|
1,987
|
| 15593 |
fat cell differentiation
|
|
increases_expression of
|
REN
|
in adipose tissue
|
|
12031955
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,009
|
| 15947 |
REN
|
|
increases_activity of
|
renin-angiotensin system
|
in Ren-2 rats
|
| 15948 |
REN
|
|
increases_activity of
|
hypertension
|
in Ren-2 rats
|
| 15950 |
REN
|
|
increases_quantity of
|
Angiotensin II
|
in Ren-2 rats
|
| 15951 |
REN
|
|
increases_activity of
|
Insulin resistance
|
in Ren-2 rats
|
|
15494608
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,020
|
| 16002 |
hypertension
|
|
increases_expression of
|
REN
|
in adipose tissue; in obese probands
|
| 16007 |
Cortisol
|
NOT |
affects_expression of
|
REN
|
in adipose tissue
|
| 16011 |
Insulin
|
NOT |
affects_expression of
|
REN
|
in adipose tissue
|
| 16016 |
Estradiol
|
NOT |
affects_expression of
|
REN
|
in adipose tissue
|
| 16021 |
Triiodothyronine
|
NOT |
affects_expression of
|
REN
|
in adipose tissue
|
| 16026 |
Angiotensin II
|
NOT |
affects_expression of
|
REN
|
in adipose tissue
|
|
12011658
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
2,036
|
| 16170 |
REN
|
|
increases_activity of
|
NADPH oxidase complex
|
in aorta; in Ren-2 rats
|
| 16176 |
REN
|
|
increases_quantity of
|
Reactive oxygen species
|
in aorta; in Ren-2 rats
|
| 16178 |
REN
|
|
increases_expression of
|
CRP
|
in aorta; in Ren-2 rats
|
| 16179 |
REN
|
|
increases_expression of
|
TNF
|
in aorta; in Ren-2 rats
|
| 16180 |
REN
|
|
increases_activity of
|
apoptotic process
|
in aorta; in Ren-2 rats
|
| 16193 |
REN
|
|
decreases_activity of
|
AKT1
|
in aorta; after insulin stimulation, in Ren-2 rats
|
| 16194 |
REN
|
|
decreases_activity of
|
NOS3
|
in aorta; after insulin stimulation, in Ren-2 rats
|
|
17533199
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,037
|
| 16201 |
REN
|
|
increases_activity of
|
response to oxidative stress
|
in skeletal muscle; in Ren-2 rats
|
| 16202 |
REN
|
|
increases_activity of
|
NF-kappaB complex
|
in skeletal muscle; in Ren-2 rats
|
| 16203 |
REN
|
|
increases_expression of
|
TNF
|
in skeletal muscle; in Ren-2 rats
|
|
18073321
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,129
|
| 17498 |
obese Zucker rat
|
|
increases_quantity of
|
REN
|
|
| 17506 |
Nebivolol
|
|
decreases_quantity of
|
REN
|
in obese Zucker rats
|
|
21177830
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,156
|
| 18056 |
Insulin
|
NOT |
affects_activity of
|
REN
|
|
| 18057 |
Glucose
|
NOT |
affects_activity of
|
REN
|
|
|
16303859
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,172
|
| 18187 |
Obesity
|
NOT |
affects_expression of
|
REN
|
in adipose tissue, in kidney
|
|
15191907
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
2,177
|
| 18214 |
REN
|
|
increases_activity of
|
renin-angiotensin regulation of aldosterone production
|
|
| 18215 |
REN
|
|
increases_quantity of
|
Aldosterone
|
|
| 18216 |
REN
|
|
increases_activity of
|
hypertension
|
|
| 18217 |
REN
|
|
increases_activity of
|
Insulin resistance
|
|
| 18218 |
REN
|
|
increases_activity of
|
NADPH oxidase complex
|
in soleus muscle
|
| 18219 |
REN
|
|
increases_quantity of
|
Reactive oxygen species
|
in soleus muscle
|
| 18220 |
REN
|
|
decreases_phosphorylation of
|
IRS1
|
in soleus muscle; at Tyr residues of IRS1
|
| 18221 |
REN
|
|
decreases_activity of
|
AKT1
|
in soleus muscle; via reduced phosphorylation
|
| 18222 |
REN
|
|
decreases_expression of
|
SLC2A4
|
in soleus muscle
|
|
18445755
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,218
|
| 18718 |
Hydrochlorothiazide
|
|
increases_quantity of
|
REN
|
in blood
|
| 18725 |
Candesartan
|
|
increases_quantity of
|
REN
|
in blood
|
|
18981327
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
3,131
|
| 28875 |
LEP
|
NOT |
affects_activity of
|
REN
|
in blood plasma
|
| 28906 |
fasting
|
|
increases_activity of
|
REN
|
in blood plasma
|
|
16714386
|
Diabetes mellitus, type II
Insulin resistance
|
|
3,251
|
| 29978 |
total sleep deprivation (TSD)
|
|
increases_quantity of
|
REN
|
|
|
16453251
|
Major depressive disorder
Circadian rhythm
|
|
5,014
|
| 49524 |
Atenolol
|
|
decreases_activity of
|
REN
|
in blood plasma
|
| 49525 |
Bisoprolol
|
|
decreases_activity of
|
REN
|
in blood plasma
|
|
10678541
|
Diabetes mellitus, type II
