|
151
|
| 582 |
SOD1-p.G85R
|
|
increases_phosphorylation of
|
MAPK8
|
if mutant SOD1 is over-expressed
|
| 585 |
SOD1-p.G93A
|
|
increases_phosphorylation of
|
MAPK8
|
if mutant SOD1 is over-expressed
|
|
18233996
|
Amyotrophic lateral sclerosis
|
|
320
|
| 1389 |
MAPK8
|
|
increases_expression of
|
VEGFA
|
|
|
16964394
|
Amyotrophic lateral sclerosis
|
|
350
|
| 1411 |
FAS
|
NOT |
increases_activity of
|
MAPK8
|
in Fas-activated motoneurons
|
|
12354397
|
Amyotrophic lateral sclerosis
|
|
368
|
| 12623 |
HSPA5
|
|
affects_activity of
|
MAPK8
|
|
|
19363290
|
Diabetes mellitus, type II
Obesity
Insulin resistance
Fatty liver disease, nonalcoholic
|
|
468
|
| 2247 |
Metformin
|
|
decreases_expression of
|
MAPK8
|
in liver
|
|
15561958
|
Diabetes mellitus, type II
Insulin resistance
|
|
469
|
| 2141 |
Parkinson disease
|
|
decreases_phosphorylation of
|
MAPK8
|
|
| 2142 |
Parkinson disease
|
NOT |
decreases_quantity of
|
MAPK8
|
|
|
17385669
|
Parkinson disease
|
|
692
|
| 3801 |
Tunicamycin
|
|
increases_activity of
|
MAPK8
|
|
| 3807 |
L-Azetidine 2-carboxylic acid
|
|
increases_activity of
|
MAPK8
|
|
|
15201339
|
Amyotrophic lateral sclerosis
|
|
693
|
| 3798 |
Tunicamycin
|
|
increases_activity of
|
MAPK8
|
|
|
15201339
|
Amyotrophic lateral sclerosis
|
|
737
|
| 4148 |
6-OHDA
|
|
increases_phosphorylation of
|
MAPK8
|
|
| 4151 |
SP600125
|
|
decreases_activity of
|
MAPK8
|
|
|
18665912
|
Parkinson disease
|
|
741
|
| 4182 |
Anisomycin
|
|
increases_activity of
|
MAPK8
|
|
| 4183 |
MAPK8
|
|
increases_activity of
|
microtubule cytoskeleton organization
|
|
| 4186 |
MAPK8
|
|
increases_phosphorylation of
|
JUN
|
|
| 4187 |
DVL
|
|
increases_activity of
|
MAPK8
|
|
| 4188 |
MAPK8
|
|
increases_activity of
|
microtubule cytoskeleton organization
|
|
|
17608927
|
Neurological
|
|
915
|
| 5529 |
PRKN
|
|
decreases_activity of
|
MAPK8
|
|
| 5532 |
PARK2-mut
|
NOT |
decreases_activity of
|
MAPK8
|
|
| 5538 |
MAPK8
|
|
increases_phosphorylation of
|
JUN
|
|
| 5541 |
MAPK8
|
|
increases_activity of
|
JUN
|
by phosphorylation
|
| 13614 |
MAPK8
|
|
increases_activity of
|
JNK cascade
|
|
|
18845538
|
Parkinson disease
|
|
964
|
| 6113 |
MAPK8
|
|
increases_phosphorylation of
|
IRS1
|
at Ser312 of IRS1
|
| 6331 |
Diabetes mellitus, type II
|
|
increases_phosphorylation of
|
MAPK8
|
in muscle, in adipose tissue
|
|
19041393
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
966
|
| 5985 |
response to endoplasmic reticulum stress
|
|
increases_phosphorylation of
|
MAPK8
|
|
|
15339911
|
Amyotrophic lateral sclerosis
|
|
989
|
| 6162 |
MAPK8
|
|
increases_activity of
|
neuron death
|
induced by Paraquat
|
|
20202476
|
Parkinson disease
|
|
1,039
|
| 6532 |
Alzheimer disease
|
|
increases_expression of
|
MAPK8
|
|
|
19712581
|
Alzheimer disease
Down syndrome
|
|
1,078
|
| 6811 |
LRRK2
|
NOT |
increases_phosphorylation of
|
MAPK8
|
|
|
20074637
|
Parkinson disease
|
|
1,086
|
| 6922 |
Lipopolysaccharide
|
|
increases_phosphorylation of
|
MAPK8
|
|
|
19276172
