|
101
|
| 337 |
SOD1-p.A4V
|
|
affects_activity of
|
response to endoplasmic reticulum stress
|
in motor neurons
|
| 342 |
SOD1-p.G85R
|
|
affects_activity of
|
response to endoplasmic reticulum stress
|
in motor neurons
|
| 343 |
SOD1-p.G93A
|
|
affects_activity of
|
response to endoplasmic reticulum stress
|
in motor neurons
|
|
18519638
|
Amyotrophic lateral sclerosis
|
|
124
|
| 444 |
Amyotrophic lateral sclerosis
|
|
affects_activity of
|
response to endoplasmic reticulum stress
|
|
|
19762508
|
Amyotrophic lateral sclerosis
|
|
143
|
| 513 |
VAPB-p.P56S
|
NOT |
affects_activity of
|
response to endoplasmic reticulum stress
|
|
| 732 |
VAPB
|
|
increases_activity of
|
response to endoplasmic reticulum stress
|
|
|
19183264
|
Amyotrophic lateral sclerosis
|
|
151
|
| 587 |
SOD1-p.G85R
|
|
increases_activity of
|
response to endoplasmic reticulum stress
|
if mutant SOD1 is over-expressed
|
|
18233996
|
Amyotrophic lateral sclerosis
|
|
172
|
| 691 |
SOD1-p.G93A
|
|
increases_activity of
|
response to endoplasmic reticulum stress
|
in motoneurons; from stage P12 up to P26
|
| 746 |
Salubrinal
|
|
decreases_activity of
|
response to endoplasmic reticulum stress
|
in mutant SOD1-G93A-fast mice
|
| 747 |
CNTF
|
|
decreases_activity of
|
response to endoplasmic reticulum stress
|
in mutant SOD1-G93A-fast mice
|
|
19330001
|
Amyotrophic lateral sclerosis
|
|
196
|
| 784 |
SOD1-p.G93A
|
|
increases_activity of
|
response to endoplasmic reticulum stress
|
|
|
18077368
|
Amyotrophic lateral sclerosis
|
|
261
|
| 1071 |
VAPB
|
|
increases_activity of
|
response to endoplasmic reticulum stress
|
if VAPB is overexpressed
|
| 1073 |
VAPB-p.P56S
|
NOT |
increases_activity of
|
response to endoplasmic reticulum stress
|
if P56S-VAPB is overexpressed
|
| 1074 |
VAPA
|
|
increases_activity of
|
response to endoplasmic reticulum stress
|
if VAPA is overexpressed
|
| 1075 |
VAPA-p.P56S
|
NOT |
increases_activity of
|
response to endoplasmic reticulum stress
|
if P56S-VAPA is overexpressed
|
| 1076 |
VAMP1
|
NOT |
increases_activity of
|
response to endoplasmic reticulum stress
|
if VAMP1 is overexpressed
|
| 1077 |
VAMP2
|
NOT |
increases_activity of
|
response to endoplasmic reticulum stress
|
if VAMP2 is overexpressed
|
|
16891305
|
Amyotrophic lateral sclerosis
|
|
368
|
| 1510 |
response to endoplasmic reticulum stress
|
|
decreases_activity of
|
IRS2
|
|
| 1517 |
HSPA5
|
|
decreases_activity of
|
response to endoplasmic reticulum stress
|
|
| 12606 |
ob/ob mouse
|
|
decreases_activity of
|
response to endoplasmic reticulum stress
|
in liver
|
| 12625 |
Obesity
|
|
increases_activity of
|
response to endoplasmic reticulum stress
|
|
|
19363290
|
Diabetes mellitus, type II
Obesity
Insulin resistance
Fatty liver disease, nonalcoholic
|
|
369
|
| 1484 |
response to endoplasmic reticulum stress
|
|
increases_quantity of
|
SREBF1c
|
in liver
|
|
19363290
|
Diabetes mellitus, type II
Insulin resistance
Fatty liver disease, nonalcoholic
|
|
421
|
| 1851 |
LRRK2
|
|
affects_activity of
|
response to endoplasmic reticulum stress
|
|
|
19251702
|
Parkinson disease
|
|
556
|
| 2878 |
response to endoplasmic reticulum stress
|
|
increases_transport of
|
HDAC6
|
into aggresome
