|
9
|
| 24 |
IL1B
|
|
decreases_expression of
|
SIRT1
|
|
| 26 |
IL1B
|
|
increases_expression of
|
NOS2
|
|
| 29 |
IL1B
|
|
increases_activity of
|
RELA
|
|
| 38 |
IL1B
|
|
increases_transport of
|
RELA
|
into nucleus
|
| 39 |
IL1B
|
|
increases_acetylation of
|
RELA
|
|
| 268 |
IL1B
|
|
increases_activity of
|
positive regulation of NF-kappaB transcription factor activity
|
|
|
19008341
|
Diabetes mellitus, type I
|
|
12
|
| 43 |
IL1B
|
|
decreases_expression of
|
SIRT1
|
|
| 44 |
IL1B
|
|
increases_expression of
|
NOS2
|
|
| 61 |
IL1B
|
|
decreases_activity of
|
insulin secretion
|
in rat islets
|
|
19008341
|
Diabetes mellitus, type I
|
|
43
|
| 101 |
IL1B
|
|
increases_activity of
|
NF-kappaB complex
|
|
|
16551748
|
Diabetes mellitus, type I
|
|
58
|
| 173 |
IL1B
|
|
increases_expression of
|
NOS2
|
|
| 174 |
IL1B
|
|
increases_expression of
|
PTGS2
|
|
| 178 |
IL1B
|
|
increases_transport of
|
RELA
|
into nucleus
|
| 179 |
IL1B
|
|
increases_transport of
|
NFKB1
|
into nucleus
|
| 185 |
IL1B
|
|
increases_activity of
|
response to oxidative stress
|
|
| 187 |
IL1B
|
|
increases_quantity of
|
H2O2
|
|
| 269 |
IL1B
|
|
increases_activity of
|
positive regulation of NF-kappaB transcription factor activity
|
|
|
19071154
|
Diabetes mellitus, type I
|
|
67
|
| 205 |
IL1B
|
|
increases_expression of
|
NOS2
|
in pancreatic islets
|
| 206 |
IL1B
|
|
increases_expression of
|
PTGS2
|
in pancreatic islets
|
| 210 |
IL1B
|
|
decreases_activity of
|
insulin secretion
|
in pancreatic islets
|
|
19071154
|
Diabetes mellitus, type I
|
|
71
|
| 217 |
IL1B
|
|
decreases_activity of
|
cell proliferation
|
|
| 220 |
IL1B
|
|
increases_expression of
|
NOS2
|
|
| 221 |
IL1B
|
|
increases_expression of
|
PTGS2
|
|
| 232 |
IL1B
|
|
increases_transport of
|
RELA
|
into nucleus
|
| 243 |
IL1B
|
|
decreases_quantity of
|
NFKBIA
|
in cytosol; in cytokine treated cells
|
| 244 |
IL1B
|
NOT |
decreases_quantity of
|
NFKBIB
|
in cytosol; in cytokine treated cells
|
| 248 |
IL1B
|
NOT |
decreases_quantity of
|
NFKBIA-p.S32A-S36A
|
in cytosol
|
| 270 |
IL1B
|
|
increases_activity of
|
positive regulation of NF-kappaB transcription factor activity
|
|
|
17521952
|
Diabetes mellitus, type I
|
|
76
|
| 239 |
IL1B
|
|
decreases_activity of
|
insulin secretion
|
in pancreatic islets
|
|
17521952
|
Diabetes mellitus, type I
|
|
98
|
| 323 |
SOD1-p.G93A
|
|
increases_quantity of
|
IL1B
|
in microglia cultures
|
|
19672969
|
Amyotrophic lateral sclerosis
|
|
320
|
| 1387 |
IL1B
|
|
increases_expression of
|
VEGFA
|
|
|
16964394
|
Amyotrophic lateral sclerosis
|
|
385
|
| 1607 |
SOD1-p.G93A
|
NOT |
affects_quantity of
|
IL1B
|
in TLR2 stimulated murine microglial cell line BV-2; if mutSOD1 is overexpressed
|
|
19091752
|
Amyotrophic lateral sclerosis
|
|
391
|
| 1685 |
SOD1-p.G93A
|
|
increases_expression of
|
IL1B
|
in spinal cord; at 110 days of age
|
| 1686 |
Lenalidomide
|
|
decreases_expression of
|
IL1B
|
in spinal cord; in SOD1(G93A) transgenic mice at 110 days of age
|
| 1687 |
Thalidomide
|
NOT |
affects_expression of
|
IL1B
|
in spinal cord; in SOD1(G93A) transgenic mice at 110 days of age
|
|
16510725
|
Amyotrophic lateral sclerosis
|
|
404
|
| 1733 |
SOD1-p.G93A
|
NOT |
affects_expression of
|
IL1B
|
in immortalized microglia
|
|
19734218
|
Amyotrophic lateral sclerosis
|
|
407
|
| 1796 |
GPAM
|
NOT |