Insulin resistance
|
|
6,524
|
| 62742 |
Polycystic ovary syndrome 1
|
|
increases_activity of
|
REN
|
in blood plasma
|
|
19056992
|
Diabetes mellitus, type II
Insulin resistance
Polycystic ovary syndrome 1
|
|
7,731
|
| 77310 |
Calcitriol
|
|
decreases_expression of
|
REN
|
|
| 77313 |
Diabetes mellitus, type I
|
|
decreases_activity of
|
REN
|
in blood plasma
|
|
26971351
|
Diabetes mellitus, type II
Insulin resistance
Cardiovascular disease
Chronic kidney disease
|
|
8,411
|
| 85585 |
REN
|
|
interacts (colocalizes) with
|
IGF2R
|
|
| 85586 |
REN
|
|
increases_activity of
|
endocytosis
|
via binding to the the
IGF-II/M6P receptor (=IGF2R)
|
| 85588 |
REN
|
|
increases_activity of
|
proteolytic activation
|
via binding to the the
IGF-II/M6P receptor (=IGF2R)
|
| 85589 |
REN
|
|
increases_activity of
|
proteolytic degradation
|
via binding to the the
IGF-II/M6P receptor (=IGF2R)
|
|
26993302
|
Alzheimer disease
Metabolic
|
|
8,590
|
| 88710 |
HFE
|
|
affects_expression of
|
REN
|
in retina
|
| 88712 |
increased iron level
|
|
increases_expression of
|
REN
|
in retina
|
|
29445185
|
Diabetes mellitus, type II
Insulin resistance
Retinopathy, diabetic
|
|
9,551
|
| 101280 |
VAV2
|
|
affects_quantity of
|
REN
|
|
|
17202406
|
Cardiovascular disease
|
|
10,961
|
| 111602 |
SLC9A3
|
|
affects_expression of
|
REN
|
|
|
9662405
|
Diarrhea 8, secretory sodium, congenital
|
|
11,717
|
| 116397 |
REN
|
|
increases_activity of
|
renin-angiotensin system
|
|
| 116400 |
Aliskiren
|
|
decreases_activity of
|
REN
|
|
|
30404071
|
Diabetes mellitus, type II
Insulin resistance
|
|
11,748
|
| 116294 |
kidney
|
|
increases_quantity of
|
REN
|
|
|
32333398
|
COVID-19
|
|
11,776
|
| 116576 |
REN
|
|
decreases_quantity of
|
Angiotensinogen
|
|
| 116577 |
REN
|
|
increases_quantity of
|
Angiotensin I
|
|
|
23463883
|
Diabetes mellitus, type II
Insulin resistance
Cardiovascular disease
|
|
12,012
|
| 117695 |
extracellular exosome
|
|
increases_expression of
|
REN
|
in cardiomyocytes; exosomes derived from cardiac fibroblasts
|
|
26497614
|
Cardiovascular disease
|
|
12,020
|
| 117795 |
REN
|
|
decreases_quantity of
|
Angiotensinogen
|
in blood plasma
|
| 117796 |
REN
|
|
increases_quantity of
|
Angiotensin I
|
in blood plasma
|
| 117797 |
REN
|
|
is_expressed_in
|
juxtaglomerular cell
|
in kidney
|
|
30934934
|
Diabetes mellitus, type II
Insulin resistance
Cardiovascular disease
|
|
12,024
|
| 117865 |
REN
|
|
increases_activity of
|
RENBP
|
|
| 117873 |
REN
|
|
increases_activity of
|
IGF2R
|
|
| 117874 |
REN
|
|
increases_activity of
|
ATP6AP2
|
|
| 117875 |
RENBP
|
|
decreases_activity of
|
REN
|
|
| 117878 |
IGF2R
|
|
increases_activity of
|
REN
|
|
| 117880 |
ATP6AP2
|
|
increases_activity of
|
REN
|
|
| 117885 |
REN
|
|
is_expressed_in
|
blood vessel wall
|
|
| 117887 |
REN
|
|
is_expressed_in
|
heart
|
|
| 117888 |
REN
|
|
is_expressed_in
|
adipose tissue
|
|
| 117889 |
REN
|
|
is_expressed_in
|
eye
|
|
| 117915 |
REN
|
NOT |
affects_quantity of
|
Angiotensin (1-12)
|
|
|
30934934
|
Diabetes mellitus, type II
Insulin resistance
Cardiovascular disease
|
|
12,056
|
| 118225 |
REN
|
|
decreases_quantity of
|
Angiotensinogen
|
in blood; via classical renin-angiotensin system
|
| 118256 |
REN
|
|
increases_quantity of
|
Angiotensin I
|
in blood; via classical renin-angiotensin system
|
| 118283 |
ATP6AP2
|
|
interacts (colocalizes) with
|
REN
|
|
| 118284 |
ATP6AP2
|
|
increases_activity of
|
REN
|
|
|
19065996
|
Diabetes mellitus, type II
Insulin resistance
|
|
12,064
|
| 118427 |
Nephropathy, diabetic
|
|
increases_quantity of
|
REN
|
in kidney
|
| 118428 |
Nephropathy, diabetic
|
|
decreases_quantity of
|
REN
|
in blood plasma
|
| 118435 |
REN
|
|
is_expressed_in
|
adipose tissue
|
|
|
19065996
|
Diabetes mellitus, type II
Insulin resistance
|
|
12,194
|
| 119752 |
REN
|
|
is_expressed_in
|
astrocyte
|
|
| 119753 |
REN
|
|
is_expressed_in
|
neuron
|
|
|
32127770
|
Neurodegenerative disorder
|
|
12,279
|
| 120458 |
Vitamin D
|
|
decreases_expression of
|
REN
|
|
|
32613681
|
COVID-19
|
|
12,285
|
| 120470 |
Lipopolysaccharide
|
|
increases_expression of
|
REN
|
in pulmonary microvascular endothelial cells
|
| 120472 |
Calcitriol
|
|
decreases_expression of
|
REN
|
in pulmonary microvascular endothelial cells
|
|
28944831
|
Lung disease
|
CIDeRplus