|
1,983
|
| 15556 |
Valsartan
|
|
decreases_activity of
|
AGTR1
|
|
|
15037562
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,987
|
| 15595 |
fat cell differentiation
|
|
increases_expression of
|
AGTR1
|
in adipose tissue
|
| 15601 |
Irbesartan
|
|
decreases_activity of
|
AGTR1
|
in adipose tissue
|
|
12031955
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,988
|
| 15613 |
Glucose
|
|
increases_expression of
|
AGTR1
|
in pancreas, in pancreatic islets
|
| 15618 |
Zofenopril
|
NOT |
increases_expression of
|
AGTR1
|
in pancreas, in pancreatic islets; after glucose stimulation
|
| 15621 |
Enalaprilat
|
NOT |
increases_expression of
|
AGTR1
|
in pancreas, in pancreatic islets; after glucose stimulation
|
|
16452552
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,989
|
| 15682 |
Angiotensin II type 1 receptor blocker
|
|
decreases_activity of
|
AGTR1
|
|
|
20809236
|
Diabetes mellitus, type II
Stroke, ischemic
Myocardial infarction
Insulin resistance
Cardiovascular disease
Nephropathy, diabetic
Retinopathy, diabetic
Neuropathy, diabetic
|
|
1,997
|
| 15770 |
Telmisartan
|
|
decreases_activity of
|
AGTR1
|
|
|
20390403
|
Diabetes mellitus, type II
Obesity
Insulin resistance
Fatty liver disease, nonalcoholic
|
|
1,999
|
| 15824 |
Valsartan
|
|
decreases_expression of
|
AGTR1
|
in adipose tissue; after high-fat diet
|
|
20100990
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,002
|
| 15887 |
Losartan
|
|
decreases_activity of
|
AGTR1
|
|
|
20808802
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,018
|
| 15991 |
Losartan
|
|
decreases_activity of
|
AGTR1
|
|
| 46088 |
AGTR1
|
|
is_expressed_in
|
adipose tissue
|
|
|
15705782
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,020
|
| 16004 |
hypertension
|
|
increases_expression of
|
AGTR1
|
in adipose tissue; in obese probands
|
| 16005 |
Cortisol
|
|
increases_expression of
|
AGTR1
|
in adipose tissue
|
| 16013 |
Insulin
|
NOT |
affects_expression of
|
AGTR1
|
in adipose tissue
|
| 16018 |
Estradiol
|
NOT |
affects_expression of
|
AGTR1
|
in adipose tissue
|
| 16023 |
Triiodothyronine
|
NOT |
affects_expression of
|
AGTR1
|
in adipose tissue
|
| 16028 |
Angiotensin II
|
NOT |
affects_expression of
|
AGTR1
|
in adipose tissue
|
|
12011658
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
2,039
|
| 16269 |
AGTR1
|
NOT |
affects_quantity of
|
mitochondrion
|
|
| 16271 |
AGTR1
|
|
affects_quantity of
|
Reactive oxygen species
|
in mitochondria
|
| 16273 |
AGTR1
|
|
affects_activity of
|
regulation of mitochondrial membrane potential
|
|
| 16283 |
AGTR1
|
|
affects_quantity of
|
Triacylglycerol
|
in skeletal muscle
|
| 16288 |
AGTR1
|
NOT |
affects_expression of
|
PPARGC1A
|
|
| 16290 |
AGTR1
|
NOT |
affects_expression of
|
TFAM
|
|
| 16296 |
AGTR1
|
|
affects_quantity of
|
Mitochondrial respiratory chain complex V
|
in mitochondria
|
| 16297 |
AGTR1
|
|
affects_quantity of
|
Mitochondrial respiratory chain complex IV
|
in mitochondria
|
| 16298 |
AGTR1
|
|
affects_expression of
|
ACADM
|
in mitochondria
|
|
19074984
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,046
|
| 16338 |
Valsartan
|
|
decreases_activity of
|
AGTR1
|
|
|
18787107
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,122
|
| 17389 |
HDL
|
|
decreases_expression of
|
AGTR1
|
in aorta
|
| 17399 |
hyperglycemia
|
|
increases_expression of
|
AGTR1
|
in aorta
|
| 17400 |
HDL
|
|
decreases_expression of
|
AGTR1
|
in aorta; if induced by hyperglycemia
|
|
19273745
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,129
|
| 17500 |
obese Zucker rat
|
|
increases_quantity of
|
AGTR1
|
|
| 17508 |
Nebivolol
|
|
decreases_quantity of
|
AGTR1
|
in obese Zucker rats
|
|
21177830
|
Diabetes mellitus, type II
Insulin resistance
|
|
6,600
|
| 63216 |
Metformin
|
|
decreases_expression of
|
AGTR1
|
in the aorta
|
|
25527624
|
Diabetes mellitus, type II
Insulin resistance
|
|
7,511
|
| 74119 |
AHR
|
|
affects_expression of
|
AGTR1
|
|
|
20878756
|
Diabetes mellitus, type II
Insulin resistance
Inflammatory bowel disease
|
|
7,665
|
| 76781 |
mir-155
|
|
decreases_expression of
|
AGTR1
|
|
|
26550492
|
Gestational diabetes mellitus
|
|
8,191
|
| 82501 |
Angiotensin II
|
|
