|
122
|
| 419 |
GSK3B
|
|
increases_phosphorylation of
|
APP
|
activated by amyloid beta peptide
|
| 481 |
GSK3B
|
|
increases_phosphorylation of
|
APP
|
at Thr743
|
| 482 |
GSK3B
|
|
increases_processing of
|
APP
|
|
|
11527574
|
Alzheimer disease
|
|
322
|
| 1269 |
NCSTN
|
|
interacts (colocalizes) with
|
APP
|
|
| 1290 |
protein processing
|
|
increases_activity of
|
APP
|
by a two-step proteolytic pathway
|
|
10993067
|
Alzheimer disease
|
|
381
|
| 1552 |
BACE1
|
|
increases_processing of
|
APP
|
|
| 1564 |
Gamma-secretase complex
|
|
increases_processing of
|
APP
|
|
|
12048259
|
Alzheimer disease
|
|
457
|
| 2181 |
Streptozocin
|
|
increases_expression of
|
APP
|
|
|
19712582
|
Alzheimer disease
|
|
485
|
| 2281 |
Amyloid beta peptide (25-35)
|
|
increases_quantity of
|
APP
|
in cytoplasm of rat hippocampal neurons; via tau protein kinase I/glycogen synthase kinase-3beta (TPK1/GSK-3B) in hippocampal neurons
|
|
8592647
|
Alzheimer disease
|
|
505
|
| 14083 |
APP
|
|
increases_quantity of
|
Amyloid beta peptide
|
|
|
11943765
|
Alzheimer disease
|
|
569
|
| 2966 |
Glucose
|
|
affects_quantity of
|
APP
|
in plasma
|
| 2967 |
Insulin
|
|
affects_quantity of
|
APP
|
in plasma
|
| 2986 |
APOE
|
|
decreases_quantity of
|
APP
|
in plasma
|
|
10670439
|
Alzheimer disease
|
|
574
|
| 3016 |
Gamma-secretase complex
|
|
affects_processing of
|
APP
|
|
|
17298085
|
Alzheimer disease
|
|
580
|
| 3103 |
Lithium
|
|
affects_processing of
|
APP
|
|
| 3140 |
GSK3A
|
|
affects_processing of
|
APP
|
|
| 3141 |
GSK3B
|
|
affects_processing of
|
APP
|
|
|
12761548
|
Alzheimer disease
|
|
613
|
| 3266 |
Metformin
|
NOT |
affects_expression of
|
APP
|
|
| 3268 |
Metformin
|
|
affects_quantity of
|
APP
|
|
|
19237574
|
Diabetes mellitus, type II
Insulin resistance
|
|
645
|
| 3424 |
GSK3B
|
|
affects_processing of
|
APP
|
APP processed to amyloid beta peptide
|
| 3427 |
CDK5
|
|
affects_processing of
|
APP
|
APP processed to amyloid beta peptide
|
|
14651959
|
Alzheimer disease
|
|
667
|
| 3599 |
APP
|
|
interacts (colocalizes) with
|
TOM complex, mitochondrial
|
in mitochondrion
|
| 3601 |
APP
|
|
interacts (colocalizes) with
|
TIM complex, mitochondrial
|
in mitochondrion
|
| 123602 |
APP
|
|
interacts (colocalizes) with
|
TIM-TOM complex, mitochondrial
|
in mitochondrion
|
|
19268425
|
Alzheimer disease
|
|
695
|
| 3828 |
LRRK2-p.G2019S
|
NOT |
increases_activity of
|
APP
|
|
|
20064389
|
Parkinson disease
|
|
717
|
| 4011 |
Lithium
|
|
affects_processing of
|
APP
|
|
| 4012 |
Valproic acid
|
|
affects_processing of
|
APP
|
|
|
15170327
|
Alzheimer disease
|
|
718
|
| 4013 |
Lithium
|
|
affects_processing of
|
APP
|
|
| 4014 |
Valproic acid
|
|
affects_processing of
|
APP
|
|
| 4023 |
GSK3B
|
|
affects_processing of
|
APP
|
|
|
15170327
|
Alzheimer disease
|
|
792
|
| 4623 |
HSPA5
|
|
interacts (colocalizes) with
|
APP
|
in endoplasmic reticulum
|
| 4628 |
STUB1
|
|
interacts (colocalizes) with
|
APP
|
|
| 4681 |
HSF1
|
|
increases_expression of
|
APP
|
during stress
|
|
19449461
|
Alzheimer disease
|
|
924
|
| 5661 |
Epigallocatechin 3-gallate
|
|
increases_processing of
|
APP
|
at alpha-C-terminal fragment of APP
|
|
16177050
|
Alzheimer disease
|
|
937
|
| 5675 |
ADAM10
|
|