|
|
14675537
|
Dementia, Lewy body
Parkinson disease
|
|
692
|
| 3797 |
Tunicamycin
|
|
increases_activity of
|
response to endoplasmic reticulum stress
|
|
| 3806 |
L-Azetidine 2-carboxylic acid
|
|
increases_activity of
|
response to endoplasmic reticulum stress
|
|
| 3814 |
response to endoplasmic reticulum stress
|
|
increases_dissociation of
|
ERN1
|
from the ER membrane
|
| 3841 |
response to endoplasmic reticulum stress
|
|
increases_activity of
|
MAPK3
|
|
|
15201339
|
Amyotrophic lateral sclerosis
|
|
694
|
| 3799 |
ERN1
|
|
increases_activity of
|
response to endoplasmic reticulum stress
|
|
|
15201339
|
Amyotrophic lateral sclerosis
|
|
714
|
| 4030 |
response to endoplasmic reticulum stress
|
|
decreases_activity of
|
APOB
|
in liver; if ER stress is lipid-induced
|
| 4031 |
response to endoplasmic reticulum stress
|
|
increases_activity of
|
Fatty liver disease, nonalcoholic
|
in liver; if ER stress is lipid-induced
|
|
18927507
|
Diabetes mellitus, type II
Abetalipoproteinemia
Insulin resistance
Fatty liver disease, nonalcoholic
Cardiovascular disease
|
|
738
|
| 4141 |
Tunicamycin
|
|
increases_activity of
|
response to endoplasmic reticulum stress
|
|
| 4144 |
Thapsigargin
|
|
increases_activity of
|
response to endoplasmic reticulum stress
|
|
| 13355 |
response to endoplasmic reticulum stress
|
|
increases_quantity of
|
SOD1 protein aggregates
|
in mutant SOD1L84V mice
|
|
17925878
|
Amyotrophic lateral sclerosis
|
|
784
|
| 4384 |
HSPA5
|
|
affects_activity of
|
response to endoplasmic reticulum stress
|
|
| 4473 |
Thapsigargin
|
|
increases_activity of
|
response to endoplasmic reticulum stress
|
|
|
19816510
|
Amyotrophic lateral sclerosis
|
|
793
|
| 4561 |
Thapsigargin
|
|
increases_activity of
|
response to endoplasmic reticulum stress
|
|
|
16835242
|
Amyotrophic lateral sclerosis
|
|
892
|
| 5260 |
Thapsigargin
|
|
increases_activity of
|
response to endoplasmic reticulum stress
|
|
| 5261 |
response to endoplasmic reticulum stress
|
|
increases_expression of
|
XBP1
|
XBP1(S) mRNA (spliced XBP1 mRNA)
|
|
19622636
|
Neurological
Amyotrophic lateral sclerosis
|
|
932
|
| 5635 |
response to endoplasmic reticulum stress
|
|
increases_quantity of
|
HSPA5
|
|
| 5640 |
response to endoplasmic reticulum stress
|
|
increases_quantity of
|
DDIT3
|
|
| 5641 |
response to endoplasmic reticulum stress
|
|
increases_phosphorylation of
|
AKT1
|
|
|
20020442
|
Amyotrophic lateral sclerosis
|
|
947
|
| 5858 |
SIRT1
|
|
affects_activity of
|
response to endoplasmic reticulum stress
|
in liver; on high-fat diet, if SIRT1 is knocked out in liver
|
|
19356714
|
Diabetes mellitus, type II
Insulin resistance
Fatty liver disease, nonalcoholic
|
|
966
|
| 5954 |
response to endoplasmic reticulum stress
|
|
increases_expression of
|
HSPA5
|
|
| 5957 |
response to endoplasmic reticulum stress
|
|
increases_expression of
|
DDIT3
|
|
| 5958 |
response to endoplasmic reticulum stress
|
|
increases_phosphorylation of
|
EIF2S1
|
|
| 5960 |
response to endoplasmic reticulum stress
|
|
increases_phosphorylation of
|
AKT1
|
|
| 5963 |
response to endoplasmic reticulum stress
|
|
increases_activity of
|
AKT1
|
|
| 5983 |
response to endoplasmic reticulum stress