affects_expression of
|
IL1B
|
|
|
17389595
|
Diabetes mellitus, type II
Insulin resistance
Fatty liver disease, nonalcoholic
|
|
661
|
| 3546 |
Status epilepticus
|
|
increases_expression of
|
IL1B
|
in pilocarpine model
|
|
17645533
|
Status epilepticus
|
|
670
|
| 3579 |
Status epilepticus
|
|
increases_expression of
|
IL1B
|
in lithium-pilocarpine model
|
| 3584 |
Edaravone
|
|
decreases_expression of
|
IL1B
|
in lithium-pilocarpine model
|
|
19951488
|
Status epilepticus
|
|
682
|
| 3712 |
Status epilepticus
|
|
increases_expression of
|
IL1B
|
in pilocarpine model
|
|
19055492
|
Status epilepticus
|
|
908
|
| 5549 |
Curcumin
|
|
decreases_quantity of
|
IL1B
|
in brain; of Tg2576 mouse
|
|
19191039
|
Alzheimer disease
|
|
947
|
| 5890 |
SIRT1
|
|
affects_quantity of
|
IL1B
|
in liver; if SIRT1 is knocked out in liver
|
|
19356714
|
Diabetes mellitus, type II
Insulin resistance
Fatty liver disease, nonalcoholic
|
|
1,092
|
| 7325 |
TLR4
|
|
increases_expression of
|
IL1B
|
|
|
18053812
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
1,100
|
| 6991 |
Parkinson disease
|
|
increases_quantity of
|
IL1B
|
in brain
|
|
20423606
|
Parkinson disease
|
|
1,102
|
| 7020 |
Alzheimer disease
|
|
increases_quantity of
|
IL1B
|
in PBMCs from AD patients compared to PBMCs in healthy controls
|
|
20462385
|
Alzheimer disease
|
|
1,103
|
| 7037 |
F2
|
|
increases_expression of
|
IL1B
|
via activation of microglia in the substantia nigra
|
| 7142 |
SP600125
|
NOT |
decreases_expression of
|
IL1B
|
|
| 7144 |
SB203580
|
NOT |
decreases_expression of
|
IL1B
|
|
|
20025058
|
Parkinson disease
|
|
1,105
|
| 7015 |
microglial cell activation
|
|
increases_quantity of
|
IL1B
|
|
|
20025058
|
Parkinson disease
|
|
1,108
|
| 7108 |
convulsive seizures
|
|
increases_expression of
|
IL1B
|
|
|
1709015
|
Epilepsy
|
|
1,110
|
| 7115 |
convulsive seizures
|
|
affects_expression of
|
IL1B
|
|
| 7118 |
IL1B
|
|
is localized in
|
glia
|
|
|
15571975
|
Status epilepticus
Epilepsy, temporal lobe
|
|
1,122
|
| 7211 |
Parkinson disease
|
|
increases_quantity of
|
IL1B
|
in striatum but not in cerebral cortex
|
|
7700568
|
Parkinson disease
|
|
1,124
|
| 7235 |
Lipopolysaccharide
|
|
increases_quantity of
|
IL1B
|
in substantia nigra
|
| 7251 |
IL1B
|
|
increases_ubiquitination/sumoylation of
|
NR4A2
|
if NURR1 is ubiquitinated by PIAS4
|
|
19345186
|
Parkinson disease
|
|
1,125
|
| 7260 |
convulsive seizures
|
|
increases_quantity of
|
IL1B
|
|
| 7262 |
IL1B
|
|
interacts (colocalizes) with
|
IL1R1
|
|
| 7268 |
IL1B
|
|
increases_activity of
|
SRC
|
|
|
19775068
|
Epilepsy
|
|
1,137
|
| 7389 |
SNCA
|
|
increases_quantity of
|
IL1B
|
in microglia
|
| 7397 |
SNCA
|
|
increases_expression of
|
IL1B
|
in microglia
|
| 7405 |
MMP3
|
|
affects_quantity of
|
IL1B
|
after stimulation with alpha-synuclein
|
| 7409 |
MMP8
|
|
affects_quantity of
|
IL1B
|
after stimulation with alpha-synuclein
|
| 7413 |
MMP9
|
|
affects_quantity of
|
IL1B
|
after stimulation with alpha-synuclein
|
| 7421 |
1rmz
|
|
decreases_activity of
|
IL1B
|
in microglia; after stimulation with alpha-synuclein
|
| 7423 |
M9I
|
|
decreases_activity of
|
IL1B
|
in microglia; after stimulation with alpha-synuclein
|
|
20511551
|
Parkinson disease
|
|
1,145
|
| 7471 |
SNCA
|
|
increases_quantity of
|
IL1B
|
|
|
17166628
|
Parkinson disease
|
CIDeRplus