|
1,983
|
| 15568 |
AGTR2
|
NOT |
affects_activity of
|
glucose import
|
in skeletal muscle
|
| 15572 |
PD123319
|
|
decreases_activity of
|
AGTR2
|
in skeletal muscle
|
|
15037562
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,987
|
| 15596 |
fat cell differentiation
|
NOT |
affects_expression of
|
AGTR2
|
in adipose tissue
|
| 15607 |
PD123319
|
|
decreases_activity of
|
AGTR2
|
in adipose tissue
|
|
12031955
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,018
|
| 46089 |
AGTR2
|
|
is_expressed_in
|
adipose tissue
|
|
|
15705782
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,020
|
| 16009 |
Cortisol
|
NOT |
affects_expression of
|
AGTR2
|
in adipose tissue
|
| 16014 |
Insulin
|
NOT |
affects_expression of
|
AGTR2
|
in adipose tissue
|
| 16019 |
Estradiol
|
NOT |
affects_expression of
|
AGTR2
|
in adipose tissue
|
| 16024 |
Triiodothyronine
|
NOT |
affects_expression of
|
AGTR2
|
in adipose tissue
|
| 16029 |
Angiotensin II
|
NOT |
affects_expression of
|
AGTR2
|
in adipose tissue
|
|
12011658
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
2,039
|
| 16268 |
AGTR2
|
|
affects_quantity of
|
mitochondrion
|
|
| 16270 |
AGTR2
|
|
affects_quantity of
|
Reactive oxygen species
|
in mitochondria
|
| 16272 |
AGTR2
|
|
affects_activity of
|
regulation of mitochondrial membrane potential
|
|
| 16274 |
AGTR2
|
|
affects_activity of
|
mitochondrion organization
|
|
| 16284 |
AGTR2
|
|
affects_quantity of
|
Triacylglycerol
|
in skeletal muscle
|
| 16287 |
AGTR2
|
|
affects_expression of
|
PPARGC1A
|
|
| 16289 |
AGTR2
|
|
affects_expression of
|
TFAM
|
|
| 16300 |
AGTR2
|
|
affects_quantity of
|
Mitochondrial respiratory chain complex V
|
in mitochondria
|
| 16301 |
AGTR2
|
|
affects_quantity of
|
Mitochondrial respiratory chain complex IV
|
in mitochondria
|
| 16302 |
AGTR2
|
|
affects_expression of
|
ACADM
|
in mitochondria
|
|
19074984
|
Diabetes mellitus, type II
Insulin resistance
|
|
11,709
|
| 116212 |
ACE inhibitor
|
|
decreases_activity of
|
AGTR2
|
|
| 116225 |
Angiotensin II type 1 receptor blocker
|
|
increases_activity of
|
AGTR2
|
|
|
29598869
|
Cardiovascular disease
|
|
11,717
|
| 116329 |
AGTR2
|
|
is_expressed_in
|
pancreatic islet
|
|
| 116414 |
AGTR2
|
|
increases_activity of
|
vasodilation
|
|
| 116415 |
hyperglycemia
|
|
decreases_expression of
|
AGTR2
|
|
|
30404071
|
Diabetes mellitus, type II
Insulin resistance
|
|
11,748
|
| 116378 |
Angiotensin (1-7)
|
|
increases_activity of
|
AGTR2
|
but with lower affinity than ANG II
|
| 116379 |
Angiotensin II
|
|
increases_activity of
|
AGTR2
|
with higher affinity than Angiotensin (1-7)
|
|
32333398
|
COVID-19
|
|
11,776
|
| 116579 |
Angiotensin II
|
|
increases_activity of
|
AGTR2
|
|
|
23463883
|
Diabetes mellitus, type II
Insulin resistance
Cardiovascular disease
|
|
11,908
