|
503
|
| 2514 |
IKBKB
|
NOT |
increases_phosphorylation of
|
ACACB
|
in vitro
|
|
18845612
|
Diabetes mellitus, type II
Insulin resistance
|
|
964
|
| 6116 |
IKBKB
|
|
increases_phosphorylation of
|
IRS1
|
at Ser312 of IRS1
|
|
19041393
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
1,092
|
| 6982 |
IKBKB
|
|
increases_phosphorylation of
|
IRS1
|
at Ser307 of IRS1
|
| 7085 |
TNFRSF1A
|
|
increases_activity of
|
IKBKB
|
|
| 7086 |
IKBKB
|
|
increases_activity of
|
I-kappaB kinase/NF-kappaB signaling
|
|
| 7087 |
IKBKB
|
|
increases_phosphorylation of
|
IRS1
|
at Ser residues of IRS1
|
| 7088 |
IKBKB
|
|
decreases_activity of
|
IRS1
|
via phosphorylation at Ser residues of IRS1
|
| 7190 |
Sodium salicylate
|
|
decreases_activity of
|
IKBKB
|
|
| 7193 |
Aspirin
|
|
decreases_activity of
|
IKBKB
|
|
| 7288 |
IKBKB
|
|
affects_activity of
|
Insulin resistance
|
|
| 7307 |
SORBS1
|
|
affects_activity of
|
IKBKB
|
|
|
18053812
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
1,159
|
| 7606 |
Aspirin
|
|
decreases_activity of
|
IKBKB
|
|
| 7607 |
Sodium salicylate
|
|
decreases_activity of
|
IKBKB
|
|
|
9817203
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,162
|
| 7675 |
IKBKB
|
|
increases_activity of
|
Insulin resistance
|
in male and female LIKK mice
|
| 7679 |
IKBKB
|
|
increases_expression of
|
G6PC
|
in LIKK mice, after feeding
|
| 7681 |
IKBKB
|
|
increases_expression of
|
PCK
|
in LIKK mice, after feeding
|
| 7682 |
IKBKB
|
|
decreases_phosphorylation of
|
Insulin receptor
|
in liver; in LIKK mice
|
| 7685 |
IKBKB
|
|
decreases_phosphorylation of
|
IRS2
|
in liver; in LIKK mice
|
| 7686 |
IKBKB
|
|
decreases_phosphorylation of
|
IRS1
|
in muscle; in LIKK mice
|
| 7689 |
IKBKB
|
|
increases_expression of
|
IL1B
|
in LIKK mice
|
| 7690 |
IKBKB
|
|
increases_expression of
|
IL6
|
in LIKK mice
|
| 7692 |
IKBKB
|
|
increases_expression of
|
IL1R1
|
in liver; in LIKK mice
|
| 7694 |
IKBKB
|
|
increases_expression of
|
IL6ST
|
in liver; in LIKK mice
|
| 7696 |
IKBKB
|
|
increases_expression of
|
CXCR
|
in liver; in LIKK mice
|
| 7697 |
IKBKB
|
|
increases_expression of
|
TLR2
|
in liver; in LIKK mice
|
| 7698 |
IKBKB
|
|
increases_expression of
|
SOCS1
|
in liver; in LIKK mice
|
| 7699 |
IKBKB
|
|
increases_expression of
|
SOCS2
|
in liver; in LIKK mice
|
| 7700 |
IKBKB
|
|
increases_expression of
|
SOCS3
|
in liver; in LIKK mice
|
| 7701 |
IKBKB
|
|
increases_expression of
|
STAT3
|
in liver; in LIKK mice
|
| 7702 |
IKBKB
|
|
increases_phosphorylation of
|
STAT3
|
in liver; in LIKK mice
|
| 7704 |
IKBKB
|
|
increases_expression of
|
SOCS1
|
in muscle; in LIKK mice
|
| 7705 |
IKBKB
|
|
increases_expression of
|
SOCS2
|
in muscle; in LIKK mice
|
| 7706 |
IKBKB
|
|
increases_expression of
|
SOCS3
|
in muscle; in LIKK mice
|
| 7707 |
IKBKB
|
|
increases_expression of
|
STAT3
|
in muscle; in LIKK mice
|
| 7708 |
IKBKB
|
NOT |
affects_activity of
|
NF-kappaB complex
|
in muscle; in LIKK mice
|
| 7710 |
IKBKB
|
|
increases_activity of
|
NF-kappaB complex
|
in liver; in LIKK mice, via selective expression of constitutively active IKK-b in hepatocytes
|
| 7711 |
IKBKB
|
|
increases_activity of
|
Diabetes mellitus, type II
|
in LIKK mice
|
| 7712 |
IKBKB
|
|
increases_activity of
