|
66
|
| 200 |
RPS6KB1
|
|
decreases_activity of
|
GSK3B
|
by phosphorylation at Ser9
|
| 203 |
RPS6KB1
|
|
affects_phosphorylation of
|
GSK3B
|
at Ser9
|
| 12858 |
RPS6KB1
|
|
increases_quantity of
|
GSK3B-phosSer9
|
|
|
8250835
|
Alzheimer disease
|
|
598
|
| 12912 |
high-phytoestrogen soy-based diet
|
|
affects_phosphorylation of
|
RPS6KB1
|
at Thr389 of RPS6KB1
|
|
18420492
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
1,467
|
| 10439 |
IL6
|
|
increases_activity of
|
RPS6KB1
|
in liver
|
| 10441 |
RPS6KB1
|
NOT |
affects_activity of
|
insulin receptor signaling pathway
|
in liver
|
|
17993646
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,146
|
| 17904 |
Metabolic syndrome
|
|
decreases_quantity of
|
RPS6KB1
|
|
|
20809949
|
Diabetes mellitus, type II
Insulin resistance
Metabolic syndrome
|
|
2,253
|
| 19258 |
PDPK1
|
|
increases_activity of
|
RPS6KB1
|
|
|
12040186
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,814
|
| 26021 |
MTOR
|
|
increases_activity of
|
RPS6KB1
|
|
|
21912508
|
Diabetes mellitus, type II
Cancer
Insulin resistance
Metabolic syndrome
|
|
2,843
|
| 26211 |
Metformin
|
|
decreases_phosphorylation of
|
RPS6KB1
|
|
|
18006825
|
Diabetes mellitus, type II
Cancer
Insulin resistance
|
|
2,904
|
| 26635 |
AMPK
|
|
decreases_activity of
|
RPS6KB1
|
|
|
17062558
|
Breast cancer
Diabetes mellitus, type II
Insulin resistance
|
|
3,762
|
| 36616 |
Insulin
|
|
increases_phosphorylation of
|
RPS6KB1
|
|
| 36617 |
Homocysteine thiolactone
|
|
decreases_phosphorylation of
|
RPS6KB1
|
after insulin stimulation
|
| 36618 |
Glutathione
|
|
increases_phosphorylation of
|
RPS6KB1
|
after homocysteine thiolactone incubation
|
|
15691882
|
Diabetes mellitus, type II
Insulin resistance
|
|
3,773
|
| 36863 |
SLC2A4
|
|
affects_activity of
|
RPS6KB1
|
in adipose tissue; if stimulated by insulin
|
|
20093359
|
Diabetes mellitus, type II
Insulin resistance
|
|
3,795
|
| 37640 |
mTORC1 complex
|
|
increases_activity of
|
RPS6KB1
|
via phosphorylation
|
| 37655 |
RPS6KB1
|
|
increases_activity of
|
cell growth
|
|
| 37662 |
mTORC1 complex
|
|
increases_phosphorylation of
|
RPS6KB1
|
at Thr389/412 of RPS6KB1
|
| 37695 |
Amino acid
|
|
increases_activity of
|
RPS6KB1
|
|
| 37696 |
Insulin
|
|
increases_activity of
|
RPS6KB1
|
|
|
18765678
|
Diabetes mellitus, type II
Insulin resistance
|
|
3,804
|
| 37863 |
Insulin
|
|
increases_phosphorylation of
|
RPS6KB1
|
in muscle, in liver
|
| 37864 |
high-fat diet
|
|
decreases_phosphorylation of
|
RPS6KB1
|
in liver; after insulin stimulation
|
| 37865 |
high-fat diet
|
|
increases_phosphorylation of
|
RPS6KB1
|
in muscle; after insulin stimulation
|
| 37867 |
leucine supplementation
|
|
increases_phosphorylation of
|
RPS6KB1
|
in muscle, in liver; in mice on high-fat diet
|
|
21731668
|
Diabetes mellitus, type II
Insulin resistance
Fatty liver disease, nonalcoholic
|
|
4,719
|
| 46982 |
RPS6KB1
|
|
increases_phosphorylation of
|
GRIA1
|
at Thr840;
|
|
21441996
|
Neurological
|
|
4,802
|
| 47501 |
Amino acid
|
|
increases_phosphorylation of
|
RPS6KB1
|
in liver
|
| 47505 |
Glucagon
|
|
decreases_phosphorylation of
|
RPS6KB1
|
in liver
|
|
15494402
|
Diabetes mellitus, type II
Insulin resistance
|
|
4,843
|
| 47844 |
FGF7
|
|
increases_activity of
|
RPS6KB1
|
|
|
16162944
|
Diabetes mellitus, type II
Insulin resistance
|
|
5,253
|
| 51220 |
CYP1A1
|
|
affects_phosphorylation of
|
RPS6KB1
|
in MCF-7 and MDA-MB-231 breast cancer cell lines
|
|
23576571
|
Breast cancer
Diabetes mellitus, type II
Insulin resistance
|
|
5,315
|
| 52022 |
RPS6KB1
|
|
affects_activity of
|
translational initiation
|
by phosphorylating the S6 protein of the 40 S ribosomal subunit and by stimulating eIF-4A helicase activity.
