|
1,592
|
| 11519 |
inflammatory response
|
|
increases_expression of
|
NOD2
|
|
| 11616 |
NOD2
|
|
affects_activity of
|
inflammatory response
|
|
|
20816778
|
Diabetes mellitus, type II
Insulin resistance
|
|
6,009
|
| 56320 |
ACAP1
|
|
interacts (colocalizes) with
|
NOD2
|
in HEK293 cells, as well as in SW480 and HT-29 intestinal epithelial cells
|
| 56328 |
NOD2
|
|
affects_activity of
|
RELA
|
|
|
17005562
|
Inflammatory bowel disease 1
|
|
6,815
|
| 66233 |
NOD2
|
|
affects_activity of
|
Inflammatory bowel disease 1
|
|
|
11385576
|
Inflammatory bowel disease 1
|
|
6,817
|
| 66281 |
NOD2
|
|
is_expressed_in
|
monocyte
|
|
| 66285 |
NOD2
|
|
increases_activity of
|
NF-kappaB complex
|
in HEK293T cells
|
| 66312 |
NOD2
|
|
interacts (colocalizes) with
|
RIPK2
|
in HEK293T cells
|
|
11087742
|
Metabolic
Inflammation
|
|
6,818
|
| 66307 |
NOD2
|
|
increases_activity of
|
NF-kappaB complex
|
together with IKKgamma
|
| 66309 |
NOD2
|
|
increases_activity of
|
NF-kappaB complex
|
together with IKKgamma
|
|
11087742
|
Metabolic
|
|
6,819
|
| 66316 |
NOD2
|
|
is_expressed_in
|
B-lymphocyte
|
|
| 66321 |
NOD2
|
|
increases_expression of
|
NFKB1
|
in B lymphocytes
|
|
23709157
|
Inflammatory bowel disease 1
Inflammatory bowel disease
|
|
6,925
|
| 67671 |
NOD2
|
|
affects_activity of
|
Inflammatory bowel disease 1
|
|
| 67672 |
NOD2
|
|
affects_activity of
|
innate immune response
|
|
| 67673 |
NOD2
|
|
increases_quantity of
|
Reactive oxygen species
|
|
| 67674 |
NOD2
|
|
affects_activity of
|
autophagy
|
|
| 67675 |
NOD2
|
|
affects_activity of
|
antimicrobial peptide production
|
|
| 68334 |
NOD2
|
|
affects_activity of
|
autophagy
|
|
|
21677747
|
Inflammatory bowel disease 1
Inflammatory bowel disease
|
|
6,949
|
| 67920 |
NOD2
|
|
affects_activity of
|
Inflammatory bowel disease 1
|
|
|
24137163
|
Inflammatory bowel disease 1
|
|
6,950
|
| 67922 |
NOD2
|
|
affects_activity of
|
Inflammasome
|
|
|
24740681
|
Inflammatory bowel disease 1
Inflammatory bowel disease
|
|
6,954
|
| 67957 |
CARD9
|
|
interacts (colocalizes) with
|
NOD2
|
|
|
17187069
|
Inflammation
|
|
6,957
|
| 68002 |
NOD2
|
|
is_expressed_in
|
paneth cell
|
|
|
26287588
|
Inflammatory bowel disease 1
|
|
6,972
|
| 68383 |
NOD2
|
|
interacts (colocalizes) with
|
RIPK2
|
if NOD2 has been activated by N-acetyl muramyl dipeptide (MDP), a component of bacterial peptidoglycan.
|
| 68388 |
NOD2
|
|
is_part_of
|
NOD2-RIPK2
|
|
| 68919 |
Peptidoglycan
|
|
increases_activity of
|
NOD2
|
|
|
21252204
|
Inflammatory bowel disease
|
|
7,038
|
| 68883 |
TRIM22
|
|
interacts (colocalizes) with
|
NOD2
|
|
|
26836588
|
Inflammatory bowel disease
|
|
7,039
|
| 68885 |
TRIM22
|
|
interacts (colocalizes) with
|
NOD2
|
in HT29 cells (human intestinal epithelial cell line)
|
| 68886 |
TRIM22 rs187416296
|
NOT |
interacts (colocalizes) with
|
NOD2
|
in HT29 cells (human intestinal epithelial cell line)
|
| 68887 |
TRIM22 rs200924168
|
NOT |
interacts (colocalizes) with
|
NOD2
|
in HT29 cells (human intestinal epithelial cell line)
|
| 68888 |
TRIM22 rs61735273
|
NOT |
interacts (colocalizes) with
|
NOD2
|
in HT29 cells (human intestinal epithelial cell line)
|
| 68889 |
TRIM22 rs12364019
|
NOT |
interacts (colocalizes) with
|
NOD2
|
in HT29 cells (human intestinal epithelial cell line)
|
| 68892 |
TRIM22
|
|
increases_ubiquitination/sumoylation of
|
NOD2
|
in HEK293 cells
|
| 68893 |
TRIM22 rs187416296
|
NOT |
increases_ubiquitination/sumoylation of
|
NOD2
|
in HEK293 cells
|
| 68894 |
TRIM22 rs200924168
|
NOT |
increases_ubiquitination/sumoylation of
|
NOD2
|
in HEK293 cells
|
| 68895 |
TRIM22 rs61735273
|
NOT |
increases_ubiquitination/sumoylation of
|
NOD2
|
in HEK293 cells
|
| 68896 |
TRIM22 rs12364019
|
NOT |
increases_ubiquitination/sumoylation of
|
NOD2
|
in HEK293 cells
|
|
26836588
|
Inflammation
|
|
7,073
|
| 69561 |
NOD2
|
|
interacts (colocalizes) with
|
ATG16L1
|
in HeLa cells
|
|
|
Inflammatory bowel disease
Inflammation
|
|
11,986
|
| 117564 |
NOD2
|
|
affects_activity of
|
Parkinson disease
|
|
|
31920912
|
Parkinson disease
|
|
12,885
|
| 123533 |
ZDHHC5
|
|
affects_activity of
|
NOD2
|
via palmitoylation
|
|
31649195
|
Inflammatory bowel disease
|
|
15,611
|
| 147962 |
ZDHHC5
|
|
affects_activity of
|
NOD2
|
via palmitoylation
|
|
|
Cardiovascular disease
|
|
15,672
|
| 148479 |
NOD2
|
|
affects_activity of
|
Blau syndrome
|
|
| 148480 |
NOD2
|
|
affects_activity of
|
granulomatous arthritis, early-onset
|
|
| 148481 |
NOD2
|
|
affects_activity of
|
uveitis
|
|
| 148482 |
NOD2
|
|
affects_activity of
|
skin rash
|
|
| 148483 |
NOD2
|
|
affects_activity of
|
camptodactyly
|
|
|
|
Developmental disorder
|
CIDeRplus