|
hyperglycemia
|
in LIKK mice
|
| 7727 |
IKBKB
|
|
increases_expression of
|
CD68
|
in liver; in LIKK mice
|
| 7728 |
IKBKB
|
|
increases_expression of
|
ADGRE1
|
in liver; in LIKK mice
|
| 13254 |
IKBKB
|
|
increases_activity of
|
increased circulating insulin level
|
in blood; in male and female LIKK mice, after fasting
|
| 13255 |
IKBKB
|
NOT |
affects_quantity of
|
Glucose
|
in blood; in male and female LIKK mice, after fasting
|
| 13256 |
IKBKB
|
NOT |
affects_quantity of
|
Fatty acid
|
in blood; in male and female LIKK mice, after fasting
|
|
15685173
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,202
|
| 8021 |
IKBKB
|
|
affects_activity of
|
improved glucose tolerance
|
in Ikbkb-Delta-hep mouse
|
| 8022 |
IKBKB
|
|
affects_quantity of
|
Glucose
|
in blood; in Ikbkb-Delta-hep mouse, after high-fat diet
|
| 8023 |
IKBKB
|
|
affects_activity of
|
Insulin resistance
|
in liver; in Ikbkb-Delta-hep mouse, after high-fat diet
|
| 8028 |
IKBKB
|
|
affects_activity of
|
Insulin resistance
|
in Ikbkb-Delta-mye mouse, after high-fat diet
|
| 13356 |
IKBKB
|
|
affects_quantity of
|
Insulin
|
in blood; in Ikbkb-Delta-hep mouse, after high-fat diet
|
| 13357 |
IKBKB
|
|
affects_activity of
|
Insulin resistance
|
after high-fat diet
|
| 13359 |
IKBKB
|
NOT |
affects_activity of
|
Insulin resistance
|
in muscle, in adipose tissue; in Ikbkb-Delta-hep mouse, after high-fat diet
|
|
15685170
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,213
|
| 8136 |
SORBS1
|
|
affects_phosphorylation of
|
IKBKB
|
in white adipose tissue; after high-fat diet
|
|
17351624
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,292
|
| 8789 |
PPARG
|
|
affects_activity of
|
IKBKB
|
in liver, in skeletal muscle; after myeloid-specific PPARG deletion
|
| 8791 |
PPARG
|
|
affects_phosphorylation of
|
IKBKB
|
in liver, in skeletal muscle; after myeloid-specific PPARG deletion
|
|
17525798
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,457
|
| 10297 |
Lipopolysaccharide
|
|
increases_phosphorylation of
|
IKBKB
|
in liver
|
|
17456850
|
Diabetes mellitus, type II
Obesity
Insulin resistance
Metabolic endotoxemia
|
|
1,579
|
| 11331 |
diet
|
|
affects_activity of
|
IKBKB
|
in hypothalamus
|
| 11333 |
overnutrition
|
|
increases_activity of
|
IKBKB
|
in hypothalamus
|
| 11336 |
IKBKB
|
|
affects_activity of
|
insulin receptor signaling pathway
|
|
| 11337 |
IKBKB
|
|
affects_activity of
|
leptin-mediated signaling pathway
|
|
| 11340 |
IKBKB
|
|
affects_activity of
|
Obesity
|
|
| 11341 |
IKBKB
|
|
affects_activity of
|
Insulin resistance
|
|
| 11342 |
IKBKB
|
|
increases_expression of
|
SOCS3
|
|
|
18854155
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
1,819
|
| 13630 |
Fatty acid
|
|
increases_activity of
|
IKBKB
|
|
|
17916553
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,836
|
| 13910 |
TLR2
|
|
affects_activity of
|
IKBKB
|
after high-fat diet
|
|
18787058
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,911
|
| 14639 |
high-fat diet
|
|
increases_activity of
|
IKBKB
|
in hypothalamus
|
| 14644 |
Palmitoyl-CoA
|
|
decreases_activity of
|
IKBKB
|
in hypothalamus
|
| 14647 |
IKBKB
|
|
affects_activity of
|
decreased food intake
|
in hypothalamus; after high-fat diet
|
| 14648 |