|
|
increases_activity of
|
MAPK3
|
|
| 5984 |
response to endoplasmic reticulum stress
|
|
increases_activity of
|
MAPK1
|
|
| 5985 |
response to endoplasmic reticulum stress
|
|
increases_phosphorylation of
|
MAPK8
|
|
|
15339911
|
Amyotrophic lateral sclerosis
|
|
975
|
| 5994 |
response to endoplasmic reticulum stress
|
|
increases_expression of
|
XIAP
|
|
| 5995 |
response to endoplasmic reticulum stress
|
|
increases_expression of
|
BIRC3
|
|
|
15339911
|
Amyotrophic lateral sclerosis
|
|
1,020
|
| 6366 |
response to endoplasmic reticulum stress
|
|
increases_quantity of
|
ERN1
|
|
| 6368 |
response to endoplasmic reticulum stress
|
|
increases_activity of
|
ATF6
|
|
| 6396 |
response to endoplasmic reticulum stress
|
|
increases_expression of
|
HSPA5
|
|
| 6398 |
response to endoplasmic reticulum stress
|
|
increases_activity of
|
EIF2AK3
|
|
| 6400 |
response to endoplasmic reticulum stress
|
|
increases_activity of
|
EIF2S1
|
|
| 6401 |
response to endoplasmic reticulum stress
|
|
increases_activity of
|
DDIT3
|
|
| 6402 |
response to endoplasmic reticulum stress
|
|
increases_activity of
|
ATF4
|
|
|
17991856
|
Amyotrophic lateral sclerosis
|
|
1,034
|
| 6499 |
VAPB-p.P56S
|
|
affects_activity of
|
response to endoplasmic reticulum stress
|
|
|
18555774
|
Amyotrophic lateral sclerosis
|
|
1,092
|
| 7354 |
response to endoplasmic reticulum stress
|
|
increases_activity of
|
Insulin resistance
|
via JNK-mediated Ser phosphorylation of IRS1
|
| 7356 |
response to endoplasmic reticulum stress
|
|
increases_activity of
|
MAPK8
|
|
|
18053812
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
1,299
|
| 8883 |
Obesity
|
|
increases_activity of
|
response to endoplasmic reticulum stress
|
in liver, in adipose tissue
|
| 8930 |
XBP1
|
|
affects_activity of
|
response to endoplasmic reticulum stress
|
|
|
15486293
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
1,306
|
| 8918 |
response to endoplasmic reticulum stress
|
|
decreases_activity of
|
insulin receptor signaling pathway
|
in liver
|
| 8922 |
response to endoplasmic reticulum stress
|
|
increases_activity of
|
MAPK8
|
in liver
|
|
15486293
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,311
|
| 8957 |
Sodium phenylbutyrate
|
|
decreases_activity of
|
response to endoplasmic reticulum stress
|
in liver, in adipose tissue
|
| 72603 |
Tauroursodeoxycholic acid
|
|
decreases_activity of
|
response to endoplasmic reticulum stress
|
in liver
|
| 72606 |
response to endoplasmic reticulum stress
|
|
increases_activity of
|
glucose import
|
in liver, in adipose tissue; via decreasing ER stress
|
|
16931765
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,371
|
| 9371 |
LRRK2
|
|
affects_activity of
|
response to endoplasmic reticulum stress
|
|
|
20720502
|
Parkinson disease
|
|
1,454
|
| 10261 |
response to endoplasmic reticulum stress
|
|
increases_expression of
|
DDIT3
|
in adipose tissue
|
| 10263 |
response to endoplasmic reticulum stress
|
|
decreases_expression of
|
CEBPA
|
in adipose tissue
|
| 10265 |
response to endoplasmic reticulum stress
|
|
decreases_expression of
|
SLC2A4
|
in adipose tissue
|
|
17698029
|
Diabetes mellitus, type II
Insulin resistance
|
CIDeRplus