|
| 117213 |
Angiotensin (1-7)
|
|
increases_activity of
|
AGTR2
|
if candesartan is coadministered
|
|
15767466
|
Cardiovascular disease
|
|
11,919
|
| 117249 |
Angiotensin (1-9)
|
|
increases_activity of
|
AGTR2
|
in cardiomyocytes
|
|
30048754
|
Cardiovascular disease
|
|
11,920
|
| 117254 |
Angiotensin A
|
|
increases_activity of
|
AGTR2
|
|
|
17138938
|
Cardiovascular disease
|
|
11,933
|
| 117312 |
Angiotensin II
|
|
interacts (colocalizes) with
|
AGTR2
|
in HEK293 cells
|
| 117313 |
Angiotensin III
|
|
interacts (colocalizes) with
|
AGTR2
|
in HEK293 cells
|
| 117314 |
Angiotensin IV
|
|
interacts (colocalizes) with
|
AGTR2
|
in HEK293 cells
|
| 117315 |
Angiotensin (1-7)
|
|
interacts (colocalizes) with
|
AGTR2
|
in HEK293 cells
|
|
21542804
|
Cardiovascular disease
|
|
11,937
|
| 117319 |
MAS1
|
|
interacts (colocalizes) with
|
AGTR2
|
|
| 117363 |
AGTR2
|
|
is_part_of
|
AGTR2-MAS1 complex
|
in astrocytes
|
|
28461604
|
Cardiovascular disease
|
|
12,012
|
| 117692 |
Angiotensin II
|
|
increases_activity of
|
AGTR2
|
in cardiac fibroblasts
|
| 117694 |
AGTR2
|
|
increases_quantity of
|
extracellular exosome
|
exosomes derived from cardiac fibroblasts
|
| 117698 |
extracellular exosome
|
|
increases_expression of
|
AGTR2
|
in cardiomyocytes; exosomes derived from cardiac fibroblasts
|
|
26497614
|
Cardiovascular disease
|
|
12,017
|
| 117743 |
Angiotensin (1-9)
|
|
increases_activity of
|
AGTR2
|
|
|
29962859
|
Cardiovascular disease
|
|
12,024
|
| 117954 |
Angiotensin II
|
|
increases_activity of
|
AGTR2
|
|
| 117955 |
AGTR2
|
|
decreases_activity of
|
cell growth
|
|
| 117956 |
AGTR2
|
|
decreases_activity of
|
cell population proliferation
|
|
| 117957 |
AGTR2
|
|
increases_activity of
|
cell differentiation
|
|
| 117958 |
AGTR2
|
|
increases_activity of
|
vasodilation
|
|
| 117959 |
AGTR2
|
|
increases_activity of
|
negative regulation of blood pressure
|
|
| 117978 |
AGTR2
|
|
is_expressed_in
|
fetus
|
|
| 117979 |
AGTR2
|
|
is_expressed_in
|
heart
|
|
| 117980 |
AGTR2
|
|
is_expressed_in
|
blood vessel
|
|
| 117981 |
AGTR2
|
|
is_expressed_in
|
brain stem
|
|
| 117982 |
AGTR2
|
|
is_expressed_in
|
liver
|
|
| 117983 |
AGTR2
|
|
is_expressed_in
|
kidney
|
|
|
30934934
|
Diabetes mellitus, type II
Insulin resistance
Cardiovascular disease
|
|
12,029
|
| 118022 |
Angiotensin (1-7)
|
|
increases_activity of
|
AGTR2
|
|
|
30934934
|
Diabetes mellitus, type II
Insulin resistance
Cardiovascular disease
|
|
12,033
|
| 118074 |
AGTR2
|
|
affects_activity of
|
mitochondrion
|
concerning mitochondria respiration
|
| 118076 |
AGTR2
|
|
affects_quantity of
|
NO
|
concerning nitric oxide production
|
|
26697984
|
Endocrine
Metabolic
|
|
12,035
|
| 118085 |
Angiotensin III
|
|
increases_activity of
|
AGTR2
|
|
| 118113 |
Angiotensin A
|
|
