|
217
|
| 873 |
CNS ischemia
|
|
increases_quantity of
|
HIF1A
|
|
|
11029549
|
Amyotrophic lateral sclerosis
|
|
289
|
| 1170 |
response to hypoxia
|
|
increases_expression of
|
HIF1A
|
already detectable after 4 h at 1% O(2)
|
| 1171 |
HIF1A
|
|
increases_expression of
|
ANG
|
|
|
19444281
|
Amyotrophic lateral sclerosis
|
|
379
|
| 1559 |
Lipophilic metal chelator DP-109
|
|
increases_quantity of
|
HIF1A
|
in SOD1(G93A) transgenic mice
|
| 1561 |
Lipophilic metal chelator DP-460
|
|
increases_quantity of
|
HIF1A
|
in SOD1(G93A) transgenic mice
|
|
17630988
|
Amyotrophic lateral sclerosis
|
|
655
|
| 3489 |
(5-[N-methyl-N-propargylaminomethyl]-8-hydroxyquinoline)
|
|
increases_expression of
|
HIF1A
|
|
| 3490 |
(5-[N-methyl-N-propargylaminomethyl]-8-hydroxyquinoline)
|
|
increases_quantity of
|
HIF1A
|
|
| 3491 |
(5-[4-propargylpiperazin-1-ylmethyl]-8-hydroxyquinoline)
|
|
increases_expression of
|
HIF1A
|
|
| 3492 |
(5-[4-propargylpiperazin-1-ylmethyl]-8-hydroxyquinoline)
|
|
increases_quantity of
|
HIF1A
|
|
|
19638399
|
Amyotrophic lateral sclerosis
|
|
1,321
|
| 9031 |
response to hypoxia
|
|
affects_activity of
|
HIF1A
|
|
| 9033 |
HIF1A
|
|
affects_expression of
|
APH1A
|
HIF-1 activated by hypoxia
|
| 9034 |
HIF1A
|
|
affects_quantity of
|
Amyloid beta peptide
|
|
| 9035 |
HIF1A
|
|
affects_activity of
|
Gamma-secretase complex
|
|
| 24457 |
Nickel
|
|
increases_quantity of
|
HIF1A
|
|
| 24458 |
HIF1A
|
|
interacts (colocalizes) with
|
ARNT
|
|
| 24459 |
HIF1A
|
|
is_part_of
|
ARNT-HIF1A complex
|
|
|
16645044
|
Alzheimer disease
|
|
1,377
|
| 9710 |
HIF1A
|
|
interacts (colocalizes) with
|
BACE1 (promoter)
|
|
| 9740 |
HIF1A
|
|
increases_expression of
|
BACE1
|
in neuronal cells; if HIF1A is overexpressed, via binding to BACE1 promoter;
|
| 9750 |
HIF1A
|
|
interacts (colocalizes) with
|
APH1A (promoter)
|
HIF-1alpha binds to the promoter of anterior pharynx-defective phenotype (APH-1).
|
| 9751 |
HIF1A
|
|
increases_expression of
|
APH1A
|
|
|
20552043
|
Alzheimer disease
|
|
1,531
|
| 10914 |
HIF1A
|
|
decreases_activity of
|
neuron death
|
|
|
20649842
|
Parkinson disease
|
|
1,532
|
| 10918 |
response to hypoxia
|
|
increases_activity of
|
HIF1A
|
|
| 10919 |
HPH
|
|
decreases_activity of
|
HIF1A
|
|
|
20649842
|
Parkinson disease
|
|
1,800
|
| 13502 |
HIF1A
|
|
interacts (colocalizes) with
|
SP1
|
|
|
15780936
|
Neurological
|
|
2,589
|
| 24432 |
ATM
|
|
affects_expression of
|
HIF1A
|
|
|
20676049
|
Diabetes mellitus, type II
Ataxia-telangiectasia
Insulin resistance
|
|
2,935
|
| 26813 |
IL1B
|
|
increases_quantity of
|
HIF1A
|
|
| 26814 |
IGF1
|
|
increases_expression of
|
HIF1A
|
|
| 26815 |
IGF2
|
NOT |
affects_quantity of
|
HIF1A
|
|
|
22249478
|
Diabetes mellitus, type II
Insulin resistance
|
|
3,432
|
| 31945 |
ElonginB/C-CUL2-VHL-RBX1 complex
|
|
decreases_activity of
|
HIF1A
|
|
|
21942715
|
von Hippel-Lindau syndrome
|
|
3,470
|
| 32427 |
response to hypoxia
|
|
increases_quantity of
|
HIF1A
|
|
|
19187226
|
Hematological
|
|
3,473
|
| 32317 |
COMMD1
|
|
decreases_activity of
|
HIF1A
|
|
|
19220812
|
Metabolic
Major depressive disorder
|
|
3,494
|
| 32445 |
COMMD1
|
|
interacts (colocalizes) with
|
HIF1A
|
|
| 32447 |
HIF1A
|
|
is_part_of
|
ARNT-HIF1A complex
|
|
| 32449 |
COMMD1
|
|
decreases_expression of
|
HIF1A
|
|
|
20458141
|
Cancer
|
|
3,495
|
| 32458 |
AKT1
|
|
increases_quantity of
|
HIF1A
|
|
| 32459 |
PIK3CA
|
|
increases_quantity of
|
HIF1A
|
|
|
12764143
|
Hepatocellular carcinoma
|
|
3,496
|
| 32463 |
NF-kappaB complex
|
|
increases_expression of
|
HIF1A
|
|
| 32464 |
IKBKB
|
|
increases_expression of
|
HIF1A
|
|
|
18432192
|
Immunological
|
|
3,497
|
| 32471 |
HIF1A
|
|
increases_activity of
|
inflammatory response
|
|
|
12628185
|
Neurological
|
|
3,500
|
| 32487 |