IKBKB
|
|
affects_activity of
|
increased insulin sensitivity
|
in hypothalamus; after high-fat diet
|
|
19116375
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
1,925
|
| 14916 |
high-fat diet
|
|
increases_phosphorylation of
|
IKBKB
|
in hypothalamus; at Ser residues
|
|
20808781
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
2,003
|
| 15921 |
Angiotensin (1-7)
|
|
decreases_expression of
|
IKBKB
|
in cardiac muscle
|
| 15935 |
Captopril
|
|
decreases_expression of
|
IKBKB
|
in cardiac muscle
|
|
19166939
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,198
|
| 18461 |
IKBKB
|
|
affects_activity of
|
Insulin receptor
|
if induced by insulin
|
| 18462 |
IKBKB
|
|
affects_activity of
|
IRS2
|
if induced by insulin
|
| 18463 |
IKBKB
|
|
affects_activity of
|
AKT1
|
if induced by insulin
|
| 18464 |
Aspirin
|
|
affects_activity of
|
IKBKB
|
|
| 18469 |
IKBKB
|
|
increases_activity of
|
Insulin resistance
|
via TNF
|
| 18470 |
TNF
|
|
affects_activity of
|
IKBKB
|
|
|
11533494
|
Diabetes mellitus, type II
Insulin resistance
|
|
3,281
|
| 30194 |
Rosiglitazone
|
|
decreases_expression of
|
IKBKB
|
|
|
21694775
|
Diabetes mellitus, type II
Insulin resistance
|
|
3,408
|
| 31670 |
IRAK1
|
|
interacts (colocalizes) with
|
IKBKB
|
|
|
11096118
|
Endocrine
|
|
3,409
|
| 31671 |
IKBKB
|
|
increases_phosphorylation of
|
NFKB1
|
|
|
10469655
|
Endocrine
|
|
3,455
|
| 32249 |
RIPK1
|
|
increases_activity of
|
IKBKB
|
|
| 32250 |
IKBKB
|
|
increases_activity of
|
toll-like receptor signaling pathway
|
|
|
19734906
|
Metabolic
Major depressive disorder
|
|
3,488
|
| 32417 |
PPM1A
|
|
increases_phosphorylation of
|
IKBKB
|
|
| 32418 |
PPM1B
|
|
increases_phosphorylation of
|
IKBKB
|
|
| 32419 |
TNF
|
|
increases_activity of
|
IKBKB
|
|
| 32420 |
IKBKB
|
|
increases_activity of
|
NF-kappaB complex
|
|
|
18930133
|
Metabolic
Major depressive disorder
|
|
3,496
|
| 32464 |
IKBKB
|
|
increases_expression of
|
HIF1A
|
|
|
18432192
|
Immunological
|
|
4,628
|
| 46200 |
IKBKB
|
|
interacts (colocalizes) with
|
CTNNB1
|
|
|
11527961
|
Metabolic
Major depressive disorder
|
|
4,629
|
| 46201 |
PELI1
|
|
interacts (colocalizes) with
|
IKBKB
|
|
|
21204785
|
Metabolic
Major depressive disorder
|
|
4,636
|
| 46211 |
IKBKB
|
|
affects_activity of
|
inflammatory response
|
|
|
18626576
|
Inflammation
|
|
4,779
|
| 47313 |
SREBF1c
|
NOT |
affects_phosphorylation of
|
IKBKB
|
in liver; after reversion of hepatic steatosis
|
|
22932913
|
Diabetes mellitus, type II
Insulin resistance
Fatty liver disease, nonalcoholic
|
|
5,252
|
| 51212 |
Breast cancer
|
|
increases_expression of
|
IKBKB
|
|
|
19995559
|
Breast cancer
Diabetes mellitus, type II
Insulin resistance
|
|
6,387
|
| 61022 |
IKBKB
|
|
affects_activity of
|
TSC1-TSC2 complex
|
|
|
25955819
|
Metabolic
|
|
6,972
|
| 68439 |
IKBKB
|
|
is_part_of
|
I-kappa-B kinase complex
|
via ubiquitination
|
|
21252204
|
Inflammatory bowel disease
|
|
6,983
|
| 68507 |
IKBKB
|
|
increases_activity of
|
NF-kappaB complex
|
only if both genes, IKKA (CHUK) and IKKB (IKBKB) are deleted
|
| 68513 |
IKBKB
|
|
decreases_activity of
|
colitis
|
only if both genes, IKKA (CHUK) and IKKB (IKBKB) are deleted
|
|
17361131
|
Inflammatory bowel disease
Inflammation
|
CIDeRplus