|
1,987
|
| 15592 |
fat cell differentiation
|
|
increases_expression of
|
AGT
|
in adipose tissue
|
| 15598 |
AGT
|
|
decreases_activity of
|
fat cell differentiation
|
in adipose tissue
|
|
12031955
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,988
|
| 15611 |
Glucose
|
|
increases_expression of
|
AGT
|
in pancreas, in pancreatic islets
|
| 15616 |
Zofenopril
|
NOT |
increases_expression of
|
AGT
|
in pancreas, in pancreatic islets; after glucose stimulation
|
| 15619 |
Enalaprilat
|
NOT |
increases_expression of
|
AGT
|
in pancreas, in pancreatic islets; after glucose stimulation
|
|
16452552
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,018
|
| 15988 |
AGT
|
|
is_expressed_in
|
adipose tissue
|
|
|
15705782
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,020
|
| 16001 |
Obesity
|
|
decreases_expression of
|
AGT
|
in adipose tissue
|
| 16006 |
Cortisol
|
NOT |
affects_expression of
|
AGT
|
in adipose tissue
|
| 16010 |
Insulin
|
NOT |
affects_expression of
|
AGT
|
in adipose tissue
|
| 16015 |
Estradiol
|
NOT |
affects_expression of
|
AGT
|
in adipose tissue
|
| 16020 |
Triiodothyronine
|
NOT |
affects_expression of
|
AGT
|
in adipose tissue
|
| 16025 |
Angiotensin II
|
NOT |
affects_expression of
|
AGT
|
in adipose tissue
|
|
12011658
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
2,168
|
| 18147 |
AGT
|
|
affects_quantity of
|
adipose tissue
|
|
| 18148 |
AGT
|
|
increases_activity of
|
hypertension
|
|
|
11606482
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,172
|
| 18183 |
Obesity
|
|
increases_expression of
|
AGT
|
in retroperitoneal adipose tissue
|
| 18184 |
Obesity
|
|
increases_quantity of
|
AGT
|
in blood
|
| 18185 |
Obesity
|
NOT |
affects_expression of
|
AGT
|
in liver, epididymal adipose tissue, subcutaneous adipose tissue
|
|
15191907
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
3,303
|
| 30350 |
Salicylate
|
|
decreases_expression of
|
AGT
|
in abdominal adipose tissue; via HSD11B1
|
| 30356 |
Salicylate
|
NOT |
decreases_expression of
|
AGT
|
in subcutaneous adipose tissue
|
|
22357964
|
Diabetes mellitus, type II
Insulin resistance
|
|
5,566
|
| 53605 |
AGT
|
|
increases_activity of
|
SDHA
|
|
|
17620599
|
Metabolic
|
|
5,631
|
| 53843 |
AGT
|
|
increases_expression of
|
MYH7
|
in cultured cardiomyocytes
|
|
23044624
|
Cardiomyopathy, hypertrophic
|
|
7,511
|
| 74117 |
AHR
|
|
affects_expression of
|
AGT
|
|
|
20878756
|
Diabetes mellitus, type II
Insulin resistance
Inflammatory bowel disease
|
|
7,841
|
| 77929 |
acute-phase response
|
|
increases_expression of
|
AGT
|
in plasma
|
|
2482266
|
Inflammation
|
|
9,074
|
| 95276 |
Pancreatic cancer
|
|
increases_expression of
|
AGT
|
|
|
21448452
|
Pancreatic cancer
|
|
11,717
|
| 116318 |
AGT
|
|
is_expressed_in
|
pancreatic alpha cell
|
|
|
30404071
|
Diabetes mellitus, type II
Insulin resistance
|
|
11,748
|
| 116302 |
Renin
|
|
decreases_quantity of
|
AGT
|
|
| 116310 |
AGT
|
|
increases_quantity of
|
Angiotensin I
|
via cleavage by renin
|
|
32333398
|
COVID-19
|
|
11,776
|
| 116576 |
REN
|
|
decreases_quantity of
|
Angiotensinogen
|
|
|
23463883
|
Diabetes mellitus, type II
Insulin resistance
Cardiovascular disease
|
|
11,917
|
| 117232 |
AGT
|
|
is_expressed_in
|
liver
|
|
| 117233 |
AGT
|
|
is_expressed_in
|
aorta
|
|
| 117234 |
AGT
|
|
is_expressed_in
|
adrenal gland
|
|
| 117235 |
AGT
|
|
is_expressed_in
|
kidney
|
|
| 117236 |
AGT
|
|
is_expressed_in
|
brain
|
|
| 117237 |
AGT
|
|
is_expressed_in
|
heart
|
|
| 117238 |
AGT
|
|
is_expressed_in
|
adipose tissue
|
|
|
8641727
|
Cardiovascular disease
|
|
11,927
|
| 117295 |