PHD-LIMD1-VHL complex
|
|
decreases_quantity of
|
HIF1A
|
|
|
22286099
|
Endocrine
|
|
3,542
|
| 32951 |
response to hypoxia
|
|
increases_expression of
|
HIF1A
|
|
|
7539918
|
Neurological
|
|
3,622
|
| 34322 |
Triiodothyronine
|
|
increases_expression of
|
HIF1A
|
in fibroblasts
|
| 34324 |
HIF1A
|
|
affects_activity of
|
canonical glycolysis
|
|
| 34325 |
HIF1A
|
|
increases_expression of
|
SLC2A1
|
|
| 34326 |
HIF1A
|
|
increases_expression of
|
SLC16A3
|
|
|
21941681
|
Diabetes mellitus, type II
Insulin resistance
Hypothyroidism
Hyperthyroidism
|
|
3,795
|
| 37658 |
HIF1A
|
|
interacts (colocalizes) with
|
mTORC1 complex
|
|
|
18765678
|
Diabetes mellitus, type II
Insulin resistance
|
|
4,051
|
| 41801 |
HIF1A
|
|
increases_expression of
|
EWSR1
|
|
|
20442286
|
Ewing sarcoma
|
|
4,096
|
| 42354 |
HIF1A
|
|
increases_expression of
|
POMC
|
|
|
21814490
|
Diabetes mellitus, type II
Insulin resistance
|
|
4,107
|
| 42396 |
HIF1A
|
|
increases_expression of
|
LEP
|
|
|
17591803
|
Colorectal cancer
Diabetes mellitus, type II
Insulin resistance
|
|
4,109
|
| 42399 |
HIF1A
|
|
increases_expression of
|
LEP
|
|
|
12215445
|
Diabetes mellitus, type II
Insulin resistance
|
|
4,137
|
| 42677 |
Diabetes mellitus, type II
|
|
decreases_expression of
|
HIF1A
|
in pancreas, in pancreatic islet
|
|
16096055
|
Diabetes mellitus, type II
Insulin resistance
|
|
4,139
|
| 42684 |
HIF1A
|
|
is_expressed_in
|
pancreatic islet
|
in normoxic beta cells and islets
|
| 42686 |
Diabetes mellitus, type II
|
|
decreases_expression of
|
HIF1A
|
in pancreas, in pancreatic islet
|
| 42687 |
HIF1A
|
|
interacts (colocalizes) with
|
ARNT
|
in pancreas, in pancreatic islet
|
| 42699 |
HIF1A
|
|
increases_expression of
|
HNF4A
|
in pancreas, in pancreatic islet
|
| 42702 |
HIF1A
|
|
increases_expression of
|
SLC2A1
|
in pancreas, in pancreatic islet
|
| 42703 |
HIF1A
|
|
increases_expression of
|
SLC2A2
|
in pancreas, in pancreatic islet
|
| 42704 |
HIF1A
|
|
increases_expression of
|
AKT2
|
in pancreas, in pancreatic islet
|
| 42705 |
HIF1A
|
|
increases_expression of
|
IRS2
|
in pancreas, in pancreatic islet
|
| 42709 |
Diabetes mellitus, type II
|
|
decreases_expression of
|
HIF1A
|
in pancreas, in pancreatic islet
|
|
20440072
|
Diabetes mellitus, type II
Insulin resistance
|
|
4,140
|
| 42685 |
HIF1A
|
|
interacts (colocalizes) with
|
ARNT
|
|
| 42689 |
HIF1A
|
|
affects_activity of
|
impaired glucose tolerance
|
|
| 42690 |
HIF1A
|
|
affects_activity of
|
reduced pancreatic beta cell function
|
|
| 42691 |
HIF1A
|
|
affects_expression of
|
SLC2A2
|
in pancreas, in pancreatic beta cells
|
| 42692 |
HIF1A
|
|
affects_expression of
|
GCK
|
in pancreas, in pancreatic beta cells
|
| 42693 |
HIF1A
|
|
affects_expression of
|
GPI
|
in pancreas, in pancreatic beta cells
|
| 42694 |
HIF1A
|
|
affects_expression of
|
PFK
|
in pancreas, in pancreatic beta cells
|
| 42695 |
HIF1A
|
|
affects_expression of
|
HNF4A
|
in pancreas, in pancreatic beta cells
|
| 42696 |
HIF1A
|
|
affects_expression of
|
PGAM2
|
in pancreas, in pancreatic beta cells
|
| 42697 |
HIF1A
|
|
affects_expression of
|
AKT2
|
in pancreas, in pancreatic beta cells
|
| 42698 |
HIF1A
|
|
affects_activity of
|
decreased intracellular ATP level
|
in pancreas, in pancreatic beta cells
|
| 42708 |
HIF1A
|
|
increases_expression of
|
ARNT
|
in pancreas, in pancreatic beta cells
|
| 42717 |
Iron chelator
|
|
increases_activity of
|
HIF1A
|
in pancreas, in pancreatic beta cells
|
| 42724 |
Iron
|
|
decreases_expression of
|
HIF1A
|
in pancreas, in pancreatic beta cells
|
|
20440072
|
Diabetes mellitus, type II
Insulin resistance
|
|
4,142
|
| 42741 |
response to hypoxia
|
|
increases_expression of
|
HIF1A
|
in liver
|
|
22051049
|
Diabetes mellitus, type II
Insulin resistance
|
CIDeRplus