|
11,065
|
| 112300 |
neural tube formation
|
|
increases_expression of
|
TMPRSS2
|
in neural tube
|
|
19592578
|
Diarrhea 3, secretory sodium, congenital, syndromic
|
|
11,676
|
| 116032 |
TMPRSS2
|
|
increases_activity of
|
viral entry into host cell
|
by activating the surface protein spike SARS-S to bind to ACE2
|
| 116055 |
TMPRSS2
|
|
affects_activity of
|
ACE2
|
via proteolytic processing to improve SARS-S-driven transduction
|
| 116058 |
TMPRSS2
|
|
increases_activity of
|
viral entry into host cell
|
via proteolytic processing of ACE2
|
| 116572 |
TMPRSS2
|
|
increases_activity of
|
SARS-CoV S protein
|
via proteolytic processing to improve binding to ACE2 and augment SARS-S-driven entry
|
| 117212 |
ADAM17
|
|
affects_activity of
|
TMPRSS2
|
|
| 136192 |
TMPRSS2
|
|
increases_quantity of
|
ACE2, soluble
|
via proteolytic processing to improve SARS-S-driven transduction
|
|
24227843
|
Immunological
SARS-CoV infection
|
|
11,683
|
| 116060 |
Androgen
|
|
increases_expression of
|
TMPRSS2
|
|
|
32301221
|
COVID-19
|
|
11,821
|
| 116762 |
TMPRSS2
|
|
increases_activity of
|
SARS-CoV S protein
|
|
|
32341442
|
COVID-19
|
|
11,827
|
| 116871 |
TMPRSS2
|
|
increases_activity of
|
viral protein processing
|
|
| 116872 |
TMPRSS2
|
|
increases_activity of
|
SARS-CoV-2 S protein
|
|
| 116877 |
Camostat mesilate
|
|
decreases_activity of
|
TMPRSS2
|
in lung cells
|
|
32142651
|
COVID-19
|
|
12,025
|
| 117881 |
Androgen
|
|
increases_expression of
|
TMPRSS2
|
|
|
10485450
|
Cancer
Endocrine
|
|
12,138
|
| 119061 |
Estradiol
|
NOT |
affects_expression of
|
TMPRSS2
|
in bronchial epithelial cells
|
|
32432918
|
COVID-19
|
|
12,185
|
| 119532 |
TMPRSS2
|
|
is_expressed_in
|
alveolar cell type II
|
|
|
32325025
|
COVID-19
|
|
12,207
|
| 119848 |
TMPRSS2
|
|
is_expressed_in
|
enterocyte
|
in small bowel,
in large bowel
|
| 119889 |
TMPRSS2
|
|
affects_activity of
|
ACE2
|
via proteolytic cleavage
|
| 119897 |
TMPRSS2
|
|
is_expressed_in
|
lung
|
|
| 119898 |
TMPRSS2
|
|
is_expressed_in
|
gastrointestinal tract
|
|
| 119899 |
TMPRSS2
|
|
is_expressed_in
|
pancreas
|
|
| 119900 |
TMPRSS2
|
|
is_expressed_in
|
liver
|
|
| 119901 |
Camostat mesilate
|
|
decreases_activity of
|
TMPRSS2
|
|
|
32294179
|
Diabetes mellitus, type II
Insulin resistance
COVID-19
|
|
12,315
|
| 120661 |
smoking
|
NOT |
affects_expression of
|
TMPRSS2
|
in pulmonary tissue
|
|
32329629
|
Inflammation
|
|
12,355
|
| 120948 |
Asthma
|
NOT |
affects_activity of
|
TMPRSS2
|
in sputum
|
| 120953 |
sex, male
|
|
increases_expression of
|
TMPRSS2
|
in sputum of asthma patients
|
| 120954 |
African American race
|
|
increases_expression of
|
TMPRSS2
|
in sputum of asthma patients
|
| 120955 |
Diabetes mellitus
|
|
increases_expression of
|
TMPRSS2
|
in sputum of asthma patients
|
|
32348692
|
Asthma
|
|
14,052
|
| 132828 |
Camostat mesilate
|
|
decreases_activity of
|
TMPRSS2
|
|
|
33188364
|
Diabetes mellitus, type II
Diabetes mellitus, type I
Insulin resistance
COVID-19
|
|
14,062
|
| 132908 |
Androgen
|
|
increases_expression of
|
TMPRSS2
|
|
|
32437244
|
COVID-19
|
|
14,083
|
| 133086 |
TMPRSS2
|
|
is_expressed_in
|
pancreatic islet
|
|
| 133090 |
hyperglycemia
|
NOT |
affects_expression of
|
TMPRSS2
|
in pancreatic islets; drug intake not considered
|
| 133094 |
aging
|
NOT |
affects_expression of
|
TMPRSS2
|
in pancreatic islets; drug intake not considered