increases_processing of
|
APP
|
if green tea (-)-epigallocatechin-3-gallate-induced
|
|
16624814
|
Alzheimer disease
|
|
952
|
| 5825 |
Insulin
|
|
affects_processing of
|
APP
|
|
| 5826 |
LEP
|
|
affects_processing of
|
APP
|
|
|
20385830
|
Alzheimer disease
|
|
976
|
| 6030 |
Alpha-secretase
|
|
increases_processing of
|
APP
|
|
|
19242462
|
Alzheimer disease
Prion disease
|
|
1,107
|
| 7349 |
increased cholesterol level
|
|
increases_processing of
|
APP
|
|
| 82834 |
increased cholesterol level
|
|
decreases_quantity of
|
APP
|
via increased APP cleavage
|
|
20462385
|
Alzheimer disease
Dementia
|
|
1,169
|
| 7758 |
IL1B
|
|
increases_expression of
|
APP
|
|
|
15290893
|
Alzheimer disease
Down syndrome
|
|
1,321
|
| 9036 |
Gamma-secretase complex
|
|
increases_processing of
|
APP
|
|
|
16645044
|
Alzheimer disease
|
|
1,418
|
| 9793 |
APP
|
|
increases_activity of
|
Ferroxidase complex
|
|
| 9795 |
zinc ion binding
|
|
decreases_activity of
|
APP
|
zinc ion (2+) binding
|
| 9799 |
APP
|
|
increases_activity of
|
Oxidoreductase, oxidizing metal ions
|
APP catalytically oxidizes Fe2+
|
| 9807 |
APP
|
|
increases_activity of
|
iron ion binding
|
Fe3+ binding; APP loads Fe3+ into transferrin
|
| 9811 |
APP
|
|
interacts (colocalizes) with
|
SLC40A1
|
in HEK293T cells and in human cortical tissue
|
| 9822 |
Zn2+
|
|
decreases_activity of
|
APP
|
|
| 9833 |
APP
|
|
increases_quantity of
|
Fe3+
|
via oxidizing Fe2+ to Fe3+
|
| 9875 |
Alzheimer disease
|
|
decreases_activity of
|
APP
|
cortical APP ferroxidase activity
|
| 104413 |
APP
|
|
decreases_quantity of
|
Fe2+
|
via oxidizing Fe2+ to Fe3+
|
|
20817278
|
Alzheimer disease
|
|
1,420
|
| 9854 |
APP
|
|
decreases_activity of
|
response to oxidative stress
|
|
| 12090 |
APP
|
NOT |
increases_quantity of
|
Iron
|
|
|
20817278
|
Alzheimer disease
|
|
1,422
|
| 9878 |
IL1B (active form)
|
|
affects_expression of
|
APP
|
at translational level
|
| 9960 |
APP
|
|
affects_activity of
|
coagulation
|
If APP is secreted
|
| 9963 |
APP
|
|
interacts (colocalizes) with
|
Factor IXa
|
If APP is secreted
|
| 9967 |
response to interleukin-1
|
|
increases_expression of
|
APP
|
|
| 9976 |
APP
|
|
decreases_activity of
|
response to oxidative stress
|
|
| 9979 |
APP
|
|
increases_activity of
|
negative regulation of neuron death
|
|
| 10036 |
astrocyte activation
|
|
increases_quantity of
|
APP
|
|
|
19021541
|
Alzheimer disease
|
|
1,441
|
| 10118 |
Metal
|
|
affects_expression of
|
APP
|
|
| 10385 |
Alpha-secretase
|
|
increases_processing of
|
APP
|
|
| 10386 |
Copper
|
|
increases_expression of
|
APP
|
Up-regulation of APP transcription
|
|
19166904
|
Alzheimer disease
Hemochromatosis, type 1
|
|
1,534
|
| 10956 |
APP
|
|
affects_activity of
|
Alzheimer disease
|
|
| 10957 |
APP
|
|
interacts (colocalizes) with
|
TNFRSF21
|
compare Corum:6056
|
|
19225519
|
Alzheimer disease
|
|
1,556
|
| 11123 |
CALHM1
|
|
affects_processing of
|
APP
|
|
|
18585350
|
Alzheimer disease
|
|
1,558
|
| 11125 |
SAMP8 mouse
|
|
increases_quantity of
|
APP
|
in the hippocampus of aged SAMP8 mice
|
| 11172 |
mir-16
|
|
affects_expression of
|
APP
|
|
| 11174 |
mir-16
|
|
decreases_expression of
|
APP
|
if mir-16 is overexpressed
|
|
20619502
|
Alzheimer disease
|
CIDeRplus