Search Results for "LEP" - 523 interactions found in 178 entries.

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Entry-ID
Interactor1 (Subject) Interaction type Interactor2 (Object) additional information
PubMed-ID
Diseases
318
1261 SREBF1 increases_expression of LEP
9421459 Diabetes mellitus, type II
Insulin resistance
323
1271 LEP decreases_activity of Insulin resistance in lipodystrophic mice
10485707 Diabetes mellitus, type II
Lipodystrophy, congenital generalized, type 1
Insulin resistance
488
2317 Pioglitazone decreases_quantity of LEP in blood
12446579 Diabetes mellitus, type II
Insulin resistance
519
2595 LEP affects_activity of AMPK
18719600 Diabetes mellitus, type II
Peutz-Jeghers syndrome
Wolff-Parkinson-White syndrome
Cardiomyopathy, hypertrophic
Insulin resistance
Metabolic syndrome
549
2832 Obesity increases_quantity of LEP in blood
2834 LEP affects_activity of Breast cancer
20028864 Breast cancer
Colorectal cancer
Diabetes mellitus, type II
Obesity
Insulin resistance
Metabolic syndrome
551
2883 LEP increases_expression of CYP19A1 in adipose stromal cells
2884 LEP decreases_expression of STK11 in adipose stromal cells
2888 LEP increases_transport of CRTC2 in adipose stromal cells; into the nucleus
19509226 Breast cancer
Diabetes mellitus, type II
Obesity
Insulin resistance
589
3106 RETN NOT affects_quantity of LEP in blood; after 4 to 6 h fasting
14976316 Diabetes mellitus, type II
Obesity
Insulin resistance
598
3186 high-phytoestrogen soy-based diet decreases_quantity of LEP
18420492 Diabetes mellitus, type II
Obesity
Insulin resistance
664
3700 LEP increases_activity of fatty acid beta-oxidation in adipose tissue, in liver, in muscle, in pancreas, in pancreatic islet
3702 LEP affects_expression of ACACA in adipose tissue; in lean ZDF rats
3704 LEP affects_expression of FASN in adipose tissue; in lean ZDF rats
3705 LEP affects_expression of Mitochondrial GPAT in adipose tissue; in lean ZDF rats
3707 LEP decreases_expression of Mitochondrial GPAT in pancreas, in pancreatic islets; in lean ZDF rats
3708 LEP decreases_expression of ACACA in pancreas, in pancreatic islets; in lean ZDF rats
3709 LEP decreases_expression of FASN in adipose tissue; in lean ZDF rats
3710 LEP increases_expression of PPARA in adipose tissue; in lean ZDF rats
10940327 Diabetes mellitus, type II
Diabetes mellitus, type I
Insulin resistance
Hypothyroidism
868
5193 SIRT1 NOT affects_quantity of LEP in blood; on high-fat diet, if SIRT1 is overexpressed
18840364 Diabetes mellitus, type II
Insulin resistance
889
13151 PPARGC1B affects_quantity of LEP in blood; if PPARGC1B expression is knocked down
19254570 Diabetes mellitus, type II
Insulin resistance
904
5373 SIRT1 NOT affects_quantity of LEP in blood; on standard diet, on high-fat diet, if SIRT1 is overexpressed
18599449 Diabetes mellitus, type II
Insulin resistance
Fatty liver disease, nonalcoholic
906
5433 SIRT1 affects_quantity of LEP in blood; if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
19549853 Diabetes mellitus, type II
Insulin resistance
952
5822 LEP affects_activity of BACE1
5824 LEP affects_activity of Gamma-secretase complex
5826 LEP affects_processing of APP
5828 LEP affects_quantity of Amyloid beta peptide
5832 LEP affects_activity of IDE
20385830 Alzheimer disease
1,037
6501 high-fat diet increases_quantity of LEP in blood
6509 PTPN1 decreases_activity of LEP if PTPN1 is overexpressed
16461936 Diabetes mellitus, type II
Insulin resistance
1,042
6528 LEP increases_phosphorylation of STAT3 in hypothalamus; if PTPN1 is knocked out in neurons
6534 PTPN1 affects_quantity of LEP if PTPN1 is knocked out in neurons
16845389 Diabetes mellitus, type II
Insulin resistance
1,092
7070 LEP affects_activity of Insulin resistance
7071 LEP affects_activity of inflammatory response
18053812 Diabetes mellitus, type II
Obesity
Insulin resistance
1,203
8064 CCR2 affects_expression of LEP in adipose tissue; in obese mice
8067 CCR2 NOT affects_quantity of LEP in blood; in obese mice
16341265 Diabetes mellitus, type II
Obesity
Insulin resistance
1,213
8120 high-fat diet increases_quantity of LEP in blood
8124 SORBS1 NOT affects_quantity of LEP in blood
17351624 Diabetes mellitus, type II
Insulin resistance
1,267
8642 PPARD NOT affects_expression of LEP in white adipose tissue
18522830 Diabetes mellitus, type II
Insulin resistance
Fatty liver disease, nonalcoholic
1,409
10035 Anakinra NOT affects_quantity of LEP in blood
17429083 Diabetes mellitus, type II
Insulin resistance
1,414
9743 ADIPOQ NOT affects_quantity of LEP in blood
12829646 Diabetes mellitus, type II
Insulin resistance
1,435
10057 high-fat high-sucrose diet increases_quantity of LEP
10089 IL1RN decreases_quantity of LEP after high-fat high-sucrose diet
18239070 Diabetes mellitus, type II
Insulin resistance
1,439
10110 LEP affects_activity of abnormal body weight
10111 IL18 affects_quantity of LEP
16732281 Diabetes mellitus, type II
Obesity
Insulin resistance
1,450
10211 IL6 decreases_quantity of LEP in blood; if IL6 is overexpressed in skeletal muscle
10230 IL6 decreases_expression of LEP in adipose tissue; if IL6 is overexpressed in skeletal muscle
18437347 Diabetes mellitus, type II
Insulin resistance
1,610
11801 LEP decreases_quantity of Lipid in adipocytes
11802 LEP NOT decreases_quantity of adipocyte in adipose tissue
18753616 Diabetes mellitus, type II
Insulin resistance
1,625
11909 STAT3 affects_quantity of LEP
15070774 Diabetes mellitus, type II
Insulin resistance
1,627
11917 LEP increases_activity of POMC-expressing neuron in the arcuate nucleus of the hypothalamus; via PI3K
18382766 Diabetes mellitus, type II
Insulin resistance
1,648
12123 LEP increases_activity of phosphatidylinositol 3-kinase signaling in central nervous system
18054313 Diabetes mellitus, type II
Obesity
Insulin resistance
1,655
12127 high-fat diet increases_quantity of LEP
12128 LEP increases_activity of STAT3 signaling pathway after low-fat diet
12130 high-fat diet decreases transport of LEP into brain
10862798 Diabetes mellitus, type II
Obesity
Insulin resistance
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