|
33
|
| 13133 |
FAS
|
|
increases_activity of
|
CASP3
|
|
|
18056484
|
Amyotrophic lateral sclerosis
|
|
46
|
| 157 |
Streptozocin
|
|
increases_activity of
|
CASP3
|
|
| 159 |
Arjunolic acid
|
|
decreases_activity of
|
CASP3
|
in STZ treated rats
|
|
19133311
|
Diabetes mellitus, type I
|
|
214
|
| 845 |
LRRK2-p.R1441C
|
|
increases_activity of
|
CASP3
|
|
| 13594 |
CASP3
|
|
affects_activity of
|
neuron apoptotic process
|
|
|
17409193
|
Parkinson disease
|
|
218
|
| 897 |
SOD1-p.G93A
|
|
increases_activity of
|
CASP3
|
at disease end stage p120
|
|
16847061
|
Amyotrophic lateral sclerosis
|
|
335
|
| 1317 |
Pilocarpine
|
|
affects_activity of
|
CASP3
|
in pilocarpine rat model
|
|
19879360
|
Status epilepticus
Epilepsy, temporal lobe
|
|
568
|
| 2961 |
Glutamate
|
|
increases_activity of
|
CASP3
|
in cortical neurons
|
| 2964 |
CASP3
|
|
increases_activity of
|
PKN1
|
in cortical neurons; induced by glutamate
|
| 15825 |
CASP3
|
|
increases_quantity of
|
PKN1-mod
|
in cortical neurons; induced by glutamate
|
|
18519042
|
Amyotrophic lateral sclerosis
|
|
594
|
| 3138 |
SOD1-p.G93A
|
|
increases_activity of
|
CASP3
|
in mitochondria
|
|
19344252
|
Amyotrophic lateral sclerosis
|
|
643
|
| 3421 |
SOD1 protein aggregates
|
|
increases_activity of
|
CASP3
|
|
|
19046404
|
Amyotrophic lateral sclerosis
|
|
672
|
| 3728 |
Status epilepticus
|
|
affects_activity of
|
CASP3
|
in lithium-pilocarpine model
|
|
20149694
|
Status epilepticus
|
|
678
|
| 3644 |
STUB1
|
|
decreases_activity of
|
CASP3
|
if CHIP is overexpressed
|
|
15358145
|
Amyotrophic lateral sclerosis
|
|
683
|
| 3724 |
PSEN2-p.N141I
|
|
increases_activity of
|
CASP3
|
by enhancing of ryanodine receptor-mediated calcium release
|
| 3769 |
Dantrolene
|
|
decreases_activity of
|
CASP3
|
PSEN2-N141I enhanced
|
| 3770 |
RYR3
|
|
increases_activity of
|
CASP3
|
mediated by an increase of intracellular calcium levels
|
|
16394273
|
Alzheimer disease
|
|
737
|
| 4131 |
6-OHDA
|
|
increases_activity of
|
CASP3
|
|
|
18665912
|
Parkinson disease
|
|
744
|
| 4207 |
SOD1-p.G37R
|
|
increases_activity of
|
CASP3
|
in skeletal muscle of transgenic mice
|
|
20223753
|
Amyotrophic lateral sclerosis
|
|
887
|
| 110475 |
p25
|
|
increases_activity of
|
CASP3
|
in transgenic mouse
|
|
15615647
|
Alzheimer disease
Tauopathy
|
|
888
|
| 5227 |
Staurosporine
|
|
increases_activity of
|
CASP3
|
|
| 5228 |
6-OHDA
|
|
increases_activity of
|
CASP3
|
|
| 5262 |
PRKN
|
|
decreases_activity of
|
CASP3
|
|
|
19801972
|
Parkinson disease
|
|
890
|
| 5256 |
PRKN
|
|
decreases_activity of
|
CASP3
|
induced by 6-OHDA
|
|
19801972
|
Parkinson disease
|
|
893