ARNTL
|
|
increases_expression of
|
AGT
|
in perivascular adipose tissue
|
| 117297 |
circadian rhythm
|
|
affects_expression of
|
AGT
|
in perivascular adipose tissue
|
|
29371216
|
Cardiovascular disease
|
|
12,012
|
| 117696 |
extracellular exosome
|
|
increases_expression of
|
AGT
|
in cardiomyocytes; exosomes derived from cardiac fibroblasts
|
|
26497614
|
Cardiovascular disease
|
|
12,020
|
| 117782 |
renin-angiotensin system
|
|
decreases_quantity of
|
Angiotensinogen
|
|
| 117784 |
AGT
|
|
is_expressed_in
|
liver
|
|
| 117785 |
AGT
|
|
is_expressed_in
|
heart
|
|
| 117786 |
AGT
|
|
is_expressed_in
|
blood vessel
|
|
| 117787 |
AGT
|
|
is_expressed_in
|
kidney
|
|
| 117788 |
AGT
|
|
is_expressed_in
|
adipose tissue
|
|
| 117789 |
inflammatory response
|
|
increases_expression of
|
AGT
|
|
| 117790 |
Insulin
|
|
increases_expression of
|
AGT
|
|
| 117791 |
Estrogen
|
|
increases_expression of
|
Angiotensinogen
|
|
| 117792 |
Glucocorticoid
|
|
increases_expression of
|
AGT
|
|
| 117793 |
Thyroid hormone
|
|
increases_expression of
|
AGT
|
|
| 117794 |
Angiotensin II
|
|
increases_expression of
|
AGT
|
|
| 117795 |
REN
|
|
decreases_quantity of
|
Angiotensinogen
|
in blood plasma
|
| 117850 |
CTSD
|
|
decreases_quantity of
|
Angiotensinogen
|
|
| 117852 |
CTSG
|
|
decreases_quantity of
|
Angiotensinogen
|
|
|
30934934
|
Diabetes mellitus, type II
Insulin resistance
Cardiovascular disease
|
|
12,021
|
| 117769 |
CTSG
|
|
decreases_quantity of
|
Angiotensinogen
|
in neutrophils
|
|
|
Cardiovascular disease
|
|
12,033
|
| 118051 |
mitochondrion
|
|
affects_quantity of
|
Angiotensinogen
|
mitochondria actively metabolize the RAS precursor protein angiotensinogen, suggesting that ANG-(1-7) may be generated within mitochondria
|
|
26697984
|
Endocrine
Metabolic
|
|
12,056
|
| 118225 |
REN
|
|
decreases_quantity of
|
Angiotensinogen
|
in blood; via classical renin-angiotensin system
|
| 118281 |
AGT rs699
|
|
increases_activity of
|
Angiotensinogen
|
|
|
19065996
|
Diabetes mellitus, type II
Insulin resistance
|
|
12,064
|
| 118434 |
AGT
|
|
is_expressed_in
|
adipose tissue
|
|
|
19065996
|
Diabetes mellitus, type II
Insulin resistance
|
|
12,191
|
| 119587 |
ethynylestradiol
|
|
increases_quantity of
|
Angiotensinogen
|
in plasma
|
| 119589 |
ethynylestradiol
|
|
increases_expression of
|
Angiotensinogen
|
in liver
|
|
8351287
|
Endocrine
|
|
12,194
|
| 119751 |
AGT
|
|
is_expressed_in
|
astrocyte
|
|
|
32127770
|
Neurodegenerative disorder
|
|
12,334
|
| 120984 |
Angiotensinogen
|
|
is_expressed_in
|
white adipose tissue
|
|
| 120985 |
Angiotensinogen
|
|
is_expressed_in
|
brown adipose tissue
|
|
| 120987 |
Obesity
|
|
increases_expression of
|
Angiotensinogen
|
in adipose tissue
|
|
31525726
|
Obesity
Cancer
|
|
12,360
|
| 121022 |
Obesity
|
|
increases_quantity of
|
Angiotensinogen
|
in blood plasma; in menopausal women
|
| 121034 |
Obesity
|
|
decreases_expression of
|
Angiotensinogen
|
in adipose tissue; in menopausal women
|
| 121035 |
weight loss
|
|
decreases_quantity of
|
Angiotensinogen
|
in blood plasma; in menopausal women
|
| 121039 |
weight loss
|
|
decreases_expression of
|
Angiotensinogen
|
in blood plasma; in menopausal women
|
|
15630041
|
Obesity
|
|
13,775
|
| 129406 |
Chronic kidney disease
|
|
increases_quantity of
|
Angiotensinogen
|
in urine
|
|
29984779
|
Chronic kidney disease
|
|
13,776
|
| 129407 |
Dopamine
|
|
decreases_quantity of
|
Angiotensinogen
|
in the proximal renal tubules
|
|
29984779
|
Renal
|
|
13,891
|
| 131273 |
Dopamine
|
|
decreases_quantity of
|
Angiotensinogen
|
in kidney
|
|
21701066
|
Renal
|
CIDeRplus