|
| 52023 |
RPS6KB1
|
|
increases_activity of
|
eukaryotic translation initiation factor 4F complex
|
by stimulating eIF-4A helicase activity;
|
|
19150980
|
Metabolic
|
|
5,423
|
| 52911 |
RPS6KB1
|
|
increases_phosphorylation of
|
GSK3B
|
|
| 52912 |
RPS6KB1
|
|
decreases_activity of
|
GSK3B
|
|
|
17052453
|
Metabolic
|
|
5,449
|
| 53210 |
hyperglycemia
|
|
increases_activity of
|
RPS6KB1
|
via MTOR-mediated phosphorylation
|
|
16344552
|
Diabetes mellitus, type II
Insulin resistance
|
|
6,069
|
| 56797 |
NIBAN1
|
|
increases_phosphorylation of
|
RPS6KB1
|
|
|
17588536
|
Metabolic
Renal cell carcinoma
|
|
6,195
|
| 57980 |
mTORC1 complex
|
|
increases_phosphorylation of
|
RPS6KB1
|
|
|
23625692
|
Glioblastoma
|
|
6,204
|
| 57875 |
RPS6KB1
|
|
affects_activity of
|
HDAC1
|
via controlling HDAC1 recruitment to the ERalpha promoter
|
| 57876 |
RPS6KB1
|
|
affects_expression of
|
ESR1
|
via HDAC1 and upon mitogenic stimuli, if overexpressed in breast cancer.
|
| 58082 |
Breast cancer
|
|
increases_expression of
|
RPS6KB1
|
|
| 58083 |
Rapamycin
|
|
decreases_phosphorylation of
|
RPS6KB1
|
|
| 58084 |
Rapamycin
|
|
decreases_activity of
|
RPS6KB1
|
|
| 58121 |
Anisomycin
|
|
increases_activity of
|
RPS6KB1
|
|
| 58145 |
RPS6KB1
|
|
increases_phosphorylation of
|
HDAC1
|
on serine 421 or 423.
|
|
25801958
|
Breast cancer
|
|
6,238
|
| 58533 |
MTOR
|
|
increases_phosphorylation of
|
RPS6KB1
|
|
| 58535 |
PHLPP1
|
|
decreases_phosphorylation of
|
RPS6KB1
|
|
| 58540 |
RPS6KB1
|
|
increases_activity of
|
translation
|
|
|
23408427
|
Metabolic
|
|
6,262
|
| 58639 |
Entinostat
|
|
decreases_phosphorylation of
|
RPS6KB1
|
in leukemia cells
|
|
18784743
|
Leukemia, acute myeloid
|
|
6,267
|
| 58988 |
Rapamycin
|
|
decreases_activity of
|
RPS6KB1
|
|
|
15448035
|
Cancer
|
|
6,272
|
| 58654 |
Rapamycin
|
|
decreases_phosphorylation of
|
RPS6KB1
|
in U251 and T98G glioma cells
|
| 58656 |
PI3K/mTOR inhibitor PI103
|
|
decreases_phosphorylation of
|
RPS6KB1
|
in U251, U87 and T98G glioma cells
|
|
24418474
|
Glioblastoma
|
|
6,273
|
| 58680 |
Rapamycin
|
|
decreases_phosphorylation of
|
RPS6KB1
|
in MDA-MB-231 breast cancer cells, in U251 glioma cells; at Thr389
|
| 58683 |
mTOR inhibitor PP242
|
|
decreases_phosphorylation of
|
RPS6KB1
|
in MDA-MB-231 breast cancer cells, in U251 glioma cells; at Thr389
|
|
23730416
|
Breast cancer
Glioblastoma
|
|
6,283
|
| 58801 |
Glioblastoma
|
|
increases_activity of
|
RPS6KB1
|
via phosphorylation
|
|
15143086
|
Glioblastoma
|
|
6,303
|
| 60415 |
caloric restriction diet
|
|
decreases_activity of
|
RPS6KB1
|
|
|
26135885
|
Metabolic
|
|
6,331
|
| 59398 |
HTR2B
|
|
increases_activity of
|
RPS6KB1
|
|
|
20099302
|
Hepatocellular carcinoma
|
CIDeRplus