|
| 5264 |
PRKN
|
|
increases_activity of
|
CASP3
|
induced by 6-OHDA
|
| 5267 |
PARK2-p.K161N
|
NOT |
decreases_activity of
|
CASP3
|
induced by 6-OHDA
|
| 5270 |
PARK2-p.R256C
|
NOT |
decreases_activity of
|
CASP3
|
induced by 6-OHDA
|
| 5273 |
PARK2-p.C418R
|
NOT |
decreases_activity of
|
CASP3
|
induced by 6-OHDA
|
| 5276 |
PARK2-p.C441R
|
NOT |
decreases_activity of
|
CASP3
|
induced by 6-OHDA
|
|
19801972
|
Parkinson disease
|
|
894
|
| 5281 |
LY 294002
|
NOT |
affects_activity of
|
CASP3
|
|
|
19801972
|
Parkinson disease
|
|
905
|
| 5390 |
CASP3
|
|
increases_processing of
|
MAPT
|
at TAU-Asp421
|
| 5395 |
CASP3
|
NOT |
affects_processing of
|
MAPT-p.D421E
|
|
| 118838 |
CASP3
|
|
increases_quantity of
|
MAPT-proc (1-421)
|
|
|
12888622
|
Alzheimer disease
|
|
907
|
| 5403 |
CASP3
|
|
increases_quantity of
|
neurofibrillary tangles
|
|
| 5404 |
CASP3
|
|
increases_processing of
|
MAPT
|
at TAU-Asp421
|
| 5408 |
CASP3
|
|
interacts (colocalizes) with
|
neurofibrillary tangles
|
|
| 118834 |
CASP3
|
|
increases_quantity of
|
MAPT-proc (1-421)
|
at TAU-Asp421
|
|
20357768
|
Alzheimer disease
Tauopathy
|
|
932
|
| 5648 |
AKT1
|
|
affects_activity of
|
CASP3
|
|
|
20020442
|
Amyotrophic lateral sclerosis
|
|
1,053
|
| 6607 |
PARK7
|
|
decreases_activity of
|
CASP3
|
under oxidative stress conditions
|
|
18042550
|
Parkinson disease
|
|
1,124
|
| 7232 |
Lipopolysaccharide
|
|
increases_activity of
|
CASP3
|
in substantia nigra
|
|
19345186
|
Parkinson disease
|
|
1,349
|
| 9297 |
PSEN1
|
|
affects_activity of
|
CASP3
|
|
|
18184791
|
Alzheimer disease
|
|
1,356
|
| 9261 |
CYCS
|
|
increases_activity of
|
CASP3
|
if cytochrome c is released from the mitochondria
|
|
16365298
|
Parkinson disease
|
|
1,398
|
| 9673 |
CASP3
|
|
increases_processing of
|
TARDBP
|
into distinct fragments of 42, 35, and 25 kDa
|
| 9676 |
GRN
|
|
affects_activity of
|
CASP3
|
|
|
17898224
|
Amyotrophic lateral sclerosis
Frontotemporal lobar degeneration with TDP43 inclusions, GRN-related
|
|
1,411
|
| 9758 |
TDP-43 neuronal inclusions
|
|
increases_activity of
|
CASP3
|
if TDP-43 is overexpressed
|
|
20133711
|
Amyotrophic lateral sclerosis
Frontotemporal lobar degeneration with TDP43 inclusions, GRN-related
|
|
1,502
|
| 10605 |
PHID
|
|
decreases_activity of
|
CASP3
|
if apoptosis has been induced by MPTP
|
|
20946892
|
Parkinson disease
|
|
1,525
|
| 10863 |
SNCAIP
|
|
decreases_activity of
|
CASP3
|
in synphilin-1/A53T alpha-synuclein double-transgenic mice
|
|
20185556
|
Parkinson disease
Synucleinopathy
|
|
1,605
|
| 11770 |
CRYAA
|
|
decreases_activity of
|
CASP3
|
|
|
21092858
|
Neurological
|
CIDeRplus