|
Parkinson disease
|
|
1,092
|
| 6983 |
MAPK8
|
|
increases_phosphorylation of
|
IRS1
|
at Ser307 of IRS1
|
| 7188 |
MAPK8
|
|
affects_activity of
|
Insulin resistance
|
|
| 7189 |
MAPK8
|
|
affects_phosphorylation of
|
IRS1
|
in liver; at Ser307 of IRS1
|
| 7309 |
SORBS1
|
|
affects_activity of
|
MAPK8
|
|
| 7319 |
MAPK8
|
|
affects_activity of
|
inflammatory response
|
in macrophages
|
| 7321 |
MAPK8
|
|
affects_activity of
|
Obesity
|
|
| 7356 |
response to endoplasmic reticulum stress
|
|
increases_activity of
|
MAPK8
|
|
|
18053812
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
1,103
|
| 7047 |
F2
|
|
increases_activity of
|
MAPK8
|
in microglia
|
| 7049 |
SP600125
|
|
decreases_activity of
|
MAPK8
|
|
|
20025058
|
Parkinson disease
|
|
1,113
|
| 7148 |
MAPK8
|
|
decreases_expression of
|
P4HA1
|
via TNFalpha
|
| 7152 |
MAPK8
|
NOT |
affects_quantity of
|
PARK7
|
|
|
18439917
|
Cardiovascular disease
|
|
1,137
|
| 7441 |
SNCA
|
|
increases_phosphorylation of
|
MAPK8
|
in microglia; together with MMP3 and MMP9
|
|
20511551
|
Parkinson disease
|
|
1,145
|
| 7478 |
SNCA
|
|
increases_phosphorylation of
|
MAPK8
|
|
|
17166628
|
Parkinson disease
|
|
1,150
|
| 7500 |
Lipopolysaccharide
|
|
increases_activity of
|
MAPK8
|
|
|
15864310
|
Parkinson disease
|
|
1,158
|
| 7590 |
MAPK8
|
|
affects_activity of
|
Obesity
|
|
| 7591 |
MAPK8
|
|
affects_activity of
|
Insulin resistance
|
|
| 7594 |
MAPK8
|
|
affects_expression of
|
TNF
|
in liver
|
| 7596 |
MAPK8
|
|
affects_expression of
|
IL6
|
in liver
|
| 7599 |
MAPK8
|
|
affects_expression of
|
IL12B
|
in liver
|
| 7602 |
MAPK8
|
|
affects_expression of
|
CCL2
|
in liver
|
| 7604 |
MAPK8
|
|
affects_expression of
|
MIF
|
in liver
|
|
16818881
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,211
|
| 8141 |
SNCA
|
|
increases_phosphorylation of
|
MAPK8
|
|
| 8146 |
SNCA
|
|
increases_activity of
|
MAPK8
|
|
|
17012252
|
Parkinson disease
|
|
1,213
|
| 8137 |
SORBS1
|
|
affects_phosphorylation of
|
MAPK8
|
in white adipose tissue; after high-fat diet
|
|
17351624
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,267
|
| 8608 |
PPARD
|
|
affects_activity of
|
MAPK8
|
in white adipose tissue
|
|
18522830
|
Diabetes mellitus, type II
Insulin resistance
Fatty liver disease, nonalcoholic
|
|
1,292
|
| 8792 |
PPARG
|
|
affects_activity of
|
MAPK8
|
in liver, in skeletal muscle; after myeloid-specific PPARG deletion
|
| 8793 |
PPARG
|
|
affects_phosphorylation of
|
MAPK8
|
in liver, in skeletal muscle; after myeloid-specific PPARG deletion
|
|
17525798
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,293
|
| 8827 |
Fatty acid
|
|
increases_phosphorylation of
|
MAPK8
|
in macrophage; in wild-type
|
| 8828 |
TLR4
|
|
affects_phosphorylation of
|
MAPK8
|
in macrophage
|
|
17053832
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,299
|
| 8907 |
Obesity
|
|
increases_activity of
|
MAPK8
|
in liver, in adipose tissue
|
|
15486293
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
CIDeRplus