interacts (colocalizes) with
|
AGTR2
|
|
| 118123 |
Angiotensin (1-9)
|
|
increases_activity of
|
AGTR2
|
|
|
30934934
|
Diabetes mellitus, type II
Insulin resistance
Cardiovascular disease
|
|
12,056
|
| 118308 |
Angiotensin II
|
|
increases_activity of
|
AGTR2
|
|
| 118311 |
AGTR2
|
|
increases_activity of
|
apoptotic process
|
|
| 118312 |
AGTR2
|
|
increases_activity of
|
vasodilation
|
|
| 118328 |
Angiotensin III
|
|
increases_activity of
|
AGTR2
|
|
| 118358 |
Angiotensin A
|
|
decreases_activity of
|
AGTR2
|
|
|
19065996
|
Diabetes mellitus, type II
Insulin resistance
|
|
12,064
|
| 118371 |
AGTR2
|
|
is_expressed_in
|
endothelium
|
|
| 118416 |
AGTR2
|
|
increases_activity of
|
phosphatidylinositol 3-kinase signaling
|
|
| 118438 |
AGTR2
|
|
is_expressed_in
|
adipose tissue
|
|
|
19065996
|
Diabetes mellitus, type II
Insulin resistance
|
|
12,084
|
| 118740 |
AGTR2
|
NOT |
increases_expression of
|
SERPINE1
|
in aortic endothelial cells
|
|
7884001
|
Cardiovascular disease
|
|
12,087
|
| 118748 |
AGTR2
|
NOT |
increases_expression of
|
SERPINE1
|
in proximal tubular epithelial cells
|
|
10432384
|
Cardiovascular disease
|
|
12,181
|
| 119465 |
AGTR2
|
|
decreases_activity of
|
hypertension
|
|
| 119466 |
AGTR2
|
|
decreases_activity of
|
cardiac hypertrophy
|
|
| 119467 |
AGTR2
|
|
decreases_activity of
|
aortic hypertrophy
|
|
| 119468 |
AGTR2
|
|
decreases_activity of
|
fibrosis
|
|
| 119469 |
AGTR2
|
|
decreases_activity of
|
response to oxidative stress
|
|
| 119470 |
AGTR2
|
|
increases_quantity of
|
Collagen
|
|
| 119471 |
AGTR2
|
|
decreases_expression of
|
TGFB1
|
|
|
24463937
|
Cardiovascular disease
|
|
12,184
|
| 119516 |
AGTR2
|
NOT |
affects_quantity of
|
Procollagen
|
in fetal lung fibroblasts; in AngII-treated cells
|
|
12754187
|
Lung disease
|
|
12,194
|
| 119750 |
AGTR2
|
|
is_expressed_in
|
central nervous system
|
|
| 119789 |
AGTR2
|
|
increases_activity of
|
neuronal sprouting
|
|
| 119792 |
Angiotensin III
|
|
interacts (colocalizes) with
|
AGTR2
|
|
| 119804 |
AGTR2
|
|
affects_quantity of
|
NO
|
in brain
|
|
32127770
|
Neurodegenerative disorder
|
|
12,334
|
| 120993 |
AGTR2
|
|
increases_activity of
|
Breast cancer
|
|
| 121001 |
AGTR2
|
|
increases_expression of
|
PTPN6
|
|
| 121003 |
AGTR2
|
|
affects_activity of
|
MTUS1
|
|
| 121004 |
AGTR2
|
|
decreases_activity of
|
AKT1
|
|
| 121005 |
AGTR2
|
|
decreases_activity of
|
NOS3
|
|
| 121006 |
AGTR2
|
|
decreases_expression of
|
KDR
|
|
| 121007 |
AGTR2
|
|
decreases_activity of
|
cell migration
|
|
|
31525726
|
Obesity
Cancer
|
|
12,341
|
| 120801 |
AGTR2
|
NOT |
affects_quantity of
|
Aldosterone
|
in adrenal glomerulosa cells
|
|
1338730
|
Chronic kidney disease
|
|
13,515
|
| 127435 |
ERBB3
|
|
interacts (colocalizes) with
|
AGTR2
|
|
|
10710290
|
Cardiovascular disease
|
CIDeRplus