|
| 133097 |
Obesity
|
|
increases_expression of
|
TMPRSS2
|
in pancreatic islets; drug intake not considered
|
|
32784802
|
Diabetes mellitus, type II
Insulin resistance
|
|
14,089
|
| 133127 |
aging
|
|
increases_expression of
|
TMPRSS2
|
in the upper and lower airways
|
| 133153 |
Pulmonary disease, chronic obstructive
|
|
increases_expression of
|
TMPRSS2
|
in the upper and lower airways
|
| 133160 |
hypertension
|
|
increases_expression of
|
TMPRSS2
|
in in peripheral blood mononuclear cells
|
| 133161 |
Asthma
|
|
increases_expression of
|
TMPRSS2
|
in in peripheral blood mononuclear cells
|
|
32537478
|
Respiratory
COVID-19
|
|
14,093
|
| 133220 |
TMPRSS2
|
|
is_expressed_in
|
alveolar cell type II
|
in lung
|
| 133222 |
TMPRSS2
|
|
is_expressed_in
|
goblet cell
|
in nose
|
| 133224 |
TMPRSS2
|
|
is_expressed_in
|
cholangiocyte
|
|
| 133226 |
TMPRSS2
|
|
is_expressed_in
|
colonocyte
|
|
| 133228 |
TMPRSS2
|
|
is_expressed_in
|
keratinocyte
|
in esophagus
|
| 133230 |
TMPRSS2
|
|
is_expressed_in
|
intestinal epithelium
|
|
| 133232 |
TMPRSS2
|
|
is_expressed_in
|
pancreatic beta cell
|
|
| 133234 |
TMPRSS2
|
|
is_expressed_in
|
renal proximal tubule
|
|
| 133236 |
TMPRSS2
|
|
is_expressed_in
|
podocyte
|
|
|
32651579
|
COVID-19
|
|
14,156
|
| 133765 |
COVID-19
|
|
increases_expression of
|
TMPRSS2
|
in alveolar epithelial (A549) cells, but not in bronchial epithelial cells
|
|
32664949
|
Pulmonary fibrosis, idiopathic
COVID-19
|
|
14,167
|
| 133869 |
TMPRSS2
|
|
is_expressed_in
|
podocyte
|
together with ACE2
|
| 135740 |
TMPRSS2
|
|
is_expressed_in
|
lung
|
together with ACE2
|
| 135742 |
TMPRSS2
|
|
is_expressed_in
|
small intestine
|
together with ACE2
|
| 135744 |
TMPRSS2
|
|
is_expressed_in
|
colon
|
together with ACE2
|
|
32236644
|
Renal
|
|
14,252
|
| 134532 |
TMPRSS2
|
|
increases_quantity of
|
ACE2, soluble
|
|
| 134533 |
TMPRSS2
|
|
increases_activity of
|
membrane protein ectodomain proteolysis
|
|
|
32669391
|
Diabetes mellitus, type II
Insulin resistance
COVID-19
|
|
14,273
|
| 134685 |
Camostat mesilate
|
|
decreases_activity of
|
TMPRSS2
|
|
|
32208987
|
COVID-19
|
|
14,353
|
| 135332 |
TMPRSS2
|
|
is_expressed_in
|
pancreatic beta cell
|
|
|
33297431
|
Diabetes mellitus, type II
Insulin resistance
COVID-19
|
|
14,393
|
| 135833 |
Chronic kidney disease
|
|
decreases_expression of
|
TMPRSS2
|
in glomeruli
|
|
33125431
|
Renal
Chronic kidney disease
|
|
14,394
|
| 135834 |
Testosterone
|
|
increases_quantity of
|
TMPRSS2
|
|
|
32726128
|
COVID-19
|
|
14,425
|
| 136143 |
TMPRSS2
|
|
increases_activity of
|
viral entry into host cell
|
|
|
33833480
|
COVID-19
|
|
14,431
|
| 136190 |
TMPRSS2
|
|
increases_quantity of
|
ACE2, soluble
|
via proteolytic processing of membrane-bound ACE2
|
| 136191 |
TMPRSS2
|
|
affects_activity of
|
SARS-CoV S protein
|
via proteolytic processing of membrane-bound S protein to improve viral entry
|
|
21068237
|
Endocrine
SARS-CoV infection
|
|
14,437
|
| 136297 |
TMPRSS2
|
|
is_expressed_in
|
enteric neuron
|
in small intestine, in large intestine
|
| 136299 |
TMPRSS2
|
|
is_expressed_in
|
glial cell
|
in small intestine, in large intestine
|
| 136301 |
TMPRSS2
|
|
is_expressed_in
|
choroid plexus epithelium
|
|
|
33122999
|
COVID-19
|
|
14,454
|
| 136422 |
ACE2
|
|
interacts (colocalizes) with
|
TMPRSS2
|
|
|
21068237
|
SARS-CoV infection
|
CIDeRplus