|
125
|
| 13588 |
SNCA
|
|
increases_activity of
|
release of cytochrome c from mitochondria
|
if SNCA is overexpressed
|
| 13589 |
SNCA-p.A53T
|
|
increases_activity of
|
release of cytochrome c from mitochondria
|
if SNCA-p.A53T is overexpressed
|
|
18322646
|
Parkinson disease
|
|
214
|
| 13590 |
LRRK2-p.R1441C
|
|
increases_activity of
|
release of cytochrome c from mitochondria
|
|
| 13591 |
LRRK2
|
NOT |
increases_activity of
|
release of cytochrome c from mitochondria
|
|
|
17409193
|
Parkinson disease
|
|
350
|
| 1427 |
FAS
|
|
increases_activity of
|
release of cytochrome c from mitochondria
|
in Fas-activated motoneurons
|
| 1428 |
p38 MAPK
|
|
increases_activity of
|
release of cytochrome c from mitochondria
|
in Fas-activated motoneurons
|
|
12354397
|
Amyotrophic lateral sclerosis
|
|
495
|
| 2384 |
release of cytochrome c from mitochondria
|
|
increases_activity of
|
neuron apoptotic process
|
|
| 2385 |
H2O2
|
|
increases_activity of
|
release of cytochrome c from mitochondria
|
|
| 2389 |
PINK1
|
|
decreases_activity of
|
release of cytochrome c from mitochondria
|
under stress conditions
|
| 2393 |
PINK1-p.W437X
|
NOT |
decreases_activity of
|
release of cytochrome c from mitochondria
|
under stress conditions
|
| 2398 |
PINK1-p.G309D
|
|
increases_activity of
|
release of cytochrome c from mitochondria
|
under stress conditions
|
| 2402 |
PINK1-p.L347P
|
|
increases_activity of
|
release of cytochrome c from mitochondria
|
under stress conditions
|
|
17579517
|
Parkinson disease
|
|
737
|
| 4129 |
6-OHDA
|
|
increases_activity of
|
release of cytochrome c from mitochondria
|
|
|
18665912
|
Parkinson disease
|
|
1,356
|
| 9253 |
BAX
|
|
increases_activity of
|
release of cytochrome c from mitochondria
|
if BAX is relocated from the cytosol to the mitochondria
|
| 9281 |
Cardiolipin
|
|
increases_activity of
|
release of cytochrome c from mitochondria
|
if cardiolipin has been oxidized by ROS
|
| 13592 |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
|
|
increases_activity of
|
release of cytochrome c from mitochondria
|
|
| 13593 |
release of cytochrome c from mitochondria
|
|
increases_activity of
|
neuron apoptotic process
|
by activating CASP9/3
|
|
16365298
|
Parkinson disease
|
|
1,424
|
| 9915 |
PINK1
|
|
decreases_activity of
|
release of cytochrome c from mitochondria
|
thus reducing mitochondrial induced apoptosis
|
|
20045449
|
Parkinson disease
|
|
1,462
|
| 10323 |
SOD1-p.G93A
|
|
increases_activity of
|
release of cytochrome c from mitochondria
|
|
| 10328 |
SOD1-p.A4V
|
|
increases_activity of
|
release of cytochrome c from mitochondria
|
|
|
20460269
|
Amyotrophic lateral sclerosis
|
|
1,463
|
| 10335 |
MutSOD1-Bcl-2 complex
|
|
increases_activity of
|
release of cytochrome c from mitochondria
|
|
|
20460269
|
Amyotrophic lateral sclerosis
|
|
1,885
|
| 14314 |
convulsive seizures
|
|
increases_activity of
|
release of cytochrome c from mitochondria
|
|
|
19178557
|
Status epilepticus
|
|
1,902
|
| 14539 |
Lipoate
|
|
decreases_activity of
|
release of cytochrome c from mitochondria
|
in pilocarpine model
|
| 14540 |
release of cytochrome c from mitochondria
|
|
increases_activity of
|
CASP3
|
in pilocarpine model
|
|
21062633
|
Epilepsy
Status epilepticus
|
|
1,957
|
| 15508 |
Oxoglutarate dehydrogenase
|
|
decreases_activity of
|
release of cytochrome c from mitochondria
|
to the cytosol
|
|
19076444
|
Alzheimer disease
|
|
2,423
|
| 22484 |
Schisandrin B
|
|
decreases_activity of
|
release of cytochrome c from mitochondria
|
into cytosol
|
|
19694182
|
Alzheimer disease
|
|
2,994
|
| 27252 |
PAX4
|
|
affects_activity of
|
release of cytochrome c from mitochondria
|
if cytokine-mediated
|
|
21521872
|
Diabetes mellitus, type II
Insulin resistance
|
|
5,022
|
| 49630 |
OLR1
|
|
increases_activity of
|
release of cytochrome c from mitochondria
|
|
|
14684629
|
Cardiovascular disease
Atherosclerosis
|
|
5,070
|
| 49871 |
response to oxidative stress
|
|
increases_activity of
|
release of cytochrome c from mitochondria
|
in cardiomyocytes
|
| 49872 |
FLT3LG
|
|
decreases_activity of
|
release of cytochrome c from mitochondria
|
in cardiomyocytes; if cytochrome c release has been induced by oxidative stress
|
| 49876 |
FLT3L-FLT3 signaling
|