increases_activity of
|
AGTR1
|
|
| 82503 |
AGTR1
|
|
increases_activity of
|
Protein kinase C
|
|
|
26043887
|
Diabetes mellitus, type II
Insulin resistance
Nephropathy, diabetic
|
|
9,551
|
| 101279 |
VAV2
|
|
affects_expression of
|
AGTR1
|
|
|
17202406
|
Cardiovascular disease
|
|
11,709
|
| 116209 |
ACE inhibitor
|
|
decreases_activity of
|
AGTR1
|
|
| 116224 |
Angiotensin II type 1 receptor blocker
|
|
decreases_activity of
|
AGTR1
|
|
|
29598869
|
Cardiovascular disease
|
|
11,717
|
| 116305 |
Obesity
|
|
increases_expression of
|
AGTR1
|
in pancreas
|
| 116324 |
AGTR1
|
|
is_expressed_in
|
pancreatic islet
|
|
| 116333 |
Insulin resistance
|
|
increases_expression of
|
AGTR1
|
in pancreas
|
| 116335 |
AGTR1
|
|
decreases_activity of
|
proinsulin synthesis
|
in pancreas
|
| 116341 |
AGTR1
|
|
increases_activity of
|
response to oxidative stress
|
in pancreas
|
| 116343 |
AGTR1
|
|
increases_activity of
|
apoptotic process
|
in pancreas
|
| 116345 |
AGTR1
|
|
increases_activity of
|
pancreas fibrosis
|
|
| 116395 |
ACE2
|
|
affects_expression of
|
AGTR1
|
in pancreas
|
| 116409 |
Angiotensin II
|
|
increases_activity of
|
AGTR1
|
|
| 116410 |
AGTR1
|
|
increases_activity of
|
vasoconstriction
|
|
| 116411 |
AGTR1
|
|
increases_activity of
|
inflammatory response
|
|
| 116412 |
AGTR1
|
|
increases_activity of
|
pancreas fibrosis
|
|
| 116413 |
AGTR1
|
|
increases_activity of
|
response to oxidative stress
|
|
| 116416 |
AGTR1
|
|
affects_activity of
|
insulin secretion involved in cellular response to glucose stimulus
|
|
| 116417 |
AGTR1
|
|
affects_activity of
|
glucagon secretion
|
|
| 116418 |
AGTR1
|
|
affects_expression of
|
IRS1
|
in pancreatic islets
|
| 116419 |
AGTR1
|
|
affects_expression of
|
IRS2
|
in pancreatic islets
|
| 116420 |
AGTR1
|
|
affects_expression of
|
Phosphatidylinositol 3-kinase
|
in pancreatic islets
|
| 116421 |
AGTR1
|
|
affects_expression of
|
AKT2
|
in pancreatic islets
|
| 116422 |
AGTR1
|
|
affects_activity of
|
SLC2A2
|
in pancreatic islets
|
| 116423 |
AGTR1
|
|
affects_activity of
|
GCK
|
in pancreatic islets
|
| 116424 |
AGTR1
|
|
increases_expression of
|
IL1B
|
in pancreatic islets
|
| 116425 |
AGTR1
|
|
increases_activity of
|
NF-kappaB complex
|
in pancreatic islets
|
| 116426 |
AGTR1
|
|
increases_expression of
|
NOS2
|
in pancreatic islets
|
| 116427 |
Valsartan
|
|
decreases_activity of
|
AGTR1
|
|
| 116433 |
TNFRSF11B
|
|
increases_expression of
|
AGTR1
|
|
|
30404071
|
Diabetes mellitus, type II
Insulin resistance
|
|
11,748
|
| 116371 |
Angiotensin II
|
|
increases_activity of
|
AGTR1
|
|
| 116372 |
Angiotensin IV
|
|
increases_activity of
|
AGTR1
|
|
|
32333398
|
COVID-19
|
|
11,757
|
| 116446 |
AGTR1
|
|
increases_activity of
|
apoptotic process
|
in alveolar epithelial cell-derived carcinoma cell line A549
|
|
11880296
|
COVID-19
|
|
11,776
|
| 116578 |
Angiotensin II
|
|
increases_activity of
|
AGTR1
|
|
|
23463883
|
Diabetes mellitus, type II
Insulin resistance
Cardiovascular disease
|
|
11,821
|
| 116760 |
MAS1
|
|
decreases_activity of
|
AGTR1
|
|
|
32341442
|
COVID-19
|
|
11,830
|
| 116887 |
AGTR1
|
|
affects_activity of
|
lung failure
|
in SARS-CoV S protein-treated mice
|
| 116888 |
AGTR1
|
|
affects_activity of
|
pulmonary edema
|
in SARS-CoV S protein-treated mice
|
|
16007097
|
SARS-CoV infection
|
|
11,899
|
| 117239 |
AGTR1
|
|
increases_activity of
|
ADAM17
|
in cerebrospinal fluid; during the development of DOCA-salt hypertension
|
|
28512108
|
Neurological
SARS-CoV infection
|
|
11,902
|
| 117160 |
AGTR1
|
|
increases_activity of
|
ADAM17
|
in the hypothalamus ; during DOCA-salt hypertension
|
|
28512108
|
Neurological
|
|
11,920
|
| 117253 |
Angiotensin A
|
|
increases_activity of
|
AGTR1
|
|
|
17138938
|
Cardiovascular disease
|
|
11,924
|
| 117260 |
AGTR1
|
|
increases_activity of
|
ADAM17
|
in myocardium
|
|
24332999
|
Endocrine
|
|
11,933
|
| 117309 |
Angiotensin II
|
|
interacts (colocalizes) with
|
AGTR1
|
in HEK293 cells
|
| 117310 |
Angiotensin III
|
|
interacts (colocalizes) with
|
AGTR1
|
in HEK293 cells
|
| 117311 |
Candesartan
|
|
interacts (colocalizes) with
|
AGTR1
|
in HEK293 cells
|
|
21542804
|
Cardiovascular disease
|
CIDeRplus