|
1,252
|
| 8470 |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
|
|
increases_activity of
|
PARP1
|
in dopaminergic neurons
|
|
19616617
|
Parkinson disease
|
|
1,253
|
| 8478 |
PARP1
|
|
increases_activity of
|
base-excision repair
|
|
| 8480 |
cellular response to DNA damage stimulus
|
|
increases_activity of
|
PARP1
|
|
|
19616617
|
Parkinson disease
|
|
6,121
|
| 57324 |
Phentolamine
|
|
increases_activity of
|
PARP1
|
|
|
26180030
|
Cancer
|
|
6,274
|
| 58694 |
NOTCH1
|
|
increases_expression of
|
PARP1
|
in U251 glioma cells
|
|
20372862
|
Glioblastoma
|
|
6,456
|
| 61405 |
Metformin
|
|
increases_activity of
|
PARP1
|
|
| 61406 |
PARP1
|
|
increases_activity of
|
apoptotic process
|
|
|
22117616
|
Diabetes mellitus, type II
Cancer
Insulin resistance
|
|
6,612
|
| 63061 |
NR1H4
|
|
interacts (colocalizes) with
|
PARP1
|
|
|
|
Diabetes mellitus, type II
Insulin resistance
|
|
6,721
|
| 65141 |
NAD+
|
|
increases_activity of
|
PARP1
|
|
| 65145 |
PARP1
|
|
affects_activity of
|
CLOCK
|
|
| 65147 |
PARP1
|
|
affects_activity of
|
Core clock complex
|
|
|
22841001
|
Diabetes mellitus, type II
Insulin resistance
|
|
6,747
|
| 65502 |
Hydroxyl radical
|
|
increases_expression of
|
PARP1
|
|
| 65505 |
PARP1
|
|
decreases_activity of
|
GAPDH
|
|
| 65506 |
PARP1
|
|
decreases_quantity of
|
NAD+
|
|
| 65565 |
PARP1
|
|
increases_activity of
|
NFAT
|
in the nucleus
|
| 65566 |
hyperglycemia
|
|
increases_activity of
|
PARP1
|
|
|
27230643
|
Diabetes mellitus, type II
Insulin resistance
Cardiomyopathy, diabetic
|
|
6,901
|
| 68128 |
Resveratrol
|
|
increases_activity of
|
PARP1
|
|
|
26706021
|
Diabetes mellitus, type II
Insulin resistance
Major depressive disorder
|
|
7,092
|
| 69791 |
ZNF423
|
|
interacts (colocalizes) with
|
PARP1
|
|
| 69792 |
ZNF423-p.P506fsX43
|
NOT |
interacts (colocalizes) with
|
PARP1
|
|
|
|
Senior-Loken syndrome 7
Nephronophthisis 14
Nephronophthisis 15
Ciliopathy
|
|
7,102
|
| 69885 |
ZNF423
|
|
interacts (colocalizes) with
|
PARP1
|
|
|
|
Nephronophthisis
Ciliopathy
|
|
7,103
|
| 70002 |
ZNF423
|
|
interacts (colocalizes) with
|
PARP1
|
|
|
|
Nephronophthisis
Ciliopathy
|
|
9,101
|
| 95462 |
PARP1
|
|
increases_activity of
|
response to cytosolic NAD+ depletion
|
via overactivation of PARP1
|
| 95541 |
PARP1
|
|
decreases_activity of
|
canonical glycolysis
|
via overactivation of PARP1,depletion of NAD+, inhibition of glycolysis, leading to sustained energy failure and ultimately cell death
|
| 95542 |
PARP1
|
|
increases_activity of
|
abnormal energy homeostasis
|
via overactivation of PARP1 and depletion of NAD+, inhibition of glycolysis, leading to sustained energy failure and ultimately cell death
|
| 95543 |
PARP1
|
|
increases_activity of
|
energy failure
|
via overactivation of PARP1,depletion of NAD+, inhibition of glycolysis, leading to sustained energy failure and ultimately cell death
|
| 95544 |
PARP1
|
|
increases_activity of
|
cell death
|
via overactivation of PARP1,depletion of NAD+, inhibition of glycolysis, leading to sustained energy failure and ultimately cell death
|
|
29967007
|
Alzheimer disease
Metabolic
|
|
9,624
|
| 101652 |
PARP1
|
|
affects_activity of
|
Cardiovascular disease
|
|
| 101654 |
PARP1
|
|
increases_activity of
|
FOXO3
|
|
|
30323296
|
Cardiovascular disease
|
|
9,791
|
| 103518 |
TRIM37
|
|
affects_activity of
|
PARP1
|
in osteosarcoma cell lines
|
|
29163677
|
Cancer
Mulibrey nanism
|
|
10,045
|
| 104921 |
CASZ1b
|
|
interacts (colocalizes) with
|
PARP1
|
|
|
26296975
|
Cardiovascular disease
|
|
12,479
|
| 121658 |
OARD1
|
|
affects_activity of
|
PARP1
|
|
|
23481255
|
Neurodegenerative disorder
|
|
14,597
|
| 137385 |
CASP3
|
|
decreases_activity of
|
PARP1
|
via cleavage
|
|
|
Cancer
Developmental
|
|
15,722
|
| 149287 |
NMNAT1
|
|
affects_activity of
|
PARP1
|
|
|
|
Ciliopathy
|
|
15,733
|
| 149401 |
RD3
|
|
affects_activity of
|
PARP1
|
|
|
|
Leber congenital amaurosis
Ciliopathy
|
|
16,351
|
| 157419 |
Systemic lupus erythematosus
|
|
decreases_activity of
|
PARP1
|
|
|
|
Systemic lupus erythematosus
|
|
16,358
|
| 157428 |
PARP1
|
|
affects_activity of
|
Coeliac disease
|
|
|
|
Immunological
|
|
16,372
|
| 157628 |
cardiac aging
|
|
decreases_quantity of
|
PARP1
|
|
|
|
Cardiovascular disease
|
|
16,383
|
| 157498 |
Diabetes mellitus, type I
|
|
increases_expression of
|
PARP1
|
in diabetic hearts.
|
|
|
Diabetes mellitus, type I
|
CIDeRplus