|
332
|
| 1311 |
Status epilepticus
|
|
increases_phosphorylation of
|
GRIA1
|
in pilocarpine model
|
|
19501060
|
Status epilepticus
|
|
526
|
| 31503 |
Polyinosinic:polycytidylic acid
|
|
increases_expression of
|
GRIA1
|
|
|
19660546
|
Epilepsy
|
|
562
|
| 2914 |
Status epilepticus
|
|
decreases_expression of
|
GRIA1
|
in lithium/pilocarpine induced model
|
|
14675153
|
Status epilepticus
|
|
583
|
| 3081 |
DLG4
|
|
increases_quantity of
|
GRIA1
|
|
|
11082065
|
Amyotrophic lateral sclerosis
|
|
754
|
| 4264 |
SKF81297
|
|
increases_phosphorylation of
|
GRIA1
|
in nNOS KO mouse model
|
|
19538708
|
Schizophrenia
|
|
776
|
| 4362 |
GRIA1
|
|
affects_activity of
|
hyperactivity
|
|
|
17684498
|
Schizophrenia
|
|
4,205
|
| 43138 |
Diabetes mellitus, type II
|
NOT |
affects_expression of
|
GRIA1
|
in retina
|
|
18258217
|
Diabetes mellitus, type II
Insulin resistance
Retinopathy, diabetic
|
|
4,697
|
| 46613 |
GRIA1
|
|
increases_activity of
|
locomotory behavior
|
in cocaine-naive animals, if wt-GluR1 is overexpessed in the NAc (nucleus accumbens) core as response to intra-NAc AMPA, but not NMDA infusions;
|
| 46615 |
GRIA1
|
|
affects_activity of
|
sensitization
|
in nucleus accumbens; of cocaine and D2 receptor
|
| 46616 |
GRIA1
|
|
affects_activity of
|
relapse behavior
|
in NAc (nucleus accumbens); during cocaine self-administration
|
| 46618 |
GRIA1
|
|
affects_activity of
|
addictive behavior
|
if GluR1/GRIA1 is exogenous overexpressed, during or after cocaine use;
|
| 46619 |
Adenylate cyclase
|
|
increases_phosphorylation of
|
GRIA1
|
at serine 845 in both wt- and pd-GluR1
|
|
18430032
|
Neurological
|
|
4,719
|
| 46763 |
Protein kinase C
|
|
increases_phosphorylation of
|
GRIA1
|
at position Ser818 and Ser831;
|
| 46776 |
CAMK2
|
|
increases_phosphorylation of
|
GRIA1
|
at position Ser831 potentiated AMPAR currents and augmented LTP;
|
| 46781 |
Protein kinase A
|
|
increases_phosphorylation of
|
GRIA1
|
at position Ser845 potentiated AMPAR currents and augmented LTP;
|
| 46796 |
GRIA1
|
|
is_part_of
|
AMPA receptor complex
|
|
| 46806 |
Dopamine
|
|
increases_phosphorylation of
|
GRIA1
|
in striatal neurons; preferentially at Ser845
|
| 46816 |
Amfetamine
|
|
increases_phosphorylation of
|
GRIA1
|
in striatal neurons; preferentially at Ser845
|
| 46873 |
DRD2
|
|
decreases_phosphorylation of
|
GRIA1
|
at Ser845
|
| 46874 |
Cocaine
|
|
increases_phosphorylation of
|
GRIA1
|
at Ser845 in the NAc (nucleus accumbens) and at Ser831 in the CPu (caudate-putamen) in cocaine-sensitized rodents
|
| 46934 |
Diamorphine
|
|
increases_phosphorylation of
|
GRIA1
|
at Ser845 in the NAc (nucleus accumbens) and at Ser831 in the CPu (caudate-putamen) in heroin self-administering rodents
|
| 46982 |
RPS6KB1
|
|
increases_phosphorylation of
|
GRIA1
|
at Thr840;
|
|
21441996
|
Neurological
|
|
4,891
|
| 48306 |
mir-137
|
|
affects_expression of
|
GRIA1
|
|
|
23637704
|
Schizophrenia
|
|
5,189
|
| 50787 |
Amyloid beta peptide oligomer, soluble
|
|
decreases_phosphorylation of
|
GRIA1
|
|
|
21665950
|
Neurological
|
|
5,190
|
| 50789 |
EGR1
|
|
increases_expression of
|
GRIA1
|
|
|
23569253
|
Neurological
|
|
5,191
|
| 50790 |
LRP1
|
|
affects transport of
|
GRIA1
|
|
|
|
Neurological
|
|
5,196
|
| 50798 |
BCL11B
|
|
affects_expression of
|
GRIA1
|
in striatal medium spiny neurons
|
|
18199763
|
Neurological
|
|
6,751
|
| 65458 |
VLDLR
|
|
interacts (colocalizes) with
|
GRIA1
|
|
| 65460 |
VLDLR
|
|
affects_quantity of
|
GRIA1
|
at the cell surface
|
|
25644714
|
Neurological
|
|
9,001
|
| 94370 |
APOE (isoform E4)
|
|
decreases_quantity of
|
GRIA1
|
in acutely Reelin
stimulated primary neurons; the cell-surface levels
|
|
20547867
|
Alzheimer disease
|
|
9,181
|
| 97337 |
CPT1C
|
|
interacts (colocalizes) with
|
GRIA1
|
|
| 97338 |
decreased CPT1C level
|
|
decreases_quantity of
|
GRIA1
|
in hippocampal neurons of CPT1C KO mice; concerning the synaptic levels of AMPAR subunits GluA1 and GluA2
|
| 97339 |
CPT1C
|
|
increases_expression of
|
GRIA1
|
|
|
26338711
|
Metabolic
|
|
10,137
|
| 105729 |
GRIA1
|
|
affects_activity of
|
sudden cardiac death
|
|
|
21658281
|
Cardiovascular disease
|
|
10,143
|
| 105768 |
Autism
|
|
increases_expression of
|
GRIA1
|
|
|
11706102
|
Autism
|
|
11,569
|
| 115343 |
GRIA1
|
|
affects_activity of
|
Autism
|
|
| 115348 |
GRIA1
|
|
increases_activity of
|
chemical synaptic transmission
|
|
|
28628100
|
Autism
Neurodevelopmental disease
|
|
11,571
|
| 115350 |
GRIA1
|
|
affects_activity of
|
Schizophrenia
|
|
| 115462 |
GRIA1
|
|
increases_activity of
|
synaptic transmission, glutamatergic
|
|
|
23053966
|
Schizophrenia
|
|
11,589
|
| 115467 |
GSG1L
|
|
interacts (colocalizes) with
|
GRIA1
|
|
|
26932439
|
Neurological
|
|
12,879
|
| 123509 |
GRIA1
|
|
affects_activity of
|
learning or memory
|
|
|
27265785
|
Neurodegenerative disorder
|
|
12,880
|
| 123486 |
GRIA1
|
|
affects_activity of
|
migraine
|
|
|
21782286
|
Neurological
|
|
16,106
|
| 155402 |
GRIA1
|
NOT |
is_part_of
|
NMDA receptor-associated protein complex (NRC)
|
in mouse brain; detected in the starting material but not in the three NRC preparations
|
| 155937 |
GRIA1
|
NOT |
is_part_of
|
NMDA receptor-associated protein complex (NRC)
|
in mouse brain; detected in the starting material but not in the three NRC preparations
|
|
|
Neurological
|
|
16,178
|
| 156383 |
GRIA1
|
|
affects_activity of
|
AMPA receptor complex
|
|
|
|
Neurological
Metabolic
|
CIDeRplus