|
decreases_activity of
|
release of cytochrome c from mitochondria
|
in cardiomyocytes; if cytochrome c release has been induced by oxidative stress
|
|
24184252
|
Myocardial infarction
|
|
5,802
|
| 54738 |
HNF1A-mut
|
|
increases_activity of
|
release of cytochrome c from mitochondria
|
|
|
11724785
|
Diabetes mellitus, type II
Insulin resistance
|
|
6,263
|
| 58955 |
Gamma-secretase inhibitor MRK-003
|
|
increases_activity of
|
release of cytochrome c from mitochondria
|
|
|
19775282
|
Cancer
Leukemia
|
|
6,900
|
| 68025 |
abnormal mitochondrial physiology
|
|
increases_activity of
|
release of cytochrome c from mitochondria
|
|
|
27127460
|
Diabetes mellitus, type II
Insulin resistance
|
|
6,902
|
| 68087 |
Metformin
|
|
increases_activity of
|
release of cytochrome c from mitochondria
|
in LAN5 neuroblastoma cells
|
| 68097 |
Insulin
|
|
decreases_activity of
|
release of cytochrome c from mitochondria
|
in LAN5 neuroblastoma cells; if cells are treated with metformin
|
|
25667085
|
Diabetes mellitus, type II
Insulin resistance
|
|
7,388
|
| 72628 |
BID
|
|
affects_activity of
|
release of cytochrome c from mitochondria
|
|
| 72638 |
protein kinase B signaling
|
|
decreases_activity of
|
release of cytochrome c from mitochondria
|
via phosphorylation
|
|
11549346
|
Atherosclerosis
|
|
7,808
|
| 78286 |
FASLG
|
|
increases_activity of
|
release of cytochrome c from mitochondria
|
in CASP8-deficient Jurkat cells
|
|
15772077
|
Cancer
|
|
10,404
|
| 107708 |
CD437
|
|
affects_activity of
|
release of cytochrome c from mitochondria
|
|
|
12958071
|
Acute promyelocytic leukemia
|
|
11,300
|
| 113587 |
BID
|
|
increases_activity of
|
release of cytochrome c from mitochondria
|
Caspase-8 then activates Bid, allowing releasing cytochrome c from mitochondria, which then forms apoptosome with caspase-3, 7 and 9
|
| 113588 |
release of cytochrome c from mitochondria
|
|
increases_activity of
|
apoptosome assembly
|
Caspase-8 then activates Bid, allowing releasing cytochrome c from mitochondria, which then forms apoptosome with caspase-3, 7 and 9
|
| 113589 |
release of cytochrome c from mitochondria
|
|
increases_quantity of
|
apoptosome
|
Caspase-8 then activates Bid, allowing releasing cytochrome c from mitochondria, which then forms apoptosome with caspase-3, 7 and 9
|
|
30590907
|
Alzheimer disease
Metabolic
|
|
11,358
|
| 114101 |
apoptotic signaling pathway
|
|
increases_activity of
|
release of cytochrome c from mitochondria
|
Cytochrome c is released from mitochondria upon activation of apoptotic pathways
|
| 114135 |
release of cytochrome c from mitochondria
|
|
increases_activity of
|
calcium ion transport
|
when cytochrome c is released from mitochondria upon activation of apoptotic pathways
|
| 114136 |
release of cytochrome c from mitochondria
|
|
increases_activity of
|
apoptotic signaling pathway
|
when cytochrome c is released from mitochondria upon activation of apoptotic pathways
|
|
19144519
|
Metabolic
|
|
11,371
|
| 113852 |
BBC3
|
|
affects_activity of
|
release of cytochrome c from mitochondria
|
|
|
11463392
|
Metabolic
|
|
11,639
|
| 115868 |
Estrogen
|
|
decreases_activity of
|
release of cytochrome c from mitochondria
|
in female heart mitochondria; estrogens protect heart mitochondria from high calcium-induced release of cytochrome c
|
|
28424375
|
Alzheimer disease
Metabolic
|
|
12,180
|
| 119454 |
decreased mitochondrion activity
|
|
increases_activity of
|
release of cytochrome c from mitochondria
|
via interaction of full-length Abeta or truncated forms with mitochondria, leading to cytochrome C release
|
|
18845536
|
Alzheimer disease
|
|
12,244
|
| 120307 |
decreased PACS2 level
|
|
decreases_activity of
|
release of cytochrome c from mitochondria
|
blocking both caspase-3 activation and the apoptotic release of ER calcium
|
| 120308 |
release of cytochrome c from mitochondria
|
|
increases_activity of
|
CASP3
|
|
|
15692567
|
Metabolic
|
|
14,229
|
| 134334 |
Angiotensin II
|
|
increases_activity of
|
release of cytochrome c from mitochondria
|
in dopaminergic neurons; via AGTR1
|
| 134336 |
Losartan
|
|
decreases_activity of
|
release of cytochrome c from mitochondria
|
in dopaminergic neurons; via AGTR1
|
|
27733642
|
Parkinson disease
|
CIDeRplus