet beta cells
46623	Inositol 1,4,5-trisphosphate		increases_activity of	ITPR	in pancreas, in pancreatic islet beta cells; via binding of IP3 to its receptor

24114586

Bipolar disorder
Diabetes mellitus, type II
Schizophrenia
Insulin resistance

5,058

49756

PLCB2

increases_quantity of

Inositol 1,4,5-trisphosphate

8245028

Neurological

5,059

49755	Inositol 1,4,5-trisphosphate		interacts (colocalizes) with	IP3R receptor complex
49774	Inositol 1,4,5-trisphosphate		is_part_of	IP3-IP3R receptor complex

16919684

Neurological

5,441

53112

LRP5

affects_quantity of

Inositol 1,4,5-trisphosphate

12509515

Diabetes mellitus, type II
Insulin resistance

6,492

61981	PLC	increases_quantity of	Inositol 1,4,5-trisphosphate
62203	Phosphatidylinositol-4,5-bisphosphate	increases_quantity of	Inositol 1,4,5-trisphosphate
62346	Inositol 1,4,5-trisphosphate	increases_activity of	calcium-mediated signaling

15471909

Metabolic

6,517

61973	Lithium	decreases_quantity of	Inositol 1,4,5-trisphosphate
62095	Inositol	increases_quantity of	Inositol 1,4,5-trisphosphate
62105	Inositol 1,4,5-trisphosphate	decreases_activity of	autophagy

16186256

Metabolic

7,296

71673

SYNJ1

decreases_quantity of

Inositol 1,4,5-trisphosphate

15474001

Diabetes mellitus, type II
Insulin resistance
Ciliopathy

7,420

72888	PLC	increases_quantity of	Inositol 1,4,5-trisphosphate
72891	Inositol 1,4,5-trisphosphate	affects_activity of	insulin secretion involved in cellular response to glucose stimulus
72892	Inositol 1,4,5-trisphosphate	increases_quantity of	Inositol 3,4,5,6-tetrakisphosphate
72893	Inositol 1,4,5-trisphosphate	increases_quantity of	Inositol 1,2,3,4,5,6-hexakisphosphate
72895	Inositol 1,4,5-trisphosphate	increases_quantity of	5-PP-InsP5
72896	Inositol 1,4,5-trisphosphate	increases_quantity of	Bisdiphosphoinositol tetrakisphosphate

26862218

Diabetes mellitus, type II
Insulin resistance

9,120

96845

PLC

increases_quantity of

Inositol 1,4,5-trisphosphate

25960051

Arterial calcification, generalized, of infancy, 1

11,358

114099	Inositol 1,4,5-trisphosphate	increases_activity of	Calcium-release channel	when activated by IP3, releasing Ca+ from ER lumen into cytoplasm
114106	Fas signaling pathway	increases_quantity of	Inositol 1,4,5-trisphosphate	via the activation of phospholipase C-gamma1, and the subsequent enhanced Ca2+ release from IP3 receptors
114107	Inositol 1,4,5-trisphosphate	interacts (colocalizes) with	ITPR	serving as second messenger
114108	Inositol 1,4,5-trisphosphate	is_part_of	ITPR-IP3 complex	localized in ER membrane; Fas-signaling-induced apoptosis involves the increase of IP3 production, via the activation of PLCG1
114109	Inositol 1,4,5-trisphosphate	increases_activity of	calcium ion import into cytosol	from ER lumen into cytosol; the activation of PLCG1 enhanced Ca2+ release from IP3 receptors, creating an increased intracellar free calcium level; IP3 acts as second messenger
114110	PLCG1	increases_quantity of	Inositol 1,4,5-trisphosphate	in cytosol; PLCG cleaves PIP2 into DAG and IP3
114111	Inositol 1,4,5-trisphosphate	increases_activity of	ITPR	localized in ER membrane; resulting in an enhanced Ca2+ release from IP3 receptors
114129	Inositol 1,4,5-trisphosphate	increases_activity of	tricarboxylic acid cycle	in mitochondria; by increasing mitochondrial matrix Ca2+ concentration

19144519

Metabolic

11,492

114705	Inositol 1,4,5-trisphosphate	increases_activity of	ITPr	generated by phospholipase C (PLC) in response to the activation of various G-protein-coupled receptors (GPCRs) or of tyrosine kinase-linked receptors
114791	Inositol 1,4,5-trisphosphate	increases_activity of	second-messenger-mediated signaling	Ca2+-release through IP3Rs requires binding of the second messenger IP3
114812	PLC	increases_quantity of	Inositol 1,4,5-trisphosphate

18478527

Alzheimer disease

11,493

114722

ATP

increases_activity of

Inositol 1,4,5-trisphosphate

ATP alone was not sufficient to open the IP3-gated channel, but addition of ATP or non-hydrolyzable ATP analogs in the presence of IP3 increased the frequency and average duration of channel openings

7686381

Metabolic

11,523

114998	Phosphatidylinositol-4,5-bisphosphate	increases_quantity of	Inositol 1,4,5-trisphosphate	PIP2 is the precursor of inositol triphosphate (IP3) resulting from cleavage by phospholipase C (PLC)
114999	Inositol 1,4,5-trisphosphate	increases_activity of	calcium ion export from endoplasmic reticulum
115002	PLC	increases_quantity of	Inositol 1,4,5-trisphosphate	when PLC is activated
115060	Inositol 1,4,5-trisphosphate	interacts (colocalizes) with	ITPR
115061	Inositol 1,4,5-trisphosphate	increases_activity of	Calcium-release channel	increased concentration of IP3 triggers the release of Ca2+ from intracellular stores after binding to IP3 receptors

23798435

Metabolic

11,762

116467

Inositol 1,4,5-trisphosphate

increases_activity of

calcium ion import into cytosol

releasing Ca2+ from the intracellular stores through IP3 receptor channels

19422456

Metabolic

14,301

134933

PLCG2-PRKCA complex

increases_quantity of

Inositol 1,4,5-trisphosphate

16923831

Metabolic

15,346

145088	Verapamil	decreases_quantity of	Inositol 1,4,5-trisphosphate	inducing the degradation of aggregate-prone proteins
145089	Loperamide	decreases_quantity of	Inositol 1,4,5-trisphosphate	inducing the degradation of aggregate-prone proteins
145090	Clonidine	decreases_quantity of	Inositol 1,4,5-trisphosphate	inducing the degradation of aggregate-prone proteins
145091	CAST	decreases_quantity of	Inositol 1,4,5-trisphosphate	inducing the degradation of aggregate-prone proteins
145092	Inositol 1,4,5-trisphosphate	decreases_activity of	autophagosome assembly	inducing the degradation of aggregate-prone proteins

Alzheimer disease