Search Results for "CLOCK" - 85 interactions found in 25 entries.

Entry-ID
Interactor1 (Subject) Interaction type Interactor2 (Object) additional information
PubMed-ID
Diseases
1,394
9961 Schizophrenia decreases_expression of CLOCK
16223876 Schizophrenia
1,740
13062 CLOCK increases_expression of PAX6
15254898 Neurological
4,230
43220 CLOCK affects_activity of circadian rhythm in ventral tegmental area
43221 CLOCK affects_expression of CACNG5 in ventral tegmental area
43223 CLOCK affects_expression of CHRNB4 in ventral tegmental area
20591414 Bipolar disorder
Major depressive disorder
Circadian rhythm
4,462
45299 PPARGC1A increases_expression of CLOCK
17476214 Diabetes mellitus, type II
Insulin resistance
5,327
52078 FOXO3 increases_expression of CLOCK in liver
52079 CLOCK affects_activity of circadian rhythm
24856209 Metabolic
Sleep disorders
6,387
61628 CLOCK is_part_of CLOCK-BMAL1 complex
25955819 Metabolic
6,456
61411 CLOCK affects_activity of circadian rhythm
61420 Metformin increases_expression of CLOCK via AMPK/NAMPT/SIRT1 signaling
22117616 Diabetes mellitus, type II
Cancer
Insulin resistance
6,583
63417 CLOCK is_part_of Core clock complex
63470 CLOCK affects_activity of polyphagia
63471 CLOCK affects_activity of hyperlipidemia
63472 CLOCK affects_activity of hyperglycemia
63473 CLOCK affects_activity of decreased circulating insulin level
63480 CLOCK affects_activity of Diabetes mellitus, type II
63516 circadian rhythm affects_expression of CLOCK in pancreas
25457619 Diabetes mellitus, type II
Insulin resistance
6,590
63321 Metformin affects_activity of CLOCK in liver; via circadian rhythm
63328 Metformin NOT affects_activity of CLOCK in muscle; via circadian rhythm
63332 circadian rhythm affects_quantity of CLOCK in liver, in muscle
63340 Metformin increases_expression of CLOCK in liver, in muscle
22968146 Diabetes mellitus, type II
Insulin resistance
6,706
64764 CLOCK increases_expression of F7
18316400 Myocardial infarction
6,721
64931 CLOCK affects_activity of circadian rhythm
64963 CLOCK interacts (colocalizes) with EP300
64965 CLOCK interacts (colocalizes) with KAT2B
64982 CLOCK increases_activity of histone acetylation
64983 CLOCK affects_expression of DBP via histone acetylation
64984 CLOCK affects_expression of PER1 via histone acetylation
65018 CLOCK interacts (colocalizes) with KMT2A
65021 CLOCK increases_activity of KMT2A
65050 CLOCK increases_acetylation of ARNTL
65051 CLOCK increases_activity of CRY1
65053 CLOCK affects_activity of NR3C1 via acetylation
65056 CLOCK affects_activity of response to glucocorticoid via acetylation of NR3C1
65077 CLOCK affects_activity of hyperglycemia
65078 CLOCK affects_activity of decreased circulating insulin level
65094 CLOCK affects_activity of hepatic steatosis
65096 CLOCK affects_activity of lipid metabolic process
65145 PARP1 affects_activity of CLOCK
22841001 Diabetes mellitus, type II
Insulin resistance
6,747
65694 CLOCK affects_activity of increased triglyceride level
65695 CLOCK affects_activity of hepatic steatosis
27230643 Diabetes mellitus, type II
Insulin resistance
Cardiomyopathy, diabetic
6,858
66800 CLOCK affects_activity of insulin secretion
66802 CLOCK affects_activity of glucose homeostasis
26331226 Diabetes mellitus, type II
Insulin resistance
6,861
66828 CLOCK increases_activity of entrainment of circadian clock
66838 CLOCK increases_expression of ARNTL
66856 CLOCK increases_expression of GYS with a peak in the active period
66857 CLOCK increases_expression of PYG with a peak in the resting period
66915 CLOCK affects_activity of abnormal circadian feeding behavior
66916 CLOCK affects_activity of abnormal energy homeostasis
66917 CLOCK affects_activity of hyperglycemia
66918 CLOCK affects_activity of decreased circulating insulin level
66919 CLOCK affects_activity of insulin receptor signaling pathway
66926 CLOCK affects_activity of leptin-mediated signaling pathway
67030 CLOCK affects_expression of mir-219
67054 mir-107 decreases_expression of CLOCK
26927084 Diabetes mellitus, type II
Cancer
Insulin resistance
7,314
71853 RAI1 increases_expression of CLOCK
22578325 Diabetes mellitus, type II
Insulin resistance
7,434
73078 CLOCK decreases_expression of COL1A1 in kidney
73080 CLOCK decreases_expression of COL4A1 in kidney
73081 CLOCK decreases_expression of Collagen in kidney
73196 CLOCK increases_expression of TGFB1 in embryonic fibroblasts
73201 CLOCK decreases_activity of response to oxidative stress in renal tubular cells
26458764 Renal
Inflammation
7,447
73304 mir-107 affects_activity of CLOCK
25522185 Diabetes mellitus, type II
Insulin resistance
Atherosclerosis
7,467
73673 ARNTL interacts (colocalizes) with CLOCK
9576906 Diabetes mellitus, type II
Insulin resistance
7,521
74300 CLOCK affects_activity of Cardiomyopathy, dilated
74301 CLOCK affects_activity of abnormal vascular endothelial cell physiology
74302 CLOCK affects_activity of atherosclerotic lesions
74303 CLOCK affects_activity of cholesterol metabolic process
25883568 Cardiovascular disease
Atherosclerosis
7,526
75633 CLOCK interacts (colocalizes) with PER (E-Box, promoter)
75634 CLOCK interacts (colocalizes) with CRY (E-Box, promoter)
75641 CLOCK is_part_of CLOCK-BMAL1 complex
75649 NR1D1 decreases_expression of CLOCK
75652 RORA increases_expression of CLOCK
75671 NAD/NADH ratio affects_activity of CLOCK
83297 PER-CRY complex decreases_expression of CLOCK
25073467 Gastrointestinal
Metabolic
7,593
75866 Obesity affects_expression of CLOCK via methylation at CpG sites
75869 CLOCK affects_activity of decreased susceptibility to weight loss via methylation at CpG sites
75871 Monounsaturated fatty acid affects_expression of CLOCK via methylation at CpG sites
75872 Polyunsaturated fatty acid affects_expression of CLOCK via methylation at CpG sites
23003921 Diabetes mellitus, type II
Obesity
Insulin resistance
8,247
83283 CLOCK affects_activity of Core clock complex
83294 ARNTL interacts (colocalizes) with CLOCK
83298 CLOCK is_part_of Core clock complex
21613214 Metabolic
8,555
88007 maternal obesity affects_activity of CLOCK in pancreas
24657938 Diabetes mellitus, type II
Insulin resistance
Fatty pancreas disease, nonalcoholic
9,629
101677 CLOCK is_part_of Core clock complex in the liver
30659595 Inflammation
10,295
106793 CLOCK NOT affects_expression of SLC6A4 in the mouse midbrain
22572884 Neurological
Metabolic
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